74 results about "Thyroid nodules" patented technology

The invention discloses a clinical data mining analysis and aided decision-making method based on an Internet integrated medical platform, and relates to the technical field of an Internet medical platform. The clinical data mining analysis and aided decision-making method includes data mining analysis and aided decision-making, wherein data mining analysis includes a multidimensional analysis algorithm module, a data mining algorithm module and a deep learning algorithm module; and aided remote decision-making includes four parts: a prediction module based on index parameters, a prediction module based on inspection report texts, a model training module and a structurized module. The clinical data mining analysis and aided decision-making method based on an Internet integrated medical platform selects several diseases as research objects for data collection and analysis, such as hyperthyroidism, diabetes, thyroid nodules and breast tumors, and collects and integrates clinical medicaldata depended the integrated platform to realize data mining analysis and aided decision-making services for clinical data diseases, such as hyperthyroidism, diabetes, thyroid nodules and breast tumors, so as to provide systematic support for clinical diagnosis of clinicians and disease research by researchers.

The invention relates to auxiliary medical diagnoses, and aims to provide a method for automatically identifying whether a thyroid nodule is benign or malignant based on a deep convolutional neural network. The method for automatically identifying whether the thyroid nodule is benign or malignant based on the deep convolutional neural network comprises the following steps: reading B ultrasonic data of thyroid nodules; performing preprocessing for thyroid nodule images; selecting images, and obtaining nodule portions and non-nodule portions through segmentations; averagely dividing the extracted ROIs (regions of interest) into p groups, extracting characteristics of the ROIs by utilizing a CNN (convolutional neural network), and performing uniformization; taking p-1 groups of data as a training set, taking the remaining one group to make a test, and obtaining an identification model through training to make the test; and repeating cross validation for p times, and then obtaining an optimum parameter of the identification model. The method can obtain the thyroid nodules through the automatic segmentations by means of the deep convolutional neural network, and makes up for the deficiency that a weak boundary problem cannot be solved based on a movable contour and the like; and the method can automatically lean and extract valuable feature combinations, and prevent the complexity of an artificial feature selection.

The present invention relates to a convolution neural network training method and an ultrasonic image recognition and location method and system. The method comprise the following steps of establishing a convolution neural network model; taking the convolution neural network model trained on ImageNet as the starting point, reading the B-ultrasonic images in the training data set by different network nodes / layers, and then fine turning the B-ultrasonic images to carry out the migration learning of the neural network model, wherein the images in the training data set come from B-ultrasound examination images of a single center and multiple machines, and are marked with pathological examination results; determining the object position and classification by regression. The invention provides an artificial intelligent identification and positioning system for realizing ultrasonic images, such as ultrasonic images of thyroid nodules, by using migration learning and depth convolution neural network, which greatly improves the accuracy of a model and realizes the shaping of a benign and malignant thyroid nodules auxiliary evaluation and positioning system thereof.

The invention discloses a thyroid nodule recognition method based on a generative adversarial network. The thyroid nodule recognition method comprises the following steps: screening the data of a patient suffering from a thyroid disease, building a thyroid nodule database, and carrying out circling marking on thyroid nodules and thyroid parenchyma; semantic segmentation: taking U-net as a condition of a generative network to generate an adversarial network model, and inputting an annotated image to realize semantic segmentation; benign and malignant classification input: after multiple convolution, activation and pooling, using a full connection layer to integrate the extracted features to realize image benign and malignant judgment by the convolutional neural network; after the lesion isinput into the convolutional neural network, automatically classifying the lesion and outputting a benign and malignant judgment result of the lesion by the convolutional neural network; and giving areference diagnosis report of the illness state of the patient according to the training result. The thyroid nodule recognition method based on a generative adversarial network can improve thyroid nodule benign and malignant judgment accuracy of doctors, can reduce the thyroid screening time of ultrasound, can reduce the working intensity of medical staff, and can increase the satisfaction degreeof patients.

The invention provides somatic mutation sites of pathogenic genes of the thyroid cancer and application thereof, specifically to a group of mutation sites of the pathogenic genes of the thyroid cancer. The mutation sites are composed of a GNAS gene mutation site, a NRAS gene mutation site, a TSHR gene mutation site, etc. The gene mutation sites provided by the invention can be used as markers for identification of benign and malignant thyroid nodules.

The invention relates to a pharmaceutical composition for treating Hashimoto's thyroiditis and a preparation method thereof. The pharmaceutical composition is composed of bupleurum, radix curcumae, prunella vulgaris, rhizoma Dioscoreae Nipponicae, thunberg fritillary bulb, radix scrophulariae, edible tulip, astragalus, dark plum and other components, and can be made into granules, capsules, tablets or pills by the conventional pharmaceutical processes. The pharmaceutical composition has the effects of soothing liver-qi stagnation, reducing phlegm, removing stasis, and softening hardness to dissipate stagnation, and applies to patients with Hashimoto's thyroiditis and thyroid nodules. Clinical studies have shown that the pharmaceutical composition can significantly improve the symptoms of Hashimoto's thyroiditis, reduce the thyroid volume and isthmus thickness, and reduce the level of TgAb and TPOAb, and the total effective rate is 97.22%. In addition, for patients with thyroid nodules, nodules can be significantly reduced or even disappeare, no significant adverse reactions are presented in the course of treatment. Experimental studies have shown that the pharmaceutical composition reduces the level of TgAb and TPOAb, and reduces inflammatory infiltration and thyroid follicular damage.

The invention discloses a thyroid nodule eliminating paste preparation for treating benign non-toxic thyroid nodules. The preparation is composed of the following medicinal raw materials in parts by weight: 6 to 11 parts of radix bupleuri, 10 to 15 parts of curcuma rhizome processed with vinegar, 15 to 20 parts of dioscorea bulbifera, 15 to 20 parts of fried semen brassicae, 6 to 11 parts of processed rhizoma cyperi, 30 to 35 parts of ternate buttercup root, 20 to 25 parts of prunella vulgaris, 10 to 15 parts of salt cake, 10 to 15 parts of rhizoma pinelliae preparata, 15 to 20 parts of laminaria, 15 to 20 parts of alga, and 30 to 35 parts of live oyster.

The present invention relates to a pharmaceutical composition for preventing or treating thyroid diseases and a food composition for improving thyroid function, comprising an extract from Lonicera caerulea L. car. Edulis fruits as an active ingredient.The composition of the present invention may be useful for preventing or treating thyroid diseases such as hypothyroidism, hyperthyroidism, thyroid nodule, or thyroditis, and improving thyroid function. Since the extract from Lonicera caerulea L. car. Edulis fruits, which is an active ingredient of the present invention, is derived from natural products, there is no concern for side effects such as toxicity compared to synthetic medicine.

The invention provides a thyroid cancer molecular diagnosis kit. The kit comprises detection reagents for at least three genes of the follows: CK19, survivin, TG, LGALS3, MET, TFF3, SERPINA1, TIMP1, FN1, TPO, TGFA, QPCT, CRABP1, FCGBP, EPS8, PROS1, LRP4, DPP4, GJB3, ST14, EVA1, SPUVE, HBB, MKRN2, MRC2, IGSF1, KIAA0830, RXRG, P4HA2, CDH3, IL13RA1, MTMR4, MDK, CITED1, CHI3L1, ODZ1, N33, SFTPB and SCEL. The benign and malignant of thyroid nodule is judged through the expression level of thyroid cancer tissue specific expression genes, and the operation is simple and convenient.

The present invention provides protein biomarkers for determining whether a thyroid nodule is malignant or benign and methods for using the same.

The invention discloses a Chinese medicinal external application medicament for treating thyroid nodules. The thyroid nodules belong to the domain of Chinese medical 'warts', and are formed by dysfunction of spleen in transportation and retaining of internal phlegm in the Adam's apple due to depression and liver dysfunction. All grass or root of common calanthe, capparis acutifolia, securidaca inappendiculata, homlockleaved moonwort, trifoliate orange, spiral shell, bryozoatum and souliea vaginata are ground into powder, a proper amount of ginger juice is added to the powder to form paste, and the paste is externally applied to an affected part; through clinical test in the hospital, the total effectiveness is 93.3 percent and is obviously superior to that of a control group; and the medicament is worthy of clinical popularization and application.

The invention discloses a combination tool for thyroid puncture. The combination tool comprises a negative pressure syringe, wherein a puncture needle is connected to one end of the negative pressuresyringe, and a liquid collection bottle and an adjustable puncture fixing device for limiting the puncture position are disposed under the negative pressure syringe. The adjustable puncture fixing device comprises a sleeve neck and a movable connection component, wherein the movable connection component comprises a first perforated plate integrally formed with the negative pressure syringe, two second perforated plates arranged in the left and right direction and integrally formed with the sleeve neck, and fastening screws that are used for fixing the first perforated plate and the second perforated plates. Two ends of the sleeve neck are connected with a velcro male face and a velcro female face, respectively, so that the function of repeated aspiration of the thyroid nodules and cysts ofa patient can be achieved, and furhter the burden of pains of the patient by multiple insertion and puncture can be alleviated. During the thyroid puncture of the patient, the combination tool can maintain the relative fixation between the thyroid puncture combination tool and the thyroid position of the patient and ensure the accuracy of diagnosis and treatment results.

The invention discloses a human thyroid cancer gene fusion kit and a detection method in the technical field of molecular biology. According to the kit, a multiple PCR capture technology and an NGS sequencing technology are adopted; the kit is used for qualitatively detecting various variants of CCC6-RET, NCOA4-RET, PAX8 / PPARG and ETV6-NTRK3 fusion genes in a thyroid nodule needle biopsy cytological uncertainty fresh tissue sample, and detection threshold values are determined according to molecular tags. Assistance can be provided for auxiliary diagnosis and treatment of thyroid cancer through detection of fusion sites of the kit in combination with clinical pathological analysis results.

The invention discloses a primer for detecting variation of benign and malignant related genes of thyroid nodules, a kit and a detection method. According to the primer, the kit and the detection method, variation of 15 loci of the six genes and variation of the three fusion genes can be detected simultaneously, and the BRAF gene, the KRAS gene, the HRAS gene, the NRAS gene, the TERT gene, the EIF1AX gene, RET / PTC1 fusion, RET / PTC3 fusion and PAX8 / PPARgamma fusion are involved. Hotspot mutation and fusion variation of the genes are closely related to the benign and malignant thyroid nodules. Therefore, the primer, the kit and the detection method are used for detecting a sample of a patient and can assist doctors in benign and malignant identification of the thyroid nodules which cannot be clearly diagnosed in the cytology, the accuracy of identifying the benign and malignant thyroid nodules is improved, excessive medical treatment for the patient with the thyroid nodules is reduced, and the primer, the kit and the detection method have important practical significance and high economic benefit for saving medical resources of China.

The invention relates to a traditional Chinese medicine composition. The traditional Chinese medicine composition comprises the following components in parts by weight: 150-299 parts of green tangerine peel, 150-299 parts of frankincense, 200-399 parts of laminaria japonica, 200-399 parts of prunella vulgaris, and 150-299 parts of fritillaria. The traditional Chinese medicine composition has efficacy for softening hardness and dissipating binds, coursing liver and rectifying qi, and activating blood to remove stasis, and can be used for preparing medicines for preventing and treating thyroid nodules.

The invention provides a medicine compound for treating thyroid nodule. The medicine compound for treating thyroid nodule is a preparation prepared from the following raw material medicines in parts by weight: 9-15 parts of rhizoma cyperi, 9-15 parts of radix paeoniae alba, 16-24 parts of alga, 8-12 parts of radix bupleuri, 12-18 parts of kelp, 30-45 parts of fritillary bulb, 8-12 parts of rhizomapinelliae, 5-7 parts of pericarpium citri reticulatae viride, 8-12 parts of pericarpium citri reticulatae, 12-18 parts of angelica sinensis, 8-12 parts of rhizoma chuanxiong, 8-12 parts of fructus forsythiae, 12-18 parts of raw oyster shell and 7-11 parts of selfheal. Experiment results prove that the medicine compound has a precise and appropriate formula, can significantly relieve clinical symptoms of a thyroid nodule patient, and effectively treats thyroid nodule, moreover, the compound is good in safety, free from toxic and side effects and convenient to use, and a novel medicine option is provided for clinics.

The invention relates to the technical field of medical diagnostics. Thyroid tumors can be divided into two types including benign tumors and cancers. The property of a thyroid nodule is difficult to determine clinically; and even if biopsy is carried out, the benign tumors and the cancers are not easy to clearly identify due to thyroid adenomas and focal nodular hyperplasia. The invention provides a blood micro-molecular metabolin specific chromatogram which is used for identifying papillary thyroid carcinomas, benign thyroid tumors and blood of normal people, and a manufacturing method of the blood micro-molecular metabolin specific chromatogram. A micro-molecular metabolin comprises two blood metabolin marks, namely palmityl carnitine and carnitine; the molecular weights of the palmityl carnitine and the carnitine are 400.2634 and 161.20; and corresponding ions detected on a mass spectrum are 404.5532 and 160.7866. A clinical experiment shows that the accuracy of applying a chromatogram formed by a specific value of the two metabolism micro-molecules to judge the thyroid cancer is 74% and the accuracy of judging non-cancer (the benign thyroid tumor and the normal people) is 72.3%. The blood micro-molecular metabolin specific chromatogram disclosed by the invention has the advantage of high sensitivity and can be prepared into a diagnosis kit for screening and auxiliary diagnosis of the thyroid cancer.

The invention discloses a pure traditional Chinese medicine preparation for treating thyroid nodule. The preparation comprises components in weight-volume ratio as follows: 15-30 parts of selfheal spikes, 15-30 parts of dandelion, 10-20 parts of fructus forsythiae, 10-20 parts of rhizoma bolbostemmae, 30-60 parts of raw oyster, 10-20 parts of ternate buttercup roots, 15-20 parts of Chinese honeylocust spine, 10-20 parts of turmeric root-tuber, 20-30 parts of unprocessed turtle shell, 5-10 parts of Indian Iphigenia bulb and 10-15 parts of muskroot-like semiaquilegia herb. All selected materialsfor treating the thyroid nodule are traditional Chinese medicinal materials, have no toxic or side effects, medicine sources are easy to obtain, the cost of medicinal materials is low, economic burden on patients cannot be caused, all medicines are compatible to have effects of removing carbuncle and stagnation, activating blood, removing stasis and resolving phlegm, the thyroid nodules can be reduced significantly, clinical symptoms of patients can be eliminated, and pain can be relieved.

The invention provides an external traditional Chinese medicine composition for treating thyroid nodules. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10 to 80 parts of spica prunellae, 10 to 80 parts of kelp, 10 to 60 parts of airpotato yam rhizome, 10 to 60 parts of bulbus fritillariae thunbergii, 10 to 60 parts of rhizoma curcumae, 5 to 30 parts of frankincense and 5 to 30 parts of myrrh. The external traditional Chinese medicine composition for treating the thyroid nodules achieves the effect of reducing the thyroid nodules and is free of toxic and side effects; meanwhile, the invention also provides a dosage form and a preparation method of the external traditional Chinese medicine composition for treating thyroid nodules, so that the external traditional Chinese medicine composition is convenient to treat and use, low in cost, simple and convenient to operate and suitable for large-scale production.

The invention relates to a thyroid nodule and tumor color Doppler imaging microwave treatment system and a needle selection method. The treatment system comprises a color Doppler imaging unit, a microwave generating unit, a water-cooled microwave radiation probe, a water-cooled circulating control unit and a microprocessor control unit, wherein the microprocessor control unit is in charge of outputting a microwave power control signal to control and regulate power of the microwave generating unit. The color Doppler imaging microwave treatment system disclosed by the invention, when used for treating thyroid nodules and tumors, can achieve transient radiation on the basis of microwave energy under color Doppler imaging, and the radiation energy is controllable; and with the application of the system, thyroid tissues of pathological change can be precisely and rapidly ablated, so that a treatment purpose is achieved.

The invention discloses seaweed kelp soup for treating thyroid nodules and lymph nodules. The seaweed kelp soup is prepared from, by weight, 10-25 parts of dandelion, 10-15 parts of spica prunellae, 5-20 parts of oysters, 20-40 parts of seaweed, 20-35 parts of kelp, 5-15 parts of flos lonicerae and 2-10 parts of radix paeoniae rubra. The seaweed kelp soup for treating the thyroid nodules and the lymph nodules has the advantages that the adopted materials are common, and mostly are common food materials, take the place of traditional medicine to replace medical therapy with food therapy, so that side effects caused by the medicine are reduced; the preparation method is simple, the soup is suitable for being self-decocted at home, the cost is reduced, and the effects are remarkable.

The invention discloses a formula of a medicine for treating thyroid nodules and a preparation method, and belongs to the technical field of medicines. The medicine is prepared from, by weight, 30 parts of raw radix astragali, 30 parts of Radix Salviae Miltiorrhizae, 30 parts of root peel of Lycium chinense Mill., Hedyotis diffusa, 20 parts of raw oysters, 20 parts of Fritillaria thunbergii Miq., 20 parts of roots of Catclaw Buttercup, 10 parts of Rhizoma Dioscoreae bulbiferae, 15 parts of algae, 6 parts of radix bupleuri, 4 parts of ginseng, 4 parts of Lilium brownii var. viridulum Baker, 4 parts of common vladimiria roots, 4 parts of wild chrysanthemum flowers and 4 parts of barbed skullcap herb. The preparation method of the medicine includes the following steps of firstly, weighing and mixing the medicinal materials; secondly, smashing the medicinal materials; thirdly, boiling the raw medicinal materials; fourthly, extracting and concentrating liquid medicine; fifthly, mixing and dissolving the concentrated solution; sixthly, regulating PH and conducting drying and processing to form the medicine. The medicine overcomes the defects of existing medicines for treating thyroid nodules and existing preparation methods.

The invention relates to a drug for treating thyroid nodule. The drug is prepared from the following raw materials in parts by weight: 15 parts of kelp, 6 parts of fructus forsythiae, 6 parts of dandelion, 6 parts of radix scrophulariae, 3 parts of prepared pinellia tuber, 12 parts of poria cocos, 9 parts of lotus seed, 6 parts of radish seed, and 4 parts of licorice. Kelp has the functions of softening hardness and dissipating binds; fructus forsythiae has the functions of clearing heat, removing toxin, eliminating swelling, and dissipating binds; dandelion has the functions of eliminating swelling, dissipating binds, draining dampness, and treating stranguria; radix scrophulariae has the functions of removing toxin and dissipating binds; prepared pinellia tuber has the functions of eliminating dampness and resolving phlegm; poria cocos has the functions of invigorating spleen and draining dampness; lotus seed has the functions of tonifying spleen and boosting kidney; radish seed has the functions of suppressing qi and resolving phlegm; and licorice coordinates the drug actions of a prescription. The components mentioned above are used together to generate the functions of moving qi and blood, expelling evil and toxin, softening hardness, and dissipating binds, and thus the drug can treat thyroid nodule. The clinical experiment results show that the drug can safely and effectively treat thyroid nodule.

Disclosed is a thyroid cancer pathogenicity-related gene fusion and mutation detection kit. The thyroid cancer pathogenicity-related gene fusion and mutation detection kit is characterized by comprising an RNA probe set, primers, blocking buffer, an RNA enzyme blocking solution, hybridization buffer, binding buffer, 1x SSC rinse liquid, 0.1x SSC rinse liquid, PCR reaction liquid and TE buffer, wherein the RNA probe set comprises 161 RNA probes with the sequences shown as Seq ID No.1-161. The thyroid cancer pathogenicity-related gene fusion and mutation detection kit is capable of detecting 5 disease-related pathogenic genes simultaneously, providing conditions for precise diagnosis and treatment of individuals suffering from thyroid cancer and evaluating cancer risks of thyroid nodule patients.

The invention relates to a traditional Chinese medicine composition and an application thereof. The traditional Chinese medicine composition comprises the following active ingredients by weight: 12-16 parts of oldenlandia diffusa, 12-16 parts of rhizoma paridis, 12-18 parts of tangerine seeds, 8-12 parts of fennel fruit, 8-12 parts of rhizoma sparganii, 8-12 parts of rhizoma curcumae, 12-16 parts of sargentgloryvine stem, 6-10 parts of angelica sinensis, 12-16 parts of Chinese honeylocust spine, 12-18 parts of selfheal spike and 12-16 parts of hawthorn fruits. The traditional Chinese medicine composition has good curative effect, fast effectiveness and small toxic and side effect in treating symptoms such as thyroid nodules, thyroid adenoma, simple goiter, hyperplasia of mammary glands, breast adenoma, uterine fibroids, ovarian cysts and benign prostate hyperplasia.

The invention discloses an endoscopic thyroid retractor. When a push-pull rod is pushed toward the direction of a guiding part, a retractor end of a retractor connecting rod slips out of a second sliding chute to stretch the anterior jugular muscle group so as to better expose a focal position of thyroid nodule, thus providing a better surgical visual field, and under a microinvasive premise, theanterior jugular muscle group is safely and reliably pulled to reach the purpose of full exposure of the thyroid focus; and when the push-pull rod is pulled away from the guiding part, the retractor end of a retractor connecting rod is withdrawn into the second sliding chute to storage the retractor connecting rod, thus being convenient for taking the endoscopic thyroid retractor out, and reducingthe probability of subsidiary-injury of the anterior jugular muscle group.

The invention relates to the field of medical detection, in particular to specific gene markers for TMT (thyroid malignant tumor) and an application of the specific gene markers. On the basis of a weighted gene coexpression network analysis method and by combination with clinical cases, the TMT is specifically correlated with abnormal expression of 17 gene markers and can be taken as a specific gene detection marker set. By means of verification of a large number of independent clinicopathological samples, specific mutation sites of 5 specific genes are further determined as molecular diagnosis markers. The related gene diagnosis marker set has important clinical application value for early molecular accurate diagnosis of the TMT, can be used for preparing a molecular diagnosis kit for detecting malignant thyroid nodules which are indeterminate according to clinical aspiration biopsy cytology, and particularly has important clinical application value for early molecular accurate diagnosis of patients with an uncertain FNAB (fine needle aspiration biopsy) cytology result of malignant thyroid nodules.

The invention discloses a Chinese medicinal external application medicament for treating thyroid nodules. The thyroid nodules belong to the domain of Chinese medical 'warts', and are formed by dysfunction of spleen in transportation and retaining of internal phlegm in the Adam's apple due to depression and liver dysfunction. All grass or root of common calanthe, capparis acutifolia, securidaca inappendiculata, homlockleaved moonwort, trifoliate orange, spiral shell, bryozoatum and souliea vaginata are ground into powder, a proper amount of ginger juice is added to the powder to form paste, and the paste is externally applied to an affected part; through clinical test in the hospital, the total effectiveness is 93.3 percent and is obviously superior to that of a control group; and the medicament is worthy of clinical popularization and application.

The invention discloses a composition for alleviating thyroid nodules and hypothyroidism and application thereof, belonging to the technical field of health food. The composition of the invention is prepared from kelp, oyster shells, licorice roots and tangerine peel. The composition of the invention is prepared from carefully selected kelp, oyster shells, licorice roots and tangerine peel which are both edible and medicinal, and the components are rationally combined to produce synergistic effect, so the composition can improve the thyroid epithelial cell proliferation and colloid deficiencyand enhance the levels of the thyroid hormones FT3, FT4 and TSH; and the composition is capable of relieving thyroid nodules and protecting thyroid functions, and has the advantages of simple combination, high safety, no toxic and side effects, fast action and definite curative effect.