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43 results about "Esophageal mucosa" patented technology
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Stomach tube preventing aspiration
InactiveCN104688546AAvoid damageLess discomfortDiagnostic recording/measuringSensorsEsophageal mucosaTime control
The invention discloses a stomach tube preventing aspiration. The stomach tube comprises a control circuit, an air pump, a PH value sensor and a stomach tube provided with an air bag, wherein the air pump is communicated with the air bag, the PH value sensor is arranged at the position which is 40cm away from an incisor, on the inner wall of the stomach tube, and the control circuit is connected with the air pump and the PH value sensor respectively. According to the stomach tube disclosed by the invention, the gastroesophageal reflux can be accurately detected in advance every time by utilizing the real-time monitoring of the PH value in an esophagus and the pressure of the air bag by the PH value sensor and a pressure sensor, so that the aspiration caused by reflux and the possibility of resulting in recessive pneumonia can be avoided; and besides, the stomach tube disclosed by the invention adopts a real-time control manner so as to automatically start the expansion of the air bag, so that the damage of esophageal mucosa due to the longstanding oppression of the air bag on the esophagus is avoided, and the substernal discomfort of users can be relieved. The stomach tube preventing aspiration, which is disclosed by the invention, can be widely applied to the field of medical apparatus.
Owner:GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND
Primers and method for detecting and typing human papilloma viruses in esophagi
ActiveCN101942440AMicrobiological testing/measurementMaterial analysis by electric/magnetic meansTime-of-flight mass spectrometryTyping
The invention relates to primers and a method for detecting and typing human papilloma viruses (HPV) infecting esophageal cells (such as esophageal mucosa cells). In particular, the invention designs a set of brand-new primers (including amplification primers and extension primers) based on the mass spectrometry detection technology of a matrix assisted laser desorption / ionization time-of-flight mass spectrometry system (MALDI-TOF-MS), thus realizing detection and typing of 15 types infecting the esophageal cells.
Owner:BGI GENOMICS CO LTD
Esophageal marker infiltration depth grade determination method and device and readable storage medium
ActiveCN113643291ARealize automatic identificationImprove recognition efficiencyImage enhancementImage analysisRadiologyEsophageal mucosa
The invention provides an esophageal marker infiltration depth grade determination method and device and a readable storage medium. The method comprises the following steps of acquiring a to-be-analyzed first esophageal mucosa image, performing first image preprocessing on the first esophageal mucosa image to obtain a preprocessed target esophageal mucosa image, determining representative color features of the target esophageal mucosa image, and based on the representative color features of the target esophageal mucosa image and a preset standard color feature library, determining an esophageal marker infiltration depth grade corresponding to the first esophageal mucosa image. According to the embodiment of the invention, automatic identification of the infiltration depth grade of the esophageal marker is realized, and the identification efficiency and the identification accuracy are improved.
Owner:WUHAN ENDOANGEL MEDICAL TECH CO LTD
Imatinib mesylate chewable tablet and preparation method thereof
InactiveCN101401794AImprove complianceImprove stabilityOrganic active ingredientsPill deliveryIrritationPharmaceutical formulation
The invention relates to the technical field of pharmaceutical preparation, in particular to a chewable tablet containing imatinib mesylate and a method for preparing the same. The chewable tablet containing the imatinib mesylate consists of the principal imatinib mesylate, a filling agent, a flavour modifying agent, a glidant, an odor modifying agent, and an adhesive. The chewable tablet containing the imatinib mesylate can be applied to patients having difficulty in orally taking the common tablets, has good drug compliance, can be dissolved in saliva after chewing and being absorbed by oral or esophageal mucosa, and has high bioavailability. The chewable tablet not only has sweet taste and good mouthfeel, but also modifies penetrating odors and has flavor; the chewable tablet is convenient to take and carry around; and the chewable tablet is prepared by a direct tabletting method, and has good drug stability, simple production process, and low cost.
Owner:BEIJING TRADE STAR MEDICAL TECH
Tissue engineering combined human body lumen succedaneum
InactiveCN101721262AImprove flexibilityStable supportTubular organ implantsHuman bodyOesophageal tube
A tissue engineering combined human body lumen succedaneum adopts a tectorial elastic supporting pipe with connecting pieces, wherein an absorbable coating is attached on the outer wall of the supporting pipe, and planted with seed cells thereon. The connecting pieces can reduce the effect of the gullet peristalsis to the planted elastic supporting pipe, and the elastic supporting pipe has favorable flexibility and stronger supporting force, therefore, the tissue engineering combined human body lumen succedaneum provided by the invention can avoid anastomotic leakage, early trachea cannula exodus and newly-born narrow gullet; in addition, the absorbable coating attached on the outer wall of the elastic supporting pipe is planted with the seed cells, thus being capable of inducing or improving the growth and covering of the newly-born esophageal mucosa. After the newly-born esophageal mucosa is covered completely, and the scar tissues of newly-born gullet are stable, the planted succedaneum can be taken out or removed under the direct view of a digestive endoscopy.
Owner:周星
Compound iodine staining diagnostic kit set for esophageal mucosa
InactiveCN103623434ASpeed up neutralizationStable concentrationIn-vivo testing preparationsI2 compoundIodine solutions
The invention discloses a compound iodine staining diagnostic kit set for esophageal mucosa. The kit set comprises a compound iodine solution and a neutralization solution, wherein the compound iodine solution is a KI and I2 compound solution, and the mass percent concentration of I2 is 1%-2.5%; the neutralization solution is a sodium thiosulfate water solution with the mass percent concentration of 3%-3.5%. The kit set is convenient to use and has a good iodine staining effect; adverse effects of patients can be effectively removed through the neutralization solution.
Owner:JIANGSU PROVINCE HOSPITAL
Chinese patent medicament for treating reflux esophagitis and preparation method thereof
InactiveCN101874842ASustained absorptionFully absorbedDigestive systemPlant ingredientsReflux esophagitisHepatic first pass effect
The invention relates to a Chinese patent medicament for treating reflux esophagitis and a preparation method thereof, and belongs to the field of Chinese medicinal preparations. The Chinese patent medicament is prepared from the following raw materials in part by weight: 10 to 25 parts of rabdosia rubescens, 20 to 30 parts of stir-fried immature bitter orange and 6 to 15 parts of liquorice root. The Chinese patent medicament is a pure Chinese medicinal preparation and is a novel gel oral administration preparation, can be adhered to esophageal mucosa for a long time after oral administration to play a role in local treatment, can avoid the first pass effect caused by oral administration, has the advantages of high medicament carrying rate, strong wall-hanging properties, continuous and complete absorption of medicaments, lasting medicinal effect and quick response, and can be adhered to the esophageal mucosa for a long time after the oral administration to play a role in local inflammation resistance.
Owner:THE FIRST AFFILIATED HOSPITAL OF HENAN UNIV OF TCM
Method for isolated culture of esophagus epithelial stem cells
ActiveCN105505860APromote proliferationPromote divisionCell dissociation methodsCulture processSodium bicarbonateEpithelium
The invention discloses a method for isolated culture of esophagus epithelial stem cells. The method comprises the steps of taking esophagus mucosa tissue and epithelium adhering to the esophagus mucosa tissue, removing muscular tissue, taking a basal layer of epithelium mucosae tissue, shearing the basal layer of epithelium mucosae tissue into bits, conducting digestion centrifugation, and spreading obtained cells in a culture flask, culture plate or culture dish coated with a matrix; then adding a DMEM / Ham's F-12 culture solution containing HEPES, sodium bicarbonate, L-glutamic acid, FBS, EGF, insulin, hydrocortisone, vibrio cholerae toxin, transferring, BPE, quasi-vitamin A and cell signaling pathway inhibitor; finally, placing the culture flask, culture plate or culture dish containing cell suspension in a 37 DEG C incubator for culture, and obtaining the single-layer epithelial stem cells in 10-14 days. According to the method, operation is convenient, safety performance is high, the esophagus epithelial stem cells are obtained through separation, the activity of the stem cells is high, and application prospects in tissue engineering and regenerative medicine are broad.
Owner:THE FIRST AFFILIATED HOSPITAL OF HENAN UNIV OF SCI & TECH
Preparation method of artificial esophagus with histological structure
InactiveCN104013998AAddressing Weaknesses of Lack of FunctionalityRelieve painProsthesisAcellular matrixLesion
The invention discloses a preparation method of an artificial esophagus with histological structure. The method is characterized by comprising the steps of: extracting a basilemma membrane protein solution from animal esophageal mucosa tissue; then preparing electrospinning / acellular matrix bracket; then preparing a polyurethane sheet with a double-sided microgroove; and finally coating the polyurethane sheet on the electrospinning / acellular matrix bracket and splicing into a tube shape longitudinally, so as to obtain the artificial esophagus with histological structure. The invention has the advantage that the method can prepare the artificial esophagus simulating histological structure of normal human esophageal, and utilizes the principles of tissue engineering to construct in vitro the artificial esophagus with similar microstructure and function as human esophagus; and the artificial esophagus is seamed with residual esophagus after resection of lesion esophagus layer by layer, so that the artificial esophagus gradually grows into a real esophagus and integrates with the original esophagus in the human body. Compared with the traditional alternatives, the artificial esophagus has structure and function similar to those of natural esophagus, and can alleviate the suffering of patients and prolong the patient's life.
Owner:NINGBO UNIV
Medicament carrying film capable of being absorbed by oral cavity and preparation method thereof
The invention provides a medicament carrying film capable of being absorbed by an oral cavity, which is characterized in that: the medicament carrying film capable of being absorbed by the oral cavityis prepared from active components of a small dose of medicaments, a water-soluble high polymer material and a pharmaceutically acceptable pharmaceutic adjuvant, wherein the pharmaceutically acceptable pharmaceutic adjuvant may be one or more of a stabilizer, a colorant, a sweetener, a correctant, a freshener and an emulsifier. The medicament carrying film capable of being absorbed by the oral cavity can be quickly dissolved in the oral cavity; the small dose of medicaments are absorbed in a form of a nonionic medicament in the pH value environment of the oral cavity; and a considerable amount of medicaments enter general blood circulation through the oral cavity, a throat and esophageal mucosa and can quickly reach the maximum plasma concentration. The medicament carrying film capable ofbeing absorbed by the oral cavity cannot generate any irritation to oral mucosa and has the advantages of adjustable mouthfeel, fragrant smell, and cool, refreshing and sweet taste. The medicament carrying film not only can refresh breath but also can better exert general action. The medicament carrying film not only can improve the compliance of patients, but also can improve the bioavailabilityof certain medicaments.
Owner:COSCI MED TECH CO LTD
Deep detection network for quantifying esophageal mucosa IPCLs vascular morphological distribution
ActiveCN112419246AEasy to detectImplement diagnosticsImage enhancementImage analysisBlood vesselEndoscopic image
The invention belongs to the technical field of medical image processing, and particularly relates to a deep detection network for quantifying esophageal mucosa IPCLs vascular morphological distribution. The deep detection network comprises a feature extraction network, a feature pyramid, a region candidate network, an interest region pooling and clustering distribution priori self-embedded cancerlesion classification network and a system for visualization on a narrow-band imaging endoscope image. The feature extraction network extracts a feature map of the input image; the feature pyramid fuses the features of different scales; the region candidate network proposes a possible lesion region; the region of interest is pooled, and the features are pooled to a suspicious lesion region; the cancer lesions are classified by a clustering distribution priori self-embedded cancer lesion classification network; and finally, visualizing is carried out on a narrow-band imaging endoscopic image,and frame selection marking is carried out on the cancer lesion by using different colors. The cancer focus of the early esophageal squamous cell carcinoma existing in the image is detected and diagnosed, the diagnosis efficiency can be effectively improved, and a doctor is assisted in obtaining higher diagnosis precision.
Owner:FUDAN UNIV
NOVEL LACTIC ACID BACTERIUM HAVING IgA PRODUCTION PROMOTING ACTIVITY, AND USE THEREOF
ActiveUS20140363880A1High IgA production inducing activityImprove featuresAntibacterial agentsCosmetic preparationsIl 2 productionFood poisoning
Disclosed are: a lactic acid bacterium belonging to Lactobacillus kunkeei, the bacterium having a higher IgA production inducing activity than that of Lactobacillus strain GG (ATCC53103), and a lower mitogenic activity and a lower IL-2 production inducing activity than those of Listeria strain EGD; and a food composition, a pharmaceutical composition, a cosmetic composition, an immunostimulant for preventing the infection by pathogens or viruses that invade through the respiratory or esophageal mucosa, and an intestinal immunostimulant for preventing or alleviating food poisoning, each of which contains the lactic acid bacterium or treated cells of the lactic acid bacterium.
Owner:YAMADA BEE COMPANY INC
Esophageal mucosa flatness quantification method and device, terminal and storage medium
ActiveCN114022880AQuantification of flatnessEasy to identifyGeometric image transformationAcquiring/recognising microscopic objectsRadiologyEsophageal mucosa
The invention provides an esophageal mucosa flatness quantification method and device, a terminal and a storage medium, and the method comprises the steps: carrying out the conversion of an RGB color space mode of a pre-obtained first dyeing amplification image of a to-be-detected esophageal mucosa, and obtaining a second dyeing amplification image of an HSI color space mode; acquiring a third dyeing magnified image corresponding to the target channel in the second dyeing magnified image; acquiring the image entropy of the third dyeing magnified image; acquiring the image curvature of the third dyeing magnified image; acquiring the surface roughness of the third dyeing magnified image; and quantifying the flatness of the esophageal mucosa to be detected based on the image entropy, the image curvature and the surface roughness. The esophageal mucosa flatness quantification is realized, and the esophageal mucosa flatness identification effect and accuracy are improved.
Owner:WUHAN UNIV
Therapeutic uses of keratinocyte growth factor-2
The present invention relates to the administration of Keratinocyte Growth Factor-2 (KGF-2) to stimulate proliferation of platelets and to increase levels of fibrinogen, albumin, globulin and total serum protein. Further, the present invention relates to administering KGF-2 to protect or treat the bladder and prostate. Moreover, the present invention relates to administering KGF-2 to stimulate growth of nasal, oral, and esophageal mucosa, lacrimal glands, salivary glands and Goblet cells.
Owner:HUMAN GENOME SCI INC
Esophageal-mucosa staining combination set
InactiveCN105396148ASpeed up neutralizationStable concentrationCompounds screening/testingOesophageal tubeStaining
The invention discloses an esophageal-mucosa staining combination set. The esophageal-mucosa staining combination set is characterized by being prepared from a staining solution and a neutralization solution; the staining solution is a compounded solution of KI and I2, wherein the mass percent concentration of the I2 in the staining solution is 1%-2.5%; the neutralization solution is a sodium thiosulfate aqueous solution with the mass percent concentration of 1%-3.5%. The esophageal-mucosa staining combination set is a combination set kit of the compounded iodine stain and a neutralization reagent, and is stable in concentration, convenient to use, rapid in neutralization and capable of rapidly removing discomfort of a patient.
Owner:JIANGSU CHENGPIN BIOTECH
Clinical gastrointestinal decompression device for gastroenterology department
InactiveCN109481313AImprove practicalityMeet the needs of useFeeding-tubesDecompression sicknessInjury cause
The invention relates to the technical field of the gastroenterology department and discloses a clinical gastrointestinal decompression device for the gastroenterology department. The clinical gastrointestinal decompression device comprises a gastrointestinal decompressor, a gastric tube is fixedly mounted at the top of the gastrointestinal decompressor, a supporting plate is fixedly connected tothe bottom of the gastrointestinal decompressor, and a supporting barrel is fixedly connected to the bottom of the supporting plate. An auxiliary screw gear is fixedly connected to the inner side of the supporting barrel and meshed with a main screw gear fixedly connected with the outer side of a spindle, and connection blocks are fixedly connected to left and right sides of the supporting barrel.The clinical gastrointestinal decompression device for the gastroenterology department can be adjusted in use according to heights required by different patients so as to meet utilization demands ofdifferent patients, practicality of the decompression device is effectively improved, an application range of the decompression device is expanded effectively, injuries caused by the gastric tube to the esophageal mucosa of the patients moving due to discomfort are avoided, pharyngeal irritation of the patients is avoided, body injuries of the patients are greatly reduced, and convenience in use is provided for doctors and patients.
Owner:李钦栋
System for the parallel delivery of an element into the esophageal mucosa
A system for inserting an element into a target tissue includes an endoscope comprising a working channel extending therethrough and an end cap comprising a cavity extending therein from an open proximal end sized to receive a distal end of the endoscope therein and a closed distal end. The cavity is open to an exterior of the end cap via a window extending laterally through a side wall thereof so that a target tissue may be received within the cavity via the window. The system also comprises a needle sized to be passed through the working channel of the endoscope so that a distal end of the needle is insertable into the cavity thereby, the needle extending longitudinally from a proximal end to a distal end and comprising a lumen for housing an element to be delivered to the target tissue.
Owner:BOSTON SCI SCIMED INC
Stomach tube
ActiveCN107456646AAccurate recordEasy to measureMedical devicesCatheterEsophageal mucosaStomach tube
The invention discloses a stomach tube. The problem is solved that because all nursing personnel master the pull-out or plug-in length of a current stomach tube by themselves according to personal nursing experience and lack uniform operation specifications and operation rules when pulling out and plugging in the stomach tube, the esophageal mucosa or the gastropore mucosa is easily damaged due to the too small or too large plug-in length of the stomach tube. According to the technical scheme, the stomach tube further includes a positioning sleeve, wherein a stomach tube body is sleeved with the positioning sleeve; an inlet and an outlet which coordinate with the stomach tube body to make the stomach tube body get through are formed in the front and rear side walls of the positioning sleeve respectively; a distance detector is arranged in the positioning sleeve and is connected with a drive mechanism controlled by the distance detector; the drive mechanism is connected to a distance indicating mechanism. By the adoption of the stomach tube, it is convenient for the nursing personnel to accurately master the pull-out or plug-in length of the stomach tube, and the situation is avoided that because the stomach tube is incorrectly plugged in, the esophageal mucosa or the gastropore mucosa is damaged.
Owner:宁波路加医疗器械有限公司
Novel fixed, recyclable and anti-displacement esophagus metal stent
The invention relates to a novel fixed, recyclable and anti-displacement esophagus metal stent. The esophagus metal stent comprises a main body part, fixing rings, anti-skidding wires and fixing clips. The main body part is tubular. The surface of the main body part is covered by a film. Additionally, edge at upper and lower ends of the main body part are covered by a skirt film formed from the film. Positions, approaching end openings, of the upper and lower ends of the main body part are equipped with shallow grooves. The multiple fixing rings are respectively arranged on the anti-skidding wires. The anti-skidding wires which are fixedly equipped with the multiple fixing rings in a penetrating manner are respectively fixed into the shallow grooves at upper and lower ends of the main bodypart. The fixing clips are arranged onto the fixing rings. The novel fixed, recyclable and anti-displacement esophagus metal stent has following advantages: the recovered fixing clips are used for fixing the stent; the stent has more reliable fixation effect without depending on friction force between the stent and an esophageal wall; the diameter of the main body part is properly reduced; pressure on the esophageal wall is minimized; discomfort of a patient is relived; hyperplasia of esophageal mucosa is avoided; and the stent is convenient to recover subsequently.
Owner:SHANGHAI FIRST PEOPLES HOSPITAL
Mouse esophageal squamous carcinoma cell line as well as establishment method and application thereof
InactiveCN113416705AStable passageQuick buildMicrobiological testing/measurementMicroorganism based processesCarcinoma cell lineOncology
The invention belongs to the technical field of tumor cell lines, and particularly relates to a mouse esophageal squamous carcinoma cell line as well as an establishment method and application thereof. The method comprises the following steps: 1) establishing a mouse orthotopic esophageal squamous cell carcinoma model: inducing cancerization of esophageal mucosa cells of a mouse by adopting a chemical reagent; 2) culturing a mouse esophageal squamous carcinoma cell line: cleaning the tumor tissue with a serum-free medium, cutting the tumor tissue into blocks, placing the blocks in a DMEM culture medium containing 20% FBS, and culturing at constant temperature; and continuously culturing and cleaning tissue blocks with cells climbing out, adding pancreatin for digestion, centrifuging, taking supernatant, re-suspending the cell precipitate, re-paving the cell precipitate in a culture bottle, and culturing to obtain the mouse esophageal squamous cell carcinoma stable cell line. According to the method, the mouse esophageal squamous carcinoma cell line capable of being stably passaged can be obtained within a short time, the tumor formation property is good, the method is a method for rapidly constructing a mouse esophageal squamous carcinoma cell model with a sound immune microenvironment, and the obtained cell line is used for in-vitro stable culture and can be repeatedly used for multiple times.
Owner:SUN YAT SEN UNIV CANCER CENT
Method for preparing pharmaceutical composition for treating reflux esophagitis
InactiveCN105012879AGood treatment effectImprove efficiencyDigestive systemHeterocyclic compound active ingredientsLansoprazoleReflux esophagitis
The invention relates to a method for preparing a pharmaceutical composition for treating reflux esophagitis. The method is characterized in that the pharmaceutical composition consists of the following medicines in parts by weight: 1 part of ebony powder, 1 part of lansoprazole, 1 part of VC and 1 part of VB1. The self-made traditional Chinese medicine ebony powder consists of 8 parts of ebony, 10 parts of lignum dalbergiae odoriferae, 6 parts of muskroot-like semiaquilegia roots and 9 parts of curcuma aromatic. The method comprises a step of uniformly mixing the extract with 1 part of lansoprazole, 1 part of VC and 1 part of VB1. The purposes of the method are achieved in the mode that according to Chinese and western medical theories, the self-made traditional Chinese medicine ebony powder is added with a proton pump inhibitor, vitamin C (VC) and vitamin B1 (VB1) and aims to prevent damage of ant-reflux barriers, prompting acid cleaning function of gullets, improving the function of the ant-reflux barriers of gullet mucous membranes, and controlling gastric emptying abnormity and esophagus reflux caused by stomach gastroduodenal malfunction.
Owner:毕伟平
Traditional Chinese medicine preparation for treating esophageal cancers and taking method of preparation
InactiveCN112755095AInhibit inflammatory developmentTreat asthenic fire upper inflammationAnthropod material medical ingredientsHydroxy compound active ingredientsNutritional deficiencyNutrition
The invention belongs to the technical field of Chinese herbal medicines, and particularly relates to a traditional Chinese medicine preparation for treating esophageal cancer inflammation. Esophageal cancers are malignant tumors occurring at esophageal mucosa, most of the esophageal cancers are squamous cell carcinomas, and a few esophageal cancers are adenocarcinoma, undifferentiated carcinoma and intratumoral carcinoma. As the esophagus is blocked by the cancer, food and saliva cannot pass through the esophagus to cause vomiting, and finally a patient suffers from insufficient nutrition and dehydration. Conventional methods for treating the esophageal cancer include surgical resection, radiotherapy and chemotherapy, but the actual curative effect is not ideal; the living quality of the patient is low, the death rate is high, the pain is great and the cost is high; and in order to relieve the pain of the patient to a certain extent, the invention hopefully provides the traditional Chinese medicine preparation for treating the esophageal cancer inflammation. The traditional Chinese medicine preparation for treating the esophageal cancer inflammation comprises 5-15 g of spica prunellae, 5-15 g of radix scrophulariae, 3-10 g of cortex phellodendri, 5-15 g of flos lonicerae, 5-15 g of fructus forsythiae, 5-15 g of herba taraxaci, 0.5-1.5 g of fructus gleditsiae, 0.5-2 g of borneol, 2-10 g of herba menthae, 2-10 g of fructus arctii, 2-10 g of radix sophorae tonkinensis, 2-10 g of bombyx batryticatus and 2-10 g of radix glycyrrhizae.
Owner:陈则均
Clinical diagnosis sampling device for digestive system department
PendingCN114732443AEasy to determineEasy to sampleSurgical needlesEsophageal mucosaMechanical engineering
The invention discloses a clinical diagnosis sampling device for the digestive system department, which comprises an inner tube, an outer tube is arranged on the outer side of the inner tube, and an air passage for air flow to pass through is arranged between the outer tube and the inner tube; the sampling mechanism is mounted on the outer side of the outer tube, the sampling mechanism is communicated with the outer tube, and the sampling mechanism is inflated to expand and then scrapes in the esophagus, so that esophageal exfoliated cells are collected; the inflating mechanism is mounted at the end parts of the inner pipe and the outer pipe, and the inflating mechanism is used for inflating gas into the sampling mechanism; sampling can be conducted at different positions of the esophagus of a patient in a staged mode through the single air bag, the specific position of a focus can be conveniently determined, on the premise that the air bag is kept inflated through the inflation mechanism, friction resistance between the air bag and the inner wall of the esophagus of the patient is reduced, and the esophagus of the patient can be more accurately positioned. The possibility of esophageal mucosa damage of a patient is reduced, and the patient can conveniently and comfortably sample.
Owner:CHANGZHOU NO 2 PEOPLES HOSPITAL
Esophageal local drug delivery device for acute radiation esophagitis
ActiveCN112741955AStable positionExtension of timeMedical devicesFeeding-tubesEsophageal wallEsophageal mucosa
The invention discloses an esophageal local drug delivery device for acute radiation esophagitis, and aims to solve the problems that liquid medicine is difficult to stay on the surface of esophageal mucosa or stays for a short time, and the liquid medicine is difficult to take and eat by swallowing. The drug delivery device comprises a capsule, a hose and a fixator, wherein the fixator comprises an ear hook, one end of the hose is connected with the capsule, an adaptive connecting piece is connected between the other end of the hose and the ear hook, the capsule comprises a capsule shell and a micro-transmission mechanism fixed in the capsule shell, the capsule shell comprises an elastic head membrane and a capsule body, A micro-motor in the micro-transmission mechanism is electrically connected with a power supply and a microcontroller, the micro-transmission mechanism comprises a spiral mechanism and a stretching mechanism, and the spiral mechanism drives the stretching mechanism to stretch the elastic head membrane, so that a gap between the periphery of the elastic head membrane and an esophageal wall is reduced, a liquid medicine column is formed, and the retention time of medicine acting on the surface of the esophageal mucosa is prolonged.
Owner:AFFILIATED CANCER HOSPITAL OF SHANDONG FIRST MEDICAL UNIV SHANDONG CANCER INST (SHANDONG CANCER HOSPITAL)
Primers and method for detecting and typing human papilloma viruses in esophagi
ActiveCN101942440BMicrobiological testing/measurementMaterial analysis by electric/magnetic meansTime-of-flight mass spectrometryTyping
Owner:BGI GENOMICS CO LTD
A method for isolating and culturing esophageal epithelial stem cells
ActiveCN105505860BPromote proliferationPromote divisionCell dissociation methodsCulture processSodium bicarbonateMuscle tissue
The invention discloses a method for isolated culture of esophagus epithelial stem cells. The method comprises the steps of taking esophagus mucosa tissue and epithelium adhering to the esophagus mucosa tissue, removing muscular tissue, taking a basal layer of epithelium mucosae tissue, shearing the basal layer of epithelium mucosae tissue into bits, conducting digestion centrifugation, and spreading obtained cells in a culture flask, culture plate or culture dish coated with a matrix; then adding a DMEM / Ham's F-12 culture solution containing HEPES, sodium bicarbonate, L-glutamic acid, FBS, EGF, insulin, hydrocortisone, vibrio cholerae toxin, transferring, BPE, quasi-vitamin A and cell signaling pathway inhibitor; finally, placing the culture flask, culture plate or culture dish containing cell suspension in a 37 DEG C incubator for culture, and obtaining the single-layer epithelial stem cells in 10-14 days. According to the method, operation is convenient, safety performance is high, the esophagus epithelial stem cells are obtained through separation, the activity of the stem cells is high, and application prospects in tissue engineering and regenerative medicine are broad.
Owner:THE FIRST AFFILIATED HOSPITAL OF HENAN UNIV OF SCI & TECH
Novel esophageal dilation balloon catheter
PendingCN111420243AReduce restenosisPrevent restenosisBalloon catheterMulti-lumen catheterEngineeringEsophageal dilatation
The invention relates to a novel esophageal dilation balloon catheter. The novel esophageal dilation balloon catheter comprises an upper-end esophageal dilation balloon, a lower-end anti-reflux balloon and a central nasal feeding tube; a stenotic esophagus is dilated by the novel esophageal dilation balloon catheter through injecting water (gas) into the upper-end balloon; gastroesophageal refluxis prevented by injecting water (gas) into the lower anti-reflux balloon; and nasal feeding can be performed through the central nasal feeding tube when the balloon is expanded or not expanded. The novel esophageal dilation balloon catheter is used after esophageal anastomosis or is used for patients with esophageal stricture, and is used for performing intermittent expansion on a stenotic esophagus or esophageal anastomosis. The water (gas) in the esophageal dilatation balloon is pumped back during dilatation intervals, so that ischemic necrosis of the esophageal mucosa due too long compression is avoided. After eating, the lower-end anti-reflux balloon is expanded so as to avoid anastomotic leakage or stenosis caused by reflux of gastric contents. According to the design, frequency of gastroscopy and contrast examinations of patients is reduced by intermittent dilation of the esophageal dilation balloon.
Owner:NANJING CHILDRENS HOSPITAL
Preparation method of artificial esophagus with histological structure
InactiveCN104013998BAddressing Weaknesses of Lack of FunctionalityRelieve painProsthesisAcellular matrixStructure and function
Owner:NINGBO UNIV
Kit for staining esophageal mucosa
InactiveCN111346238AEasy diagnosisEasy to monitorLuminescence/biological staining preparationVitamin CEsophageal Squamous Dysplasia
The invention relates to a kit for staining esophageal mucosa. A staining solution used in esophageal mucosa staining by the kit is a compound iodine solution, and a neutralizing solution is a vitaminC solution. The staining solution is 20mL of the compound iodine solution and consists of iodine, potassium iodide and distilled water, wherein each milliliter of the compound iodine solution contains 0.02g iodine and 0.04g potassium iodide, the iodine content of the compound iodine solution is 2%, and the concentration of iodine is 60mg / mL. The neutralizing solution is 20mL of the vitamin C solution, wherein the vitamin C content is 2%. The invention overcomes the defect that iodine can stimulate and erode mucosa of upper digestive tracts. According to the invention, the standardization kitset comprising the compound iodine solution staining solution and vitamin C solution neutralization solution is convenient to use, can neutralize iodine staining in time, relieves discomfort symptomsof patients after iodine staining in time, and improves compliance of the patients, so that the detection rate of esophageal squamous dysplasia and canceration is greatly increased.
Owner:金多晨
a stomach tube
ActiveCN107456646BAccurate recordEasy to measureMedical devicesCatheterEsophageal mucosaNursing care
Owner:宁波路加医疗器械有限公司
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