The invention belongs to the technical field of Chinese herbal medicine and relates to externally applied medicine for treating beriberi and a preparation method of the externally applied medicine. The externally applied medicine solves the technical problems that the compatibility is not reasonable enough and the curative effect is poor in the prior art. The externally applied medicine comprises the following components in parts by weight: 1-3 parts of fructus cnidii, 4-6 parts of folium artemisiae argyi, 1-3 parts of radix angelicae pubescentis, 2-4 parts of grassleaf sweelflag rhizome, 2-4 parts of rhizoma atractylodis, 8-12 parts of mint, 4-6 parts of amoorcorn tree bark, 4-6 parts of radix scutellariae, 2-4 parts of radix sophorae flavescentis, 1-3 parts of fructus kochiae, 4-6 parts of oriental wormwood, 2-4 parts of gardenia, 12-18 parts of honeysuckle, 8-12 parts of ginger, 2-4 parts of tea, 1-3 parts of radix stemonae, 4-6 parts of Chinese lobelia, 4-6 parts of tuber fleeceflower stems, and 10-14 parts of rice vinegar. The externally applied medicine has the advantages that the externally applied medicine has the effects of alleviating pain, stopping pyemia, sterilizing, preventing inflammation and viruses, removing necrotic tissues, promoting tissue regeneration and improving immune cell functions. In addition, the externally applied medicine is simple to manufacture, low in cost, good in effect and suitable for industrial processing and production.