The invention provides a
microfluidic chip for constructing a bionic
lung cancer brain metastasis model to solve the problem of the current difficulty in constructing a
blood brain barrier for the
lung cancer brain metastasis and incapability to achieve intuitive observation and the like. The
microfluidic chip comprises a bionic
lung portion and a bionic brain portion and is characterized in thatthe bionic lung portion is disposed on the upstream of the
chip and comprises a three-layer structure including an upper substrate layer, an intermediate
porous film layer and a lower substrate layer.The three-layer structure is provided with a gas channel, a liquid channel and a vacuum channel. The bionic brain portion is disposed on the downstream of the
chip, and comprises a two-layer structure including an upper substrate layer and a lower substrate layer. The upper substrate layer is a cover layer. The lower substrate layer comprises a brain
parenchyma chamber, and a blood brain barrierring is arranged outside the brain
parenchyma chamber. A
blood vessel cavity is arranged outside the
blood brain barrier ring. The
blood vessel cavity is connected with the liquid channel on the lowersubstrate layer of the bionic lung portion through a connecting channel. The
blood brain barrier ring is provided with a
micro gap structure communicated with the brain
parenchyma chamber and the vascular chamber. The vascular chamber and the brain parenchyma chamber are provided with an inlet and an outlet for the liquid to flow in and out.