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Application of ampelopsis grossedentata water extract in preparation of preparation for improving liver injury

A technology for liver injury and acute liver injury, applied in the application field of preparations, can solve the problems of low safety and many adverse reactions, and achieve the recovery of liver function, the improvement of intestinal microecological disorders, and the relief of intestinal microecological disorders. Effect

Inactive Publication Date: 2021-05-25
刘洪涛
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, for the treatment of liver injury, drugs such as polyene phosphatidylcholine, reduced glutathione, diammonium glycyrrhizinate, compound glycyrrhizin, magnesium isoglycyrrhizinate, bicyclol, Liuwei Wuling tablets, etc. are usually used, but these drugs Less safety, more adverse reactions
However, there is no research report on the regulation of intestinal microecological disorder caused by liver injury with vine tea as the main component.

Method used

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  • Application of ampelopsis grossedentata water extract in preparation of preparation for improving liver injury
  • Application of ampelopsis grossedentata water extract in preparation of preparation for improving liver injury
  • Application of ampelopsis grossedentata water extract in preparation of preparation for improving liver injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038]Example 1 Preparation of Vine Tea Water Tip

[0039]This example is used to illustrate the preparation process of the vine tea piping, the specific preparation process is:

[0040]S1, grind the dry vine tea and leaves into a fine powder, add water in the proportion of the vine tea powder and the water to 1: 10, and cook at 90 ° C for 1 h.

[0041]S2, the centrifugation of the collected step S1 is collected, and the precipitation obtained by step S1 is added to the proportion of the precipitation and water to 1:10, and the cooking at 90 ° C for 1 h, combined with the supernatant, and centrifuen again.

[0042]S3, the collected centrifugation obtained by collecting step S2, adding the precipitation obtained by step S2 in accordance with the proportion of the precipitation and water to 1:10, simply cook at 90 ° C for 1 h, combined with three supernatants, and centrifuen again.

[0043]S4, the supernatant obtained by step S3 is sprayed into powder at 180 ° C, 2.0 bar, to obtain a vine tea.

Embodiment 2

[0044]Example 2 Vine Tea Water Tropic to CCL4Inhibitory effect of liver inflammation of acute liver injury mice and improvement in intestinal microorological disorders

[0045]In order to study vine tea water extract to CCL4Inhibitory effects of liver inflammation of acute liver injury mice and improvements in intestinal microorganisms, establish CCL4Induced acute liver injury mouse model and administration, and treats liver injury clinical drug liver Tales as a positive control. Specifically, the following steps:

[0046](1) Male C57BL / 6 mice with 4-6 years of age, a weight of 20 ± 2 g is randomly divided into a blank control group (CTRL), acute liver injury (A-CCL)4), Acute liver damage plus liver Thai (A-CCL4-Gtl), acute liver injury, vine tea group (A-CCL4-VT).

[0047](2) Feeding conditions maintain suitable temperature and humidity, day and night rhythm, feeding normal standard feed and sterile drinking water. After a week of environmental adhesion, the CTRL group injected 6ml / kg b...

Embodiment 3

[0052]Example 3 Vine Tea Water Tropics to CCL4Inducing chronic liver injury mice weight regulatory effect and improvement of intestinal microorological disorders

[0053]In order to study the avine tea water extract to CCL4The body mass adjustment effect of induced chronic liver injury and the inhibitory effect of liver inflammation, establishing CCL4Induced chronic liver injury mouse model and administration. Specifically, the following steps:

[0054](1) Male C57BL / 6 mice with 4-6 years of age, weight of 20 ± 2 g were randomized into a blank control group (CTRL), chronic liver injury (CCL)4), Chronic liver injury plus liver Thai (CCL4-Gtl), chronic liver injury, vine tea group (CCL4-VT).

[0055](2) Feeding conditions maintain suitable temperature and humidity, day and night rhythm, feeding normal standard feed and sterile drinking water. After a week of environmental adhesion, the CTRL group injected 3ml / kg body weight, Olive Oil, CCL4Group, CCL4-Gtl group and CCL4-VT group 1 ml / kg ...

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Abstract

The invention belongs to the technical field of medicine and health food, and particularly relates to application of an ampelopsis grossedentata water extract in preparation of a preparation for improving liver injury. The ampelopsis grossedentata water extract disclosed by the invention can be used for effectively regulating intestinal flora disorder, improving intestinal barrier function damage and reducing inflammatory response of liver injury by regulating diversity of intestinal flora of mice, obviously increasing SOD (superoxide dismutase) content of serum of the mice and improving oxidation resistance of liver cells. The invention has positive application value for treating and preventing acute and chronic liver injury by regulating intestinal microecological disorder by utilizing the ampelopsis grossedentata water extract, improving liver dysfunction of patients and delaying the development of liver fibrosis of the patients. The ampelopsis grossedentata water extract and the composition thereof can be used for preventing and treating diseases for improving intestinal microecological disorder caused by various reasons.

Description

Technical field[0001]The present invention belongs to the technical field of medical care food, in particular, involving the application of the aqueous extract of vine tea in preparations for improving liver injury.Background technique[0002]The intestinal microformation is a huge ecosystem that is the main intestinal integration with its adjacent microorganisms. The beneficial bacteria and harmful bacteria in the intestinal microorphous system are constrained, depending on each other, forming the intestinal flora steady state on the quality and quantity; once the internal and external environment of the body changes, the beneficial bacteria is inhibited, and the harmful bacteria is propagated, which can lead to Intestinal flora disorders, resulting in pathological performance, causing a series of clinical symptoms called intestinal flora disorders. The latest parenteral microbiomics reveals the change trend of intestinal microorganisms under physiological pathological conditions, an...

Claims

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Application Information

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IPC IPC(8): A61K36/87A61K31/702A61P1/16A61P1/00A61K127/00A61K135/00
CPCA61K31/702A61K36/87A61P1/00A61P1/16A61K2300/00
Inventor 刘洪涛李莹郑军平杨化冰张志刚程雪胡海明孔明望
Owner 刘洪涛
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