37results about How to "Reduce inflammatory factors" patented technology

The invention discloses oligomerization nucleic acid inhibiting an MYD88 gene. The oligomerization nucleic acid is double-strand RNA (ribonucleic acid), a basic group of the oligomerization nucleic acid comprises an antisense strand and a positive-sense strand, the antisense strand comprises SEQ. ID NO.12 components, more than 70% of the components are homologous, the positive-sense strand comprises oligomerization nucleic acid reversely and complementarily paired with the antisense strand, more than 50% of sequences are homologous, and the positive-sense strand and the antisense strand can form a double-strand structure after annealing. The invention further discloses DNA (deoxyribonucleic acid) containing the oligomerization nucleic acid, a carrier, a composition and an application of the oligomerization nucleic acid. The oligomerization nucleic acid has a remarkable inhibiting function for an MYD88, can achieve an inflammation inhibition function in an animal experiment, remarkably reduces various inflammatory factors and is a quite promising inflammation therapy medicine.

A therapeutic effect of Nurr1 and Foxa2 in inflammatory neurologic disorders by M1-to-M2 polarization of glial cells is provided. Specifically, a method of converting glial cells from an M1 phenotype to an M2 phenotype, wherein Nurr1 and Foxa2 are introduced into the glial cells to be overexpressed in the glial cells and a method of preventing or treating an inflammatory neurologic disorder, which includes glial cells into which Nurr1 and Foxa2 are introduced, or a viral vector loaded with Nurr1 and Foxa2, are provided.

The invention discloses the application of sulfated mannoglucuronic acid hexasaccharide in preventing and treating atherosclerosis. The invention discloses that sulfated mannoglucuronide oligosaccharides can effectively inhibit the inflammatory factors in macrophages related to atherosclerosis and the absorption effect of macrophages on oxidized low-density lipoprotein, thereby contributing to the development of atherosclerosis The prevention and treatment of sclerosis provide new means.

The invention discloses an immunologic tolerance dendritic cell, a preparation method thereof and a special culture medium. The culture medium is formed by the way that mesenchyma stem cells are added into a dendritic cell culture medium. The preparation method comprises: the precursors and the inducible factors of dendritic cells are added into the culture medium. The co-culture proportion of the mesenchyma stem cells to the dendritic cells is (1-2) to (1-10), preferably 1 to 1; the precursors of the dendritic cells are CD34<+> cells; and the inducible factors comprise GM-CSF, TNF- alpha, IL-4 and LPS. The invention provides the application of the immunologic tolerance dendritic cell during preparing immunologic tolerance medicine for organisms. The immunologic tolerance dendritic cell can lowly express co-stimulatory molecule, reduce inflammatory factors, increase the secretion of suppressor cytokines, have vasculogenesis activity, and inhibit the multiplication of variant T cells. The invention has the advantages of simple operation, convenience and practicality, and establishes a stable culture technical system for selective activation dendritic cells.