92 results about "Skin ulcer" patented technology

The invention discloses a solid phase synthesis method and a liquid phase synthesis method of chitosan and / or zinc, silver, bismuth and rare earth metal composite of chitosan derivative. The solid phase synthesis comprises the following steps: (1) grinding chitosan and / or chitosan derivative to fine powder; (2) grinding the oxides of zinc and / or silver and / or bismuth and rare earth metal to fine powder of which content is 0.0005-2wt% of the weight of chitosan and / or chitosan derivative; (3) mixing the fine powders obtained in step (1) and step (2) and fully grinding for 1-6h to obtain the chitosan and / or metal composite of chitosan derivative. The product of the preparation method can be used to cure diseases such as female vaginitis, cervicitis, cervical erosion, bedsore, skin ulcer, fireburn, empyrosis, trauma, other dermatitis disease, tinea of feet and hands and the like and can be used to prepare various surgical dressings such as film, sponge, gynecological suppository, adhesivefilm and the like.

The invention discloses a liquid-phase synthesis method of silver-chitosan and / or chitosan derivative nanocomposite. The obtained product has the functions of promoting wound surface healing, arresting bleeding, relieving pain, resisting inflammation and sterilizing bacteria, is suitable for female vaginitis, cervicitis, cervical erosion, bedsore, dermal ulcer, burn, scald, trauma, other skin phlogosis, tinea of feet and hands and the like, and can also be used for preparing various trauma dressings such as thin films, sponges, suppositories for gynecology, application films and the like.

The invention discloses a short interfering ribonucleic acid (siRNA) molecule for promoting scarless healing of skin wounds, a cocktail combination of a plurality of siRNA molecules targeting a plurality of related genes of scarless healing of wounds, and a pharmaceutical composition taking the siRNA molecule or the cocktail combination thereof as an active ingredient. Proven by cell experiments and mouse and pig skin wound models, the pharmaceutical composition can promote scarless healing of skin wounds resulted from traumata, surgical operation, or diabetes skin ulcer and the like, wherein the siRNA molecule can target genes causing pathological repair of wounds or adverse reactions; the siRNA double chains have different lengths and different tail ends and can target a homologous sequence of the same gene of cells of human, mouse and pig; the plurality of siRNAs in the cocktail combination can simultaneously inhibit various related genes of wound inflammation and revascularization, and has more obvious drug effects; and pharmaceutical carriers such as histidine-lysine polymer, dendritic polymer or liposome and the like in the pharmaceutical composition in a nanoparticle form can enhance the siRNA to be introduced into the skin tissue.

The invention relates to a medicine adopting deerskin as a raw material and a preparation method thereof, in particular to a health product or food processed by deerskin and a preparation method thereof. Deerskin ointment is prepared by deerskin, motherwort, astragalus root, Chinese date, angelica sinensis, sugar candy, yellow wine, sweet osmanthus honey and agal-agal. The invention aims to solve the problems existing in the aspects of waste, insufficient development and utilization, difficult absorption and utilization by human bodies, and the like of a plurality of prior deerskin resources. The deerskin ointment has the obvious effect on symptoms of woman leucorrhoea, uterine bleeding, kidney deficiency, spermatorrhea, skin ulcer breeding, and the like.

A preparing method of nano-silver containing medical chitosan thermosensitive hydrogel is disclosed. A product of the method is a novel medical material. The thermosensitive hydrogel has good bacteriostatic functions for Gram-negative bacteria represented by escherichia coli, Gram-positive bacteria represented by staphylococcus aureus and fungi represented by candida albicans, and is wide in bacteriostatic spectrum, free of cell toxicity, efficient and low in toxicity. After uniform spraying of the thermosensitive hydrogel, a gel film layer can be formed on the surface of a wound. The thermosensitive hydrogel is durable in bacteriostatic functions and good in gas permeability and hygroscopicity, has functions of promoting wound surface healing, arresting bleeding, arresting pain, reducing inflammation and sterilizing, can be used for burn, scald, trauma, and other large-area irregular wounds, is capable of rapidly arresting bleeding and pain, preventing infection and promoting wound healing, and can be used for bedsore, skin ulcer, tinea manus and pedis, woman colpitis, cervicitis, cervical erosion, and other skin inflammation diseases.

The invention relates to a slow-releasing agent of antibiotics containing aminoglycoside, comprising slow-releasing micro-sphere containing slow-releasing findings and aminoglycoside antibiotics, and special dissolvent containing suspending adjuvant agent such as sodium carboxymethyl cellulose with the adhesive degree being 100cp-3000cp (at 20-30 Deg. C). The slow-releasing findings comprises EVAc, polyphenyl, PLA, PLGA, decanedioic acid copolymer, albumen glue and gelatin; the slow-releasing micro-sphere can be produced to slow-releasing implanting agent and unguent agent. When the slow-releasing implanting agent and injection is placed or injected into bacteria, the medicine can be released slowly for more than 5-30 days, and toxicity is dramatically reduced at the same time when effective medicine concentration is got and maintained. The said slow-releasing agent is specially effective for chronic medullitis, bedsore, intractable ulcer on skin, diabetes femoral head necrosis and other abscessus, which are caused by Staphylococcus, Streptococcus, Streptococcus, acne Propionibacteriaceae, Enterobacter, Enterobacter, gonotoxin or parameningococcus.

The invention discloses a mesoporous lime-silicate xerogel, which contains silicon oxide, or silicon oxide and calcium oxide. In the power X-ray diffraction (XRD) pattern, 1 to 3 peaks are between 0 to 2 degrees on the abscissa 2 theta and holes of the mesoporous lime-silicate xerogel are orderly arranged. The invention also discloses the preparation method and the application in preparing drugs or materials for curing skin ulcer. The mesoporous lime-silicate xerogel of the invention, with even aperture size, high porousness, even arrangement of holes and good hole appearance, can effectively promote the healing of ulcer in a simple use method and can cure skin ulcer by compounding with drugs or growth factors. Te mesoporous lime-silicate xerogel can be used for curing skin ulcer on different medical occasions, such as cervical erosion, diabetic ulcer, wound surface due to operation and trauma, bedsore, stress ulcer, skin and mucosal ulcer, erosive lesion, local II or III burn and scald wound, wound difficult to heal, etc.

The invention relates to the technical field of medical supplies, specifically to a liquid adhesive bandage and a preparation technology thereof. The liquid adhesive bandage is prepared by free radical polymerization of an acrylate soft monomer, an acrylate hard monomer, a functional monomer, an initiator and a solvent for the preparation of a film-forming main body and with the assistance of a functional auxiliary agent. The liquid adhesive bandage can be applied on a wounded part, and then a layer of soft, non-toxic and non-irritating skin protection film which is not easy to peel off is rapidly formed on the wound surface. The film has good water resistance, air permeability and adhesiveness, prevents outside foreign matter and microorganisms from invading and infecting wounds, and hasthe effect of protecting the wound surface and promoting wound healing. The liquid adhesive bandage is direct and simple to use, is beautiful, comfortable and effective, is suitable for wounds of burn, scald, bruise, scratch, dactylotome cracking, chapped skin, chilblain, etc. and small wounds caused by other trauma, has hemostasis and wound protection effects, and is also suitable for superficialwounds caused after face-lifting, skin ulcer of patients with diabetes or chemotherapy, etc.

The invention relates to an external traditional Chinese medicine composition for treating swelling and pain, cut wounds and skin ulcers. The traditional Chinese medicine composition is prepared by processing raw material medicines of purple perilla, peppermint, manchurian wild ginger, Chinese rhubarb, mirabilite, fineleaf schizonepeta herb, common bletilla pseudobulb, divaricate saposhnikovia root, rhizome of swordlike atractylodes and liquorice root; and an external preparation prepared from the traditional Chinese medicine composition and auxiliary agents comprises powder, tinctures, sprays, patch, paste and ointments. The invention also relates to a preparation method of the traditional Chinese medicine composition and the preparation. The traditional Chinese medicine composition disclosed by the invention has the advantages of quick action, high cure rate, significant analgesic effect, strong stasis-eliminating and swelling-removing effects and short wound healing time in treating anonymous swelling and pain, cut wounds and skin ulcers.

The invention generally relates to a liquid topical pharmaceutical composition used in treating various skin wounds. The composition is characterized by strong moisture absorption and retention capabilities and being able to quickly seal the wound. The composition can resist oxidation, effectively inhibit bacteria and sterilization, protect germinal cells from further damage, eliminate wound swelling and promote wound healing. The pharmaceutical composition can be widely used in the treatment of burn, skin abrasion, laceration, infectious skin ulcer and wound exposure, save dressing and be used in a convenient and highly effective way.

The invention relates to a slow-releasing agent or rslow-releasing implanting agent containing antibiotics. The injection comprises slow-releasing micro-sphere and dissolvent. The slow-releasing micro-sphere contains slow-releasing findings and antibiotics, and dissolvent contains suspending adjuvant agent such as sodium carboxymethyl cellulose with the adhesive degree being 100cp-3000cp (at 20-30 Deg. C). The slow-releasing findings comprises EVAc, polyphenyl, PLA, PLGA, decanedioic acid copolymer, albumen glue and gelatin; the slow-releasing implanting agent is prepared with slow-releasing micro-sphere or through other methods. When said antibiotics is placed or injected into bacteria, the medicine can be released slowly for more than 10 days, and toxicity is dramatically reduced at the same time when effective medicine concentration is got and maintained. The said slow-releasing agent is specially effective for chronic medullitis, bedsore, intractable ulcer on skin, diabetes femoral head necrosis and other abscessus, which are caused by Staphylococcus, Streptococcus, Streptococcus, acne Propionibacteriaceae, Enterobacter, Enterobacter, gonotoxin or parameningococcus.

The invention relates to a prone position rehabilitation mattress. The prone position rehabilitation mattress comprises a support part which is placed on a bedstead, and a flexible contact part arranged on the support part, wherein the flexible contact part comprises a first air bag, a water bag and a second air bag which are distributed along the length direction of a hospital bed; and the firstair bag and the second air bag are respectively provided with a first control element for inflating / deflating air, the water bag is provided with a second control element for inflating / deflating liquid, the first air bag and the second air bag are respectively used for contacting and supporting upper limbs and lower limbs of a patient, and the water bag is used for contacting and supporting the chest and the abdomen of the patient. The rehabilitation mattress is compact in structure and convenient to use, the condition that the patient can maintain the prone position for a long time is facilitated, the problems of damage caused by pressing, skin ulcer caused by pressing and the like are not liable to cause, the patient can be assisted to expel phlegm, the phlegm expelling effect is increased, the prone position rehabilitation mattress is particularly suitable for patients suffering from corona virus disease 2019 at the period of corona virus disease 2019, and increment of treatment effects is facilitated.

The invention belongs to an externally used heavy-metal-free ointment for treating skin wounds and a preparation method thereof. The ointment is prepared by using the following raw materials by weight: 20-35g of golden thread, 10-25g of baical skullcap root, 10-25g of amur cork-tree, 20-42g of danshen root, 10-20g of Hibiscus mutabilis leaf, 15-35g of giant knotweed rhizome, 15-38g of garden burnet root, 15-35g of common bletilla rubber, 10-25g of cape jasmine fruit, 10-25g of gromwell root, 10-25g of suberect spatholobus stem, 5-15g of borneol, 10-30g of calamine, 10-25g of beeswax, 50-100g of Vaseline and 600-1000g of vegetable oil. The externally used ointment prepared in the application does not contain heavy metal elements and can treat various new and old open skin wounds such as incised wounds, blunt force injuries, accidental injuries, burns due to hot liquid or fire and ecthyma, which are called as various surgical injuries, accidental wounds, infected wounds, chronic skin ulcers, pressure sores and the like, and the wound healing time is short.

The invention discloses a marine bacterium capable of antagonizing pathogenic vibrio splendidus and an application of the marine bacterium. The marine bacterium is characterized in that the marine bacterium is a marine-derived vibrio 33 preserved in a common microorganism center of a China committee for culture collection of microorganisms on May 30, 2016, and the preservation number is CGMCC No. 12561. The vibrio 33 is derived from a healthy marine organism, screened by a filtering paper method and authenticated as a vibrio by 16S rRNA (ribosomal ribonucleic acid). The vibrio 33 obviously functions in inhibiting the growth and infection process of important pathogenic vibrio splendidus of 'skin ulcer syndrome' of apostichopus japonicus. The marine bacterium has the advantages that equivalent vibrio splendidus and vibrio 33 are added into seawater, the quantity of the vibrio splendidus can be reduced by 86.7%, the relative survival rate of the apostichopus japonicus can be increased by 50% as the vibrio 33 is added in the process of infecting the apostichopus japonicus by the vibrio splendidus, and the marine bacterium is expected to play an important role in control of the pathogenic vibrio splendidus and apostichopus japonicus diseases caused by the pathogenic vibrio splendidus.

The invention discloses a traditional Chinese medicine preparation for treating skin ulcers. The traditional Chinese medicine preparation comprises the following raw medicines in parts by weight: 1-3 parts of raw astragalus, 0.5-2 parts of Chinese angelica, 1-3 parts of red sage root, 0.5-2 parts of frankincense, 0.5-2 parts of myrrh, 0.5-2 parts of cutch, 0.5-2 parts of cassia twig, 2-4 parts of mirabilitum dehydratum, 0.5-2 parts of coptis and 0.5-2 parts of prepared rhubarb. The traditional Chinese medicine preparation disclosed by the invention can be prepared into tablet, mixture, granula and capsule and has the efficacies of tonifying qi, activating blood, regenerating tissue and healing ulcer when externally applied; and the preparation is mainly used for treating various skin ulcers in later stages and particularly suitable for treating diseases such as lower limb varicose vein type ulcers, traumatic ulcers, infectious ulcers and the like which have the cardinal symptoms that pus and slough at the skin wound are completely dropped, the wound healing speed is slow, the granulation tissue is dark red and the skin surrounding the ulcer is dark. The invention also discloses a preparation method of various dosage forms of the traditional Chinese medicine preparation.

The invention belongs to the technical field of traditional Chinese medicines and particularly relates to a medicinal composition for treating carbuncle, subcutaneous ulcer, furuncle and boil and a preparation method of the medicinal composition. The medicinal composition for treating the carbuncle, subcutaneous ulcer, furuncle and boil is prepared from the following raw materials in parts by weight: 6 to 21 parts of realgar, 2 to 18 parts of calomelas, 12 to 24 parts of pearl powder, 6 to 36 parts of alum, 12 to 33 parts of dried alum, 1 to 36 parts of moschus, 9 to 30 parts of borax, 9 to 27parts of borneol and 1000 parts of an excipient. According to the preparation method disclosed by the invention, 8 kinds of medicinal materials listed in the 'Chinese pharmacopoeia' are only adoptedand are reasonably matched to form a novel preparation; the medicinal composition can be used for treating breast hyperplasia, carbuncle, subcutaneous ulcer, furuncle and boil, herpes zoster, scald, ulcer, mastitis, skin ulcer, the breast hyperplasia, hemorrhoids and the like and has wide application range.

The invention discloses an application of curcumin-zinc compound in preparing a health-care nursing product. According to the application of the curcumin-zinc compound in preparing the health-care nursing product, the curcumin-zinc compound is found to have good bacteriostasis and analgesia action and can be used for treating common diseases, such as retinopathy, skin ulcer and the like caused by bacterial infection, pain and diabetic complications, has an obvious curative effect on treating various senile diseases and has wide application. The curcumin-zinc compound can be used for preparing medicines and also can be used for preparing various health-care products. According to the curcumin-zinc compound, the problems of single medicine adaptive symptom and poor curative effect commonly existing in the traditional senile disease treatment are overcome. The curcumin-zinc compound has the advantages of simple preparation method and wide application prospect.

The invention relates to a Chinese medicinal preparation extracted from pollen and bee glue, which can be used for treating rhinitis, skin ulcer, tumor and polypus.

The invention discloses a preparation method of a wet skin ulcer nursing and repairing composite ointment for a radiotherapy department. The preparation method comprises the following specific steps:step 1, selecting high-quality raw materials including rhizoma coptidis, rhizoma polygoni cuspidati, radix ampelopsis, radix astragali seu hedysari, herba rubi, herba portulacae, radix sophorae flavescentis and cortex phellodendri; sieving all the raw materials and removing inferior products; step 2, putting the raw materials sieved in step 1 into an ultrasonic washing machine and adding clean water and a sodium hydroxide solution; rapidly washing by utilizing ultrasonic waves; step 3, rapidly drying the high-quality raw materials washed in step 2 in warm air and putting the raw materials intoa drying box and drying at high temperature; and step 4, grinding and crushing the dried raw materials by utilizing a crusher and a grinding machine. The ointment has remarkable curative effects on wet skin ulcers, angiitis ulcers, acnes and the like, has a rapid pain stopping effect, is convenient to use and low in treatment cost and has no scars after healing; and the ointment is a first-choicemedicine for treatment and is suitable for treating wounds in hospitals and families.

The invention relates to a medicament for comprehensively treating a plurality of skin diseases, which is a perfect prescription clinically tested for years and belongs to a natural traditional Chinese medicine extract. The medicament is prepared by extracting the effective components of the following traditional Chinese medicines by weight portion: 2 of calomeas, 20 of heavy sulfur powder, 20 of khosam, 30 of stemona root, 50 of radix sophorae falvescentis, 30 of quintupling shell, 10 of macrostem onion juice and 20 of purple garlic, and then sterilizing and condensing the effective components to be prepared into ointment which is known as potent skin-cleaning ointment for short and has the functions of heat and toxic material elimination, desinsection, sterilization and virus prevention; the extract liquid of astragalus root, long-nosed pit viper oil, carotene, aloe and pearl powder, which is known as lotion for short, has the functions of nourishing skin myocyte, eliminating skin ulcer, generating muscle, moisturizing and protecting the skin, resisting inflammation and improving partial immunity; and when the extract liquid is dissolved in 95-percent alcohol, the ointment and the extract liquid which are proportionally mixed can be used for external applying to treat seborrheic dermatitis, comedo, acne, scabies, impetigo, flat warts, ringworm, tinea corporis, solar dermatitis, ecthyma, and the like, has reliable curative effect in treating a plurality of recurring skin diseases, has little side effect and high cure rate and can really achieve the aim of curing a plurality of diseases with one prescription and curing a specific disease completely with one prescription.

The invention discloses a skin antibacterial liquid. The skin antibacterial liquid comprises the following raw materials in parts by weight, 16.13-3.22 parts of perfoliote knotweed herb, 5.33-1.06 parts of baical skullcap root, 5.38-1.09 parts of coptis root, 6.45-1.29 parts of amur corktree bark, 10.75-2.15 parts of astragalus root, 3.23-0.65 parts of divaricate saposhnikovia root, 2.15-0.43 parts of Artemisia argyi, 1.09-0.22 parts of Eucalyptus, 4.3-0.86 parts of honeysuckle, 3.23-0.65 parts of licorice and 1.09-0.22 parts of borneol. Through the mutual effect of pure traditional Chinese medicine extraction and excellent formula traditional Chinese medicinal materials, the traditional Chinese medicine composition has obvious curative effects on burns and scalds, skin ulcer, acne, urticaria, herpes zoster, eczema, pustule and the like, and also has multiple curative effects on more than thirty skin diseases such as prickly heat, Hong Kong feet, skin itch and allergic skin diseases; the traditional Chinese medicine composition can be used for preventing a patient from being repeatedly infected by bacteria and conveniently solving the skin problem of the patient, has different degrees of bacteriostatic action on staphylococcus aureus, diplococcus pneumoniae, streptococcus deep haemolyticus, corynebacterium diphtheriae, pseudomonas aeruginosa and bacillus anthracis, effectivelyimproves the effects of sterilization, bacteriostasis, inflammation resistance and allergy resistance, improves the treatment effect and is convenient to use.

The invention discloses a medicine and a preparation method thereof. The medicine is prepared from Lysimachia foenum-graecum Hance, ivy tree leaves, alums, Chinese galls and charred garden burnet roots. The invention is a traditional Chinese medicinal granule, with the following advantages: easy carrying and storage, high efficiency, small irritation, no toxicity, safety, high water solubility, good stability, etc. The invention can be made into different specifications according to actual requirements, such as 5 gram / bag, 10 gram / bag, etc.; and the invention can also be made into different dosage forms according to different people's needs, such as lotion, spray, ointment, etc.

The invention relates to compositions used to relieve, improve, prevent and / or treat stretch marks and / or skin ulcers preferably of ischemic origin. The invention also relates to the composition, dosage form and uses thereof.

A Chinese medicine for treating ulcerative pyogenic sore, skin ulcer, etc is prepared from 7 Chinese-medicinal materials including borneol, aucklandia root, safflower, Chinese angelica root, etc. Its advantages are quickly taking its high curative effect and short course of treatment.

The invention provides a traditional Chinese medicine liniment for treating dog and cat skin diseases and a preparation method thereof. The traditional Chinese medicine liniment is prepared from the following raw materials in parts by weight: 4 parts of ampelopsis japonica, 2 parts of cortex dictamni, 2 parts of coptis chinensis and 2 parts of radix sophorae flavescentis. The compound traditionalChinese medicine liniment for external use is researched and developed and used for diagnosing and treating clinical skin diseases of pets. The liniment not only can effectively relieve pruritus symptoms of organisms, but also can treat skin injury symptoms such as skin ulcer according to symptoms, and strives for enough time for accurate and complete diagnosis of skin diseases by clinical first-line pet doctors.

The invention discloses an infant anus skin care solution, comprising the following components according to weight percent: 0.2-1.4% of high molecular weight silicone oil (n=5500-9000); 30-50% of 10 centipoises of silicone oil; the proportion of the high molecular weight silicone oil to the silicone oil with viscosity thereof being less than 30 centipoises is (0.1-2.0):100; the silicone oil with viscosity thereof being less than 30 centipoises can be selected out of dimethyl polysiloxane, methyl phenyl oxosilane, ring-shaped oxosilane, amino-group modified silicone oil or linear chain or ring-shaped dimethyl silscone and the like. Compared with the prior art, the invention has the beneficial effects that with the skin care solution wiped on the skin around the anus of the infant, excrement residue can be prevented from entering wrinkles of the skin around the anus of the infant, thus keeping the skin around the anus clean, effectively avoiding rubefaction, itch, inflammation, skin ulcer and other symptoms caused by stimulus of excrement and assault of pathogenic bacteria to the skin around the anus of the infant.

The invention provides a treatment drug for skin ulcers and belongs to the technical field of medicine.The treatment drug aims at solving the treatment problem of the skin ulcers.It is analyzed that the skin ulcers are caused by the fact that external bacterium and damp toxins take advantage of a weak point due to deficiency of the kidney and spleen and low immunity, blood stasis blocking is caused, and the damp toxins are latent.Traditional Chinese medicine with the effects of tonifying the kidney and spleen, dispelling wind and resolving dampness and promoting blood circulation to remove blood stasis is combined and is prepared from 15 parts of poria, 15 parts of fructus forsythiae, 15 parts of coix seeds, 15 parts of radix lsatidis, 15 parts of honeysuckle flowers, 15 parts of radix rehmanniae, 10 parts of algae, 10 parts of bighead atractylodes rhizomes, 15 parts of radix achyranthis bidentatae, 15 parts of radix scrophulariae, 10 parts of radix scutellariae, 10 parts of spina gleditsiae, 10 parts of scorpions and 7 parts of liquorice roots.The treatment drug for the skin ulcers is correct in medical theory analysis and remarkable in treatment effect.

The invention relates to the technical field of traditional Chinese medicine compounds, and particularly relates to external cold compress gel for closed soft tissues. The external cold compress gel is prepared from borneol, frankincense, myrrh, radix angelicae dahuricae, dragon's blood and the like. Sodium alginate and collagen are used as carriers, the borneol, the frankincense, the myrrh, the radix angelicae dahuricae, the dragon's blood and some natural polymer substances are matched, and effective ingredients permeate subcutaneously by a transdermal absorption process to achieve a coolingeffect. The gel is applied to burn, scald, knife wound, frostbite, skin ulcer, nasal cavity, bedsore, postoperative parts and the like of a body in an in-vitro application mode, the effective ingredients go round along with meridians and collaterals and are used for wound surfaces to achieve the effects of stopping bleeding, diminishing inflammation, converging and repairing, wound surface inflammation and exudate adsorption drying are quickly achieved, healing and scabbing are repaired, the healing course is shortened, and the gel does not enter the digestive system in the body and has no harm or toxic or side effects. Cooling substances do not contain ingredients playing a pharmacological, immunological or metabolic role.