163 results about "Reflux esophagitis" patented technology

The invention discloses a compound or its salt shown in the formula (I) and usage of the compound as a potassium competitive acid blocker or a gastric acid secretion inhibitor. The compound has a proton pump (H+ / K+)-ATPase inhibitory effect and can be used for preventing, treating and inhibiting diseases related to gastric acid secretion, such as peptic ulcer, zollinger-ellison syndromes, gastritis, erosive esophagitis, reflux esophagitis and symptomatic gastroesophageal reflux diseases.

The invention discloses an American cockroach medicinal composition for curing ulcers or ulcerative inflammation. The medicinal composition is mainly prepared from an active ingredient mixture prepared by mixing an American cockroach extract and montmorillonite powder. The weight part ratio of the American cockroach extract to the montmorillonite powder is equal to 0.8-1.2:0.5-6. A preparation method of the American cockroach medicinal composition for curing the ulcers or the ulcerative inflammation comprises the following steps of: preparing the American cockroach extract, mixing active ingredients, and preparing medicaments. The medicinal composition has simple preparation method, fully exerts effects of the American cockroach extract, and has obvious effects of effectively curing diseases such as oral ulcers, recurrent aphthous ulcers, oral lichen planus, oral mucosal injury (behcet disease, herpes simplex, leukoplakia, discoid lupus erythematosus, hand-foot-and-mouth disease, scalds, chemotherapy, radiotherapy and the like) caused by various reasons, reflux esophagitis, eophageal ucers, radiation esophagitis, ulcerative colitis, radiation proctitis, and diarrhea, and hematochezia with mucosal injury, and the like.

The invention discloses a pharmaceutical preparation used for treating erosive reflux oesophagitis, a gastroesophageal reflux disease, maintaining a long-term therapy to prevent the recurrence of oesophagitis for a cured patient, controlling the symptoms of gastroesophageal reflux diseases, eradicating helicobacter pylori jointly medicated with an appropriate antimicrobial therapy, healing duodenal ulcer related to helicobacter pylori infections and preventing the recurrence of peptic ulcer related to helicobacter pylori, and particularly relates to a prepared sustained-release oral formulation adopting esomeprazole magnesium as the ingredient. The pharmaceutical preparation aims to supplement the deficiency of the prior art and provide a sustained-release esomeprazole magnesium dropping pill. The sustained-release esomeprazole magnesium dropping pill overcomes the defects in the prior art effectively, guarantees no occurrence of an obvious quality change for the drug during the effective storage period and has the advantages of controllable release time, full release and high bioavailability simultaneously.

A liposome of lansoprazole is prepared from lansoprazole, phosphatide, cholesterol and the supporting agent chosen from sorbitol, mannitol, cane sugar, sodium chloride, water-soluble starch, etc. It is used for treating gastric ulcer, duodenal ulcer, reflux esophagitis, etc. Its preparing process is also disclosed.

The invention provides a preparation method of a traditional Chinese medicine for treating blood stasis type reflux oesophagitis, and belongs to the technical field of preparation methods of traditional Chinese medicines. Currently, omeprazole is adopted to treat blood stasis type reflux oesophagitis, and contraindicated for use by patients allergic to the medicament, patients with serious renal insufficiency, pregnant women and infants. The preparation method is characterized by comprising the following steps of immersing the following 35 Chinese medicines in water, namely trogopterus dung, pseudo-ginseng, circium japonicum, camellia, common cephalanoplos herb, osbeckia chinensis, folium artemisiae argyi, cactus, hairyvein agrimony, rhizoma bletillae, stove, carbonized hair, rumex japonicus, marmor serpentinatum, radix boehmeriae, madder, salvia plebeian, hollyhock flower, eclipta, clove, fiveleaf akebia fruit, illicium verum, murraya jasminorage, aspongopus, sword bean, elecampane, szechwan Chinaberry fruit, mysorethorn, three-nerved spicebush root, rhizoma nardostachyos, ambergris, radix curcumae, peach kernels, safflower and liquorice; decocting with slow fire; filtering and removing slag to obtain decoction, which is the traditional Chinese medicine for treating blood stasis type reflux oesophagitis. The Chinese medicine lotion has the advantages of small toxic and side effect of prepared Chinese medicine decoction, short course of treatment and high cure rate.

The invention relates to the field of a traditional Chinese medicine, and discloses a traditional Chinese medicine for treating reflux esophagitis. The traditional Chinese medicine for treating the reflux esophagitis is prepared from banksian rose, dandelion, corydalis tuber, myrrh, inula flower, ruddle, ginseng, ginger, licorice, ginger processed pinellia, Chinese-date, coptis chinensis, fructus evodiae, calcined concha arcae and cuttlebone. The traditional Chinese medicine for treating the reflux esophagitis disclosed by the invention is good in a curative effect, and high in recovery rate; and the total effective rate achieves 94.9%.

The invention discloses a traditional Chinese medicine composition for treating reflux esophagitis and a preparation method of a granule formulation thereof. The traditional Chinese medicine composition is composed of 19 traditional Chinese medicine including cowherb seeds, radix clematidis, earthworm, angelica, radix bupleuri, officinal magnolis flowers, ligusticum wallichii, rhizoma corydalis, tangerine peels, cuttle bones, bulbs of thunberg fritillary, coptis, fructus evodiae, yam, poria cocos, rhizoma atractylodis, dendrobe, bletilla and liquorice. The preparation method includes taking the 19 traditional Chinese medicine as main drugs, and taking sucrose and dextrin as excipient. The cowherb seeds which are a drug for activating blood circulation, diminishing swelling and promoting lactation, the radix clematidis which is a drug for rheumatism and the earthworm which is a decoction of medicinal insects are creatively taken as the main drugs to prepare the traditional Chinese medicine composition, so that conventional drugs are challenged and creatively applied, and treatment effect is greatly improved.

The invention provides a traditional Chinese medicine composition for curing reflux esophagitis, which is prepared by adopting resurrection plant, pericarpium citri reticulatae, marigold flower, syzygium aromaticum, muskroot-like semiaquilegia roots, dysosma difformis, dregea volubilis, bamboo shavings, pinellia ternata and polygonum cuspidatum. The traditional Chinese medicine composition can beclinically used for curing the reflux esophagitis.

The invention provides a medicine for treating gastroesophageal reflux disease. The medicine is characterized by being prepared from the following medicine materials by weight: 6-12 parts of folium eriobotryae, 0.5-2 parts of platycodon grandiflorum and 6-12 parts of largehead atractylodes rhizome. The invention also provides the application of the medicine in drugs for treating gastroesophageal reflux disease, reflux esophagitis and non-erosive gastroesophageal reflux disease. The medicine for treating gastroesophageal reflux disease has the advantages that the clinical symptoms can be remarkably relieved when the medicine is used for treating the gastroesophageal reflux disease, symptoms of heartburn, acid regurgitation, anabole, causalgia post sternum, pharyngeal discomfort, belching, epigastric distention, epigastric pain are significantly improved, and the general curative effect of the medicine is similar to that of common clinically used acid-suppressive drug omeprazole and is similar to that of traditional Chinese medicine compositions disclosed in comparison files, but the medicine provided by the invention has advantages in improving individual symptoms; the medicine provided by the invention prepared from pure traditional Chinese medicine materials, has no toxic and side effects, and can be easily accepted by patients; the material components are less, the materials are abundant and low in price and are easily obtained, and the preparation process is simple and is suitable for being widely generalized and used.

The invention relates to a Chinese medicinal medicament for treating reflux esophagitis. The medicament consists of the following components by weight: 5-8g of wine-fried coptis root, 7-10g of wine-fried rhubarb, 10-15g of bran-fried large-head atractylodes rhizome, 7-10g of bran-fried pawpaw, 10-15g of earth-fried concha arcae, 5-8g of earth-fried calyx kaki, 7-10g of earth-fried cuttlebone, 10-15g of oven earth, 4-6g of medicinal evodia fruit, 10-15g of vinegar-treated white paeony root, 5-8g of Chinese date and 5-8g of lotus rhizome node. An appropriate amount of turmeric root-tuber or areca nut, fried rice sprout or fried wheat sprout or ginger and ruddle can be added according to the condition of a patient. The medicament has the effects of regulating qi, invigorating the blood, soothing liver, harmonizing stomach, dispersing the depressed liver-energy, harmonizing stomach, lowering adverse qi, stopping acid and guiding air downwards. As proved by clinical tryout, a good treatment effect is achieved, the curative rate is up to 92 percent, and the effective rate is over 98 percent.

The invention discloses a traditional Chinese medicine for treating spleen-deficiency and qi stagnation-type reflux esophagitis. The traditional Chinese medicine comprises finger citron flower, quisqualis leaf, fructificatio hexagoniae apiariae, bighead atractylodes rhizome, tangerine seed, stem of Hainan pepper, adenophora root, rhizoma atractylodis, bunge auriculate root and Chinese magnoliavine. The traditional Chinese medicine is used for clinically treating spleen-deficiency and qi stagnation-type reflux esophagitis.

The invention provides an enzyme beverage with healthcare effects of strengthening the spleen and nourishing the stomach and a preparation process thereof. A unique traditional Chinese medicine secret recipe is taken as a raw material for fermenting to prepare a live-bacteria enzyme beverage. The enzyme beverage has the effects of repairing gastric mucosa fall-off and treating reflux esophagitis, chronic gastritis and gastric and duodenal ulcer, and is beneficial for people suffering from stomach trouble. The reasonable traditional Chinese medicine formula is combined with the enzyme technology, active ingredients of Chinese herbal medicines are enriched and purified through action of microorganisms, and co-act with regulatory factors such as enzyme to achieve better effect, and therefore, the enzyme beverage is safe, healthy, mild in acting effect, and has the healthcare effects of strengthening the spleen and nourishing the stomach.

The present invention relates to a domperidone gel preparation for curing reflux esophagitis. Said preparation includes active component and matrix, in which the active component includes the solution made up by using domperidone, polyvinylpyrrolidone and water. Its taste is good, and its stability is better.

The invention relates to a Chinese herbal medicine for treating reflux esophagitis. The Chinese herbal medicine is prepared from the following medicinal materials in parts by weight: 8 parts of indigofera pseudotinctoria, 7 parts of cuttlebone, 7 parts of rhizoma cyperi, 6 parts of fructus amomi, 12 parts of rhizoma polygonati odorati, 14 parts of white paeony root, 6 parts of gecko, 4 parts of herba cistanches, 6 parts of herba gynostemmatis pentaphylli, 8 parts of root of Chinese thorowax, 9 parts of prunella vulgaris and 7 parts of lilium brownie. Clinical experiments show that the Chinese herbal medicine can safely and effectively treat reflux esophagitis.

The invention discloses a traditional Chinese medicine for treating liver-stomach disharmony-caused reflux esophagitis. The traditional Chinese medicine is prepared from cystopteris japonica luerss, root-bark of Japanese plum, rhizoma corydalis, orange peel, phoenix-tail fern, Bambusa sinospinosa Mc Clure, anise, magnolia cortex, pinellia ternate and mica. The traditional Chinese medicine can be used for treating liver-stomach disharmony-caused reflux esophagitis.

The invention discloses a stomach-comforting pharmaceutical composition and application thereof. The stomach-comforting pharmaceutical composition comprises the following materials in parts by weight: 5-7 parts of fried radix bupleuri, 9-11 parts of scutellaria baicalensis, 1-3 parts of oroxylum indicum, 14-16 parts of fried white paeony root, 9-11 parts of fried white atractylodes rhizome, 9-11 parts of fried fructus aurantii, 14-16 parts of poria cocos, 9-11 parts of processed pinellia tuber, 14-16 parts of dandelion, 1-3 parts of fructus amomi, 9-11 parts of Sichuan mangnolia officinalis, 9-11 parts of wrinkled giant hyssop, 9-11 parts of perilla stems, 9-11 parts of Thunberg fritillary bulb and 9-11 parts of bletilla striata. The stomach-comforting pharmaceutical composition disclosed by the invention is rigorous in component, integrally regulated from multiple layers, multiple links and multiple target points, remarkable in clinical curative effect for treating reflux esophagitis, obviously improves symptoms, can reduce pathogenetic condition relapse of a patient and can reduce dependence on a proton pump, and is free of toxic and side effect.

The invention discloses a lansoprazole N crystal form and a preparation method and application thereof. The X-ray powder diffraction of the lansoprazole N crystal form has characteristic peaks when the diffraction angle 2(theta) is 5.438, 7.062, 8.230, 9.216, 11.022, 11.789, 12.610, 13.541, 20.603, 21.862 and 26.242. The preparation method comprises the following steps of: dissolving lansoprazole in ethyl acetate or a mixed solvent of n-butyl alcohol and water; cooling to separate out crystals; and filtering and drying to obtain the lansoprazole N crystal form. The new lansoprazole crystal form disclosed by the invention is easy to prepare; the preparation method requires little solvent and is simple to operate, and the production cost is low; the reaction conditions are mild, and the control is easy; and the reproducibility is good, and a target product crystal form can be stably obtained. Through the method disclosed by the invention, the prepared lansoprazole crystal form has high purity and low impurity content, maintains all pharmacologic characteristics of lansoprazole, and can be used for treating gastric ulcer, duodenal ulcer and reflux esophagitis and eradicating helicobacter pylori.

The invention relates to the technical field of tissue engineering, in particular to a synthesized patch with a wireless stimulation function and used for resisting reflux esophagitis. The synthesized patch comprises an upper layer, a lower layer and an implant type wireless stimulating device and is characterized in that one side of each of the upper layer and the lower layer is provided with a circular notch, the angle of each circular notch is 270 degrees, the edge part of the upper layer is connected with the edge part of the lower layer to allow the two circular notches to be connected correspondingly, sealed space is formed between the upper layer and the lower layer, and the implant type wireless stimulating device is disposed in the sealed space; the upper layer and the lower layer are made of materials with the shape memory feature, the upper layer is a teflon layer, and the lower layer is an expanded teflon layer. The synthesized patch has the advantages that the synthesized patch can be used to repair expanded esophageal hiatus, the lower esophageal sphincter is stimulated through the wireless stimulating device, the two major causes, namely hiatus hernia and lower esophageal sphincter relaxation, of the reflux esophagitis are treated effectively, and an evident effect is achieved.

The invention relates to a Chinese patent medicament for treating reflux esophagitis and a preparation method thereof, and belongs to the field of Chinese medicinal preparations. The Chinese patent medicament is prepared from the following raw materials in part by weight: 10 to 25 parts of rabdosia rubescens, 20 to 30 parts of stir-fried immature bitter orange and 6 to 15 parts of liquorice root. The Chinese patent medicament is a pure Chinese medicinal preparation and is a novel gel oral administration preparation, can be adhered to esophageal mucosa for a long time after oral administration to play a role in local treatment, can avoid the first pass effect caused by oral administration, has the advantages of high medicament carrying rate, strong wall-hanging properties, continuous and complete absorption of medicaments, lasting medicinal effect and quick response, and can be adhered to the esophageal mucosa for a long time after the oral administration to play a role in local inflammation resistance.

Provided is a traditional Chinese medicine for treating qi deficiency and blood stasis type reflux esophagitis. The traditional Chinese medicine is prepared from cherry leaves, paniculate swallowwort root, herba lycopi, rosa davurica pall, gizzard pepsin, martianus dermestoides, radix rhapontied, long pepper, fructus mori albae and hirudo nipponia whitman. The traditional Chinese medicine can be used for treating qi deficiency and blood stasis type reflux esophagitis in clinics.

Provided is a food or drink composition for improving reflux esophagitis or skin diseases, containing fermented Eastern prickly pear.

The invention discloses a preparation method of a traditional Chinese medicine for treating constipation-predominant reflux esophagitis and belongs to the technical field of preparation methods of traditional Chinese medicines. At present, bismuth potassium citrate is usually employed for treating the constipation-predominant reflux esophagitis, and the contraindication is that allergies, patients with severe renal impairment and pregnant patients are disabled. The technical scheme of the preparation method comprises: taking senna leaf, cape jasmine fruit, pagodatree pod, garden burnet root, Chinese arborvitae twig, immature bitter orange, officinal magnolia bark, longstamen onion bulb, areca peel, peach seed, Chinese angelica, figwort root, black sesame, hemp fruit, Chinese dwarf cherry seed, honey, apricot seed, coffee senna seed, common alstonia bark or leaf, common lophatherum herb, mung bean, mongolian dandelion herb, stonecrop, shortstalk slimtop meadowrue root, breynia fruticosa, small-leaved desmodium, physalis alkekengi, corydalis saxicola bunting, uniflower swisscentaury root, olive, lemmaphyllum microphyllum presl, creeping rostellularia herb, gamboges, potentilla discolor, rhubarb and liquoric root; soaking the thirty six traditional Chinese medicines into water, and decocting by mild fire, wherein the decocted soup is the traditional Chinese medicine for treating the constipation-predominant reflux esophagitis. The preparation method of the traditional Chinese medicine for treating the constipation-predominant reflux esophagitis has the advantages that the prepared traditional Chinese medicine liquid is small in side effect, short in course of treatment and high in cure rate.

The invention relates to the field of anti-ulcer medicines, and in particular relates to a lansoprazole crystal compound. The character of the lansoprazole crystal compound is crystal; the chemical name of the lansoprazole crystal compound is 2-[[[3-methyl-4-(2,2,2-trifluoroethoxyl)-2-pyridyl] methyl] sulfinyl]-1H-benzimidazole, namely C16H14F3N3O2S; according to a mass spectrum, the molecule ion peak of the product is [M+H]<+>; and the mass-to-charge ratio m / z is 370. The preparation method comprises the following steps of: performing a condensation reaction and an oxidation reaction, and then performing refining. According to the lansoprazole crystal compound, proper raw materials are adopted, and the cost is low; the crystal compound has extremely good treating effects for ulcer diseases such as gastric ulcer, duodenal ulcer, refractory ulcer, reflux esophagitis and pancreatic original ulcer after being taken properly; an experiment shows that the lansoprazole crystal compound is basically non-toxic, can treat the ulcer in a more quick and effective manner and is low in recurrence rate; through repeated experimental selection, the defined preparation method is simple and feasible; the selected raw materials are readily available; and the cost is low.

The invention discloses a preparation method of a traditional Chinese medicine for treating pharyngalgia type reflux esophagitis and belongs to the technical field of the preparation method of the traditional Chinese medicine. The existing medicine for treating the pharyngalgia type reflux esophagitis is primarily ranitidine with contraindications for the people which are allergic to the medicine and other H2 receptors, pregnant women and breast feeding women. The technical scheme of the invention is as follows: the preparation method comprises the following steps of: putting and soaking 26 traditional Chinese medicines consisting of umbellate rockjasmine herb or fruit, orpine, fruticose breynia juvenile branchlet and leaf, hastate phymatopsis herb with root, blackberry lily, puffball (cloth bag), chinese lantern-plant, subprostrate sophora, Chinese white olive, manyleaf paris rhizome, diversecolor cinquefoil, radix berberidis, sticktight, Japanese cayratia herb, tuopangen, radix stellariae dichotomae, wood sorrel, ceanothus, villosulous veronicastrum herb or root, daghestan sweetclover herb, coffee senna, common alstonia bark or leaf, lophatherum gracile, mung bean, chrysanthemum and liquorice in water, decocting with slow fire, and filtering to remove the slag for co-decocting liquid medicine, wherein the decocted liquid medicine is the traditional Chinese medicine for treating the pharyngalgia type reflux esophagitis. The preparation method has the advantages that the prepared traditional Chinese liquid medicine is small in side effect, short in treatment course, high in recovery rate and capable of avoiding adverse reactions caused by antibacterial agents of Western medicine.

The invention discloses a traditional Chinese medicine composition for treating reflux esophagitis. The traditional Chinese medicine composition is prepared from the following medicinal materials in parts by weight: 15 parts of codonopsis pilosula,15 parts of calcined sepium, 8 parts of poria cocos, 8 parts of rhizoma atractylodis macrocephalae, 8 parts of rhizoma pinellinae praeparata, 8 parts of scutellaria baicalensis, 8 parts of fructus aurantii, 8 parts of mangnolia officinalis, 8 parts of radix bupleuri, 8 parts of dandelion, 6 parts of radix glycyrrhizae preparata, 35 parts of milk-soaked peach, 6 parts of maifanitum, 5 parts of fructus hordei germinatus, 4 parts of black bindweed, 5 parts of haloid salt, 5 parts of caragana microphylla and 4 parts of milk skin. A clinical experiment proves that through selecting proper medicinal materials and proportions thereof, the traditional Chinese medicine composition disclosed by the invention has the efficacies of harmonizing the stomach, calming adverse-rising energy, regulating the flow of vital energy, removing dampness, tonifying the stomach and lubricating the intestines, and is high in recovery rate on treatment of reflux esophagitis, low in cost, safe and free of toxic or side effect.

The object of the present invention is to provide a compound useful as a renal disease preventive and / or therapeutic agent. The inventors of the present invention investigated compounds having a trypsin inhibitory activity, verified that a guanidinobenzoic acid compound has a trypsin inhibitory activity, and achieved the present invention. This guanidinobenzoic acid compound can be used as: a renal disease preventive and / or therapeutic agent that serves as a substitute drug in a low-protein diet regimen; and a preventive and / or therapeutic agent against diseases to which trypsin contributes such as pancreatitis, reflux esophagitis, hepatic encephalopathy, and influenza.

The invention discloses a Chinese medicinal composition for gastritis and esophagitis and a preparation process thereof. The effective component of the Chinese medicinal composition is prepared from dozens of medicinal materials such as virgate wormwood herb, Chinese gall, nutgrass galingale rhizome, largetrifoliolious bugbane rhizome, liquorice root, Indian bread, immature orange fruit, largeheadatractylodes rhizome, Chinese thorowax root, chicken's gizzard-membrane, tangerine peel, peony, malt, medicated leaven and the like through extraction. The specific medicinal active components in thecomposition have the effects of soothing the liver and reinforcing the stomach, purgating bowels, descending adverse-rising, notifying the kidney and dissolving stasis, and are clinically used for treating chronic gastritis, chronic superficial gastritis, chronic atrophic gastritis, erosive gastritis, bile reflux gastritis, reflux esophagitis and gastroneurosis.

The invention provides medicine for treating reflux esophagitis. The medicine is prepared from piper cubeba, poria cocos, mangnolia officinalis, thunberg fritillary bulb, cortex phellodendri, galangal, myristica fragrans, milkvetch roots, cuttlebone, selaginella tamariscina, dendrobium, cornus officinalis, radix angelicae, cattail pollen, bupleurum, spreading hedyotis herb, American ginseng, polygonum hydropiper, orchis morio and nodding clinacanthus. The medicine has the advantages that clinical symptoms of reflux esophagitis can be fast controlled, mucous membrane histopathologic changes can be fast restored, the state of the illness can be fast controlled, the long-term therapeutic effect is good, and few side effects exist, and is worthy of clinical application and popularization.

This invention is a solid-liquid double chambers transfusion of injection bemegridethiazole, and it contains a bigger chamber and a smaller one. The smaller chamber is used to fill injection bemegridethiazole, while the bigger one is used to fill transfusion liquid. In the smaller chamber, each application unit contains 5mg-800mg sterile bemegridethiazole; In the bigger chamber, each application unit contains 100mg-50000mg isotonic conditioning agent, 0mg-4000mg sodium sulfite and 50mL-1000mL water for injection. The solid-liquid double chamber transfusion of injection bemegridethiazole is mainly used to short-term treat duodenum ulcer, gastric ulcer, pathological hyper stomach-acid secretion and reflux esophagitis. Closely before using this product, press the bigger chamber with hand and the two chambers will be dredged, rock back and forth to mix the medicine liquid even and intravenous drip. This production brings convenience to rescue personnel in clinical usage.