84 results about "Liver dysfunction" patented technology

The invention relates to a non-invasive apparatus system for monitoring drug hepatotoxicity, and its uses in monitoring drug-induced hepatotoxicity and abnormal liver function.

The invention relates to a glycyrrhizic acid derivative, preparation thereof and use thereof. The derivative has high water solubility and high storage stability and is suitable to be used in medicaments and health-care products for treating or preventing hepatitis, liver cirrhosis, hemorrhagic fever of liver damage and liver dysfunction syndrome, allergic purpura, psoriasis vulgaris, eczematousdermatitis and the like.

The present invention provides methods and kits for detecting and monitoring liver damage in a subject. The methods and kits rely on the correlation between the presence or increase in a kallikrein-like peptidase in a sample from the subject and liver disease. Additionally, the present invention provides in vivo and in vitro methods for detecting toxicity of a therapeutic agent. Methods for detecting, diagnosing, or monitoring liver damage by measuring a panel of components, including kallikrein-like peptidase, along with other blood enzymes and / or complement components are also provided.

The present invention provides a bilirubin reducing means which can minimize a risk such as the onset of an infection or the occurrence of blood coagulation and can reduce physical, temporal and economical burdens imposed on a patient suffering from liver dysfunction. A bilirubin denaturating apparatus includes a dialyzing portion which has a dialyzing column for performing dialysis of blood using hollow fibers incorporated therein; an infusion supply portion which supplies an infusion used for dialysis in the dialyzing portion to the dialyzing portion; and a blood circulating portion which feeds blood to the dialyzing portion and returns the blood dialyzed by the dialyzing portion, wherein the dialyzing portion includes a radiation means which radiates green light to the hollow fibers, and the radiation means radiates the green light to the hollow fibers for converting fat-soluble bilirubin in the blood flowing in the inside of the hollow fibers into water-soluble bilirubin thus eluting the water-soluble bilirubin in the infusion.

The invention provides a composite body health care paste and a preparation method thereof. The body health care paste is composed of, by mass, 150-200 g of ginseng, 220-280 g of poria cocos, 220-280 g of Chinese yam, and 80-120 g of pericarpium citri reticulatae. The composite body health care paste has the effects of tonifying spleen and boosting lung, and regulating Qi to resolve phlegm, and is used for the symptoms of Qi deficiency in spleen and lung, intolerance of cold and auto-sweating, being easy to catch external infection, cough and asthma and excessive phlegm, and body fatigue, diarrhea, loose stool and the like. The body health care paste is divided into a formula for men and a formula for women, wherein the formula for men has the effects of tonifying the Qi and fortifying spleen, benefitting the kidney for securing essence, and is used for treating body deficiency and Qi deficiency, spleen deficiency and diarrhea, kidney deficiency and seminal and urine emission, impotence and premature ejaculation; and the formula for women has the effects of tonifying the Qi and fortifying spleen, nourishing blood and soothing liver, and is used for treating symptoms such as weary looking, dismayed mood and palpitation, sweating as soon as movement, poor sleep, irregular menstruation and the like due to Qi deficiency and hemophthisis, liver dysfunction, and disharmony of Chong and Ren channels.

The invention discloses an oral medicinal composition of glycyrrhizic acid or glycyrrhetate and a preparation method thereof. The composition consists of a plurality of units, wherein each unit consists of an outer layer enteric coating and content; and the content contains glycyrrhizic acid or glycyrrhetate and at least one intestinal absorption accelerator. The composition can be used for treating chronic hepatitis and improving liver dysfunction.

The purpose of the present invention is to provide a Hugan products and their preparation methods, as described including chrysanthemum, dandelion, wolfberry, cassia seed, Angelica dahurica and schisandrin, carried out by a special combination of natural herbs, effective prevention, and treatment to improve liver dysfunction, such as the role of disease, and its preparation method is simple, stable process conditions suitable for the scale of chemical production.

Assays are provided for erectile and bladder dysfunction and vascular health (e.g., cardiovascular disease, hypertension), where the assays detect the expression of one or more of the human Vcsa1 gene family. The assays are also useful for monitoring the efficacy of treatment of these disorders.

Methods and compositions for treating conditions including liver dysfunction, e.g., associated with fatty liver; glucose intolerance; and others, by administering compositions comprising anti-LPS immunoglobulin enriched colostrum preparations.

The invention discloses a Chinese herba preparation for treating cardiac neurosis. According to traditional Chinese medicine, the cardiac neurosis belongs to categories of 'palpitation' and 'insomnia'. Timidity due to insufficiency of qi and deficiency of blood of the heat and depression cause stasis and liver dysfunction, which causes blood stasis and heart vessel blockage stasis in course of time, or qi and yin deficiency and loss of nourishment of the mind result in dysfunction of vessels of the heart. The Chinese herba preparation comprises traditional Chinese medicines: large leaf moss, ophiopogon latifolius, lanjiang lily bulb, abrus cantoniensis hance, white selfheal, poncirus trifoliate, pericarpium citri reticulatae viride, corydalis tuber, false hellebore, amber, and radix glycyrrhizae preparata, and all the traditional Chinese medicines are decocted into decoction. Clinical tests of the institute show that the total effective rate reaches 95.8%, so that the Chinese herba preparation is obviously superior to the control group.

The present invention provides a metabolism regulating and liver protecting nutritional supplement, a preparation method and applications thereof. The metabolism regulating and liver protecting nutritional supplement contains 10 to 50 parts of alpha-ketoglutarate bis-arginine and is effervescent tablet or buccal tablet. On the other hand, the present invention provides a preparation method for the metabolism regulating and liver protecting nutritional supplement. The method comprises four steps of dispensation, pulverization, pelletization, and obtain the finished product. The present invention also provides applications of the metabolism regulating and liver protecting nutritional supplement on alleviating hangover to protect liver and daily care. The metabolism regulating and liver protecting nutritional supplement can regulate the liver dysfunction, and can directly and quickly provide nutrient and plenty of cell energy for liver cells to absorb and utilize, thereby maintaining the normal functions and health of the liver

The invention discloses a Chinese medicinal composition for treating enterophthisis with a syndrome of stagnation of the liver-Qi attacking spleen. When a person is damaged by excess of seven emotions and has an emotional stress, the person is in disorder of qi movement and has liver failure, the spleen is invaded unreasonably, and the healthy transportation is lost, so that the person suffers from abdominal pains and diarrhea. Liver dysfunction results in chest distress and rib-side distention. Belching with reduced appetite, a pink tongue and stringy pulse shows a phenomenon of liver-yang hyperactivity and spleen deficiency. The Chinese medicinal composition is prepared from traditional Chinese medicinal materials including herb of stickyhair pearleverlasting, caraway, dutchmanspipe root, nard, clerodendron bungei root, wild sorghum, orange peel, roots of uraria crinit, clove tree back and red garden burnet. The Chinese medicinal composition is prepared into a decoction in a drug manufacturing room of our hospital, and clinical tests show that the total effective rate of the composition is 97.5% and the curative effect is very significant.

The invention provides a peptide and a composition thereof for improving liver dysfunction, wherein the peptide and the composition thereof can take a preventive effect or a curative effect on liver dysfunction and can be used for preparing drugs and food. The liver dysfunction particularly refers to a non-alcoholic fatty liver disease (NAFLD), nonalcoholic steatosis hepatitis (NASH) or liver dysfunction caused by hepatitis viruses, alcohol, stress, drug or immunologic abnormality.

The invention discloses the application of gastrodine to the preparation of caspase-3 active inhibitor and belongs to the field of pharmacy. The gastrodine is applied to the preparation of caspase-3 active inhibitor, the caspase-3 active inhibitor can be used for treating diseases including neurodegenerative diseases, cardiovascular and cerebrovascular diseases, osteoarthritis, rheumatoid arthritis, and the like, specifically such as Parkinson disease, Alzheimer disease, amyotrophic lateral sclerosis, Huntington disease, traumatic brain injury, spinal cord injury, severe hepatitis, liver dysfunction, osteoarthritis, rheumatoid arthritis, acquired immunodeficiency syndrome, myocardial infarction, cerebral ischemia and the like. The application of gastrodine has the advantage of blocking the specific protease needed by apoptosis without any adverse reaction which is caused by the application of the majority of broad spectrum drugs.

The invention discloses a nutrition additive of young bird livestock and poultry feed, which comprises: soybean fermentation residue powder, soybean polypeptide powder, cellulase, protease, vitamin D2, D3, vitamin B1, B2, B6, B12, vitamin K, biotin D, vitamin E, mineral powder, and astragalus polysaccharide. The nutrition additive of young bird livestock and poultry feed of the invention can solve symptoms of body low immunity, weak stress resistance, liver dysfunction, digestion dysfunction, infectious disease susceptibility, poor appetite, appetite loss, slow growth, and the like caused by poor nutrient absorption due to poor gastrointestinal digestion absorption functions of young birds, livestock and poultry. When the nutrition additive of young bird livestock and poultry feed of the invention is added into daily ration reasonably, the nutrition additive can promote growth of intestinal villi, improve young animal gastrointestinal functions, improve the feed conversion rate, reduce material consumption, improve immunity and disease-prevention and disease-resistance capabilities of animal bodies, give play to dual effects of nutrition and immunity improvement, and thus improve economic benefits of farmers; the nutrition additive is an indispensable nutritional additive for the development of ecological healthy breeding, and is worthy of popularization.

The invention discloses a Chinese medicinal external lotion for treating neonatal jaundice. The pathogenesis of the neonatal jaundice is that the spleen and stomach have pathogenic dampness implication, liver dysfunction is caused, and the bile overflows and becomes yellow. Therefore, the Chinese medicinal external lotion is prepared from the Chinese medicaments including golden-rod, small-leaved desmodium, multiflora rose, abrus cantoniensis hance, calanthe discolor lindl, desmodium styracifolium and radix curcumae which have the effects of clearing heat and promoting diuresis, dispersing the liver depression, removing stasis to relieve dyspepsia and removing blood stasis. The prepared Chinese medicinal external lotion is used for soaking and washing the body surface of a newbron, and clinical tests show that the visible efficiency and the total efficiency reach 77.3% and 96.0% respectively and are obviously superior to those of a control group; the serum bilirubin is reduced to a normally needed time which is obviously shorter than that of the control group; and the sleeping quality is better than that of the control group. The treatment method is simple and the cost is low, so that the Chinese medicinal external lotion is worthy of clinical popularization and application.

The invention relates to a compound electrolyte glucose injection and a preparation method thereof. The injection is prepared from the following components in 500ml: 0.8-4.0g of sodium chloride, 0.1-0.4g of magnesium chloride, 0.07-0.34g of calcium chloride, 0.5-2.5g of sodium acetate, 0.2-1.0g of malic acid, 15-45g of glucose and 0.05-0.45g of sodium hydroxide and pH regulator which is used for regulating pH to 4.5-5.5. The preparation method comprises the following steps: liquid preparing, filtering, filling, capping, sterilizing and inspecting with a light, wherein the step of liquid preparing adopts a mode of combining concentrated preparation and diluted preparation, low temperature is adopted in the concentrated preparation process, nitrogen is introduced in the whole liquid preparation process for protecting from light. The electrolyte glucose injection prepared by adopting the method has good drug stability and small side effect, patients have high compliance and safety, the requirement of patients for fluid infusion and electrolyte disturbance in an operating process can be met, and the injection is applicable to liver dysfunction, severe shock and child patients.

The present invention derives from the finding that increased levels of Toll like receptor 4 (TLR4) is associated with liver failure and renal dysfunction and / or brain dysfunction and that by decreasing TLR4 levels in vivo, the kidney and brain consequences of liver disease that are precipitated by superimposed infection or inflammation may be reduced. Accordingly, the invention provides TLR4 antagonists for use in a method of treating an individual suffering from liver disease presenting with renal or brain dysfunction.

This invention relates to methods of isolating hepatoblasts utilizing panning techniques and fluorescence activated cell sorting. This invention further relates to isolated hepatoblasts and to a method of treating liver dysfunction as well as to methods of forming artificial livers.

The invention discloses a Chinese medicinal external application medicament for treating thyroid nodules. The thyroid nodules belong to the domain of Chinese medical 'warts', and are formed by dysfunction of spleen in transportation and retaining of internal phlegm in the Adam's apple due to depression and liver dysfunction. All grass or root of common calanthe, capparis acutifolia, securidaca inappendiculata, homlockleaved moonwort, trifoliate orange, spiral shell, bryozoatum and souliea vaginata are ground into powder, a proper amount of ginger juice is added to the powder to form paste, and the paste is externally applied to an affected part; through clinical test in the hospital, the total effectiveness is 93.3 percent and is obviously superior to that of a control group; and the medicament is worthy of clinical popularization and application.

The invention belongs to the field of food processing, and in particular discloses a processing technology of purple potato rose. The processing technology comprises the process flows of burdening, kneading dough, pressing the dough, pressing wrappers or manually rolling wrappers, forming, fermenting, steaming and cooking, cooling and packaging, as well as carrying out quick-freezing and storing in a warehouse. The finished product is relatively intense in the fragrance of purple potato and wheat, and is sweet and soft in taste; on the basis of avoiding the use of pigment and a color fixative, the produced purple potato rose can keep the natural color, flavor and nutrition of the purple potato, so that the health performance and the sensory quality of the food are improved. The purple potato rose has the health efficacies of preventing hypertension, relieving liver dysfunction, resisting cancers, resisting fatigue, resisting aging and nourishing blood, and is suitable for the tastes of peoples at different ages; and the purple potato rose is safe and free from toxicity and harm, and the purple potato rose is high in market economic benefit as well as development and application prospects.

Methods of using hepatic progenitors in treating liver dysfunction are provided. More particularly, methods of using hepatic progenitor cells, including hepatic stem cells, in treating liver dysfunction in the absence of immune-suppressing amounts of an immunosuppressant.

An object of the present invention is to provide a novel antischistosomal agent, and more specifically, to provide a novel drug capable of inhibiting a growth of schistosomes in vivo to prevent development of liver dysfunction due to eggs of the schistosomes in the case of infection with the schistosomes. The novel antischistosomal agent includes as an active ingredient a peroxide derivative. Specifically, the novel antischistosomal agent includes as an active ingredient a peroxide derivative represented by the general formula (I):where C represents an alicyclic hydrocarbon ring group which may be substituted, and n represents an integer of 1 to 6.

Plant extracts compositions comprising extracts of Curcuma longa, Phyllanthus emblica and Gymnosporea montana and at least a carrier. The extracts used to prepare the composition are prepared from specific parts of the respective plants like extract of Curcuma longa; Phyllanthus emblica and Gymnosporea montana are prepared from tubers, fruits and leafs of respective plants. The compositions can be used to treat liver dysfunction.

The invention relates to usage of Roxadustat in preparation of drugs for treating sepsis. In order to solve the problem of lack of therapeutic drugs for treating sepsis and organ dysfunction, such asheart dysfunction, liver heart dysfunction and the like, the invention provides novel usage of Roxadustat in preparation of drugs for treating sepsis as well as organ dysfunction, such as heart dysfunction, liver heart dysfunction and the like, thereby effectively reducing fatality rate of sepsis as well as treating organ dysfunction, such as cardiovascular dysfunction, liver dysfunction and the like, caused by sepsis.

The invention discloses a traditional Chinese medicine composition for treating phlegm-dampness stagnation type fatty liver. Fatty liver equivalently belongs to the category of 'accumulation', 'phlegm', 'hypochondriac pain' and the like in traditional Chinese medicine. The pathogenesis of the fatty liver can be summarized as follows: liver dysfunction, liver blood stasis, dysfunction of the spleen in transport, non-dispelling of damp evil, internal phlegm turbidity, dysfunction of kidney for activation of Qi and phlegm stagnation. The phlegm-dampness stagnation type fatty liver is caused by qi stagnation and blood stasis due to long-time phlegm-damp accumulation. The traditional Chinese medicines which include cremanthodium, ligularia sibirica, fomitopsis officinalis ames, saltliving wormwood leaves, beautiful galangal fruit, phellandrium, trema cannabina, water spinach root, triptophenolide and flos rosae rugosae and have the effects of eliminating phlegm and dispelling dampness as well as soothing the liver and regulating qi-flowing for strengthening the spleen are selected; the traditional Chinese medicines are decocted with water into a decoction by a preparation room. Clinical tests show that the total effective rate reaches 97.5% and is obviously better than 78.9% of a control group, and the traditional Chinese medicine composition is worth of clinical popularization and application.

The invention relates to novel application of massoia lactone and 5-hydroxy-2-caproleic acid. An animal model test proves that for a CCL4 induced mouse hepatic fibrosis and liver cirrhosis model, after massoia lactone or 5-hydroxy-2-caproleic acid is used for intervention, the abnormal liver function can be remarkably improved, the serum aspartate amino transferase, glutamic-pyruvic transaminase and the total bilirubin level are lowered, the content of hepatic tissue hydroxyproline is decreased, hepatic stellate cell activation is inhibited, the type I collagen expression is reduced, and liver tissue collagen deposition is restrained; for a HepG-2 nude-mouse transplanted tumor model, after massoia lactone or 5-hydroxy-2-caproleic acid is used for intervention, increase of the weight and size of transplantation tumors can be remarkably inhibited. Accordingly, the two compounds can be used for preparing liver fibrosis, liver cirrhosis and liver cancer resistance drugs.

The invention belongs to the technical field of medicine and health food, and particularly relates to application of an ampelopsis grossedentata water extract in preparation of a preparation for improving liver injury. The ampelopsis grossedentata water extract disclosed by the invention can be used for effectively regulating intestinal flora disorder, improving intestinal barrier function damage and reducing inflammatory response of liver injury by regulating diversity of intestinal flora of mice, obviously increasing SOD (superoxide dismutase) content of serum of the mice and improving oxidation resistance of liver cells. The invention has positive application value for treating and preventing acute and chronic liver injury by regulating intestinal microecological disorder by utilizing the ampelopsis grossedentata water extract, improving liver dysfunction of patients and delaying the development of liver fibrosis of the patients. The ampelopsis grossedentata water extract and the composition thereof can be used for preventing and treating diseases for improving intestinal microecological disorder caused by various reasons.

This invention is related to the field of hypercholesterolemia. In particular, the invention provides compositions and methods to modulate circulating levels of low density lipoproteins by altering the conformation of the protein PCSK9 using synthetic ligands and / or synthetic ligand derivative sequences of 3-8 amino acids ranging between 350-2,000 Da. Altering the conformation of PCSK9 affects the interaction between PCSK9 and an endogenous low density lipoprotein receptor, and can lead to reduced or increased levels of circulating LDL-cholesterol. High LDL-cholesterol levels are associated with increased risk for heart disease. Low LDL-cholesterol levels may be problematic in other conditions, such as liver dysfunction; thus, there is also utility for ligands which can raise LDL levels.

The invention relates to a solid preparation of febuxostat or a medicinal salt thereof and a preparation method thereof. The solid preparation comprises nano capsules of the febuxostat or the medicinal salt thereof and medicinal auxiliary materials, wherein in the nano capsules, the weight ratio of ivabradine or a medicinal salt thereof to a carrier material is 7-13:1; the carrier material is a composition prepared from xanthan gum-silk fibroin-aerosil; and the weight ratio of the xanthan gum to the silk fibroin to the aerosol is 1.5-4.5:1:1. The solid preparation and the preparation method thereof have the advantages of determining optimized preparation conditions such as encapsulation rate of over 95 percent through the selection of the optimized proportion, the melting temperatures and the insulation measures of the xanthan gum, the silk fibroin and the aerosol and the influences of various factors on the preparation, avoiding medicament burst release, reducing adverse reactions and improving the compliance of a patient so as to avoid the adverse reactions such as liver dysfunction, respiratory tract infection, diarrhea, headache, joint related symptoms, muscular skeleton / connective tissue symptoms and the like.