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Medicine for treating non-alcoholic steatohepatitis

A steatohepatitis, non-alcoholic technology, applied in the field of medicine, can solve the problems of lack of drugs, no obvious effect of reversing the disease, etc.

Pending Publication Date: 2021-08-06
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, clinical research on NASH still lacks certain effective drugs. Existing drugs such as silymarin can only delay the development of the disease, but have no obvious effect on reversing the disease.

Method used

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  • Medicine for treating non-alcoholic steatohepatitis
  • Medicine for treating non-alcoholic steatohepatitis
  • Medicine for treating non-alcoholic steatohepatitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The role of kinsenoside (KD) in the treatment of NASH.

[0037] In this experiment, 150 SPF male C57 mice aged 6-8 weeks were purchased and raised in the SPF Experimental Animal Center of Tongji Medical College, Huazhong University of Science and Technology. They were given standard diet and drinking water, and the room temperature was controlled at 23±2°C. Days later, intragastric administration was started. The experimental protocol involving mice was approved by the Animal Experiment Ethics Committee of Tongji Medical College, Huazhong University of Science and Technology. Mice were randomly divided into blank group (control group), model group (model group), KD low dose group (40mg / kg KD), KD medium dose group (20mg / kg KD), KD high dose group (10mg / kg KD) , positive drug silymarin group (100mg / kg) and positive drug Fuzhenghuayu group (1.5g / kg). The model group and each administration group were fed with MCD (methionine-choline deficiency) feed, and the normal cont...

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Abstract

The invention belongs to the field of medicines and provides a medicine for treating non-alcoholic steatohepatitis (NASH). A compound kinsenoside (3-(R)-3-beta-D-glucopyranosyloxbutanolide has a good treatment effect on NASH of mice induced by using an MCD feed (methionine-choline-deficient feed), can effectively reduce liver fat accumulation, relieve liver injury, reduce inflammatory infiltration and oxidative stress injury, and reduce expression of fibrosis marker gene and protein so as to prevent NASH from developing to hepatic fibrosis, indicating that the kinsenoside can be used as a medicine for treating NASH.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to a medicine for treating liver diseases, in particular to a medicine for treating non-alcoholic steatohepatitis (NASH), that is, an application of a glycoside compound in the preparation of a medicine for treating NASH. Background technique [0002] With the development of my country's economy, people's living standards continue to improve, and people's lifestyles have undergone significant changes. The incidence of non-alcoholic fatty liver disease continues to increase. At present, the disease has become one of the most common chronic liver diseases in my country. Nonalcoholic fatty liver disease mainly refers to the excessive deposition of fat in liver cells caused by factors other than clear liver injury and alcohol, and the disease spectrum includes nonalcoholic simple fatty liver, nonalcoholic steatohepatitis and related liver cirrhosis And hepatocellular carcinoma, once such ...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P1/16A61K36/898
CPCA61K31/7048A61P1/16A61K36/898
Inventor 张勇慧邓艳芳
Owner HUAZHONG UNIV OF SCI & TECH
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