30 results about "Esophageal Tissue" patented technology

A system for stapling tissue comprises a flexible endoscope and an operative head including a pair of opposed, curved tissue clamping jaws sized to pass through an esophagus, the jaws being moveable with respect to one another between an open tissue receiving configuration and a closed tissue clamping configuration, a first one of the curved jaws including a stapling mechanism and a second one of the jaws including a staple forming anvil surface, the stapling mechanism including staple slots through which staples are fired arranged in a row extending from a proximal end of the first jaw to a distal end thereof in combination with a control handle which, when the operative head is in an operative position within one of a patient's stomach and esophagus, remains outside the patient, the control handle including a first actuator for moving the jaws relative to one another and a second actuator for operating the stapling mechanism.

The present invention relates to devices, and methods for using the devices, to create and secure a tissue fold during an endoluminal medical procedure. The devices and methods may be used for folding and securing, for example, a fundus wall onto an esophagus wall or esophageal tissue in the region of the lower esophageal sphincter (LES) to reduce the diameter of the esophagus opening in that region. One aspect of the invention includes forming the tissue fold by closing a grasping arm that is pivotably connected to an overtube that has been positioned at the juncture of the fundus wall and esophagus wall. A further aspect of the invention includes tissue clips configured to be inserted and positioned through an endoluminal device.

A system and method for automatically analyzing impedance and pH data from an esophageal probe includes a data collection system that collects and stores the output from the sensors for a certain period of time to locate reflux episodes in the waveforms. The data analysis system uses wavelet analysis to assist in locating bolus entry and exit points in the waveforms and to smooth waveforms for additional analysis. It also distinguishes between candidate acid reflux episodes and candidate non-acid reflux episodes for determining actual acid reflux episodes and non-acid reflux episodes, and it distinguishes between, and provides different signal processing for, signals from patients that have healthy esophageal tissue and those that have diseased esophageal tissue.

The invention discloses an automatic segmentation method and a system of an esophageal endoscopic OCT image hierarchy structure. The method comprises the following steps: image preprocessing, whereinan image is filtered and searched, and pixel values are complemented; image planarization, wherein the whole esophageal tissue in the image is straightened and corrected; segmentation of an image organization layer, wherein a current segmentation layer is used as a reference and the searching area of a next layer to be segmented is obtained in a mode of translating certain pixels downward and segmentation layer by layer is performed; image unplanarization, wherein the segmented image is inversely translated to obtain the final segmentation result. The invention provides a scheme for respondingto interference of a probe protective film, tissue liquid and the like, so as to avoid subsequent influences on tissue layer segmentation. The invention combines the Canny edge detection with the gradient operator, and proposes a new image segmentation method weight design scheme. The scheme uses the Canny operator to improve the precision of edge detection, and uses the gradient operator to compensate the missing edge in the Canny operator. The accuracy of segmentation is improved by combining the two operators.

An apparatus for monitoring for accumulation of lung fluid comprises a feeding tube having first electrode(s) positioned thereon for electrical contact with tissue of an esophagus of a target patient including a lower esophageal sphincter (LES) and / or tissue in proximity to the LES, second electrode(s) sized and shaped for contacting skin of the target patient, and a non-transitory memory having stored thereon code instructions for applying alternating current(s) to pair(s) of first and second electrodes, measuring a voltage over the pair(s), and computing an estimate of a change of lung fluid relative to a baseline in lung(s) of the target patient according to the applied alternating current and measured voltage, wherein applying the at least one alternating current, measuring the voltage and computing the estimate of the change in lung fluid are iteratively executed for monitoring the target patient for accumulation of lung fluid while the feeding tube is in use.

The invention relates to a preparation technique of a biochemically emulated tissue engineering gullet, which is a bio-active molecule adopts electrical weaving method to weave biodegradalbe polyester polymer for a second time, thus obtaining basement membranes of epithelium similar with gullet and an asymmetric porous nano fiber structure arranged in sequence and similar with muscular layer structure, and the fiber is chemically modified to ingraft the surface of the biochemically emulated tissue engineering gullet and facilitate the growth of cells. The porous nano fiber similar with the basement membranes can support the growth of gullet epithelium, while the oriented fiber arranged in sequence is helpful for inducing the oriented growth of gullet smooth muscle cells, and the porous nano fiber can is cultured for 3 to 4 weeks in DMEM wholly culture medium, thus preparing a biochemically emulated tissue engineering gullet with both epithelium and muscular layer. The gullet of the invention completely simulates the normal gullet tissue of human body in microstructure causing the man made gullet constructed in vitro to be much closer to human gullet in structure and functions, andthe ingrafted bio-active molecules are beneficial for retaining the original form and bio-functions of the body cells for the cells ingrafted to the bio-active molecules, and can be used for the restoration and construction of diseased gullet.

The invention relates to a preparation for detecting, diagnosing or evaluating prognosis of esophageal cancer, a drug for treating esophageal cancer and application of RND2 gene, belonging to the technical field of tumor molecular biology. The esophageal cancer detection, diagnosis or prognosis evaluation preparation of the present invention includes a detection product of RND2 gene mRNA expression level, or a detection product of RND2 protein expression level; RND2 protein belongs to the Rnd subfamily in the Rho GTPase superfamily, the present invention For the first time, it was discovered that the expression of RND2 gene is related to esophageal cancer. By detecting the expression of RND2 in the esophageal tissue of the subject, it can be judged whether the subject has esophageal cancer, or whether the subject has the risk of esophageal cancer. By increasing the expression of RND2 protein and supplementing the lack or insufficiency of endogenous RND2 protein, the esophagus cancer caused by RND2 protein deficiency can be treated or alleviated.

There is provided system for monitoring spontaneous breathing of a mechanically ventilated target individual, including: a feeding tube for insertion into a distal end of an esophagus of the individual, sensor(s) disposed on the feeding tube at a location such that the sensor(s) is located at the distal end of the esophagus of the individual when the feeding tube is in use, wherein the sensor(s) is positioned for sensing values by contact with the tissue of the esophagus including a lower esophageal sphincter (LES) and / or tissue in proximity to the LES, and code for computing an indication of a frequency band of diaphragm movement of the individual according to an analysis of values sensed by the sensor(s), and for adjustment of parameter(s) of a mechanical ventilator for mechanically ventilating the individual, wherein the instructions for adjustment are computed while the feeding tube is in use.

The invention discloses an automatic segmentation method and a system of an esophageal endoscopic OCT image hierarchy structure. The method comprises the following steps: image preprocessing, whereinan image is filtered and searched, and pixel values are complemented; image planarization, wherein the whole esophageal tissue in the image is straightened and corrected; segmentation of an image organization layer, wherein a current segmentation layer is used as a reference and the searching area of a next layer to be segmented is obtained in a mode of translating certain pixels downward and segmentation layer by layer is performed; image unplanarization, wherein the segmented image is inversely translated to obtain the final segmentation result. The invention provides a scheme for respondingto interference of a probe protective film, tissue liquid and the like, so as to avoid subsequent influences on tissue layer segmentation. The invention combines the Canny edge detection with the gradient operator, and proposes a new image segmentation method weight design scheme. The scheme uses the Canny operator to improve the precision of edge detection, and uses the gradient operator to compensate the missing edge in the Canny operator. The accuracy of segmentation is improved by combining the two operators.

The invention discloses a CHKA gene that can function as a molecular marker for early diagnosis of esophageal cancer. Experiments prove that compared with normal esophageal tissues, the CHKA gene in esophageal cancer tissues has significantly increased expression, and RNA interference experiments prove that CHKA can affect proliferation of esophageal cancer cells. According to study results herein, it is possible to develop medicine to inhibit CHKA gene expression so as to clinically prevent and treat the esophageal cancer.

The invention discloses a molecular marker-ABLIM3 gene and its expression product for early diagnosis of esophageal cancer. The present invention uses QPCR and Western blot methods to prove that the ABLIM3 gene is differentially expressed in esophageal cancer tissue and normal esophageal tissue, and can be used as an index for early diagnosis of esophageal cancer. In addition, the present invention also discloses that the ABLIM3 gene and its expression product can be used as a target for the treatment of esophageal cancer and used to guide the research and development of new drugs.

An airway management device (10) for a human or animal subject (20) includes an airway tube (101) having a first end for disposal external to the subject (20) and a second end (102) for disposal in a portion of an airway of the subject (20). A light emitting element (108) and a photo-sensing element (109) may be disposed at the second end (102) of the airway tube (101). The light emitting element (108) may be configured to transmit light to tissue adjacent to the light emitting element (108). The photo-sensing element (109) may be configured to receive reflectance spectra (204) from the tissue. The location of the second end (102) of the airway tube (101) may be determined from characteristics of the reflectance spectra (204) of the tissue.