111 results about "Farnesoid X receptor" patented technology
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The bile acid receptor (BAR), also known as farnesoid X receptor (FXR) or NR1H4 (nuclear receptor subfamily 1, group H, member 4) is a nuclear receptor that is encoded by the NR1H4 gene in humans.
The invention relates to preparation of carboxylic acid derivatives and application of the carboxylic acid derivatives serving as an FXR (farnesoid X receptor) antagonist and particularly provides a compound shown as a formula (I), or a pharmaceutically acceptable salt of the compound and a preparation method of the compound. In the formula (I) as shown in the specification, R1 is selected from hydrogen, methyl, methoxyl, halogen, nitryl and carboxyl; X is selected from NH or O; n1 is 0 or 1; n2 is 0 or 1; R1 and a radical as shown in the specification are positioned at any substitution positions of a benzene ring. The compound shown as the formula (I) or the pharmaceutically acceptable salt thereof has a pharmacological effect of blood fat reduction and can be used as the FXR antagonist.