242 results about "Skin ulcerations" patented technology

Provided is a method of treating skin ulcers and related complications in patients by administering an oxidative reduction potential (ORP) water solution that is stable for at least twenty-four hours.

The present invention generally relates to the transdermal delivery of substances and, in some embodiments, to the transdermal delivery of beneficial substances by a hostile biophysical environment. In one aspect, various methods for the transdermal delivery of beneficial substances are disclosed. By creating a hostile biophysical environment, beneficial substances may be delivered, according to certain embodiments, through the stratum corneum of the skin into the body. Beneficial substances include, but are not limited to, pharmaceutical agents, drugs, vitamins, co-factors, peptides, dietary supplements, and others. The beneficial effects disclosed include, for instance, relief of pain and inflammation, prevention and healing of ulcers of the skin, relief of headache, improved sexual function and enjoyment, growth of hair on the scalp, improving muscle size and / or function, removing body fat and / or cellulite, treating cancer, treating viral infections and others. A hostile biophysical environment may also be used in conjunction with systems and methods for increasing local blood flow, according to one set of embodiments. For example, by using a nitric oxide donor such as L-arginine, local blood flow may be increased, e.g., by transdermally delivering the nitric oxide precursor. The nitric oxide donor may be the sole cause of increased blood flow, or it may be supplemented with an adjunct such as theophylline.

Methods for treating and / or preventing skin ulcers are provided featuring administration of pharmaceutical compositions comprising inhibitors of activity or expression Of Lp-PLA2 protein to patients subject to or at risk of developing skin ulcers.

The invention discloses a nanocomposite of silver, chitosan and / or a chitosan derivative and a preparation method thereof. The preparation method comprises the steps of evenly mixing the chitosan and / or the chitosan derivative fine powder with silver nitrate fine powder and fully grinding for 1-3 hours with the weight proportion of the chitosan and / or the chitosan derivative to the silver nitrate of 100: 0.0005-0.5; adding a reducing agent with the reduction equivalence ratio of the reducing agent to the silver nitrate of 1: 1-2: 1 and fully grinding for 2-6 hours, thereby obtaining the nanocomposite of the silver, chitosan and / or the chitosan derivative with the silver particle size of 1-100nm. The nanocomposite has the effects of promoting wound healing, stopping bleeding, alleviating pain, anti-inflammation and sterilization, can be used for treating female vaginitis, cervicitis, cervical erosion, bedsores, skin ulcers, burns, scalds, trauma and other skin inflammation, tinea manus and pedis and the like, and can also be used for preparing a variety of trauma dressings, such as thin films, sponges, gynecological suppositories, patches and the like.

A carbon dioxide-containing viscous composition wherein carbon dioxide bubbles are retained in an aqueous viscous composition. Use of the composition makes it possible to treat or ameliorate itching accompanying mucocutaneous diseases or mucocutaneous disorders, mucocutaneous injury, dental diseases, skin ulcer, cryesthesia and numbness caused by peripheral circulatory disorders, musculoskeletal diseases, nervous system diseases, keratosis, constipation, unwanted hair re-growing after depilation, cosmetic troubles in the skin or hair, partial obesity, etc. while exerting little side effects.

An agent for treating or ameliorating diabetic complications which contains at least one potassium channel activator as an active ingredient. The drug is expected to show a therapeutic or ameliorating action on diabetic complications such as retinopathy, neuropathy, nephropathy, peripheral circulation disorders, and skin ulcerations; it also proves effective in preventing, ameliorating, alleviating and gaining recovery from various symptoms and abnormalities caused by those diseases, as exemplified by blindness, proteinurea, pain, numbness, psychroesthesia, intermittent claudication and gangrene.

[Problems] To provide a novel external agent for treatment of skin ulcer which has an excellent healing effect on intractable skin ulcer such as bedsore, diabetic skin ulcer and ischemic skin ulcer.[Means for Solving Problems] The agent is characterized in that it comprises a composition containing at least one selected from the group consisting of granulocyte colony stimulating factor (G-CSF), stromal cell-derived factor-1 (SDF-1) and CD41-positive cells, and a hydrophilic high molecular substance.

The invention is directed to a method for treating ulcers, including ulcers of the lower leg, by topical plus oral administration of proanthocyanidins to a patient.

The invention relates to a stem cell preparation for repairing skin ulcer. The stem cell preparation consists of mesenchymal stem cells and exogenous cell factors. The stem cell preparation is prepared from the mesenchymal stem cells in combination with the exogenous cell factors, so that the directional differentiation of the mesenchymal stem cells towards endothelial cells is promoted; and through the paracrine of the mesenchymal stem cells as well as the exogenous cell factors, the growth of the endothelial cells is stimulated, fibroblast and capillary growth as well as collagen synthesis and granulation in a wound surface are enhanced, and the proliferation of skin keratinocytes and endothelial cells is improved, so that the purpose of rapidly and effectively repairing skin with ulcer injury is achieved.

The invention provides a preparation to prevent and cure endometritis of milch cow. It comprises soluble staphylococcus enzyme, Lysozyme, bacteriostatic peptide and carrier. It has strong sterilizing effect, wide sterilizing spectrum and strong stability, easy to accept by human body. The curative effect is quick and it is convenient to use. It can be applied to prevent and cure not only endometritis of milch cow, but also bacterial infectious diseases of milch cow or other animals such as acute and chronic mastitis, colpitis, foot&mouth disease, stomatitis, etc.

The present invention relates to Periplaneta Americana or its ethanol extract for the treatment of inflammation. Specifically, said inflammation includes cervical erosion, ulcerative colitis, skin ulcer, mucosal ulcer and postoperative condyloma acuminatum. Treating said disorders by Periplaneta Americana or its ethanol extract has the advantages of effectively reducing bleeding, shortering healing time, significant curative effect, no adverse reactions and low cost. Periplaneta Americana or its ethanol extract provides a new selection for the clinical treatment of cervical erosion, ulcerative colitis and postoperative condyloma acuminatum.

Disclosed are a medicament for the treatment of burns and sore and ulcer diseases, and a wound plaster made of the same. The invention belongs to the technical field of traditional Chinese medicine, and specifically relates to a medicament for the treatment of burns and sore and ulcer diseases. The medicament mainly comprises, by weight, 35 to 65 parts of rosin, 20 to 40 parts of borneol, 30 to 90 parts of beeswax and 500 to 1000 parts of sesame oil. All the components in the invention are in reasonable allocation and complement each other. The utilization of the invention enables effective treatment of burns and scalds and skin ulcer, alleviating pains of patients.

The invention discloses a preparation method of medical temperature-sensitive hydrogel. The preparation method comprises the following steps: taking carboxymethyl chitosan, polyvinyl alcohol, sodium alginate and silver nitrate as raw materials; dissolving and mixing; then adding an ascorbic acid water solution and glutaraldehyde; obtaining crude gel by adopting a microwave radiation method; washing the crude gel with diluted acetic acid and water; drying the crude gel in vacuum at 40 DEG C until the weight is constant, so as to obtain the medical temperature-sensitive hydrogel. The medical temperature-sensitive hydrogel disclosed by the invention has a relatively good antibacterial effect, has a wide antibiotic spectrum and no cell toxicity and has high efficiency and low toxin; after the medical temperature-sensitive hydrogel is uniformly sprayed, one layer of a gel thin film is formed on the surface of a wound and has a lasting antibacterial effect and good air permeability and moisture retention; the medical temperature-sensitive hydrogel has the effects of promoting wound healing, stopping bleeding, stopping pain, resisting inflammation and sterilizing, can be used for large-area irregular traumas including burns, scalds, traumas and the like and can also be used for other skin inflammations including bedsores, skin ulcers, tinea manus and pedis, female vaginitis, cervicitis, cervical erosion and the like.

A gel of asiaticoside for promoting healing of wound and treating burn, wound, skin ulcer, scleroderma, etc is prepared from asiaticoside and proper auxiliary. Its preparing process is also disclosed.

Pharmaceutical compositions including tetrasilver tetroxide (Ag4O4), such as in crystalline form, and methods of using such compositions for the prevention, treatment, and management various of dermatological skin conditions and diseases. In one embodiment, these compositions are substantially free of added persulfates. These dermatological conditions and diseases that may be prevented, treated, or managed with the compositions of the invention vary and include, but are not limited to, eczema, psoriasis, dermatitis, disease-induced skin ulcers, undefined tropical diseases, shingles, rashes, bedsores, cold sores, blisters, boils, herpes simplex, acne, pimples, skin chafing, skin cracking, itchiness, skin peeling, and warts.

The invention relates to a traditional Chinese medicine powder for eliminating slough and promoting granulation and a preparation method thereof, frankincense, myrrh, catechu, borneol, musk, dragon's blood, sanchi, fossilized and crab spawn are taken as raw materials, the traditional Chinese medicine powder is characterized in that the contents (weight) of the raw materials are as follows: 5-15g of frankincense, 5-15g of myrrh, 5-15g of catechu, 5-15g of dragon's blood, 5-15g of sanchi, 1-6g of borneol, 0.1-1g of musk, 1-6g of fossilized and 5-12g of crab spawn, and the herbal medicines are well prepared according to the standards and ground to fine powder for standby. The invention has the advantages that, the cost of the raw materials is low, the traditional Chinese medicine powder can kill bacteria, remove suppuration and eliminate sore of various types of ulcerative skin stubborn diseases in a short period of time and simultaneously has the effects of eliminating slough and promoting granulation, thereby being applicable to all the skin ulcers and all the ulcerative running sores, malignant tumors, unhealed wounds and other symptoms, such as ulcers of upper and lower extremities, periostitis, unknown running sores, and the like; the effect is significant, the treatment course is short, the medical cost is low, and the economic burden of patients is reduced.

The invention discloses a medicine for treating skin ulceration and relates to a Chinese medicine. The medicine is prepared by the following raw materials of certain weight portions: 5 to 10 portions of borneol, 5 to 10 portions of dragon's blood and 30 to 60 portions of pearl. 2 to 10 portions of notoginseng and 1 to 5 portions of common bletilla rubber can also be added. The preparation method is as follows: the raw materials are ground into fine powder, mixed uniformly, sterilized, dried and packaged. The medicine prepared by the method of the invention has good effect on skin ulceration caused by erosion of vulva (decubitus ulcer and eczema), burn and scald, etc.

Disclosed is a natural hirudin ointment, wherein the formula contains natural hirudin and conventional ointment matrix, and each 100g of the ointment contains natural hirudin 100-200000 international units. The ointment can be used for treating thrombotic phlebitis, burns, skin cracks, skin ulcer, chilblain, acne, acne and hemorrhoid.

The invention relates to a TCM compound external liniment liquid for antiphlogosis and sterilization and a preparation method, and belongs to the technical field of Chinese medicines. TCM active ingredients that are honeysuckle, scutellaria, safflower, Astragalus roots, rhizoma ligustici wallichii, myrobalam, rhubarb and blood of dragon are mixed and then decocted with water, so that the TCM compound external liniment liquid is made; wherein, the components has the weight as follows: the honeysuckle is 12 to 18g, the scutellaria is 9 to 15g, the safflower is 8 to 15g, the Astragalus roots is 12 to 24g, the rhizoma ligustici wallichii is 8 to 15g, the myrobalam is 12 to 18g, the rhubarb is 12 to 20g, and the blood of dragon is 3 to 6g. The invention has the preparation method for preparing the external liniment liquid that: the medicinal materials are mixed by weight rate, decocted, concentrated and filtered after being stood to cold, and then are added with anionic surfactant that is sodium dodecyl sulfate and broad-spectrum antibacterial preservative that is nipagin esters; the solution is stirred uniformly after dissolution, and then is potted and sterilized, so that the external liniment liquid is made. The TCM compound external liniment liquid is adopted to sterilize and diminish inflammation without allergic reaction, so as to lead the wound to close up rapidly; the TCM compound external liniment liquid is used for skin ulcer and bedsore, and is more particularly applied to the patients suffered from combined multiple skin ulcer of diabetes mellitus.

A novel polypeptide, and an antibacterial agent, antifungal agent and / or antiseptic containing as an effective ingredient the polypeptide are disclosed. The polypeptide of this invention has an amino acid sequence shown in SEQ ID NOs:1 to 12 and 13 to 31. This antibacterial agent, antifungal agent and / or antiseptic is useful for the prevention, amelioration or treatment of diseases such as burn, decubitus, wound, skin ulcer, leg ulcer, diabetic ulcer, occlusive arterial disease and arteriosclerosis obliterans, cellulitis, acute lymphangitis, lymphadenitis, erysipelas, skin abscess, necrotizing subcutaneous infection, staphylococcal scalded skin syndrome (SSSS), folliculitis, facial furuncle, suppurative hidradenitis, carbuncle, infectious paronychia, erythrasma and severe infection (sepsis).

The invention relates to a Chinese herbal medicine compound bait, as well as a preparation method and application of the Chinese herbal medicine compound bait. The Chinese herbal medicine compound bait comprises the following Chinese herbal medicine components by weight percent: 20-30% of radix pseudostellariae, 5-10% of cordyceps sinensis, 10-15% of lycium chinense, 10-15% of clove, 10-15% of honeysuckle, 10-15% of radix bupleuri, 5-10% of liquorice, 5-10% of radix astragali, 1-5% of poria cocos and 1-5% of borneol; and the Chinese herbal medicine compound bait comprises the following basic bait components by weight percent: 30-35% of sea mud, 10-15% of kelp meal, 4-6% of shell powder, 10-15% of sargassum thunbergii powder, 0.5-1% of spiral seaweed, 3-5% of fish meal, 3-5% of vegetable protein, 1-3% of shrimp meal, 2-3% of scallop skirt, 0.6-0.8% of yeast tablets, 2-2.2% of composite mineral salt and 1.8-2% of multivitamin. The Chinese herbal medicine components are mixed into the basic bait components according to the ratio of 2-5%, and the mixture has the particle size of 250-300 meshes. The Chinese herbal medicine compound bait provided by the invention is capable of obviously increasing the weight gain rate and survival rate of stichopus japonicus, reducing the splanchnic ratio, and improving the immunity of the stichopus japonicus; and the Chinese herbal medicine compound bait is free from toxic and side effects, can be used for remarkably improving the 'skin ulceration syndrome' resistance of the stichopus japonicus and has the advantages of reducing the food coefficient as well as NH3-N content and chemical oxygen demand (COD) content in aquaculture water, and the like, thus having good guiding significance for increasing the yield of stichopus japonicus aquaculture and the prevention and treatment of diseases.

The present invention provides a Chinese medicine and Western medicine combined liniment for external application for curing the diseases of chronic intractable dermatitis, dermophytosis, tinea cruris, tinea manuum, tinea pedis, psoriasis, ulcer of skin, infection of skin, scabies, pruritus cutanea, tinea unguium and leuconychia, etc. with obvious therapeutic effect. Said medicine preparation is made up by using the Chinese medicinal materials of cnidium seed, stemona root, sulfur, shrubalthea bark, mylabris, camphor and salicylic acid. Besides, said invention also provides the concrete steps of its preparation process.

This invention relates to agents for treating, ameliorating, or preventing diabetic complications specifically diabetic neuropathy and skin ulceration by topical application of materials containing one or more arterial or venous dilation components and one or more fast sodium channel inhibitors. Particularly, the invention relates to treating or ameliorating agents that contain minoxidil and its related congeners, which have both potassium channel agonist properties and nitric oxide agonist properties as an active ingredient and which are effective against diabetic complications such as neuropathy, peripheral circulation disorders and skin ulcerations. Unique methods of delivery including delivery through impregnated socks or gloves to match the distribution of pain are also noted.

The bedsore ointment as one externally applied medicine consists of angelica, white beeswax, dragon's blood, Chinese goldthread, pearl powder and sesame oil. The bedsore ointment can treat effectively bedsore, diabetes ulcer, nervous ulcer, radioactive ulcer, wound infection, eczema, zoster, boil, carbuncle, erysipelas, etc. owing to its functions of removing necrosis, promoting blood circulation, promoting granulation, stopping pain, promoting healing and moistening skin. The bedsore ointment has small scar formed, convenient use, no toxic side effect, low cost, fast and determined curative effect.

The invention relates to a light-medicine-combined treatment device for skin ulcers, comprising an outer layer, a luminous layer, a medicine patch layer and a light parameter controller. The outer layer is a basic structure of the whole device, made from a flexible material and arranged at the outermost layer, the medicine patch layer is arranged on the innermost layer and laid with an external aid medicine for treating skin ulcers, and the luminous layer is arranged between the outer layer and the medicine patch layer and comprises optical fiber cloth and a plurality of LED luminous devices which are connected around the optical fiber cloth, are electrically connected with the light parameter controller and control the lamination parameters of the LED luminous devices. The invention realizes a unique treatment method of combining LED illumination and external medicine application, has the advantages of remarkable effect, simple operation and portability, and is suitable for treating skin ulcers.

A system and method for facilitating the healing of a skin ulcer, such as a diabetic ulcer, on a treatment region of a body. Ultrasound waves are transmitted to the treatment region. Interferential electrical stimulation is applied to the treatment region, simultaneously with the ultrasound transmission. The treatment region may be massaged with a massaging device during the treatment session. A gel may be applied onto the treatment region to facilitate the ultrasound transmission and electrical stimulation. A measurement system may be used to obtain accurate measurements of the skin ulcer, to provide a quantitative determination of the healing progression.