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Preparation method of medical temperature-sensitive hydrogel

A temperature-sensitive hydrogel and aqueous solution technology, applied in the fields of application, medical science, bandages, etc., can solve the problems of the preparation method and application of medical temperature-sensitive hydrogel that have not been reported

Inactive Publication Date: 2017-10-24
李永生
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, using carboxymethyl chitosan, polyvinyl alcohol and sodium alginate as raw materials, the preparation method and application of medical temperature-sensitive hydrogel containing nano-silver have not been reported.

Method used

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  • Preparation method of medical temperature-sensitive hydrogel
  • Preparation method of medical temperature-sensitive hydrogel

Examples

Experimental program
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Effect test

Embodiment 1

[0033] Embodiment 1 A kind of preparation method of medical thermosensitive hydrogel is:

[0034] (1) Mix carboxymethyl chitosan and polyvinyl alcohol, the amount of carboxymethyl chitosan is 1 / 6 of the mass of polyvinyl alcohol, add water, and prepare a polyvinyl alcohol solution with a mass fraction of 4%, completely After dissolving, let stand for 3 hours;

[0035] (2) Take sodium alginate, the amount of sodium alginate is 1 / 10 of the mass of polyvinyl alcohol, add water to dissolve, and prepare a sodium alginate solution with a mass fraction of 3%;

[0036] (3) Take silver nitrate, the amount of silver nitrate is 1 / 50 of the mass of polyvinyl alcohol, add water, and prepare a silver nitrate aqueous solution with a mass concentration of 0.01%;

[0037] (4) Mix the obtained solution of step (1) and step (2), and slowly add the aqueous solution of silver nitrate obtained in step (3) dropwise into the mixed solution under vigorous stirring, and continue to stir and react for ...

Embodiment 2

[0040] Embodiment 2 A kind of preparation method of medical thermosensitive hydrogel is:

[0041] (1) Mix carboxymethyl chitosan and polyvinyl alcohol, the amount of carboxymethyl chitosan is 1 / 2 of the mass of polyvinyl alcohol, add water, and prepare a polyvinyl alcohol solution with a mass fraction of 8%, completely After dissolving, let stand for 5 hours;

[0042] (2) Take sodium alginate, the amount of sodium alginate is 1 / 5 of the mass of polyvinyl alcohol, dissolve it in water, and prepare a sodium alginate solution with a mass fraction of 3%;

[0043] (3) Take silver nitrate, the amount of silver nitrate is 1 / 40 of the mass of polyvinyl alcohol, add water, and prepare a silver nitrate aqueous solution with a mass concentration of 0.8%;

[0044] (4) Mix the obtained step (1) and step (2), and slowly add the silver nitrate aqueous solution obtained in step (3) dropwise to the mixed solution under vigorous stirring, and continue to stir and react for 4 hours after the dr...

Embodiment 3

[0047] Embodiment 3 A kind of preparation method of medical thermosensitive hydrogel is:

[0048] (1) Mix carboxymethyl chitosan and polyvinyl alcohol, the amount of carboxymethyl chitosan is 1 / 5 of the mass of polyvinyl alcohol, add water, and prepare a polyvinyl alcohol solution with a mass fraction of 5%, completely After dissolving, let stand for 3.5 hours;

[0049] (2) Take sodium alginate, the amount of sodium alginate is 1 / 9 of the mass of polyvinyl alcohol, dissolve it in water, and prepare a sodium alginate solution with a mass fraction of 3%;

[0050] (3) Take silver nitrate, the amount of silver nitrate is 1 / 48 of the mass of polyvinyl alcohol, add water, and prepare a silver nitrate aqueous solution with a mass concentration of 0.05%;

[0051] (4) Mix the obtained step (1) and step (2), and slowly add the silver nitrate aqueous solution obtained in step (3) dropwise to the mixed solution under vigorous stirring, and continue to stir and react for 2.5 hours after the...

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Abstract

The invention discloses a preparation method of medical temperature-sensitive hydrogel. The preparation method comprises the following steps: taking carboxymethyl chitosan, polyvinyl alcohol, sodium alginate and silver nitrate as raw materials; dissolving and mixing; then adding an ascorbic acid water solution and glutaraldehyde; obtaining crude gel by adopting a microwave radiation method; washing the crude gel with diluted acetic acid and water; drying the crude gel in vacuum at 40 DEG C until the weight is constant, so as to obtain the medical temperature-sensitive hydrogel. The medical temperature-sensitive hydrogel disclosed by the invention has a relatively good antibacterial effect, has a wide antibiotic spectrum and no cell toxicity and has high efficiency and low toxin; after the medical temperature-sensitive hydrogel is uniformly sprayed, one layer of a gel thin film is formed on the surface of a wound and has a lasting antibacterial effect and good air permeability and moisture retention; the medical temperature-sensitive hydrogel has the effects of promoting wound healing, stopping bleeding, stopping pain, resisting inflammation and sterilizing, can be used for large-area irregular traumas including burns, scalds, traumas and the like and can also be used for other skin inflammations including bedsores, skin ulcers, tinea manus and pedis, female vaginitis, cervicitis, cervical erosion and the like.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a preparation method of a medical temperature-sensitive hydrogel. Background technique [0002] Carboxymethyl chitosan is a water-soluble chitosan derivative with many properties, such as strong antibacterial, fresh-keeping effect, and an amphoteric polyelectrolyte. It has many applications in cosmetics, fresh-keeping, medicine, etc. It is also one of the chitosan derivatives that have been studied more in recent years. Silver ions have attracted widespread attention in the early days due to their excellent antibacterial and bactericidal properties, and have broad application prospects in the fields of medical materials and antibacterial materials. The cells treated with low-concentration silver ions have no obvious changes in cell aggregation, cell deformation, cell lysis, etc. It can be seen that a small amount of silver ions has no obvious harmful effect on the human body, an...

Claims

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Application Information

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IPC IPC(8): A61L26/00A61L24/08A61L24/06A61L24/00
Inventor 不公告发明人
Owner 李永生
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