The invention relates to a special clinical nutrient composition for liver diseases and a preparation method of the composition. The special clinical nutrient composition comprises protein, fat, carbohydrate, dietary fibers, macro-elements, trace elements, vitamins, dietary essence, medicinal and edible components, natural plant compounds and new resource food, wherein the new resource food comprises hyriopsis cumingii polysacchride, and the medicinal and edible components comprise mint, Indian bread, barbary wolfberry fruits, common floweringquince fruits, common yam rhizome, mulberry fruits, spina date seeds and citrons. The preparation method includes the steps: preparing the components into powder in advance; uniformly mixing the powder to prepare corresponding dosage forms. The medicinal and edible components are subjected to water extraction, concentration and spray drying to prepare the powder, and the vitamins and the fat are microencapsulated into the powder. By screening and matching the components, the nutrient composition can provide needed energy, key nutrients and necessary trace elements for patients suffering from the liver diseases, the liver diseases are treated and liver cells are protected under the synergistic action of the components, and development of the liver diseases is slowed down.