Tissue engineering combined human body lumen succedaneum

Abstract

A tissue engineering combined human body lumen succedaneum adopts a tectorial elastic supporting pipe with connecting pieces, wherein an absorbable coating is attached on the outer wall of the supporting pipe, and planted with seed cells thereon. The connecting pieces can reduce the effect of the gullet peristalsis to the planted elastic supporting pipe, and the elastic supporting pipe has favorable flexibility and stronger supporting force, therefore, the tissue engineering combined human body lumen succedaneum provided by the invention can avoid anastomotic leakage, early trachea cannula exodus and newly-born narrow gullet; in addition, the absorbable coating attached on the outer wall of the elastic supporting pipe is planted with the seed cells, thus being capable of inducing or improving the growth and covering of the newly-born esophageal mucosa. After the newly-born esophageal mucosa is covered completely, and the scar tissues of newly-born gullet are stable, the planted succedaneum can be taken out or removed under the direct view of a digestive endoscopy.

Description

technical field [0001] The invention relates to a human cavity tube substitute, in particular to a human body cavity tube substitute used in esophageal reconstruction and tracheal reconstruction. Background technique [0002] In the prior art, when the esophagus needs to be resected due to tumors, it is usually solved by lifting the stomach or intestinal tract and anastomosis with the proximal end of the esophagus to reconstruct the digestive tract. disease; and when the tracheal lesion needs to resect the trachea more than 3cm, there is no ideal substitute for tracheal reconstruction. [0003] Taking the esophagus as an example, esophageal cancer is a common disease in China, ranking second in the incidence rate of common malignant tumors, with an incidence rate of 21 / 100,000, that is, more than 273,000 new patients each year, and the current incidence rate is still rising Trends are extremely harmful. At the same time, esophageal injuries caused by various reasons, espec...

AI Technical Summary

Problems solved by technology

[0006] At present, clinically, other tissues or organs of the patient are mainly used to restore and reconstruct the esophageal passage, such as lifting the stomach or intestines from the abdominal cavity to the chest cavity or anastomosis of the neck with the retained normal esophageal stump to restore and reconstruct the esophageal passage. The traditional surgical method has the following disadvantages: large surgical trauma, long time, shift of organ anatomical position, affecting cardiopulmonary function and digestive dysfunction, etc.

[0011] Since Berman et al. took the lead in replacing esophageal defects with special polyethylene tubes in 1953, silicone rubber, Dacron, Teflon, carbon fiber, and various metal materials have been used successively for research and manufacture. Artificial esophagus, but failed to achieve the desired effect

In 1991, Purushotham et al. conducted research on the application of absorbable acellular scaffold materials to manufacture artificial esophagus. The method was to use biodegradable materials and non-degradable polymer materials to form a complex, and to perform esophageal reconstruction by inducing recipient esophageal tissue regeneration. Although Satisfactory results have been obtained in animal experiments, but there are also many defects. Such experimental methods are only applicable to a short range of esophageal defects, and there are still differences in the structure and function between the induced regeneration esophageal tissue and its own esophageal tissue. big gap

In 2000, Yamamoto et al. applied tissue engineering technology to study human esophagus. This is the application of the concept of "tissue engineering" in which autologous tissue cells are used to cultivate tissue grafts with physiological functions in vitro. The effect of tissue-engineered esophagus in specific clinical applications has not yet It can be seen

In 2005, Japan's Watanabe M et al. used nickel-titanium memory alloy rings to manufacture a peristaltic artificial esophagus, and used sheep for animal experiments, and the results are yet to be seen.

[0022] (4) The newborn esophagus will be narrowed

[0024] To sum up: in the prior art, there is still a lack of an anastomotic leak after implantation, which can induce and promote the growth and coverage of the new esophageal mucosa, can effectively resist the contraction force of the new esophageal scar tissue, and prevent the stenosis of the new esophagus. An artificial esophagus that can be taken out or removed in a non-invasive or minimally invasive way after the new esophageal mucosa is completely covered and the new esophageal scar tissue is stable

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