Szechwan Chinaberry fruit extract and application thereof

A technology of Fructus Fructus Fructus and extract, applied in the field of Fructus Fructus Fructus, to achieve the effects of easy recovery and recycling, high efficiency, and easy industrial production

Active Publication Date: 2013-02-27
SHANGHAI GREEN VALLEY PHARMA
View PDF1 Cites 11 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the correlation between the pharmacological activity of Toosendan and its chemical components still needs to be further studied.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Szechwan Chinaberry fruit extract and application thereof
  • Szechwan Chinaberry fruit extract and application thereof
  • Szechwan Chinaberry fruit extract and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The preparation of embodiment 1 toosendan extract

[0030] Get 4 kg of Toosendan medicinal material, crush it into a coarse powder, and reflux extract it with 50 L of 75% ethanol for 3 times, each time for 2 hours, combine the extracts, recover the solvent under reduced pressure, and obtain 550 g of Toosendan extract, disperse it with 4 L of water, and use Ethyl acetate was shaken and extracted 4 times, 4 L each time, the ethyl acetate extracts were combined, and the solvent was recovered under reduced pressure to obtain Toosendan extract (180 g).

Embodiment 2

[0031] The separation and identification of chemical constituents in the extract of Toosendan in embodiment 2

[0032] Take Toosendan extract (100 g) obtained in Example 1, perform normal pressure silica gel column chromatography, petroleum ether (60-90° C.)-ethyl acetate system gradient elution, and obtain 140 fractions, which were detected by TLC and combined There are 10 components (F1~10). Using various adsorption materials such as silica gel, reversed-phase silica gel, gel, etc., through various separation methods such as normal pressure column chromatography, medium pressure column chromatography and high pressure liquid phase preparation technology, the compound is separated from F6 (Fr 87~92) 1 (51 mg) and compound 2 (14 mg); compound 3 (22 mg) was obtained from F5 (Fr 73-86); compound 4 (300 mg) was obtained from F8 (Fr 98-109).

[0033] MS, NMR and other data of compounds 1, 2 and 4 were confirmed as Nimbolin A (Nimbolinin A), Nimbolin B (Nimbolinin B) and 1-deacety...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses Szechwan Chinaberry fruit extract and application thereof. The Szechwan Chinaberry fruit extract contains one out of four limonin components including melia toosendan Lining, neper Lining A, neper Lining B, 1-de-acetyl group neper Lining B; the main preparation steps are as follows: selecting Szechwan Chinaberry fruit medical material, adopting water or an alcohol-water mixed solvent for extraction, mixing the extracting solution and concentrating, so as to obtain the Szechwan Chinaberry fruit extract; dispersing the Szechwan Chinaberry fruit extract to water, extracting for 3-5 times by using an organic solvent which cannot be dissolved with water, mixing and concentrating the extracts, and drying to obtain the Szechwan Chinaberry fruit extract. The invention simultaneously discloses the application of the Szechwan Chinaberry fruit in medicine and pesticide preparation; and the Szechwan Chinaberry fruit has the pharmacological actions of anti-inflammation, anti-tumor and the like. The Szechwan Chinaberry fruit extract is clear in effective components, simple in preparation process and easy for realization of industrial amplification, and has good application value.

Description

technical field [0001] The invention relates to a Toosendan extract, and also relates to a preparation method of the Toosendan extract and its application in the field of medicine and pesticides. technical background [0002] Toosendan is the mature fruit of Melia toosendan Sied.Et Zucc., a plant of Meliaceae. It is a traditional Chinese medicine. Abdominal pain and other syndromes have a history of nearly 2,000 years of medication, which are recorded in Chinese pharmacopoeias. Modern research results show that Toosendan extract has various pharmacological activities such as antibacterial, antiviral, anti-inflammatory, analgesic, and insecticidal. Limonoids are the main pharmacologically active ingredients in Melia plants, which are complex triterpenoids substituted by polyoxo groups, and the structure of the nucleus is changeable, and there is no difference between different plant varieties and different parts of the same plant. There is a big difference. In recent years...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K36/58A61K31/585A01N65/24C07J73/00A61P29/00A61P35/00A01P3/00A01P7/04
Inventor 刘江云沈丽琴蔡金娜张燕刘艳丽杨世林
Owner SHANGHAI GREEN VALLEY PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap