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Ointment of natural hirudin

A technology of natural hirudin and ointment, applied in the directions of ointment delivery, peptide/protein components, skin diseases, etc., can solve the problems such as no research report on natural hirudin, slow absorption, poor efficacy, etc., to prevent scar hyperplasia and half-life Prolonged, fast-acting results

Inactive Publication Date: 2006-10-04
周维海
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when taken, the natural hirudin contained is easily destroyed by pepsin, and the absorption rate is slow, and the curative effect is poor.
[0004] So far, there is no research report about using natural hirudin to make ointment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Formula: 1 gram of natural hirudin freeze-dried powder (antithrombin activity 100AT-U per gram), 25 grams of petrolatum, 15 grams of lanolin, 15 grams of liquid paraffin, 3 grams of glyceryl monostearate, and 41 grams of distilled water.

[0020] Preparation method: first dissolve natural hirudin freeze-dried powder with distilled water to obtain natural hirudin solution, and set aside; take petroleum jelly, lanolin, liquid paraffin, and glyceryl monostearate to heat and melt, and obtain an ointment base after cooling; then natural hirudin Add the hirudin solution into the ointment base, and stir evenly to obtain 100 grams of the ointment, each gram of the ointment contains natural hirudin 1AT-U.

Embodiment 2

[0022] Formula: 5 grams of natural hirudin freeze-dried powder (antithrombin activity 10,000 AT-U per gram), 20 grams of petrolatum, 13 grams of lanolin, 18 grams of liquid paraffin, 5 grams of glyceryl monostearate, and 39 grams of distilled water.

[0023] Its preparation method is identical with embodiment 1. But in the 100 gram ointment that makes, every gram ointment contains natural hirudin 500AT-U.

Embodiment 3

[0025] Formula: 10 grams of natural hirudin freeze-dried powder (antithrombin activity 20,000 AT-U per gram), 25 grams of petrolatum, 15 grams of lanolin, 20 grams of liquid paraffin, 8 grams of glyceryl monostearate, and 22 grams of distilled water.

[0026] Its preparation method is identical with embodiment 1. But in the 100 gram ointment that makes, every gram ointment contains natural hirudin 2000AT-U.

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PUM

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Abstract

Disclosed is a natural hirudin ointment, wherein the formula contains natural hirudin and conventional ointment matrix, and each 100g of the ointment contains natural hirudin 100-200000 international units. The ointment can be used for treating thrombotic phlebitis, burns, skin cracks, skin ulcer, chilblain, acne, acne and hemorrhoid.

Description

technical field [0001] The invention belongs to an external preparation mainly for treating superficial thrombophlebitis, burn, skin wrinkle, skin ulcer, chilblain, acne, acne, female genital itching, hematoma, acne, hemorrhoid, softening scar and preventing scar hyperplasia . Background technique [0002] Hirudin is a substance with significant biological activity extracted from the salivary glands or the saliva secreted by blood-sucking leeches such as Japanese medical leeches and Philippine leeches (commonly known as Phnom Penh leeches). It is a low-molecular-weight polypeptide composed of 65-66 amino acids. , with a molecular weight of only 7000 Daltons, it has a strong inhibitory effect on thrombin, and is the strongest natural specific inhibitor of thrombin found so far in the world. coagulant of heparin. The main performances are as follows: 1. In terms of anticoagulation, hirudin has high selectivity and specificity in inhibiting thrombin. ...

Claims

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Application Information

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IPC IPC(8): A61K38/16A61K9/06A61P17/02A61P17/10A61P17/04
Inventor 周维海
Owner 周维海
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