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Traditional Chinese medicine composition for treating reflux esophagitis and preparation method of granule formulation thereof

A technology of reflux esophagitis and composition, which is applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problems of high drug withdrawal recurrence rate, long treatment time, high treatment cost, etc., and achieve cure High efficiency, easy to take, and the effect of protecting esophageal mucosa

Inactive Publication Date: 2014-01-08
SHANDONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since ancient times, people have often said that "ten people have nine stomachs", but they don't know that the incidence of reflux esophagitis is getting higher and higher, and it is often mistaken for stomach problems and affects treatment, especially with the improvement of living standards and modern life. The acceleration of the pace, the change of diet structure and the increase of food safety risk have increased the incidence of this disease year by year. However, due to the general lack of understanding of this disease, coupled with various problems such as treatment methods and medical expenses, many patients have not Get timely and effective treatment and cause serious consequences
Western medicine treatment of this disease is mainly to suppress gastric acid, promote gastric emptying and protect esophageal mucosa, but the treatment time is long, the treatment cost is high, side effects are large, and recurrence is easy
According to statistics, the recurrence rate of drug withdrawal is as high as 80%, so it is necessary to find a new drug with low price and good effect.

Method used

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  • Traditional Chinese medicine composition for treating reflux esophagitis and preparation method of granule formulation thereof
  • Traditional Chinese medicine composition for treating reflux esophagitis and preparation method of granule formulation thereof
  • Traditional Chinese medicine composition for treating reflux esophagitis and preparation method of granule formulation thereof

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Effect test

Embodiment 1

[0043] Liu XX, male, 65 years old, a cadre, experienced burning pain behind the sternum, pantothenic acid abdominal distension, hiccups and belching due to emotional stimulation more than ten years ago. After gastroscopy and other examinations, he was diagnosed as reflux esophagitis. He used a variety of western medicines for treatment , The effect is not good enough, the symptoms recur, and even sometimes dysphagia, often relapsed due to emotional stimulation, the tongue is dark, the coating is white and greasy, and the pulse is stringy and astringent. Gastroscopy: esophageal mucosal congestion and erosion, with local ulcers. Diagnosed as reflux esophagitis (grade III), taking the granules of the present invention, 10 servings (1 pack) each time, 3 times a day, 4 weeks as a course of treatment, the symptoms gradually alleviated after taking the medicine for one week, and the symptoms basically disappeared after 8 weeks , re-examination gastroscope: mild hyperemia of esophagea...

Embodiment 2

[0048] Li XX, female, 39 years old, a driver, suffered from reflux esophagitis for more than 7 years. She often experienced retrosternal burning pain, pantothenic acid nausea, belching and hiccups. She had been treated with Chinese and Western medicines for many times, but the effect was not good. Recently, due to work fatigue and irregular diet, the above symptoms recurred and aggravated. The tongue was dark red, the tongue coating was yellow and greasy, and the pulse was stringy and rapid. Gastroscopy: strip-like hyperemia and erosion of esophageal mucosa. Diagnosed as reflux esophagitis (level II), take 10 servings (1 pack) of Liuxian Granules of the present invention each time, 3 times a day, 4 weeks as a course of treatment, take 2 courses of treatment altogether, the symptoms disappear completely, and the gastroscope is checked again : There was no abnormality in the esophageal mucosa.

[0049] When preparing the Chinese medicine granule that embodiment two cases take, ...

Embodiment 3

[0053] Zhang X, male, 21 years old, a student, studied nervousness and irregular eating half a year ago and liked to eat spicy food, and developed epigastric burning, pantothenic acid, belching, self-administration of omeprazole and other drugs did not work well, and the symptoms were mild and severe at times. Gastroscopy in a certain hospital was diagnosed as reflux esophagitis (grade I), with red tongue and greasy fur. Give Liuxian granules of the present invention 10 portions (1 pack) each time, 3 times a day, 4 weeks as a course of treatment, take 4 weeks and 1 course of treatment altogether, the symptoms disappear completely, and the reexamination gastroscopy: no abnormality is found in the esophageal mucosa.

[0054] When preparing the Chinese medicine granules that embodiment three cases take, each raw material proportioning is:

[0055] The ratio of the main ingredients is: 10 parts of Wang Buliuxing, 6 parts of Clematis, 6 parts of Dilong, 10 parts of Magnolia officin...

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Abstract

The invention discloses a traditional Chinese medicine composition for treating reflux esophagitis and a preparation method of a granule formulation thereof. The traditional Chinese medicine composition is composed of 19 traditional Chinese medicine including cowherb seeds, radix clematidis, earthworm, angelica, radix bupleuri, officinal magnolis flowers, ligusticum wallichii, rhizoma corydalis, tangerine peels, cuttle bones, bulbs of thunberg fritillary, coptis, fructus evodiae, yam, poria cocos, rhizoma atractylodis, dendrobe, bletilla and liquorice. The preparation method includes taking the 19 traditional Chinese medicine as main drugs, and taking sucrose and dextrin as excipient. The cowherb seeds which are a drug for activating blood circulation, diminishing swelling and promoting lactation, the radix clematidis which is a drug for rheumatism and the earthworm which is a decoction of medicinal insects are creatively taken as the main drugs to prepare the traditional Chinese medicine composition, so that conventional drugs are challenged and creatively applied, and treatment effect is greatly improved.

Description

technical field [0001] The invention relates to a traditional Chinese medicine for treating reflux esophagitis and a preparation method thereof, belonging to the technical field of traditional Chinese medicines. Background technique [0002] Reflux esophagitis is caused by a variety of factors that cause the contents of the stomach or duodenum to flow back into the esophagus, resulting in damage to the esophageal mucosa and lesions such as inflammation and erosion of the esophageal mucosa. In severe cases, it may be combined with esophageal ulcers or strictures, often causing heartburn , pantothenic acid, belching, retrosternal pain, or difficulty swallowing. Since ancient times, people have often said that "ten people have nine stomachs", but they don't know that the incidence of reflux esophagitis is getting higher and higher, and it is often mistaken for stomach problems and affects treatment, especially with the improvement of living standards and modern life. The accel...

Claims

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Application Information

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IPC IPC(8): A61K36/8984A61K9/16A61P1/04
Inventor 孟玲
Owner SHANDONG UNIV OF SCI & TECH
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