293 results about "Parenchyma" patented technology

Aspects of the present disclosure include a surgical device comprising electrodes on the sides of an end of an effector to aide in sealing during various surgical procedures, such as a liver resection. During a sealing procedure, the surgeon may wipe the surgical site with the end effector, causing the electrodes to touch the fractured area. Electrosurgical energy may be applied to the electrodes during the wiping, causing coagulation of smaller vessels, such as tiny blood vessels and bile ducts in the parenchyma of the liver. In some cases, due to the nature of some smaller vessels, electrosurgical energy should be delicately applied to cause sealing but to avoid overly damaging the remaining tissue. In some embodiments, the thin design of the electrodes allows for an appropriate amount of electrosurgical energy to be applied to the fractured area.

Aspects of the present disclosure include a surgical device comprising electrodes on the sides of an end of an effector to aide in sealing during various surgical procedures, such as a liver resection. During a sealing procedure, the surgeon may wipe the surgical site with the end effector, causing the electrodes to touch the fractured area. Electrosurgical energy may be applied to the electrodes during the wiping, causing coagulation of smaller vessels, such as tiny blood vessels and bile ducts in the parenchyma of the liver. In some cases, due to the nature of some smaller vessels, electrosurgical energy should be delicately applied to cause sealing but to avoid overly damaging the remaining tissue. In some embodiments, the thin design of the electrodes allows for an appropriate amount of electrosurgical energy to be applied to the fractured area.

An image navigation integrated dental implant system includes a control unit for storing and transmitting data streams, a scan module electrically connected to the control unit for scanning and taking the pictures of the soft tissue and hard tissue of the parenchyma of the oral cavity of a patient and the related external skin color and transmitting the obtained data to the control unit, a design module electrically connected to the control unit for receiving the oral cavity data from the control unit and using the data to design a oral cavity simulation diagram, and a navigator module electrically connected to the control unit for receiving the oral cavity data and photographing the oral cavity and then providing a picture to guide the dentist to perform the dental implant surgery.

Embodiments herein provide a non-invasive tracking system that accurately predicts the location of tumors, such as lung tumors, in real time, while allowing patients to breathe naturally. This is accomplished by using Electrical Impedance Tomography (EIT), in conjunction with spirometry, strain gauge and infrared sensors, and by using sophisticated patient-specific mathematical models that incorporate the dynamics of tumor motion. With the direction and speed of lung tumor movement successfully tracked, radiation may be effectively delivered to the lung tumor and not to the surrounding healthy tissue, thus increased radiation dosage may be directed to improving local tumor control without compromising functional parenchyma.

Devices and methods are disclosed for achieving hemostasis in solid visceral wounds. Such devices and methods are especially useful in the emergency, trauma surgery or military setting. In such cases, the patient may have received trauma to the abdominal viscera. The devices utilize flexible, variable depth transfixing bolts that penetrate the viscera. These bolts are pulled tight to bring the tissue into apposition and hold said tissue in apposition while the wound heals. These bolts overcome the limitations of sutures that are currently used for the same purposes. The bolts come in a variety of lengths and diameters. Since the bolts are flexible, the curvature may be adjusted by the surgeon. The devices are flexible, bendable, and conformable in their wet or dry state. They can be used either straight or through a broad range of curvatures to suit the needs of various pathologies. The bolts include pressure plates that are capable of exerting compressive pressure over broad areas of visceral wounds without causing tearing of the friable parenchyma. The bolts may be placed and removed by open surgery or laparoscopic access.

The invention provides a method for preparing an SIS tissue restoring material. The method comprises the following steps: carrying out sterilizing treatment, degreasing treatment, cell free treatment and absterging treatment according to an arbitrary sequence at the lower layer of small intestinal mucosa; and finally preparing the material through freezing and drying. The SIS tissue restoring material can be used as an independent and common support vector for a growth factor, a cell, a drug and the like, and becomes a tissue engineering material through in-vitro culture. The material is a natural and nontoxic biological material without antigenicity and immunity. The SIS tissue restoring material can be used for restoring hernia, defect of skin, urinary system tissue defect, mucosa defect and other periphery and internal parenchyma defects.

Cell-loaded devices or prostheses having various applications such as insertion into body passages are disclosed. The prostheses include cell carrier portions which are compatible with living tissue and which are loaded with therapeutic cell populations, and the prostheses can be applied within or replace one or more of narrow segments, environments which may be difficult to access or luminal areas of the body such as parts of blood vessels. In the context of blood vessels, the cell-loaded devices or prostheses can line or otherwise treat with therapeutic cell populations inner walls of damaged blood vessels and surrounding parenchyma or other organs.

The invention discloses a CT image pulmonary parenchyma three-dimensional semantic segmentation method based on a deep neural network. The segmentation method comprises an offline part and an online part. The offline part comprises four steps: preprocessing a data set; Constructing a full convolutional neural network framework; Constructing a GRU cyclic convolutional neural network framework; Network training. The online part comprises the following five steps: preprocessing an image; Extracting and fusing pixel features; Extracting and fusing voxel characteristics; Performing segmented output; Segmentation result evaluation. The feature fusion comprises feature fusion between an encoding layer and a decoding layer and feature fusion between anatomical structure layers. A deep neural network model with a gating circulation unit is designed, and spatial features are extracted by using anatomical structure prior information of a lung to effectively represent an apparent evolution relationship between fault sequences, so that accurate three-dimensional semantic segmentation is carried out on lung parenchyma in a CT image.

A lesion area detection unit detects an abnormal peripheral structure (lesion area), a pulmonary blood vessel extraction unit extracts a branch structure (pulmonary blood vessel) from the three-dimensional medical image, an associated blood vessel identification unit identifies an associated branch structure functionally associated with the abnormal peripheral structure based on position information of each point in the extracted branch structure, and an associated lung parenchymal area identification unit identifies an associated peripheral area (lung parenchyma) functionally associated with the identified associated branch structure based on the position information of each point in the extracted branch structure.

A catheter for use in neurosurgery, and a method of positioning neurosurgical apparatus. The catheter has a fine tube arranged for insertion into the brain parenchyma of a patient with an external diameter of not more than 1.0 mm. The catheter and method may be used in stereotactically targeting treatment of abnormalities of brain function, and for the infusion of therapeutic agents directly into the brain parenchyma. This is advantageous when a therapeutic agent would have widespread unwanted effects which could be avoided by confining the delivery to the malfunctioning or damaged brain tissue.

Techniques capable of selectively affecting and adjusting a volume of neural tissue in the brain, parenchyma of the spinal cord, or a peripheral nerve are disclosed. A lumen having at least one opening at its distal end that is capable of directing a lead outwardly along a predetermined trajectory is preferred. The lumen is capable of accepting a plurality of leads that can project outward in different directions from the distal end of the lumen. The leads have one or more electrodes at its ends and are thereby configured by the lumen in accordance with a predetermined two- or three-dimensional geometry. Anode / cathode relationships may be established between the electrodes by the operator to stimulate the neural tissue surrounding these electrodes. The operator may also adjust the stimulation to selectively stimulate the desired portion of the brain, spinal cord, peripheral nerve. Sensor feedback may be implemented to adjust the treatment therapy.

A system and method for 3D visualization of a pair of lungs are provided. The method comprises: segmenting image data of the pair of lungs and lung parenchyma; generating a 3D map as a function of the segmented image data; and rendering the 3D map as a color-coded semi-transparent 3D volume, wherein an opaque region highlights an area of interest.

A catheter for use in neurosurgery, and a method of positioning neurosurgical apparatus. The catheter has a fine tube arranged for insertion into the brain parenchyma of a patient with an external diameter of not more than 1.0 mm. The catheter and method may be used in stereotactically targeting treatment of abnormalities of brain function, and for the infusion of therapeutic agents directly into the brain parenchyma. This is advantageous when a therapeutic agent would have widespread unwanted effects which could be avoided by confining the delivery to the malfunctioning or damaged brain tissue.

The invention discloses a supervoxel sequence lung image 3D pulmonary nodule segmentation method based on multimodal data. The method comprises the following steps: A) extracting sequence lung parenchyma images through superpixel segmentation and self-generating neuronal forest clustering; B) registering the sequence lung parenchyma images through PET / CT multimodal data based on mutual information; C) marking and extracting an accurate sequence pulmonary nodule region through a multi-scale variable circular template matching algorithm; and D) carrying out three-dimensional reconstruction on the sequence pulmonary nodule images through a supervoxel 3D region growth algorithm to obtain a final three-dimensional shape of pulmonary nodules. The method forms a 3D reconstruction area of the pulmonary nodules through the supervoxel 3D region growth algorithm, and can reflect dynamic relation between pulmonary lesions and surrounding tissues, so that features of shape, size and appearance of the pulmonary nodules as well as adhesion conditions of the pulmonary nodules with surrounding pleura or blood vessels can be known visually.

The invention relates to the field of cell engineering and particularly relates to a method for separating human adipose-derived stem cells from human adipose tissues. According to the method, by adding a small amount of low-molecular-weight heparin calcium into normal saline, a mixed solution is obtained and used as a cleaning fluid to clean the human adipose tissues, residual impurities such as red blood cells in the human adipose tissues can be well removed and thus human adipose-derived stem cells with relatively higher purity can be separated, the content of the parenchyma cell is significantly reduced, the differentiation induction of the human adipose-derived stem cells is facilitated, the consumption amounts of collagenase I, trypsase and a serum-free culture medium can be reduced and the cost of the process is also decreased. In addition, by centrifuging and digesting the human adipose tissues for 1 hour at a speed of 150r / min, the human adipose-derived stem cells with significantly better activity can be obtained.

Surgical methods of and kits for applying and stabilizing a mass of fibrin sealant or platelet concentrate at the site of surgical attachment of an implantable medical device to effect hemostasis to stem internal bleeding at the site of surgical attachment are disclosed. A mass of fibrin sealant or platelet concentrate is applied onto a porous fabric, whereby the mass is supported in the interstices or pores of the fabric, and the supported mass is applied against the site of high pressure blood leakage. The supported mass achieves hemostasis as it does not wash away from the site. The present invention is particularly useful to effect hemostasis at sutures and suture holes extending through thin-walled tissue valves and grafts when such tissue valves or grafts are sutured in place, particularly at high blood pressure sites as at the valve annulus of the aortic valve or the aorta.

The present invention relates to a gelatin / biological activity glass compounded sponge dressing and a preparation method thereof, belonging to the biomaterial field. The dressing is characterized in that a solution of a content of between 1 and 30 percent is prepared with gelatin as the raw material; the biological activity glass powder with a weight percentage of between 2 and 20 percent, prepared by the fusion method or the sol-gel method, is put into the solution; and then a mixed solution is obtained by magnetic stirring. The mixed solution is poured into a mould, the liquid layer is up to between 1 and 8 mm, the mixed solution is kept stand for 0.5 to 3 h, and then the prefreezing temperature is controlled between 20 DEG C below zero and 80 DEG C below zero; the lyophilization is controlled to be carried out at a temperature of 40 DEG C below zero and a pressure of between 5 and 10 KPa. The section of the present invention is of a double layer composite structure with a thickness of between 0.5 and 5 mm, wherein, the upper layer is a loose porous layer, and the lower layer is a dense powder layer, the thickness of the powder layer being up to between 0.1 and 2.0 mm. The double layer sponge dressing is flexible, which can be used as a parenchyma wound restoring material. Particularly, the double sponge dressing is suitable for any one of parenchyma ulcers of cervix erosions, oral ulcers, bedsores, sinuses, fat liquescency wounds, venereal disease ulcers, hemorrhoids, diabetes ulcers, etc. and the long-term erosions thereof.

The invention discloses an isolated culture method of human adipose-derived stem cells and a construction method of a stem cell bank. The isolated culture method comprises the following steps of: (1) collecting a human adipose tissue; (2) obtaining and separating the human adipose-derived stem cells; (3) culturing the stem cells; (4) detecting and cryopreserving; and (5) constructing the stem cell bank. According to the invention, the mixed collagenase prepared from D-Hanks balanced salt solution and containing type I and type VI collagenases is employed to digest the adipose tissue so that the tissue is digested more thoroughly, the number of parenchyma cells is obviously reduced and tissue blocks are removed; the MCDB-201 culture solution containing 10-15% of fetal calf serum and 10<3>-10<5>U / Ml LIF (Leukemia Inhibitory Factor) is used for culturing the isolated stem cells so that the cells proliferate quickly and are good in morphology; the differentiation of the stem cells can be effectively inhibited and the characteristics of the primary stem cells are ensured; and in the meantime, the human adipose-derived stem cells can be promoted to grow for a long time, and to keep the features such as self-renewal and multipotential differentiation; and moreover, the obtained stem cells are saved in the bank constructed so that better-quality seed cell source is guaranteed.

Providing is cellular aggregates derived from corneal endothelial cells that, when transplanted, readily adhere to the parenchyma of cornea and function in a manner equivalent to corneal endothelial cells, and a method of transplantation of the cellular aggregates. Cellular aggregates derived from corneal endothelial cells. The cellular aggregates derived from corneal endothelial cells is prepared by culturing human corneal endothelial cells in a medium containing fetal bovine serum, growth factor and glucose; and then float culturing the cells obtained in a medium containing growth factor. A method of transplantation into the anterior chamber the cellular aggregate or the cellular aggregate prepared by the above method, comprising inserting a tube into the parenchyma of cornea, introducing the cellular aggregate into the anterior chamber through the inserted tube, and causing the cellular aggregate that has been introduced to adhere to Descemet's membrane by assuming in a downward-facing position.

A system and method for 3D visualization of a pair of lungs are provided. The method comprises: segmenting image data of the pair of lungs and lung parenchyma; generating a 3D map as a function of the segmented image data; and rendering the 3D map as a color-coded semi-transparent 3D volume, wherein an opaque region highlights an area of interest.

A lesion area detection unit detects an abnormal peripheral structure (lesion area), a pulmonary blood vessel extraction unit extracts a branch structure (pulmonary blood vessel) from the three-dimensional medical image, an associated blood vessel identification unit identifies an associated branch structure functionally associated with the abnormal peripheral structure based on position information of each point in the extracted branch structure, and an associated lung parenchymal area identification unit identifies an associated peripheral area (lung parenchyma) functionally associated with the identified associated branch structure based on the position information of each point in the extracted branch structure.

The invention relates to a method for extracting lignin-sulphonate from the waste solution of sodium sulfite bamboo pulp, which is characterized in that: red liquor is filtered for removing fibrils by a sieve; the filtered red liquor is delivered into a filtering machine for removing parenchyma cells, solid impurities and particles; then the red liquor is delivered into a purification and separation system for eliminating inorganic salt, organic carboxylate, small molecular saccharides substances and small molecular lignin-sulphonate; the purified red liquor is concentrated to proper concentration after evaporation; the concentrated red liquor can be directly or added with material to be put into a drying system for becoming dry powder, thus obtaining a finished product. The method has the advantages that the method solves problems interfering in the development of paper making enterprises of China that uses a sulphite method for pulping, provides an effective implementation technical proposal and builds a production line with advanced environmental friendliness, typicality and practicability, which contributes to the waste solution treatment and discharge of the paper making industry of China.

When brain images are inputted through MRI (Magnetic Resonance Imaging) and subjected to image processing to assist the diagnosis of brain diseases, functional and morphological images in an ASL coordinate system are inputted from the head of a subject by an ASL (Arterial Spin Labeling) imaging method using an MRI device. The inputted functional images are subjected to mask processing to extract only the region of cerebral parenchyma, and functional images of only the extracted region of the cerebral parenchyma are thereby produced and displayed to be overlaid on the morphological images. In this manner, a functional image such as a perfusion weighted image of only the region of the cerebral parenchyma can be extracted and displayed overlaid on a morphological image.

A magnetic resonance method for imaging blood volume in parenchyma via magnetic transfer (MT) includes: determining a MT effect of parenchyma; determining a MT effect of tissue; and quantifying the parenchymal blood volume using the difference between the MT effect of parenchyma and the MT effect of tissue. In one embodiment, the parenchymal blood volume is quantified through the following: MTRpar=MTRtissue(1−BV / Vpar), where MTRpar is the magnetization transfer ratio of parenchyma, MTRtissue is the magnetization transfer ratio of tissue, BV is the blood volume, and Vpar is a total parenchymal water volume.

The invention designs a lung parenchyma CT image segmentation method based on a deep convolutional neural network. The method comprises the steps that 1, using The VGG-16 network improved by cavity convolution to extract the convolution characteristics of lung parenchyma in lung CT images;; 2, constructing a multi-scale feature supercolumn descriptor based on multi-layer extraction; And 3, learning a nonlinear predictor for classifying pixels. Results show that the method can realize accurate lung parenchyma image segmentation, compared with the prior art, the method has the advantages that the segmentation accuracy and speed are improved, and the problems of low manual segmentation efficiency, low accuracy, excessive consumption of manpower resources and the like of the lung parenchyma image are successfully solved.

Compositions and methods useful in determining the major morphological types of lung cancer are provided. The methods include detecting expression of at least one gene or biomarker in a sample. The expression of the gene or biomarker is indicative of the lung tumor subtype. The compositions include subsets of genes that are monitored for gene expression. The gene expression is capable of distinguishing between normal lung parenchyma and the major morphological types of lung cancer. The gene expression and somatic mutation data are useful in developing a complete classification of lung cancer that is prognostic and predictive for therapeutic response. The methods are suited for analysis of paraffin-embedded tissues. Methods of the invention include means for monitoring gene or biomarker expression including PCR and antibody-based detection. The biomarkers of the invention are genes and / or proteins that are selectively expressed at a high or low level in certain tumor subtypes. Biomarker expression can be assessed at the protein or nucleic acid level.

This disclosure relates to a low density lipoprotein-like cationic solid lipid nanoparticle targeting liver cells including parenchyma cells and non-parenchyma cells, a composition for liver target delivery, a composition for diagnosis and / or treatment of liver disease comprising the same, and a method for liver targeting of an active ingredient.

The invention discloses a thyroid nodule recognition method based on a generative adversarial network. The thyroid nodule recognition method comprises the following steps: screening the data of a patient suffering from a thyroid disease, building a thyroid nodule database, and carrying out circling marking on thyroid nodules and thyroid parenchyma; semantic segmentation: taking U-net as a condition of a generative network to generate an adversarial network model, and inputting an annotated image to realize semantic segmentation; benign and malignant classification input: after multiple convolution, activation and pooling, using a full connection layer to integrate the extracted features to realize image benign and malignant judgment by the convolutional neural network; after the lesion isinput into the convolutional neural network, automatically classifying the lesion and outputting a benign and malignant judgment result of the lesion by the convolutional neural network; and giving areference diagnosis report of the illness state of the patient according to the training result. The thyroid nodule recognition method based on a generative adversarial network can improve thyroid nodule benign and malignant judgment accuracy of doctors, can reduce the thyroid screening time of ultrasound, can reduce the working intensity of medical staff, and can increase the satisfaction degreeof patients.

The invention discloses a method of preparing microfibrillated cellulose from bamboo parenchyma cells, which comprises following steps: (1) separation of the bamboo parenchyma cells: performing chemical separation or drying and crushing process to raw materials, sieving the treated raw materials through a 20-mesh sieve screen to obtain the parenchyma cells; (2) chemical pre-treatment: adding the parenchyma cells to a phenethyl alcohol solution for extraction, adding a 1-3% sodium chlorite solution for treating the parenchyma cells for one hour, and adding the parenchyma cells in an alkaline solution for treating the parenchyma cells for two hours, treating the parenchyma cells in a diluted hydrochloric acid solution for two hours, and finally washing the parenchyma cells with deionized water to neutralization; and (3) dispersing the treated parenchyma cells in deionized water to form a 1% suspension liquid, and performing high-frequency ultrasonic treatment or high-pressure homogenizing treatment. According to the method, the bamboo parenchyma cells are separated through the sieving process in early stage to prepare the microfibrillated cellulose. The raw materials are wide in sources and are low in cost. The method is simple and easy to carry out, is high in production efficiency, can reach 90% in yield and can basically achieve all-conversion of the raw materials.