45 results about "Serum transaminase" patented technology

The invention relates to nucleic acid constructs and gene therapy vectors that comprise an ATP7B variant for use in the treatment of conditions associated with a deficiency or dysfunction of Copper-transporting ATPase 2, and particularly of Wilson's disease. An AAV vector devised according to the invention significantly reduced urine Cu excretion, and liver Cu content in Wilson's disease mice treated with the vector, while ceruloplasmin activity was significantly restored. On the other hand, the administration of the vector resulted in the normalization of serum transaminases' levels and of liver histology, together with a marked reduction of the inflammatory infiltrate.

The invention discloses the application of a traditional Chinese medicine composition in the preparation of medicines for preventing and treating novel coronavirus combined with liver damage. The present invention screens the intervention effect of the traditional Chinese medicine composition on the novel coronavirus (SARS-CoV-2), and the screening experiment shows that the traditional Chinese medicine composition provided by the present invention has a certain anti-new coronavirus (SARS-CoV-2) effect, and It can significantly reduce serum transaminase and bilirubin in patients with new coronavirus (SARS‑CoV‑2), improve liver function, and can assist in the treatment of new coronavirus and the liver damage caused by it, and can significantly improve clinical symptoms and increase the cure rate.

The invention discloses a liver-protecting rhizoma polygonati tablet and a preparation method thereof. The liver-protecting rhizoma polygonati tablet is prepared by the steps of taking rhizoma polygonati, mulberry, celery seeds, championella sarcorrhiza and mallow leaf as raw materials; preparing the mulberry and mallow leaf into slurry, and extracting the championella sarcorrhiza and the celery seeds; immersing the rhizoma polygonati into liquid medicine prepared by mixing the slurry and the extract, repeatedly steaming and drying, thereby obtaining the rhizoma polygonati liver-protecting tablet. The product can achieve the effects of obviously decreasing the serum transaminase and effectively relieving repeated courses of disease of chronic hepatitis, and particularly has excellent curative effects on chemical liver injury.

The invention relates to the field of research of traditional Chinese medicine and specifically relates to a new application of emodin-8-O-beta-D-glucoside in preparation of liver-protecting and gallbladder-benefiting medicaments. The invention further prepares a liver-protecting and gallbladder-benefiting preparation and the active ingredient of the liver-protecting and gallbladder-benefiting preparation is emodin-8-O-beta-D-glucoside. According to the new application disclosed by the invention, research based on an ANIT (alpha-naphthylisothi)-induced intrahepatic cholestasis model of a rat proves that emodin-8-O-beta-D-glucoside is capable of significantly reducing serum transaminase level, promoting bile excretion, increasing the flow rate of bile and realizing liver-protecting and gallbladder-benefiting effects on intrahepatic cholestasis diseases, and great economic benefits and extensive social benefits can be created by application of the emodin-8-O-beta-D-glucoside to research and development of the liver-protecting and gallbladder-benefiting medicaments.

The invention relates to a lotus leaf extract, a preparation method and the application thereof; wherein, the extract takes the lotus leaf as raw material, the lotus leaf is quenched, filtered and decompressed by the blended solution of the acetone and water to recycle the acetone and obtain lotus leaf aqueous solution, and then the lotus leaf aqueous solution is respectively leached by ethyl acetate and normal butanol to obtain ethyl acetate extract and normal butanol extract. The ethyl acetate extract and normal butanol extract of the lotus leaf respectively lavage a mouse; carbon tetrachloride induces the liver damage of the laboratory mouse; ALT and AST value in the blood serum of the mouse and the SOD and MDA value in the hepatic tissue are detected; experiments show that the ethyl acetate extract and normal butanol extract of the lotus leaf can effectively reduce the ALT, AST and MDA value of the carbon tetrachloride hepatic tissue mouse and can obviously increase the SOD vitality of the hepatic cell of the mouse. The results show that the ethyl acetate extract and normal butanol extract of the lotus leaf have the function of reducing serum transaminase and lipid peroxidation, thereby illustrating that the ethyl acetate extract and normal butanol extract of the lotus leaf have the function of protecting the liver.

A Chinese medicine with immune regulation function for treating alcoholic liver cell injury and relative hyper-serum-transaminase contains ganoderic polyose and cordycepic polyose.

The invention discloses a medicine of miR-221 and an inhibitor thereof for preparing a medicine for regulating and controlling liver fat deposition, liver fibrosis or hepatocellular carcinoma. The miR-221 and the inhibitor thereof can be used as a detection target; and the liver fat infiltration level, liver collagen fiber deposition, plasma cholesterol level and serum transaminase are reduced by inhibiting the activity of the miR-221, insulin resistance is improved or malignant proliferation of liver cells is inhibited, and a new medication approach is provided for treating, preventing or delaying the liver diseases caused by metabolic disorders.