Transdermal delivery of beneficial substances effected by a hostile biophysical environment
a biophysical environment and beneficial substance technology, applied in the direction of drug compositions, inorganic non-active ingredients, metabolic disorders, etc., can solve the problems of limited amount of pharmaceutical agents that can be delivered through simple diffusion, and limited current technology. , to achieve the effect of improving the transdermal delivery of substances and limited amount of pharmaceutical agents
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example 1
[0055]In this example, a 57 year old woman with severe arthritis in her hands and fingers applied a cream comprising a hostile biophysical environment, along with 10% w / v ibuprofen and 12.5% w / v L-arginine, to her hands. She rubbed the cream into the skin of her hands and fingers until completely absorbed. Within 10 minutes she noticed substantial relief from the pain. Within 30 minutes the pain was completely gone. Pain relief persisted for several hours.
example 2
[0056]In this example, a 37 year old man with shoulder pain applied a cream comprising a hostile biophysical environment, along with 10% w / v ibuprofen and 12.5% w / v L-arginine, to the painful shoulder. He rubbed the cream in until it was completely absorbed. Within 30 minutes the pain was completely gone. The pain never returned.
example 3
[0057]A 54 year old woman with a severe headache in her right temple applied a cream comprising a hostile biophysical environment, 10% w / v ibuprofen, and 12.5% w / v L-arginine to the painful temple. She rubbed the cream in until completely absorbed. Within 10 minutes substantial relief of the headache was achieved. Within 20 minutes the pain was gone. The pain never returned.
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