Preparation for detection, diagnosis or prognostic evaluation of esophageal cancer, medicament for treating esophageal cancer and application of RND2 gene

Abstract

The invention relates to a preparation for detection, diagnosis or prognostic evaluation of an esophageal cancer, a medicament for treating the esophageal cancer and an application of an RND2 gene, and belongs to the technical field of tumor molecular biology. The preparation for detection, diagnosis or prognostic evaluation of the esophageal cancer disclosed by the invention comprises a detectionproduct for the mRNA (messenger Ribonucleic Acid) expression level of the RND2 gene, or a detection product for the expression amount of an RND2 protein; the RND2 protein belongs to the Rnd subfamilyof the Rho GTPase superfamily. The situation that the expression of the RND2 gene is related to the esophageal cancer is discovered by the invention for the first time. By detecting the expression ofthe RND2 in the esophageal tissue of a subject, whether the subject suffers from the esophageal cancer or not or whether the subject is at risk of suffering from the esophageal cancer or not can be judged. By improving the expression of the RND2 protein and supplementing the missing or deficiency of the endogenous RND2 protein, the esophageal cancer caused by lack of the RND2 protein can be treated or alleviated.

Description

technical field [0001] The invention relates to a preparation for detecting, diagnosing or evaluating prognosis of esophageal cancer, a drug for treating esophageal cancer and application of RND2 gene, belonging to the technical field of tumor molecular biology. Background technique [0002] Esophageal cancer (Esophageal Carcinoma, EC) is one of the most common malignant gastrointestinal tumors in my country, ranking fifth in the death rate of various cancers. In the 2008 World Cancer Incidence and Death Report released by the International Agency for Research on Diseases, it was pointed out that China is a high incidence area of ​​esophageal cancer in the world, and more than half of the world's esophageal cancer occurs in China. [0003] However, corresponding to the grim epidemiological situation of esophageal cancer is the lack of early diagnosis of esophageal cancer. Most patients are already in the advanced stage of esophageal cancer when they see a doctor. The overal...

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Problems solved by technology

[0004] The publication number is CN105734159A Chinese invention patent application discloses a molecular marker of esophageal squamous cell carcinoma, which points out that the detection primer of CCKBR gene can be used as a diagnostic product for esophageal squamous cell carcinoma, but it only detects CCKBR in patients with esophageal squamous cell carcinoma. The low expression indicates that the CCKBR gene is related to the occurrence and development of esophageal squamous cell carcinoma, but the detection primers of CCKBR gene have not been used to evaluate and predict the survival of patients with esophageal squamous cell carcinoma, and there is no effective preparation for evaluating the prognosis of esophageal cancer

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