A preparing method of nano-silver containing medical chitosan thermosensitive hydrogel
A temperature-sensitive hydrogel, chitosan technology, applied in medical science, bandages, etc., can solve the problems of preparation methods and applications that have not been reported, and achieve the effects of preventing wound infection, broad application prospects, and promoting cell growth.
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Embodiment 1
[0038] Example 1 A preparation method of a medical chitosan thermosensitive hydrogel containing nano silver:
[0039](1) Grind chitosan (the chitosan used in this example was purchased from Zhejiang Aoxing Biotechnology Co., Ltd., Zhejiang) and silver nitrate into fine powders, and mix them. The mass ratio of chitosan to silver nitrate is 100:0.002 , fully and quickly ground for 1.5 hours, and irradiated with ultraviolet light for 4 hours to obtain chitosan nano-silver complex;
[0040] (2) dissolving the chitosan nano-silver complex obtained in step (1) with an aqueous solution of acetic acid with a concentration of 0.1mol / L, and preparing a chitosan nano-silver complex solution with a mass concentration of 1%;
[0041] (3) Add 56% sodium β-glycerophosphate solution to the chitosan nano-silver complex solution obtained in step (2),
[0042] The volume ratio of the chitosan nano-silver complex solution to the sodium β-glycerophosphate solution is 10:1, stir rapidly, add sat...
Embodiment 2
[0044] Example 2 A preparation method of a medical chitosan thermosensitive hydrogel containing nano silver:
[0045] (1) Grind chitosan (the chitosan used in this example was purchased from Zhejiang Aoxing Biotechnology Co., Ltd., Zhejiang) and silver nitrate into fine powders, and mix them. The mass ratio of chitosan to silver nitrate is 100:0.1 , fully and quickly ground for 4 hours, and irradiated with ultraviolet light for 20 hours to obtain chitosan nano-silver complex;
[0046] (2) dissolving the chitosan nano-silver complex obtained in step (1) with an aqueous solution of acetic acid with a concentration of 0.25mol / L, and preparing a chitosan nano-silver complex solution with a mass concentration of 2.5%;
[0047] (3) Add 56% sodium β-glycerophosphate solution to the chitosan nano-silver complex solution obtained in step (2),
[0048] The volume ratio of the chitosan nano-silver complex solution to the sodium β-glycerophosphate solution is 10:3, stir rapidly, add sa...
Embodiment 3
[0050] Example 3 A preparation method of a medical chitosan thermosensitive hydrogel containing nano silver:
[0051] (1) Grind chitosan (purchased from Shandong Jiafeng Marine Biotechnology Co., Ltd.) and silver nitrate into fine powders respectively, mix them, the mass ratio of chitosan and silver nitrate is 100:0.005, fully and quickly grind for 1.8 hours, UV light irradiation for 6 hours to obtain chitosan nano-silver complex;
[0052] (2) dissolving the chitosan nano-silver complex obtained in step (1) with an aqueous solution of acetic acid with a concentration of 0.12mol / L, and preparing a chitosan nano-silver complex solution with a mass concentration of 1.5%;
[0053] (3) Add 56% sodium β-glycerophosphate solution to the chitosan nano-silver complex solution obtained in step (2),
[0054] The volume ratio of chitosan nano-silver complex solution to β-sodium glycerophosphate solution is 10:1.5, stir rapidly, add saturated disodium hydrogen phosphate buffer solution ...
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