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Traditional Chinese medicine extraction for preventing and curing osteoporosis and its preparation method

An osteoporosis, extract technology, applied in food preparation, drug combination, pharmaceutical formula, etc., can solve the problems of low toxicity and no new compound has been found, and achieve significant preventive effect

Inactive Publication Date: 2007-12-12
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0022] ⑤ Toxicity The alkaloids contained in Phellodendron Phellodendri are less absorbed in the intestinal tract, so the toxicity is low, and the gastrointestinal administration of various quaternary ammonium bases contained in it is also less toxic, but injection administration may have greater toxicity
[0096] Through literature search, etc., so far, no relevant reports have been found on the new compound preparation of extracts from Atractylodes atractylodes, Cortex Phellodendri, and Achyranthes bidentata.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0414] Embodiment 1, the preparation of this Chinese medicine extract capsule

[0415] (1) Prescription

[0416] The Chinese herbal extract 1000.0g

[0417] Microcrystalline Cellulose 1000g

[0418] Sodium carboxymethyl starch 140g

[0419] Anhydrous ethanol amount

[0420] Talc powder 80g

[0421]

[0422] Made a total of 10000 capsules

[0423] (2) Preparation process According to the above prescription, take the raw material drug, the Chinese medicine extract and other auxiliary materials in the prescription respectively, pass through a 100-mesh sieve, put it in 60°C and dry it, weigh the prescription amount of the Chinese medicine extract and microcrystalline cellulose, carboxymethyl Mix evenly with equal amount of starch sodium, use appropriate amount of ethanol to make soft material, granulate with 30 mesh sieve, dry at 50-60°C for 2 hours, granulate with 30 mesh sieve, add talcum powder and carboxymethyl starch in the prescribed ...

Embodiment 2

[0424] Embodiment 2, the preparation of this Chinese medicine extract tablet

[0425] Take 80g of the Chinese medicine extract, 80g of microcrystalline cellulose, 15g of lactose, and 60g of pregelatinized starch, sieve, mix evenly, make a soft material with an appropriate amount of 10% PVP ethanol solution, granulate, dry, and add magnesium stearate 3g, whole grain, compressed into tablets, made into 1000 pieces.

Embodiment 3

[0426] Embodiment 3, the preparation of this Chinese medicine extract tablet

[0427] (1) Prescription

[0428] The Chinese herbal extract 1000.0g

[0429]Microcrystalline Cellulose 1170.0g

[0430] Pregelatinized starch 690.0g

[0431] Lactose 125.0g

[0432] 5% PVP absolute ethanol appropriate amount

[0433] Magnesium Stearate 15.0g

[0434]

[0435] A total of 10,000 pieces were made

[0436] (2) Preparation process

[0437] According to the above prescription, weigh the main drug and auxiliary materials of the prescription amount, mix them evenly according to the method of equal volume addition, and then carry out the processes of making soft materials, granules, drying, and granulation according to the prescription process items, and after calculating the tablet weight, use single punching A tablet machine and a 10.5mm shallow concave die were used to press the tablet, and the hardness of the bare chip was controlled to be 5-...

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PUM

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Abstract

The invention relates to a Chinese traditional medicine extract for preventing and treating osteoporosis and its preparation method and application. The extract mainly comprises rhizoma atractylodis volatile oil, total alkaloid of Phellodendron amurense, and total saponins of radix achyranthis bidentatae and total sterone of radix achyranthis bidentatae; can be used for preventing and / or treating osteoporosis and relevant disorder, which has gradually become important pathogenesis influencing life-quality. The extract has easily-accessible raw materials, simple preparation, high extraction efficiency, strong pharmacological action, stable quality, high safety, low toxicity, and controllable quality. The invention comprises three Chinese traditional medicines in classical prescription, come to optima activity for resisting osteoporosis, reduces adverse side effect, and provides a new medicament source for preventing, diagnostic ting, detecting, protecting, treating and researching these diseases and their relevant diseases.

Description

technical field [0001] The present invention relates to the technical fields of medicine, food and beverage, in particular to a traditional Chinese medicine extract and its preparation method and application, more specifically to a traditional Chinese medicine extract prepared from Atractylodes atractylodis, Phellodendron Phellodendron and Achyranthes bidentata And its preparation method and use. Background technique [0002] (1) Overview of research on osteoporosis [0003] Osteoporosis is a common and frequently occurring senile disease. With the aging of the population, osteoporosis seriously affects the quality of life of the elderly, especially postmenopausal women. It is reported that more than 80 million people in China suffer from this disease and need treatment. According to statistics, there are about 25 million people in the United States and about 8 million people in Japan. Among bedridden elderly people, 20% are caused by osteoporosis, which leads to fragilit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/756A61K36/718A23L1/30A23L2/52A61P19/10A23L33/105
Inventor 黄宝康秦路平张巧艳郑汉臣张宏韩婷
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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