154 results about "Benzopyrone" patented technology

The invention discloses a preparation method of an agricultural bactericide. The method includes following steps: carrying out a reaction between 3-isochromanone, which is used for a starting raw material, and an acetol of a formamide compound, performing hydrolysis to obtain 4-([alpha]-hydroxyl)-methylene-2-H-benzopyrane-3-(4H)-one, performing methylation to obtain 4-(methoxylmethylene)-3-isobenzopyrone, preparing (E)-2-(2-halomethyl)-3-methoxylmethyl acrylate from the 4-(methoxylmethylene)-3-isobenzopyrone in methanol, a third inert solvent and a halogenation reagent, and performing a reaction between the (E)-2-(2-halomethyl)-3-methoxylmethyl acrylate and 2-hydroxyl-6-trifluoromethylpyridine or 6-trifluoromethyl-2-pyridine alkoxide to obtain picoxystrobin. The method is short in reaction processes, is mild in conditions, is simple and convenient in post treatment, is less in waste gas, waste water and waste solid, is high in yield and is suitable for industrial production. Appearance of the agricultural bactericide is good and an external standard content of the agricultural bactericide is more than 98%.

The invention discloses a method for synthesizing high-efficiency green agriculture bactericide. The method comprises the following steps: preparing 4-(alpha-hydroxyl) methylene-2-H-benzopyran-3-(4H)-ketone by taking 3-isodihydrocoumarin as an initial raw material, performing methylation to obtain 4-(methoxy-methylene)-3-isobenzopyrone, reacting 4-(methoxy-methylene)-3-isobenzopyrone with a halogenations reagent and methanol to obtain (E)-2-(2-halogen methyl phenyl)-3-methoxy-methyl acrylate, and reacting (E)-2-(2-halogen methyl phenyl)-3-methoxy-methyl acrylate with 2-hydroxyl-6-trifluoromethyl picoline or 6-trifluoromethyl-2-pyridine alcoholate, thereby obtaining picoxystrobin. The method is short in reaction step, gentle in condition, simple, convenient and feasible in aftertreatment, less in waste water, waste gas and waste residue, low in cost, high in yield, applicable to industrialization production and good in product appearance, and the external standard content is greater than 98%.

Benzopyranone Compounds having the following structure:wherein R1, R2, X, Y and n are as defined herein, are disclosed. The Benzopyranone Compounds are useful for treating or preventing a bone-resorbing disease, a neoplastic disease, arthritis, a disease exacerbated by the presence of estrogen or a disease improved by the presence of estrogen, comprising administering an effective amount of a Benzopyranone Compound to a patient in need of the treating or preventing; activating the function of estrogen receptor (“ER”) in a bone cell; inhibiting the function of ER in a cancer cell; inhibiting the expression of interleukin-6 (“IL-6”) in a cell; and inhibiting the growth of a neoplastic cell, comprising contacting the cell with an effective amount of a Benzopyranone Compound.

The present invention provides compositions of matter, kits and methods for their use in the treatment of cancer. In particular, the invention provides compositions and methods for treating cancer in a subject by inhibiting a poly-ADP-ribose polymerase, as well as providing formulations and modes of administering such compositions.