31 results about "Stress ulcer" patented technology

The invention provides methods of treating and preventing asthma, laryngitis, symptomatic gastroesophageal reflux disease, pregnancy-induced gastroesophageal reflux disease, noncardiac chest pains, coughing, apnea, dyspepsia, inflammatory bowel disease, irritable bowel syndrome, gastritis, stress ulcers, bleeding peptic ulcers, acute gastrointestinal bleeding, infectious enteritis, collagenous colitis, lymphocytic colitis, chronic diarrhea in immunocompromised patients, esophageal ulcers in immunocompromised patients, idiopathic gastric acid hypersecretion, gastroparesis, gastrointestinal motility disorders, Zollinger-Ellison syndrome, short bowel syndrome, emesis, regurgitation, early satiety, chronic sore throat, abdominal pain, abdominal bloating, nausea, sour stomach, diarrhea, constipation, bacterial infections, refractory ulcers, gastrointestinal disorders induced by NSAIDs, Barrett's esophagus, gastrointestinal disorders caused by steroids, gastrointestinal disorders induced by cholinergic compounds, and fungal or viral-induced ulcers in the gastrointestinal tract by administering a therapeutically effective amount of at least one proton pump to a patient in need thereof. The invention also provides on demand relief of symptoms associated with gastroesophageal reflux disease (GERD), and provides relief from symptoms caused by the consumption of excessive amounts of food and / or alcohol by administering a therapeutically effective amount of at least one proton pump inhibitor to a patient in need thereof. The invention also provides methods for treating parasitic infections, such as malaria, by administering a therapeutically effective amount of at least one proton pump inhibitor to a patient in need thereof.

The invention provides an injection for treating a peptic ulcers and a preparation method thereof. The powder injection provided by the invention comprises the active ingredients of Ilaprazole sodium and excipient, wherein the ratio of the both in parts by weight is (1:1)-(1:30), and the preferable ratio is (1:10)-(1:18). The preferable prescription of the powder injection provided by the invention comprises 1 part of Ilaprazole sodium, 1-30 parts of excipient, 0-10 parts of antioxidant and / or 0-0.3 part of metal ion complexing agent; and a right amount of inorganic base is added to regulate the pH value to 9.0-12.0. The Ilaprazole sodium freeze-dried powder injection provided by the invention has stable quality, and is suitable for treating peptic ulcer bleeding and stress ulcers and preventing upper gastrointestinal bleeding caused by serious diseases.

The invention provides an injection for treating a peptic ulcers and a preparation method thereof. The powder injection provided by the invention comprises the active ingredients of Ilaprazole sodium and excipient, wherein the ratio of the both in parts by weight is (1:1)-(1:30), and the preferable ratio is (1:10)-(1:18). The preferable prescription of the powder injection provided by the invention comprises 1 part of Ilaprazole sodium, 1-30 parts of excipient, 0-10 parts of antioxidant and / or 0-0.3 part of metal ion complexing agent; and a right amount of inorganic base is added to regulate the pH value to 9.0-12.0. The Ilaprazole sodium freeze-dried powder injection provided by the invention has stable quality, and is suitable for treating peptic ulcer bleeding and stress ulcers and preventing upper gastrointestinal bleeding caused by serious diseases.

A medicament for prophylactic and / or therapeutic treatment of a disease selected from the group consisting of a neurodegenerative disease such as amyotrophic lateral sclerosis and Alzheimer's disease, rheumatic disease such as rheumatoid arthritis, ischemic heart disease such as myocardial infarction, stress ulcer, dermatitis, arteriosclerosis and hyperlipidemia, which comprises fineparticles of a noble metal such as platinum or an alloy containing a noble metal (e.g., platinum colloid) as an active ingredient.

The invention provides roxatidine acetate hydrochloride used for injection and a preparation method thereof. The roxatidine acetate hydrochloride is prepared by taking the roxatidine acetate hydrochloride as a raw material; adding glycine or mannitol as an excipient; and freezing and drying after preparing the raw material and the excipient into a liquid medicament. The prepared roxatidine acetate hydrochloride used for the injection is used for upper gastrointestinal hemorrhage caused by gastric ulcer, stress ulcer and hemorrhagic gastritis and preanesthetic medication. The product obtained by the method has good quality, exact curative effect and stable quality.

The invention provides a nutritional composition capable of promoting wound healing, bedsore restoration, and postoperative stress ulcer healing. The nutritional composition is capable of shortening the length of stay of patients at the perioperative period, reducing medical cost, and reducing mortality. The nutritional composition is prepared via combination of collagen peptide, wheat peptide, and casein hydrolysate at a certain ratio.

The present invention relates to the new use of Shiliangcha extract in preparing medicine. Shiliangcha extract is mainly volatile oil prepared with the leaves of calycanthaceae plants, and with the main components including 1.8-cineole, broneol, linalool, benzyl alcohol, benzyl acetate, farnesol, terpineol, 1H-indole, etc. Pharmacological test shows that Shiliangcha extract has obvious effects of inhibiting diarrhea, stress ulcer and enteric hyperanacinesia, and lowering the gastric secretion and total acid displacement. It has high curative effect on abdominal mass and has also excellent curative effect on respiratory tract diseases.

A method for producing paeonoside metabolic hormone-I by fermenting short Lactobacillus is carried out by inducing L.brevis AS 1.12 into culture medium with tomato juice 200g / L, protein peptone 7.5g / L, yeast paste 7.5g / L, glucose 10g / L, Tween-80 0.3 ml / L and pH=7.0-8.5, anaerobic culturing at 25-37 degree for 12-24 hrs, centrifugal collecting bacterial cells, washing by normal saline, centrifuging, dispersing obtained cells into buffer liquid of 0.05M phosphate, adding into substrate paeonoside or its analogs hydroxy-paeonoside or methyl-paeonoside or benzoyl-paeonoside or mixture of paeonoside and its analogs, converting at 30-40 degree for 2-24 hrs, extracting by ethyl acetate, drying concentrated extract to obtain concrete, chromatographying by silica-gel column to obtain final product. It's simple, cheap, efficient, fast and controllable and has friendly environment. It can be used for anti-inflammatory, stress ulcer, analgesic and antispasmodic, ecstatic coronary blood vessel, myocardial ischemia and platelet aggregation-inhibition.

The invention relates to a pharmaceutical composition containing Ilaprazole or a salt thereof and a preparation method thereof. The pharmaceutical composition contains or consists of Ilaprazole or a salt thereof and a Ilaprazole derivative, wherein the amount of the Ilaprazole derivative is not higher than 1.3wt% (less than 1.3wt%). The pharmaceutical composition can be used for treating peptic ulcer bleeding and stress ulcer and preventing upper gastrointestinal hemorrhage caused by severe diseases.

The invention discloses a group of serum metabolite micromolecule markers related to the diagnosis of ischemic stroke complicated with stress ulcer. The biomarkers include one or more of glycine, phenylalanine, ornithine, palmitoleic acid, arachidonic acid, and oleic acid. The analysis and detection method based on the biomarker group has advantages of high sensitivity, high throughput and simpleoperation; the accurate diagnosis of ischemic stroke complicated with stress ulcer can be realized; and a diagnostic reagent for the ischemic stroke complicated with stress ulcer can be prepared.

The present invention discloses new type of compounds 2, 3, 4, 6, 8-pentamethoxyl-dibenzofuran extracted from haw root and its medicinal use. These compounds have activity of inhibiting semicarbazide sensitive amine oxidase (SSAO). The raised activity of SSAO is related with several kinds of serious diseases, and in the case of existing transition metal, the deaminated products of SSAO, formaldehyde and hydrogen peroxide, will generate free radicals, the accumulation of which may result in oxidizing damage to human body and cause diseases, such as stress ulcer, atherosclerosis, heart disease, malignant tumor, etc.

The present invention discloses one kind of pinellia tuber extract and its preparation process, medicine composition and use. The pinellia tuber extract is prepared with fresh pinellia tuber, and through air dying, crushing to operate pinellia tuber meal, heat reflux or percolating with organic solvent and / or water for 2-4 times to obtain the extracted liquid, concentrating and drying the extract liquid. The pinellia tuber extract has excellent effects of relieving cough, eliminating phlegm, stopping vomiting, diminishing inflammation, etc. and may be used in treating pneumosilicosis, cough, gastric ulcer, arrhythmia, tumor and other diseases.

The invention discloses alpha-type, beta-type, kappa-type, niu-type and omega-type compounds with a new molecular structure of esomeprazole strontium. The compounds have the characteristics of being more easily and quickly prepared with low energy consumption, and having less hygroscopicity, good storage stability, good accessibility and the like. The compounds are suitable for preparing medicinesor medicine compositions for treating diseases such as gastroesophageal reflux diseases, erosive reflux esophagitis, upper gastrointestinal hemorrhage, stress ulcer and duodenal ulcer of human beingsor animals, eradicating helicobacter pylori and Zollinger-Ellison syndrome, preventing recurrence of peptic ulcer related to helicobacter pylori, and preventing recurrence of cured esophagitis patients by long-time maintaining treatment, and adverse reactions in treatment are reduced.

A new application of rabeprazole in pharmacy. The invention belongs to the technical field of medicine, and relates to a new application of rabeprazole in medicaments for treating stress ulcer with bleeding.

The invention belongs to the field of medicine and relates to the medical use of arctigenin, in particular to the use of arctigenin in the preparation of medicines for treating peptic ulcer diseases, preferably an injection preparation thereof. Studies have shown that arctigenin has inhibitory effects on water-immersion stress gastric ulcer in rats, pyloric ligation gastric ulcer, gastric ulcer induced by absolute ethanol in mice, and experimental duodenal ulcer in rats. Index; It has a significant inhibitory effect on acetic acid-induced ulcerative colitis in rats. When arctigenin is used in the treatment of peptic ulcer disease, it has the advantages of definite curative effect and low toxicity and side effects, so it has broad application prospects.

The invention provides novel application of erucyl amide, and particularly provides application of erucyl amide for preparing a medicine for treating myocardial damage. Due to a built stress ulcer animal model, a result shows that erucyl amide has the protecting effect on the immersion-binding stress mouse heart; due to Western Blot analysis, it finds that after erucyl amide is adopted, BCL-2 and BAX have the biologic effect consistent with the positive control medicine metoprolol, and the result prompts that the erucyl amide has the certain effect of resisting mouse stress myocardial damage, and is related to BCL-2 and BAX signal paths.

The invention discloses a Chinese medicine preparation for curing cerebral vascular stress ulcer bleeding. According to the pathogenesis of the cerebral vascular stress ulcer bleeding, traditional Chinese medicines of franchet groundcherry, root of fortune apios, chondrilla piptocoma, begonia yunnanensis levl, root of chinese ixora flower, wild soybean plant, humulus lupulus L. Var. cordifolius(Miq.) Maxim. and asiatic striga herb, which have the efficacy of clearing away heat and toxic materials, promoting blood circulation to remove blood stasis, and regulating Qi-flowing for strengthening spleen, are selected to be made into paste, and through clinical tests, the effective rate is 90%, which is much better than 50% in the control group.

The invention discloses a group of serum metabolic small molecular markers related to the diagnosis of ischemic stroke complicated by stress ulcers. The biomarkers include glycine, phenylalanine, ornithine, palmitoleic acid, arachidose One or more of alkenoic acid and oleic acid. The analysis and detection method based on this group of biomarkers has the advantages of high sensitivity, high throughput, and easy operation. It can realize the accurate diagnosis of ischemic stroke complicated by stress ulcer, and can be applied to the preparation of ischemic stroke complicated by stress ulcer. Diagnostic reagents for sexual ulcers.

The invention belongs to the technical field of medicine, and relates to a new application of rebeprazole in drugs for treating acute gastric mucosal injury caused by non-steroidal anti-inflammatory drugs and stress ulcer with bleeding.

The invention provides a preparation method of roxatidine acetate hydrochloride for injection. The preparation method includes: using roxatidine acetate hydrochloride as raw material and glycine, mannitol, sodium sulfite and edetate disodium as auxiliary materials to prepare liquid medicine, performing ultrafiltration on the liquid medicine, and freeze drying the liquid medicine to prepare a freeze-drying preparation. The prepared roxatidine acetate hydrochloride for injection is applicable to upper gastrointestinal hemorrhage caused by gastric ulcer, stress ulcer and hemorrhagic gastritis and preanesthetic medication. The preparation method has the advantages that the stability of the roxatidine acetate hydrochloride solution for injection is increased, the related substances of the roxatidine acetate hydrochloride for injection are evidently reduced during preparing, split charging and freeze drying, evident content change is avoided, and the prepared roxatidine acetate hydrochloride preparation for injection is good in stability during transportation and storage; the preparation method is simple in process, low in energy consumption and convenient to operate, and the roxatidine acetate hydrochloride preparation prepared by the method is good in quality, definite in curative effect and stable in quality.

The invention discloses special nasal-feeding fluid food for a stress ulcer patient at a minimal bleeding period. The preparation method of the nasal-feeding fluid food comprises the following steps of (1) mixing flour and water, and uniformly blending the flour and the water to a milky state; (2) adding milk into the mixture obtained in the step (1), and uniformly stirring the milk and the mixture; (3) heating the mixture obtained in the step (2) with slow fire, continuously stirring the mixture, and heating and stirring the mixture for 1 to 1.5 minutes; and (4) pouring egg liquid into the mixture obtained in the step (3), heating the mixture with the egg liquid with slow fire, continuously stirring the mixture, and heating and stirring the mixture for 1 to 1.5 minutes to obtain the nasal-feeding fluid food. The proportion of the raw materials is as follows: 40g to 60g of egg liquid, 80ml to 120ml of milk and 200ml to 300ml of water are added into every 50g of flour, and the egg liquid is the mixture obtained by uniformly stirring egg white and egg yolk of a plurality of eggs. The nasal-feeding fluid food has the advantages that the healing of an ulcer surface can be effectively promoted; the taste is good; no additive is added; the materials are easily available, and simplicity in production can be realized.

A coated dripping pill of omeprazole for treating gastric ulcer, duodenal ulcer, stress ulcer, reflux esophagitis, etc is prepared from omeprazole, polyethylene glycol (1000-2000) and polyalkoxyl-40 stearate.

A coated dripping pill of omeprazole for treating gastric ulcer, duodenal ulcer, stress ulcer, reflux esophagitis, etc is prepared from omeprazole, polyethylene glycol (1000-2000) and polyalkoxyl-40 stearate.

The invention relates to a pharmaceutical composition containing ilaprazole sodium and a preparation method thereof. The pharmaceutical composition is prepared from the ilaprazole sodium and ilaprazole derivatives, wherein the ilaprazole derivatives comprise ilaprazole sulfone, ilaprazole thioether, ilaprazole carboxyl ylide, ilaprazole hydroxyl ylide, ilaprazole mercaptomethyl ylide, ilaprazole methyl ylide, ilaprazole thiocyanmethyl ylide, ilaprazole dithiodimer, ilaprazole trithiodimer and ilaprazole nitrogen oxide. The pharmaceutical composition can be used for treating peptic ulcer hemorrhage and stress ulcer, and preventing upper gastrointestinal hemorrhage caused by serious illnesses.

The invention discloses a mesoporous lime-silicate xerogel, which contains silicon oxide, or silicon oxide and calcium oxide. In the power X-ray diffraction (XRD) pattern, 1 to 3 peaks are between 0 to 2 degrees on the abscissa 2 theta and holes of the mesoporous lime-silicate xerogel are orderly arranged. The invention also discloses the preparation method and the application in preparing drugs or materials for curing skin ulcer. The mesoporous lime-silicate xerogel of the invention, with even aperture size, high porousness, even arrangement of holes and good hole appearance, can effectivelypromote the healing of ulcer in a simple use method and can cure skin ulcer by compounding with drugs or growth factors. Te mesoporous lime-silicate xerogel can be used for curing skin ulcer on different medical occasions, such as cervical erosion, diabetic ulcer, wound surface due to operation and trauma, bedsore, stress ulcer, skin and mucosal ulcer, erosive lesion, local II or III burn and scald wound, wound difficult to heal, etc.

The invention discloses a drug for severe pneumonia and a preparation method thereof. Medicinal active ingredients of the drug include raw gypsum, rhizoma anemarrhenae, polished round-grained rice, raw licorice, bulbs of thunberg fritillary, snake gourd seeds, rhizoma pinellinae praeparata, radix platycodi, fried Chinese ephedra herbs, almonds, ginseng, the root of dwarf lilyturf, fruits of Chinese magnoliavine, the root bark of the peony tree and the root of common peony. The drug has the effects of clearing away heat and phlegm, promoting catharsis, supplementing qi, strengthening the body resistance, activating blood circulation, removing blood stasis, and protecting the spleen and the stomach; the drug for treating the severe pneumonia has high practicability, and the anti-infection ability of antibiotics is enhanced through the compound effect of clearing the lungs and removing the phlegm; through the effect of supplementing the qi and strengthening the body resistance, the immunity and disease resistance are improved, and infections of fungi, viruses and non-specific pathogens are reduced; through the compound effect of ventilating lung qi, respiratory functions are improved,and coughing, expectoration and the like are reduced; through the effect of cooling the blood and promoting the blood circulation, the incidence of coagulation disorders is reduced; through the effect of tonifying the stomach and protecting the spleen, appetite and disease recovery are promoted, and the occurrence of stress ulcers and bacteria group displacement is reduced.

A method for producing paeonoside metabolic hormone-I by fermenting short Lactobacillus is carried out by inducing L.brevis AS 1.12 into culture medium with tomato juice 200g / L, protein peptone 7.5g / L, yeast paste 7.5g / L, glucose 10g / L, Tween-80 0.3 ml / L and pH=7.0-8.5, anaerobic culturing at 25-37 degree for 12-24 hrs, centrifugal collecting bacterial cells, washing by normal saline, centrifuging, dispersing obtained cells into buffer liquid of 0.05M phosphate, adding into substrate paeonoside or its analogs hydroxy-paeonoside or methyl-paeonoside or benzoyl-paeonoside or mixture of paeonoside and its analogs, converting at 30-40 degree for 2-24 hrs, extracting by ethyl acetate, drying concentrated extract to obtain concrete, chromatographying by silica-gel column to obtain final product. It's simple, cheap, efficient, fast and controllable and has friendly environment. It can be used for anti-inflammatory, stress ulcer, analgesic and antispasmodic, ecstatic coronary blood vessel, myocardial ischemia and platelet aggregation-inhibition.

The invention proposes a new application of erucamide, in particular the application of erucamide in the preparation of medicine for treating myocardial injury. Through the stress ulcer animal model established by the present invention, it was found that erucamide has a protective effect on the heart of water immersion-restraint stress mice, and by Western Blot analysis, it was found that BCL-2 and BAX appeared after using erucamide. The biological effect was consistent with that of the positive control drug metoprolol, and the results suggested that erucamide had a certain anti-stress myocardial injury effect in mice, and was related to BCL‑2 and BAX signaling pathways.

An application of a melancholy-dispelling liver-soothing capsule in preparation of antiulcer medicines is disclosed. Animal experiments and research show that: the melancholy-dispelling liver-soothing capsule has certain protection functions for an absolute-ethanol-induced acute gastric ulcer model, a water-immersion-induced stress ulcer model and a chronic acetic acid ulcer model.