Total triterpenes of solidago canadensis extracts, preparation method and use thereof

Abstract

The invention relates to the preparing method and application of the total triterpene extracts from American solidago decurense. The total triterpene glycosides in the total triterpene extracts include Solidago decurense saponin 1,2,3 and 4, which can prevent and / or treat esophageal cancer, senile dementia, respiratory tract disease caused by different kinds of inflammation such as laryngopharyngitis and tracheitis. The diseases mentioned has been the main pathogeny that influences the quality of human life. The preparing technology of the extract is very simple, the extracting efficiency is very high; the extracts have strong pharmacologic action, stable quality and controllable quality; it's safe with less toxicity. The American Solidago decurense has damaged Chinese natural resources and ecological environment seriously as foreign invasive plant, it has been removed as weeds in many places. The invention can change waste into treasure while providing a new medicine source for preventing, diagnosing, detecting, protecting, treating and researching the mentioned diseases.

Description

technical field [0001] The present invention relates to the technical fields of medicine, food and beverage, in particular to a traditional Chinese medicine extract and its preparation method and application, more specifically to a total triterpene extract of the traditional Chinese medicine Solidago americana and its preparation method and application . Background technique [0002] (1) Research overview of Solidago americana [0003] 1 Overview [0004] Solidago americana, also known as solidago canadensis, is the whole plant, root or rooted whole plant of solidago canadensis (Solidago canadensis) in the Compositae plant. Solidago americana was first recorded in the "Plant Names and Facts" mountain grasses, and it is mainly distributed in East China, Central South, Shaanxi, Taiwan and other places. [0005] Solidago is a genus in the family Compositae. There are about 120 species of Solidago genus in the world, and 4 species are distributed in China, namely Solidago de...

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Problems solved by technology

[0081] Tetrahydroaminoacridine is the first cholinesterase inhibitor approved by the FDA and clinically used to treat Alzheimer's disease, but regulations still need to be improved

[0088] The disadvantage of tacrine is that it has a great impact on liver function and transaminase index, which restricts the development of the market, and its sales growth is far behind other AD drugs

And because the vast majority of patients with esophageal cancer are already in the advanced stage when they are diagnosed, not only the local lesions have been extensively infiltrated, but also the distant spread of subclinical lesions or lymph node metastasis have been found. Autopsy found that many cases that were considered to be locally early died at the time of death. More than half of them have distant metastasis, more than 70% have extensive lymph node invasion, and less than 1 / 3 of the cases can be curatively resected. The 5-year survival rate of conventional radiotherapy is only 13%. The main cause of failure accounts for more than 80%. It can be seen that the treatment of esophageal cancer is far from enough by surgery and radiotherapy alone.

[0226] Through literature search, etc., so far, no relevant reports on the total triterpene extract of Solidago americana and its preparation method and use have been found.

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