626 results about "Pharmacologic action" patented technology

The invention relates to the technical field of application of bacteroides fragilis, and in particular relates to application of bacteroides fragilis in preparation of a composition for treating inflammatory bowel diseases. The experiments show that bacteroides fragilis is safe and nontoxic and strong in pharmacologic action, and has good treating effect of treating inflammatory bowel diseases, thereby indicating that the bacteroides fragilis has good edible and medicinal prospects. According to the invention, a novel use of bacteroides fragilis is explored and a novel application field is developed. Bacteroides fragilis as a probiotic can be used for preparing foods or medical compositions for treating inflammatory bowel diseases so as to provide health-cared foods or treating medicines suitable for human body to take.

Particles which include a bioactive agent are prepared to have a desired matrix transition temperature. Delivery of the particles via the pulmonary system results in modulation of drug release from the particles. Sustained release and / or sustained pharmacologic action of the drug can be obtained by forming particles which include a combination of phospholipids that are miscible in one another and have a high matrix transition temperature.

The invention relates to methods of increasing the bioavailability of orally administered epothilones. Epothilones administered by the methods of the invention are sufficiently bioavailable to have a pharmacological effect. The invention further relates to pharmaceutical compositions, pharmaceutical dosage forms, and kits for use in the methods of the invention.

The invention relates to health-preserving fungal tea and application thereof. The health-preserving fungal tea is prepared from the raw materials by weight fraction: 10 to 50 percent of edible or medicinal fungal fruit body and 50 to 90 percent of tea. The invention provides health-preserving fungal tea with simple and scientific matching and application thereof in anticancer aspect, so that the nutritive value and pharmacological action of single product are greatly improved. Through scientific matching, the actions of the active substances of the edible or medicinal fungal fruit body and tea are multiplied, so that the nutritive value and pharmacological action are greatly improved. By scientific matching, the fungal tea has unique mouthfeel and flavor, can serve as tea or tea bag to be directly soaked for drinking, can also be prepared into fungal tea beverage, oral liquid, polysaccharide capsule, tablets and the like, and has the efficacies of conditioning yin-yang balance of the functions of five internal organs, improving organism immunity, improving fatigue state, conditioning endocrine dyscrasia, improving blood pressure, blood sugar and blood fat, strengthening body, expelling toxin and protecting liver, preventing disease and radiation, reducing weight and fat, resisting tumor and aging and the like.

The invention discloses a method for manufacturing salvianolic acid A of danshen root, which is characterized in that total salvianolic acid in the danshen root is transformed into salvianolic acid A by adopting a certain method. The method increases greatly the extraction yield of salvianolic acid A. The salvianolic acid A is prepared into tablets, capsule, granula, soft capsule, micro pill, dripping pill and oral liquid, which have good pharmacological action indicated by pharmacological experiments.

The invention relates to a tea saponin bath lotion and its making method. The tea saponin bath lotion comprises tea saponin essence and additives. The tea saponin is a pentacyclic triterpene saponin substance, has the performance of emulsifying, dispersing, wetting and foaming, and the pharmacological actions of resisting permeability and reducing inflammation, etc. With an inhibiting effect on a variety of skin pruritus and no toxic or side effect, the tea saponin has the characteristics of abundant foam, durability, strong detergency and the like, and can be compounded with other surfactants to prepare the bath lotion. Without toxic or side effect, the bath lotion has the effects of skin moistening, skin care, and water replenishing.

The invention relates to a method for improving the yield of arginine by the mutation of Corynebacterium crenatum N-acetyl glutamic acid kinase. L-arginine is one of semi-essential basic amino acids for a human body, and has various particular physiology and pharmacology functions. High-yield arginine mutant strain C. crenatum SYPA5-5 is compounded into the arginine through a circulating way, and N-acetyl glutamic acid kinase (NAGK) is a key enzyme in the compounding way and is subject to the feedback inhibition of the product arginine. By using an overlapping PCR (Polymerase Chain Reaction) technique, a GAT (glycerol phosphate acyl transferase) codon used for coding aspartic acid is used for substituting a GGA (General Gonadotropic activity) codon used for coding glycine at the site 287 in the coding NAGK albumen, and the NAGK which has high activity and arginine with obviously reduced by the feedback inhibition can be obtained after the mutation. An argBSD gene is brought into the Corynebacterium crenatum of the high-yield arginine through pJCl-tac, and the expression volume of the key enzyme is further improved. The final acid yield is increased to 36.3g / L from original 28g / L, and the yield of the L-arginine is increased by 29.7 percent.

The invention discloses a normal-temperature preparation method for ultrafine powder hawthorn. The method comprises the following steps of: cleaning hawthorn, and drying till the water content is less than or equal to 10 percent; smashing the hawthorn at the normal temperature to obtain coarse powder of which the granularity is 60-80 meshes; putting the coarse powder into a rod mill for smashing,conveying into the special bilateral airflow sieving machine through wind for sieving with a 500-mesh sieve, sieving to obtain powder of which the particle diameter is less than or equal to 25 micrometers, and conveying to a cyclone aggregator through airflow generated by a draught fan for collecting to obtain finished ultrafine powder coccidia powder; and collecting powder which is not sieved with the 500-mesh sieve with a funnel, and conveying to the rod mill through a pipeline for smashing circularly once again. The method has the advantages that: the entire preparation process is performed at the normal temperature without low temperature or special additional conditions; the particle diameter of prepared finished hawthorn micro powder is less than or equal to 25 micrometers, the cell-wall breaking rate and biological availability are greatly increased, and the pharmacological action of a medicament is enhanced; and due to the adoption of the bilateral airflow sieving machine, thepreparation process of ultrafine powder hawthorn is simplified, and the aim of controlling the quality standard of Chinese medicinal powder is fulfilled.

The invention relates to a setwall extract with hypnotic sedative activity and the preparation thereof and also comprises the application of the extract in the pharmacy field. The extract essentially consists of setwall naphtha, valerienic acid, total valepotriate, etc. The pharmacodynamical experiment shows that the setwall extract made by the technology has the marked pharmacological actions of mitigation, hypnosis, anti-depression, spasmolysis, analgesis, the regulation of blood fat, anti-tumor, antibiosis, antivirus and the like and can be developed into medicine or food with health care function.

The invention discloses a preparation method for salvianolic acid A in salvia miltiorrhiza and is characterized in that the method takes salvianolic acid B in the salvia miltiorrhiza as the raw material and converts the salvianolic acid B into the salvianolic acid A in the salvia miltiorrhiza after adjusting pH value to 3.5-6.0 and chemical reaction, thus greatly increasing the extraction yield of the salvianolic acid A; the pharmacological tests prove that a preparation prepared by the salvianolic acid A in the salvia miltiorrhiza has excellent pharmacological action.

There exists a strong desire both for pharmaceutical compositions which rapidly exhibit pharmacological effects without an increase in the size of the dosage form or a decline in quality due to interactions between a pharmaceutically active ingredient and the disintegrant, and also for a method of preparing such pharmaceutical compositions. Such a desire is especially acute with regard to, for example, preparations which contain a drug such as an analgesic or a quick-acting hypoglycemic drug that requires the rapid appearance of pharmacological effects following administration, preparations which have a high content of the pharmaceutically active ingredient, and preparations which contain two or more different pharmaceutically active ingredients. Thus, the object of the present invention is to improve the disintegratability of the pharmaceutical compositions without increasing the size of the dosage form and without a decline in quality due to interactions between the pharmaceutically active ingredient and the disintegrant. The present invention provides a method for preparing a pharmaceutical composition having a rapid disintegration time, comprising: blending, in the pharmaceutical composition containing a pharmaceutically active ingredient, at least one disintegrant and at least one water-soluble salt having a pH being from 3 to 9 in an aqueous solution of 2.5% concentration. The invention also provides a premix composition obtained by the preliminary mixture of a disintegrant with a water-soluble inorganic salt having a pH of from 3 to 9 in an aqueous solution of 2.5% concentration.

The invention relates to a preparation method of effective fractions of shining wintersweet leaf, a preparation method and a use of a preparation thereof, in particular to an application of the effective fractions of the shining wintersweet leaf and the preparation thereof in drugs used for preventing and treating respiratory system diseases as well as in anti-cold drugs, antimicrobial drugs, anti-inflammation drugs, antiviral drugs, antifungal drugs, etc. In the invention, the volatile effective fractions and non-volatile effective fractions are added to the crude drug of the shining wintersweet medicinal material with a weight ratio of the actual extraction amount of the shining wintersweet to the effective fractions being 1.0-2.6:0.5-3.5, thus the effective fractions of the shining wintersweet leaf are obtained. A preparation of the effective fractions of the shining wintersweet can be made into granules, soft capsules, capsules, drop pills, tablets, compound capsules, dispersible tablets, etc. In the invention, the preparation of the shining wintersweet is deeply developed, which ensures that the preparation is rich in active ingredients, has definite effective ingredients, obvious pharmacological action and significant improvement of drug action. Besides, the preparation has stable performance and controllable quality, is safe and reliable, has less dosage, and is favorable for transportation and storage of the medicine as well as for patients to take.

The invention relates to the technical field of new-resource food processing, and in particular relates to a preparation method of an inulin chewable tablet. The inulin chewable tablet is prepared by using inulin as a main raw material and adding auxiliary materials through screening, producing soft materials, granulating, drying, straightening and tableting sequentially. According to the chewable tablet prepared by the method, the disintegration time is between 10 and 15 minutes, the hardness is between 50 and 55N, and the tablet weight different limit is within 3.0 percent. The inulin chewable tablet has smooth taste, compatible sour and sweet, good disintegration and good chewing property, is convenient to carry and take, realizes that the health-care function and pharmacologic action of inulin can be maintained, and is an excellent nutrition for people at all ages.

The preparation method of low molecular weight chondroitin sulfate is characterized by that it utilizes animal soft bone and / or marketable general macromolecular chondroitin sulfate as raw material, and adopts the conventional production process and the special processes of acid hydrolysis, ultrafiltration with ultrafiltration membrane and concentration to obtain the chondroitin sulfate whose molecular weight is less than 1000 daltons. Said product features high purity, good biological activity, high internal biological utilization rate and strong pharmacologic action, etc. and can be used asimportant raw material of medicine product, health-care product, cosmetics and food.

The invention relates to a long-acting Exendin-4 analogue and a synthesis method thereof. Exendin-4 is transformed to obtain the Exendin-4 analogue having longer pharmacological action time, synthesis of a target polypeptide is rapidly achieved by a microwave-promoted solid phase synthesis method, and a crude product is purified and freeze-dried to obtain the Exendin-4 analogue.

The invention relates to a Chinese traditional medicine extract for preventing and treating osteoporosis and its preparation method and application. The extract mainly comprises rhizoma atractylodis volatile oil, total alkaloid of Phellodendron amurense, and total saponins of radix achyranthis bidentatae and total sterone of radix achyranthis bidentatae; can be used for preventing and / or treating osteoporosis and relevant disorder, which has gradually become important pathogenesis influencing life-quality. The extract has easily-accessible raw materials, simple preparation, high extraction efficiency, strong pharmacological action, stable quality, high safety, low toxicity, and controllable quality. The invention comprises three Chinese traditional medicines in classical prescription, come to optima activity for resisting osteoporosis, reduces adverse side effect, and provides a new medicament source for preventing, diagnostic ting, detecting, protecting, treating and researching these diseases and their relevant diseases.

A method for identifying a target protein of a compound having a pharmacological action by detecting a tertiary structural change of a target protein by binding a compound having a pharmacological action to a target protein with the use of a molecular chaperone protein having a characteristic of binding to a protein by recognizing a tertiary structural change of the protein is disclosed. Further, a method for screening a therapeutic agent for diabetes using a target protein of biguanide which is a therapeutic agent for diabetes and was found by the identification method, a screening tool which can be used in the screening method and a pharmaceutical composition for treating diabetes containing a substance obtained by the screening method are disclosed.

The invention relates to a long-effecting exenatide (Exendin-4) analogue and a synthetic method thereof. The Exendin-4 is modified to obtain the Exendin-4 analogue with longer pharmacologic action time, the synthesis of target polypeptide is quickly realized through an orthogonally protection strategy solid-phase synthesis method, and a crude product is purified and freeze-dried to obtain the Exendin-4 analogue.

The invention relates to the technical field of application of bacteroides fragilis, and in particular relates to application of bacteroides fragilis in preparing a composition for preventing and treating acute radiation enteritis. Experiments show that bacteroides fragilis is safe, nontoxic and strong in pharmacologic action and has a good preventing and treating effect to acute radiation enteritis, thereby indicating that the bacteroides fragilis has good edible and officinal prospects. The invention explores novel use of bacteroides fragilis and develops a novel application field. Bacteroides fragilis serving as probiotic can be used for preparing foods or medical compositions for preventing and treating acute radiation enteritis.

The invention discloses an abalone and dried scallop sauce. The sauce mainly comprises abalones, dried scallops, ham, and peeled shrimps. According to the invention, pharmacological effects of abalones, dried scallops and peeled shrimps are fully developed, health-care efficacies are emphasized, and local flavors of the aquatic products are improved. With the sauce, user appetite can be promoted.The invention also discloses a preparation method of the abalone and dried scallop sauce. The method is simple and convenient. According to the method, existing can processing equipments such as mixers, boiling furnaces and choppers can be used in productions.

The invention provides application of a compound with the structure as shown in the formula (I) in the specification, or a medical salt, a hydrate or a solvate, of the compound, in preparation of a medicine for treating nervous system diseases relevant to the dopamine receptor, and a preparation method of the compound with the structure as shown in the formula (I) in the specification or the medical salt, the hydrate or the solvate, of the compound. The compound has multiple pharmacologic functions such as mu-opioid receptor excitation and dopamine D2 receptor blocking, and has good physicochemical properties and oral bioavailability, and integral animal experiment shows that the compound has remarkable and long-lasting analgesia and calm activity and can be applied to treatment on pain and other mental diseases.

The invention discloses an application of coptisine or physiologically acceptable salt thereof in preparing medicines for preventing and curing myocardial ischemic diseases. The coptisine or the physiologically acceptable salt thereof has pharmacological actions of protecting myocardial ischemic injury as well as preventing and curing myocardial ischemic diseases, has an effect of protecting myocardial mitochondria function, and has pharmacological actions of eliminating superoxide anion radical and protecting cardiocytes from being injured by free radicals. The invention discloses a compound containing the coptisine or physiologically acceptable salt and a pharmaceutically acceptable carrier and / or accessory. The coptisine is a monomeric compound extracted from rhizoma coptidis and other commonly used traditional Chinese medicines or folk herbs, which has the advantages of low toxicity and wide raw material resources.

The invention belongs to the technical field of metabonomics, and provides Xiaoyao San metabolic markers in a biological sample, and a detection method and an application thereof. A pharmacological action mechanism of Xiaoyao San for treating depression is defined. The metabolic markers are 4-oxo hex-2-ene dioic acid, creatinine, L-cystathionine and acetylphosphate. A UPLC-Q-TOF / MS technology is adopted for analyzing the plasma and metabolic profile change of patients in a drug administration group and a control group of the Xiaoyao San, and then a multivariate statistical analysis method and an orthogonal partial least square discriminant analysis (OPLS-DA) method are adopted for screening the changes of the metabolic markers of the Xiaoyao San after 8-week treatment. The study is used as a first clinical metabonomics study of the Xiaoyao San; the influence of the metabolic level of the Xiaoyao San is found; the action mechanism of the Xiaoyao San is preliminarily illuminated in metabolic pathway; and a new method is provided for predicting the pharmacological mechanism of the Xiaoyao San for treating the depression.

The invention discloses a preparation method of cajanin and substances with a similar structure. According to the invention, acyl acetate and diketene are subject to a condensation reaction, such that an intermediate compound II is obtained; the intermediate compound II is subject to an alkylation reaction and a halogenation reaction, such that an intermediate compound IV is obtained; the intermediate compound IV is subject to a condensation reaction with an organic phosphine reagent, and is subject to a witting reaction, such that a compound VI is obtained; the compound VI is subject to a dehydrocarbylation and pentanol iosprene conversion reaction, and the reactant is hydrolyzed or alcoholyzed, such that cajanin I and substances with the similar structure are obtained. According to the invention, cajanin and substances with the similar structure are prepared through a chemical synthetic method. The technical process adopted by the synthetic route is easy to operate, the yield is good, and the product purity is high. The method provided by the invention assists in providing a basis for further researches, developments and applications of various pharmacologic actions of cajanin.

The invention relates to the preparing method and application of the total triterpene extracts from American solidago decurense. The total triterpene glycosides in the total triterpene extracts include Solidago decurense saponin 1,2,3 and 4, which can prevent and / or treat esophageal cancer, senile dementia, respiratory tract disease caused by different kinds of inflammation such as laryngopharyngitis and tracheitis. The diseases mentioned has been the main pathogeny that influences the quality of human life. The preparing technology of the extract is very simple, the extracting efficiency is very high; the extracts have strong pharmacologic action, stable quality and controllable quality; it's safe with less toxicity. The American Solidago decurense has damaged Chinese natural resources and ecological environment seriously as foreign invasive plant, it has been removed as weeds in many places. The invention can change waste into treasure while providing a new medicine source for preventing, diagnosing, detecting, protecting, treating and researching the mentioned diseases.

The invention discloses a coelenterazine analog and a preparing method and application thereof. The coelenterazine analog has the general structure formula (I) shown in the description, wherein R1, R2 and R3 in the formula are different substituents. According to application of the compound as a bioluminescence substrate, the existence and quantity (including the enzyme level, the cell level and the animal level) of coelenterazine luciferase can be detected with bioluminescence, and the in vitro, cell and in vivo distribution imaging of luciferase can be detected; the compound can serve as a report signal to detect the pharmacologic action and the toxic effect of medicine on the enzyme level, the cell level and the animal level under the existence of luciferase.

Pharmacological test shows that the externally-used preparation of Cetirizine has ideal allergy resistant and anti-inflammatory action to the rat passive cutaneous anaphylaxis (Rat PCA) model and dimethylbenzene caused mouse otitis model, and also prevents the adverse effect to the central system caused by whole body administration. It is also found in the test, that the externally used preparation of Cetirizine also has very fine inhibitory action to dinitrofluorobenzene caused mouse porphyria hypersensitivity (PTH), the novel pharmacological action of the Cetirizine shows that the Cetirizine external preparation has good therapeutic action to skin inflammations which mainly include porphyria hypersensitivity.

The invention relates to a preparation method for extracting an effective part from traditional Chinese medicine radix bupleuri and an application of the effective part obtained by utilizing the method and a preparation thereof in medicines for preventing and treating liver fibrosis, hepatocirrhosis, chronic hepatitis and the like. The preparation of the effective part of the radix bupleuri can be granules, soft capsules, capsules, dripping pills, tablets, dispersing tablets, effervescence tablets, injection and the like. The invention has simple operation method and utilizes a modern medicine effect sieving technology, an extracting and purifying technology, a preparation technology and a quality control technology to carry out deep development on the radix bupleuri preparation; the effective part of the radix bupleuri and the preparation thereof obtained by utilizing the technological method of the invention are rich in active components, have definite effective components, obvious pharmacological action, obviously enhanced medicine effect, stable performance, controllable quality, safety, reliability and small dose and are beneficial to the transportation and storage of the medicine and the taking of a patient.

The invention discloses Szechwan Chinaberry fruit extract and application thereof. The Szechwan Chinaberry fruit extract contains one out of four limonin components including melia toosendan Lining, neper Lining A, neper Lining B, 1-de-acetyl group neper Lining B; the main preparation steps are as follows: selecting Szechwan Chinaberry fruit medical material, adopting water or an alcohol-water mixed solvent for extraction, mixing the extracting solution and concentrating, so as to obtain the Szechwan Chinaberry fruit extract; dispersing the Szechwan Chinaberry fruit extract to water, extracting for 3-5 times by using an organic solvent which cannot be dissolved with water, mixing and concentrating the extracts, and drying to obtain the Szechwan Chinaberry fruit extract. The invention simultaneously discloses the application of the Szechwan Chinaberry fruit in medicine and pesticide preparation; and the Szechwan Chinaberry fruit has the pharmacological actions of anti-inflammation, anti-tumor and the like. The Szechwan Chinaberry fruit extract is clear in effective components, simple in preparation process and easy for realization of industrial amplification, and has good application value.

To prepare a novel indazole derivative useful as a medicine and to find out a new pharmacological activity of the derivative. The compound is represented by the general formula [I] and has excellent Rho-kinase inhibitory activity. In the formula, ring X is a benzene ring or pyridine ring; R<1> and R<2> each is hydrogen or alkyl; R<3> and R<4> each is halogeno, hydrogen, OH, alkoxy, alkenyloxy, alkynyloxy, cycloalkyloxy, cycloalkenyloxy, aryloxy, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, carboxy, hydrocarbonyl, alkylcarbonyl, etc.; and R<5> is halogeno, hydrogen, OH, alkoxy, aryloxy, alkyl, or aryl. These groups may be substituted.