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Mesoporous calcium silica xerogel for treating skin ulcer and preparation and use thereof

A mesoporous calcium-silicon, skin ulcer technology, applied in skin diseases, pharmaceutical formulations, active ingredients of aluminum/calcium/magnesium, etc. problems, to achieve the effects of pain relief, excellent moisturizing, and sufficient safety

Inactive Publication Date: 2009-01-21
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The technical problem to be solved by the present invention is to provide a new method for overcoming the defects of the existing mesoporous calcium-silica xerogels with uneven pore size distribution, disorderly arrangement and disorder, as well as the defects of the existing methods and techniques for treating skin ulcers. A kind of mesoporous calcium silica gel and its preparation method and application

Method used

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  • Mesoporous calcium silica xerogel for treating skin ulcer and preparation and use thereof
  • Mesoporous calcium silica xerogel for treating skin ulcer and preparation and use thereof
  • Mesoporous calcium silica xerogel for treating skin ulcer and preparation and use thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0058] Add 2g of P123 (polyoxyethylene ether-polyoxypropylene ether-polyoxyethylene ether triblock copolymer) into ethanol aqueous solution, stir at 40°C for 4 hours, add 4.25 grams of TEOS to the above solution, and then add 80ml 2mol / L hydrochloric acid solution, after stirring for 1h, slowly drop Ca(NO 3 ) 2 Solution (Ca(NO 3 ) 2 2.0 g), after stirring for 24 hours, the solution was transferred to a polytetrafluoroethylene-lined reactor and placed in an oven for crystallization at 110°C for 1 day, and the resulting solution was washed with deionized water, filtered, and dried at room temperature ; Use an air atmosphere on a program temperature-controlled tube furnace to raise the temperature to 500° C. at 1° C. / min, and keep the temperature constant for 6 hours to remove the surfactant. After calcination, cool naturally, pass the powder through a 150-mesh standard sieve, and seal it for later use. The powder is calcium-calcium-silica xerogel (see figure 1 ). The calc...

Embodiment 2

[0060] At room temperature, 1 g of P123 was added to 1 g of absolute ethanol (analytically pure), slowly added dropwise, and after uniform stirring, 2.08 g of tetraethyl orthosilicate (TEOS, analytically pure), 1.71 g of Ca(NO 3 ) 2 and 0.2 gram of hydrochloric acid (1mol / L), and then uniformly stirred for 2 hours, the sol was poured into a polyethylene mold and aged for 2 days, and then dried at 100°C for 12-24 hours. The sample was put into a corundum crucible, heated to 600°C with a program-controlled electric furnace, cooled naturally, ground through a 100-mesh standard sieve, and sealed for later use. The powder is a calcium-silica xerogel containing calcium, denoted as L-2, with a pore size of 3nm and a specific surface of 650m 2 / g, the porosity is 90%, the percentage of the molar weight of silicon oxide to the total molar weight of silicon oxide and calcium oxide is: 80%.

Embodiment 3

[0062] According to TEOS: CaCl 2 :CTAB:NH 3 .H 2 O:H 2 O=1:0.10:0.6:0.47:65 molar ratio, weigh 1g cetyltrimethylammonium bromide (CTAB), dissolve it in ethanol aqueous solution, then add ammonia water, and keep the system at a constant temperature of 35°C Stir for 1 hour to dissolve, slowly add tetraethyl orthosilicate, then CaCl 2 . Stirring was continued for 4-5 hours. Move it into a polytetrafluoroethylene mold to obtain a sol; age the sol at 37° C. for 48 hours, and dry it at 100° C. for 18 hours to obtain a gel. The sample was placed in a muffle furnace at a heating rate of 5°C / min, and baked at 550°C for 6 hours to remove the template. Calcium-containing calcium-silica xerogel material obtained after calcination, with a pore size of 2nm and a specific surface area of ​​600m 2 / g, the porosity is 80%, the percentage of the molar weight of silicon oxide to the total molar weight of silicon oxide and calcium oxide is: 91%.

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Abstract

The invention discloses a mesoporous lime-silicate xerogel, which contains silicon oxide, or silicon oxide and calcium oxide. In the power X-ray diffraction (XRD) pattern, 1 to 3 peaks are between 0 to 2 degrees on the abscissa 2 theta and holes of the mesoporous lime-silicate xerogel are orderly arranged. The invention also discloses the preparation method and the application in preparing drugs or materials for curing skin ulcer. The mesoporous lime-silicate xerogel of the invention, with even aperture size, high porousness, even arrangement of holes and good hole appearance, can effectively promote the healing of ulcer in a simple use method and can cure skin ulcer by compounding with drugs or growth factors. Te mesoporous lime-silicate xerogel can be used for curing skin ulcer on different medical occasions, such as cervical erosion, diabetic ulcer, wound surface due to operation and trauma, bedsore, stress ulcer, skin and mucosal ulcer, erosive lesion, local II or III burn and scald wound, wound difficult to heal, etc.

Description

technical field [0001] The invention relates to a xerogel and its preparation method and application, in particular to a mesoporous calcium silica xerogel and its preparation method and application. Background technique [0002] Skin ulcer refers to a class of diseases caused by different causes of body surface tissue necrosis, ulceration, and defect. Skin ulcer is a disease characterized by ulcerative lesions of the skin and mucous membranes. During the course of the disease, there are pathological changes such as wound exudation, infection, and erosion, as well as skin and mucous membrane ulceration and soft tissue damage, and ultimately rely on connective tissue and epithelial tissue to repair the wound. However, after human skin and mucous membranes are injured, not only the morphology and function of the cells in the injured area undergo pathophysiological changes, but also the injured cells and dead cells release a large number of active substances, such as histamine,...

Claims

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Application Information

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IPC IPC(8): A61K33/06A61K9/00A61P17/02
Inventor 刘昌胜魏杰戴程隆袁媛
Owner EAST CHINA UNIV OF SCI & TECH
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