70 results about "Inflammatory infiltration" patented technology

The invention relates to a pharmaceutical composition for treating Hashimoto's thyroiditis and a preparation method thereof. The pharmaceutical composition is composed of bupleurum, radix curcumae, prunella vulgaris, rhizoma Dioscoreae Nipponicae, thunberg fritillary bulb, radix scrophulariae, edible tulip, astragalus, dark plum and other components, and can be made into granules, capsules, tablets or pills by the conventional pharmaceutical processes. The pharmaceutical composition has the effects of soothing liver-qi stagnation, reducing phlegm, removing stasis, and softening hardness to dissipate stagnation, and applies to patients with Hashimoto's thyroiditis and thyroid nodules. Clinical studies have shown that the pharmaceutical composition can significantly improve the symptoms of Hashimoto's thyroiditis, reduce the thyroid volume and isthmus thickness, and reduce the level of TgAb and TPOAb, and the total effective rate is 97.22%. In addition, for patients with thyroid nodules, nodules can be significantly reduced or even disappeare, no significant adverse reactions are presented in the course of treatment. Experimental studies have shown that the pharmaceutical composition reduces the level of TgAb and TPOAb, and reduces inflammatory infiltration and thyroid follicular damage.

The invention discloses an in vitro construction method of liver organs and applications. Mouse hepatocytes are extracted to induce to construct liver organs; the forms of the liver organs are observed under a microscope; and immunofluorescence and PCR identification are performed on dryness and epithelial cell properties. An acute hepatic failure mouse model after 70% hepatectomy is established;the liver functions on the first, fourth and seventh day after operation are evaluated after the liver organs are transplanted; liver-to-body ratio is compared; and the treatment effects of the liverorgans on acute hepatic failure are verified through HE staining and immunohistochemistry. Inflammations such as HE staining and ki-67 staining and proliferation indexes show that proliferation can beobviously enhanced after the liver organs are transplanted. The liver organs have strong dryness and proliferation functions; the liver functions of acute hepatic failure mice after 70% hepatectomy can be effectively relieved, and the liver-to-body ratio can be increased; and liver regeneration and repair of acute hepatic failure after 70% hepatectomy can be promoted by relieving inflammatory infiltration of livers.

The invention discloses a compound preparation for treating cecal granuloma and a preparation method thereof. The compound preparation comprises chloroquine phosphate, diiodohydroxyquinoline, chlorogenic acid, liquiritin, cistanoside, ursolic acid, polysavone, levamisole, albendazole, okra powder, lactein, vitamin B1, lactalbumin and arginine. The compound preparation can effectively expand intestinal tubes, prevent intestinal obstruction, prevent mesentery and intestinal wall inflammatory infiltration and edema, prevent intestinal wall fibrosis, adjust body metabolism, improve immunity, reduce drug side effects and treat cecal granuloma and has a wide application prospect.

The invention discloses application of dipyridamole or pharmaceutically acceptable salt thereof in preparation of a medicine for preventing and/ or treating lung inflammation. The dipyridamole can inhibit the conversion of fibroblasts into myofibroblasts; meanwhile, the dipyridamole can also improve the respiratory function of a bleomycin-induced pulmonary fibrosis model rat, reduce the inflammatory infiltration of lung tissues and reduce the pathological states such as fibroblast proliferation and collagen accumulation in the lung tissues; and the dipyridamole has relatively high bonding strength with a 3CL enzyme as a pneumonia target triggered by a novel coronavirus in 2019 years, and has relatively high inhibitory activity on the 3CL enzyme of the coronavirus and a Vero E6 cell infected by the coronavirus, indicating that the dipyridamole has the effects of preventing and treating pulmonary fibrosis and pneumonia triggered by the novel coronavirus in 2019 years, and can be preparedinto a pneumonia medicine for application.

The invention relates to a method and a system for analyzing an eye picture and attribute information. The method comprises the following steps: acquiring the eye picture of a user suffering from keratitis and the attribute information of the user; judging classification information of the eye picture according to the inflammatory infiltration and/or ulcer shape of the eye picture; and according to the attribute information and the classification information, obtaining the probability that the keratitis suffered by the user belongs to different categories. A professional ophthalmologist is notneeded. The probability of the keratitis type of the user can be obtained only by uploading the eye picture and the attribute information, reliable reference data are provided for the user or doctorsto make diagnosis and treatment decisions, the method can be popularized to primary hospitals, more primary crowds are popularized, the defect that existing medical resources are not evenly distributed is overcome, and burdens of professional ophthalmologists are relieved.

The invention relates to application of an eIF3I-PDL1-IRS4 axis in preparation of a medicine for treating refractory ulcer. It is found that: when PDL1 is used for treating wounds, tissue formation, inflammation fading and reduction in vascularity can be induced; epithelization is accelerated; inflammation is relieved; healing of diabetic ulcer (DU) wounds is helped; in a DU wound surface, the expression of IRS4 is increased; the expression of the IRS4 of HaCaT cells is knocked down; the proliferation and migration of the cells are increased; when the eIF3I is over-expressed in HaCaT cells, the proliferation and migration of the cells are remarkably increased; and inflammatory infiltration is relieved. The invention prompts that the targeted eIF3I-PDL1-IRS4 axis can be used as a novel treatment method for treating refractory ulcer, chronic inflammation after injury, infection and other types of wounds.

The invention belongs to the field of medicines and provides a medicine for treating non-alcoholic steatohepatitis (NASH). A compound kinsenoside (3-(R)-3-beta-D-glucopyranosyloxbutanolide has a good treatment effect on NASH of mice induced by using an MCD feed (methionine-choline-deficient feed), can effectively reduce liver fat accumulation, relieve liver injury, reduce inflammatory infiltration and oxidative stress injury, and reduce expression of fibrosis marker gene and protein so as to prevent NASH from developing to hepatic fibrosis, indicating that the kinsenoside can be used as a medicine for treating NASH.

The invention belongs to the technical field of medicines for treating asthma, and particularly relates to application of polygonatum odoratum polysaccharide in preparation of medicines for treating asthma. Experimental research finds that the polygonatum odoratum polysaccharide can improve release of allergic asthma related cell factors in an airway, reduce the number of eosinophilic granulocytes, reduce serum total IgE, improve allergy conditions and improve pathological conditions such as lung inflammatory infiltration, goblet cell metaplasia and pulmonary parenchyma of asthma mice. Therefore, the polygonatum odoratum polysaccharide can be used for preparing the medicine for treating asthma.

The invention relates to a compound preparation for treating rheumatoid arthritis. The compound preparation is prepared from the following crude drugs in parts by weight: 5 to 12 parts of fried fructus arctii, 4 to 11 parts of bombyx batryticatus, 8 to 15 parts of radix notoginseng, 4 to 12 parts of radix angelicae pubescentis, 3 to 9 parts of radix gentianae macrophyllae, and 4 to 12 parts of rhizoma pinelliae. The animal experiment shows that the compound preparation can reduce an inflammatory infiltration area, bony defects and articular cartilage defects of TNF-Tg rheumatoid arthritis mice, can promote lymphatic return and can alleviate ankle joint inflammatory injury. The traditional Chinese medicine compound preparation can improve the rheumatoid arthritis symptom, and can avoid the inconvenience caused by the temporary decoction of the traditional Chinese herbal decoction before the administration and the likeliness in mildew; and in addition, the invention also provides a preparation method of the compound preparation.

The invention relates to novel application of Metrnl, belongs to the technical field of medicine and in particular relates to application of the Metrnl in atherosclerosis (AS) resistance. A Metrnl<-/->ApoE<-/-> double-knockout mouse AS model and an EC-Metrnl<-/->ApoE<-/-> mouse AS model are constructed, experiments show that the severity of AS of the two Metrnl knockout mice is higher than that ofcontrol mice, reflected in that aortas of the Metrnl knockout mice havemore atherosclerotic plaques than those of control mice, the area ratio of the atherosclerotic plaques of the aortas of the Metrnl knockout mice is higher than that of control mice, the thickening degree and inflammatory infiltration degree of root atherosclerosis of the aortas of the Metrnl knockout mice are higher than thoseof control mice and the expression level of inflammatory factors of the aortas of the Metrnl knockout mice is increased. The invention proves that the Metrnl can be applied to AS resistance by experimentsfor the first time.

The invention provides a sunflower disc extract, a medicine containing the sunflower disc extract as well as a preparation method and application of the medicine, and belongs to the technical field of biological medicines. The preparation method of the sunflower disc extract comprises the following steps: mixing crushed sunflower discs with water, carrying out extracting, adding cellulase into the obtained water extract, carrying out hydrolyzing to obtain hydrolysate, carrying out solid-liquid separation on the hydrolysate, and collecting liquid components to obtain the sunflower disc extract. The sunflower disc extract prepared by the invention can significantly inhibit the increase of MDA content, liver index, ALT and AST activity caused by alcohol acute liver injury, effectively inhibit the reduction of SOD activity in the liver, and reduce the liver tissue injury degree of mice, and HE staining shows that the sunflower disc extract can alleviate the inflammatory infiltration phenomenon of liver cells. The sunflower disc extract has an obvious repairing effect on alcohol-induced acute liver injury of mice.

The invention discloses a Chinese herbal medicine composition with effects of diminishing inflammation and relieving itching. The Chinese herbal medicine composition comprises the following components in parts by mass: 55-65 parts of fructus cnidii, 15-25 parts of realgar, 25-35 parts of rheum officinale, 10-20 parts of borneol, 1-2 parts of dragon's blood, 10-20 parts of red flower, 10-20 parts of Red Paeony Root, 5-15 parts of Ligusticum wallichii, 25-35 parts of pawpaw, 5-15 parts of Angelica sinensis, 5-15 parts of Coptis chinensis, 5-15 parts of cortex moutan, 10-20 parts of the seed of cowherb, 10-20 parts of selfheal and 15-25 parts of honeysuckle. The invention also discloses a method for preparing the Chinese herbal medicine composition with effects of diminishing inflammation and relieving itching. The Chinese herbal medicine composition disclosed by the invention has the effects of killing parasites to relieve itching, inducing diuresis to remove turbidity, clearing away heat and toxic materials, promoting blood circulation and expelling wind, inhibiting release of inflammatory factors and alleviating inflammatory infiltration, and good effects of diminishing inflammation and relieving itching are achieved.

The invention discloses an application of various rosa roxburghii aqueous extracts in preparation of drugs, health-care products and health-care food for preventing and/or treating alcoholic liver disease. Provided are drugs and health-care products for preventing and treating alcoholic liver disease, wherein the drugs and health-care products comprise 20-99% of the rosa roxburghii aqueous extracts. The invention also provides health-care drinks suitable for patients with alcoholic liver disease, wherein the health-care drinks comprise 0.5-33% of the rosa roxburghii aqueous extracts; the invention also provides a blended alcoholic drinks comprising 0.5-7% of the rosa roxburghii aqueous extracts; the invention also provides fruit-flavored beer drinks comprising 0.5-4% of the rosa roxburghiiaqueous extracts; the invention also provides additive grape wine comprising 0.5-2% of the rosa roxburghii aqueous extracts; the invention also provides blended grape wine drinks comprising 0.5-2% ofthe rosa roxburghii aqueous extracts. Through implementation of the most recognized model of alcoholic liver disease in mice, the rosa roxburghii aqueous extracts with various concentrations are found out to alleviate the liver pathological changes induced by alcohol in different extents; liver enlargement, weight gain, fat accumulation and inflammatory infiltration degree are significantly improved; biochemical and pathological indicators are significantly reduced. The rosa roxburghii aqueous extracts can prevent and treat alcoholic liver disease, can be used as drugs separately or in combination, and is used for developing corresponding drugs, health-care products or health-care food.

The invention relates to a composition for repairing epithelial injury of bladders and urinary tracts. The composition is composed of two or three components selected from a group including hyaluronic acid, chitosan and chondroitin sulphate. Clinical animal experiments show that the composition for repairing epithelial injury of bladders and urinary tracts disclosed by the invention is capable of obviously repairing epithelial injury of bladders due to protamine sulphate or cyclophosphamide, obviously reducing the bladder epithelial injury range and the injury degree and lightening the inflammatory infiltration degree.

The invention discloses application of glutathione (GSH) to preparation of a drug for preventing and treating central nervous system infection caused by salmonella typhimurium. A mouse meningitis model with the single-side ventricle being injected with the salmonella typhimurium SL1344 is provided, it is proven that the GSH has good treating activity, an experiment proves that the GSH can significantly prolong the median survival time of mice, the meningitis EAE score is increased, brain edema and inflammatory infiltration are relieved, and in addition, the GSH can relieve brain cell apoptosisby lowering phosphorylation of JNK.