The invention provides a production method of a large caliber high steel-grade corrosion-resistant seamless steel tube with the diameter of phi 219.0-phi460.0mm, which comprises the steps of the techniques of: steel making, tube rolling, thermal treatment and processing of the steel tube, and the like, and produces the large caliber high steel-grade corrosion-resistant seamless steel tube with the diameter of phi 219.0-phi460.0mm. The method has the effects of solving the problem of extremely unfavorable influence of the harmful elements such as P, S, and the like on the corrosion resistance of a petroleum-special tube and obtaining a high-quality round billet, adopts the combination of phi 460 three-roller retained mandrel POF rolling mill with high-end thermal rolling control technique to obtain fine quality tube bodies with different sizes, and obtains pipeline tubes with eligible surface quality and combination property by reasonable thermal treatment technique and the control technique of the residual stress of the steel tube, which not only has high strength and excellent corrosion-resistant property but also has good toughness. The invention has the beneficial effects that the steel tube has good physical-chemical properties, high tube body size precision, and convenience for use as well as being beneficial for the safety of long-distance delivery ducts, and can be widely used for the acid oil-gas fields containing hydrogen sulfide.