45 results about "Serum transaminase" patented technology

The invention discloses Lachnum sp., an extracellular polysaccharide thereof and application of the extracellular polysaccharide in preparing lipid-lowering liver-favoring medicaments. The invention is characterized in that a Lachnum sp. strain with the collection number of CCTCC (China Center for Type Culture Collection) No: M 2011196 is activated and inoculated to a fermentation culture medium, thus preparing the Lachnum sp. extracellular polysaccharide. When the administration dosage is 150-300 mg / (kg bw), the prepared Lachnum sp. extracellular polysaccharide can significantly lower the levels of serum lipid and liver lipid and atherosis index of high-lipid mice, and increase the level of serum high-density lipoprotein cholesterol and the excretion amount of feces lipid. When the administration dosage is 75-300 mg / (kg bw), the prepared Lachnum sp. extracellular polysaccharide can significantly lower the activity of serum aminotransferase and malondialdehyde content in liver tissues of high-lipid mice, and increase the activity of sudismase in the liver tissues. The prepared Lachnum sp. extracellular polysaccharide has obvious effects of lowering blood lipid, lowering liver lipid, and treating hepatic injury and dysfunction caused by high lipid, has no toxic or side effects, and can be prepared into tablets or capsules for clinical application.

The invention provides a liver-protecting and alcohol-dispelling beverage. The liver-protecting and alcohol-dispelling beverage comprises the following raw materials: radix puerariae, semen hoveniae,herba dendrodii officinalis and potassium sorbate, wherein the weight ratio of the radix puerariae to the semen hoveniae is 1:5 to 1:6. The invention further provides a preparation method of the liver-protecting and alcohol-dispelling beverage. The liver-protecting and alcohol-dispelling beverage provided by the invention can reduce the serum transaminase level, has a protection effect on the liver, and realizes the effect of inhibiting alcohol-induced acute liver injury by improving partial oxidative stress, thereby achieving a better alcohol-dispelling curative effect.

The invention discloses a composite microbial agent for detoxifying liver and a preparation method thereof, the composite microbial agent comprises a strain and an adsorption carrier; wherein the strain is prepared by using Streptococcus thermophilus, Lactobacillus casei and Bacillus megaterium. the strain comprises the following components by weight percentage: 30-40% of Streptococcus thermophilus, 25-35% of Lactobacillus casei and 25-35% of Bacillus megaterium, and the weight ratio of the total strain to the adsorption carrier is 1:0.9-1:1.1. The synergistic effect is generated by reasonablecombination of Streptococcus thermophilus, Lactobacillus casei and Bacillus megaterium. The beneficial bacteria can degrade the pesticide residues in fruits and vegetables, food additive residues, excessive fat intake, alcohol and other harmful substances, which can reduce the burden on the liver, and can help the digestion and absorption of nutrients in the food and supplementing various vitamins and amino acids, can significantly reduce serum transaminase, effectively alleviates the disease relapse of chronic hepatitis, and has good curative effect for chemical liver injury.

The invention relates to nucleic acid constructs and gene therapy vectors that comprise an ATP7B variant for use in the treatment of conditions associated with a deficiency or dysfunction of Copper-transporting ATPase 2, and particularly of Wilson's disease. An AAV vector devised according to the invention significantly reduced urine Cu excretion, and liver Cu content in Wilson's disease mice treated with the vector, while ceruloplasmin activity was significantly restored. On the other hand, the administration of the vector resulted in the normalization of serum transaminases' levels and of liver histology, together with a marked reduction of the inflammatory infiltrate.

The invention discloses the application of a traditional Chinese medicine composition in the preparation of medicines for preventing and treating novel coronavirus combined with liver damage. The present invention screens the intervention effect of the traditional Chinese medicine composition on the novel coronavirus (SARS-CoV-2), and the screening experiment shows that the traditional Chinese medicine composition provided by the present invention has a certain anti-new coronavirus (SARS-CoV-2) effect, and It can significantly reduce serum transaminase and bilirubin in patients with new coronavirus (SARS‑CoV‑2), improve liver function, and can assist in the treatment of new coronavirus and the liver damage caused by it, and can significantly improve clinical symptoms and increase the cure rate.

The invention discloses a liver-protecting rhizoma polygonati tablet and a preparation method thereof. The liver-protecting rhizoma polygonati tablet is prepared by the steps of taking rhizoma polygonati, mulberry, celery seeds, championella sarcorrhiza and mallow leaf as raw materials; preparing the mulberry and mallow leaf into slurry, and extracting the championella sarcorrhiza and the celery seeds; immersing the rhizoma polygonati into liquid medicine prepared by mixing the slurry and the extract, repeatedly steaming and drying, thereby obtaining the rhizoma polygonati liver-protecting tablet. The product can achieve the effects of obviously decreasing the serum transaminase and effectively relieving repeated courses of disease of chronic hepatitis, and particularly has excellent curative effects on chemical liver injury.

The invention relates to the field of research of traditional Chinese medicine and specifically relates to a new application of emodin-8-O-beta-D-glucoside in preparation of liver-protecting and gallbladder-benefiting medicaments. The invention further prepares a liver-protecting and gallbladder-benefiting preparation and the active ingredient of the liver-protecting and gallbladder-benefiting preparation is emodin-8-O-beta-D-glucoside. According to the new application disclosed by the invention, research based on an ANIT (alpha-naphthylisothi)-induced intrahepatic cholestasis model of a rat proves that emodin-8-O-beta-D-glucoside is capable of significantly reducing serum transaminase level, promoting bile excretion, increasing the flow rate of bile and realizing liver-protecting and gallbladder-benefiting effects on intrahepatic cholestasis diseases, and great economic benefits and extensive social benefits can be created by application of the emodin-8-O-beta-D-glucoside to research and development of the liver-protecting and gallbladder-benefiting medicaments.

The invention relates to a traditional Chinese medicinal composition for improving a liver function. The traditional Chinese medicinal composition is prepared from effective components and pharmaceutically acceptable auxiliaries, and is characterized in that the effective components are prepared from the following raw materials in parts by weight: 20-30 parts of cornus officinalis, 20-30 parts of smoked plum, 15-20 parts of astragalus, 15-20 parts of Chinese angelica, 10-15 parts of abrus cantoniensis hance, and 10-15 parts of rabdosia lophanthide. The traditional Chinese medicinal composition has the effects of nourishing and protecting liver and reducing serum transaminase.

The invention relates to a lotus leaf extract, a preparation method and the application thereof; wherein, the extract takes the lotus leaf as raw material, the lotus leaf is quenched, filtered and decompressed by the blended solution of the acetone and water to recycle the acetone and obtain lotus leaf aqueous solution, and then the lotus leaf aqueous solution is respectively leached by ethyl acetate and normal butanol to obtain ethyl acetate extract and normal butanol extract. The ethyl acetate extract and normal butanol extract of the lotus leaf respectively lavage a mouse; carbon tetrachloride induces the liver damage of the laboratory mouse; ALT and AST value in the blood serum of the mouse and the SOD and MDA value in the hepatic tissue are detected; experiments show that the ethyl acetate extract and normal butanol extract of the lotus leaf can effectively reduce the ALT, AST and MDA value of the carbon tetrachloride hepatic tissue mouse and can obviously increase the SOD vitality of the hepatic cell of the mouse. The results show that the ethyl acetate extract and normal butanol extract of the lotus leaf have the function of reducing serum transaminase and lipid peroxidation, thereby illustrating that the ethyl acetate extract and normal butanol extract of the lotus leaf have the function of protecting the liver.

A Chinese medicine with immune regulation function for treating alcoholic liver cell injury and relative hyper-serum-transaminase contains ganoderic polyose and cordycepic polyose.

The invention discloses a medicine of miR-221 and an inhibitor thereof for preparing a medicine for regulating and controlling liver fat deposition, liver fibrosis or hepatocellular carcinoma. The miR-221 and the inhibitor thereof can be used as a detection target; and the liver fat infiltration level, liver collagen fiber deposition, plasma cholesterol level and serum transaminase are reduced by inhibiting the activity of the miR-221, insulin resistance is improved or malignant proliferation of liver cells is inhibited, and a new medication approach is provided for treating, preventing or delaying the liver diseases caused by metabolic disorders.