319 results about "Anti osteoporosis" patented technology

Provided is a composition containing placenta extracts as active ingredients. Placenta extracts are natural substances extracted from placentas of livestock and show effects that can replace steroids and reduce adverse effects of steroids, so that placenta extracts have a wide range of applications including contraceptives, anti-osteoporosis drugs, anti-anemic drugs, therapeutic agents for wasting diseases of muscular atrophy, agents for treating sexual dysfunction, therapeutic agents for wounds, and adipocyte differentiation stimulating agents for improving meat quality of livestock, etc.

The epimedium extract which can be used for preparing medicine for curing osteoporosis is obtained by using Chinese medicinal materials epimedium through the processes of decocting in water, alcohol precipitation, macroporous resin adsorption, collecting eluent and concentrating eluent.

Disclosed is a antihypelipidemic and antihyperglycemic health food for preventing diseases including cardiovascular disease, diabetes, adjusting internal secretion, resisting osteoporosis and cancer, and beauty treatment. The raw materials include soybean powder 15-30 parts, pumpkin powder 15-30 parts, soybean isoflavones 0.5-1.5 parts, soybean saponin 2-5 parts, astragalus root 10-20 parts, wolfberry fruit 10-15 parts, kudzuvine root 10-15 parts, Chinese yam 10-15 parts, lotus plumule 6-10 parts, Siberian solomonseal rhizome 6-10 parts, cassia seed 6-10 parts, lily 5-8 parts, mulberry leaf 5-8 parts and ginseng 3-5 parts.

The present invention relates to an application of iridoid in the preparation of anti-osteoporosis medicines, which belongs to the medicines technical field. The invention provides an application of iridoid which is shown in a general formula I in the preparation of medicines used for treating and / or preventing osteoporosis. Experiments found that ALP activity in UMR106 cells is taken as guidance for tracing and separating an extract of iridoid possessing general formula I, the extract and each separated component are researched from the aspects of osteoblast propagation and antioxidation activity, the iridoid possessing the general formula I has the effects of substantially promoting alkaline phosphatase activity and osteoblast differentiation, so that the iridoid has anti-osteoporosis effect and can be used for preparing the medicines used for treating or preventing osteoporosis. The component of specnuezhenide and a compound G13 possesses the effects of substantially promoting the alkaline phosphatase activity and osteoblast differentiation, and the specnuezhenide has effects for obviously promoting UMR-106 cell proliferation, a better effect is obtained when the specnuezhenide is used for anti-osteoporosis effect.

The invention discloses multifunctional medical biological bone cement. The multifunctional medical biological bone cement is prepared from the following raw materials in percentage by mass: 5%-15% of polyacrylic acid microspheres, 20% of bioactive glass, 64.9%-74.9% of calcium phosphate bone cement and 0.1% of nanometer alendronate sodium microspheres, wherein the sum of the mass percentages of the raw materials is 100%. The multifunctional medical biological bone cement has the function of water absorption self-expansion; the using amount of the bone cement can be reduced, and further the leakage of the bone cement is reduced; the multifunctional medical biological bone cement has relatively good tissue compatibility, can be used for inducing the formation of new bones and enhancing the strength of vertebral bodies, is degradable in vivo without in vivo foreign matter residues; and meanwhile, the controlled-release alendronate sodium has the effects of resisting osteoporosis, reducing the absorption of bones and furthering enhancing the vertebral bodies. Therefore, the multifunctional medical biological bone cement has the advantages of little consumption, promotion of bone formation and bone absorption resistance when applied to vertebroplasty.

An orally or parenterally administrable agent for anti-osteoporosis, comprising trehalose as an effective ingredient and optionally another ingredients, that exerts a satisfactory therapeutic / prophylactic effect on osteoporosis with lesser side effects.

The invention relates to the use of Sambucus Williamsii Hance as osteoporosis resisting medicament, and the use of lignan compounds and phenolic acid compounds as osteoporosis resisting medicament, wherein the lignan compounds and phenolic acid compounds are prepared through the steps of ethanol heating backflow of Sambucus Williamsii Hance stems and branches, extracting ethanol extract, suspending in water and extracting with chloroform, acetic acid ethyl ester, and n-butyl alcohol, disintegrating with chemical means. The invention shows no side action of estrogen samples.

A process for extracting triterpenoid from the dried root of Achyranthes bidentata includes such steps as pulverizing, hot reflux extracting in alcohol, extracting with ethyl acetate 1-4 times, mixing with distilled water, extracting with n-butanol 1-4 times and extracting with water. The liquid extract can be used to treat osteoporosis, especially the osteoporosis of women, with high curative effect.

The invention relates to a Chinese traditional medicine extract for preventing and treating osteoporosis and its preparation method and application. The extract mainly comprises rhizoma atractylodis volatile oil, total alkaloid of Phellodendron amurense, and total saponins of radix achyranthis bidentatae and total sterone of radix achyranthis bidentatae; can be used for preventing and / or treating osteoporosis and relevant disorder, which has gradually become important pathogenesis influencing life-quality. The extract has easily-accessible raw materials, simple preparation, high extraction efficiency, strong pharmacological action, stable quality, high safety, low toxicity, and controllable quality. The invention comprises three Chinese traditional medicines in classical prescription, come to optima activity for resisting osteoporosis, reduces adverse side effect, and provides a new medicament source for preventing, diagnostic ting, detecting, protecting, treating and researching these diseases and their relevant diseases.

The invention relates to a modified zebra fish drug metabolism modeling method, which specifically comprises the steps of (1) enriching metabolites by virtue of a zebra fish metabolism model; (2) separating and analyzing the enriched metabolic components of the zebra fish in the last step by using modern chromatography or the hyphenated technique thereof, capturing or knocking out target components or metabolites; (3) collecting zebra fish germ cells; (4) putting zebra fish embryos in three days after fertilization in a culture plate which holds an embryo culture medium and administrating a drug; (5) dyeing the bones of the zebra fish; and (6) detecting and analyzing the dyed bones of the zebra fish. According to the invention, an adolescent zebra fish osteoporosis model is applicable to in-vivo effective evaluation of anti-osteoporosis activity of Chinese herbal medicinal ingredients such as trace ingredients; an adult zebra fish metabolism model is simple in metabolites and efficient in enrichment; the modern chromatography or the hyphenated technique thereof provide powerful guarantee for the separation and analysis of the complex Chinese herbal medicinal system and the metabolic components. The model obtained by the method has the outstanding advantage that the separation and analysis of Chinese herbal medicinal original-form ingredients and the metabolic components are integrated with the in-vivo anti-osteoporosis activity evaluation, and simple and efficient.

The invention discloses the application of cimig-jackfruit triterpane compound in preventing osteoporosis and climacteric metancholia. The method for preparing said triterpenes compound comprises: collecting dry root of C. dahurica, C. heracleifolia and C. foetida, disintegrating, heating with 50-70% ethanol or propanol, refluxing, extracting for 1-4 times; merging extract, compression condensing to remove dissolvent from extract and getting ethanol or propanol concrete; extracting with benzinum purificatum and acetic acid ethyl ester for 1-4 times, getting ester extract; activated char column chromatography, washing with 95-100% ethanol, separating with positive phase and reverse phase silica gel column, purifying and getting following 24 kinds of triterpenes compound, the compound is cycloartanes.

The invention belongs to the technical field of medicines and particularly relates to a construction method and an application of an osteoporosis zebra fish model. The construction method comprises the following steps: constructing transgenetic zebra fish with green fluorescence of a skeleton report after obtaining a promoter of a specific transcription factor of osteoblast by virtue of applying a tol2-gateway technique; constructing the glucocorticoid induced osteoporosis zebra fish model by using the transgenetic zebra fish; and meanwhile, estimating the model by applying a bone-strengthening and kidney-tonifying traditional Chinese medicine herba epimedii general flavone. The osteoporosis model constructed by the method provided by the invention is convenient, feasible and effective, and is suitable for high throughput screening of anti-osteoporosis drugs. Compared with the conventional chemical staining methods, the construction method is more stable, time-saving and efficient.

The invention provides a benzo five-membered unsaturated heterocycle compound and a preparation method thereof. The compound has the structure shown in the general formula (I). A test shows that the compound has the activity for up regulating the bone morphogenetic protein BMP-2 expression and the function of resisting osteoporosis. The invention also provides a medicine composition containing the compound as the active ingredient. An in-vitro activity test shows that the compound represents obvious up-regulating function for the bone morphogenetic protein BMP-2 expression; and an SAMP6 rapidageing mice in-vivo activity test result shows that the compound has the function of improving the osteoporosis of ageing model mice. The invention provides a basis for further research and development of the osteoporosis-resisting medicine of the compound.

The invention discloses a nutrient compound type yogurt and a preparation method thereof. Ingredients used and percentages of the nutrient compound type yogurt are as follows: 40 to 80 percent of fresh milk or 6 to 15 percent of milk powder, 0.1 to 15 percent of nutrient complex substance (mixture of one or two or three of collagen protein, sweet potato and oats), 2 to 10 percent of white sugar, 2 to 8 percent of a mixed fermenting agent mixing with bulgaria lactobacillus and streptococcus thermophilus and the margin is water. The yogurt of the invention is characterized in that: the nutrient complex substance is added with the collagen protein, the sweet potato and the oats, thus being capable of realizing nutrient complementation of animals and plants, wherein, the collagen protein contained has the effects of facial beautification and skin maintenance, anti-osteoporosis, etc. The cancel prevention of the sweet potato ranks the first among fruits and vegetables and the sweet potato can promote the absorption and utilization ratio of protein; the content of protein contained in the oats ranks at top among grain crops, the oats also contains 8 kinds of amino acids needed by human body, the calcium content of the oats is also higher than other food crops and the contents of vitamins B1 and B2 are also quite abundant. Compared with the existing yogurt, the nutrient supplementation of the yogurt of the invention is more reasonable and complete, thus being a health-care food being applicable both to the old and the young.

The invention relates a preparation containing organic effective components and having curative and healthy functions on osteoporosis and cardiovascular and cerebrovascular diseases. The preparation is prepared by mixing vitamin K2 0.01 to 0.5 g with coenzyme Q10 5 to 10 g, heating with walnut oil 300 g at 40 DEG C, stirring to dissolve, adding walnut oil 599.5 to 694.99 g under stirring, and mixing uniformly to obtain a mixed solution 1000 g. The solution can be further packaged to soft capsule or hard capsule, and the vitamin K2 is one or a plurality of kinds of vitamin K2 (5) to K2 (50). The preparation can be used for prevention and assistant treatment of the cardiovascular disease, and has the healthy and the curative effects on increasing bone density and resisting osteoporosis.

The invention discloses a Chinese traditional medicine sevenlobed yam rhizome osteoporosis-preventing activity extractive and the extraction process of active ingredient as well as the use for curing osteoporosis. The process uses Chinese traditional medicine of sevenlobed yam rhizome and the dried tuber of freshly collected sevenlobed yam rhizome as raw materials, and adopts solvent extraction method, resin absorption method, reserve-phase pole chromatography and opposite phase pole chromatography to prepare the extractive. Moreover the process uses sevenlobed yam rhizome activity extractive as raw material, and adopts reserve-phase pole chromatography, opposite phase pole chromatography, reserve-phase preparation thin layer chromatography, opposite phase preparation thin layer chromatography, crystallization method and preparation liquid phase chromatogram for separation to obtain each monomer composite. The sevenlobed yam rhizome extractive and partial monomer composites obtained from the process are applied in preparing the drug of preventing osteoporosis.

The invention discloses a method for preparing fish egg sugar protein peptide with an anti-osteoporosis effect. The method comprises the following steps: performing freeze drying on the fish eggs, and performing ungrease treatment by using ethanol; performing freeze drying on the fish eggs subjected to ungrease treatment, adding protease for hydrolyzing, regulating pH value of the hydrolysate into neutral after the hydrolysis is ended, performing ultrafiltration and desalting the supernatant fluid of the centrifuged hydrolysate, concentrating and drying to obtain the fish egg sugar protein. The prepared fish egg sugar protein peptide can be used for preparing health-care food, functional food or medicines for preventing and treating osteoporosis. The used raw materials are rich and readily available, the product can perfectly keep the structure of sialic acid in the fish egg sugar protein, and the method is simple in process steps, low in equipment investment, free in environmental pollution and suitable for industrial production. The product has high anti-osteoporosis activity and can be develop the food or medicines with the effects of safely and effectively preventing and treating osteoporosis; and meanwhile, the defects of the development and utilization of fish egg sugar protein are overcome, and a novel way for high-valued processing of fish eggs is developed.

The invention provides a total-nutrient formulated food, a specific total-nutrient formulated food or a non-total-nutrient formulated food eaten by patients with osteoporosis. According to the requirements of general rules for formulated foods with special medical purposes, the formula is developed by combining with the physical characteristics of the patients with osteoporosis, integrating the research results of the advanced physiology, medicines, nutriology and clinical application and the like in the Harvard University of the modern America and depending on the essential theory of the traditional Chinese medicine, i,e., elimination of internal heat for replenishing and balanced nursing (the common nursing of liver, spleen and kidney as the main principle). The total-nutrient formulated food is formed by mixing multiple medicinal-edible traditional-Chinese-medicine extract essence, multiple probiotics and oligopeptide as main raw materials and adopting prebiotics, carbohydrate, amino acid, multiple vitamins and minerals as auxiliary materials, not only can be used as single nutrition to meet the nutritional requirement of patients with osteoporosis, but also can realize the effects of tonifying the kidney and strengthening the bones, nourishing the kidney and moistening the lung, tonifying the spleen and benefiting qi, promoting reunion of fractured bones, building the body, warming the kidney and supporting yang and resisting the osteoporosis.

The invention provides a drug composition for curing climacteric syndrome and a preparation method thereof. The drug is made of raw medicines such as radix rehmanniae preparata, broomrape, milk veteh, epimedium and psoralea and can be processed into any one of clinically acceptable oral liquid, syrup, tablets, capsules, granular formulation and soft capsules. The drug composition can replenish vital essence to tonify the kidney, relieves liver qi stagnation, invigorate spleen and stomach, replenish qi and blood, activate blood and dissolve stasis, is used for curing the climacteric syndrome with the symptoms such as insomnia, amnesia, dizziness, tinnitus, inappetence, soreness-tired of waist and knee, depression, irritability, testiness and sexual function decrement and also can delay aging, enhance immunity and prevent osteoporosis.

The invention discloses dual-functional oleanolic acid derivatives as well as a preparation method and application thereof. The oleanolic acid derivatives comprise pyrazole, isoxazoles oleanolic acid derivatives, quinoxalines oleanolic acid derivatives, oxazole, thiazoles oleanolic acid derivatives and pyrans oleanolic acid derivatives. The oleanolic acid derivatives disclosed by the invention have anti-inflammatory, anti-viral, anti-tumor and immune regulating effects and important biomedical activities such as inhibiting platelet aggregation and are widely used in the preparation of a medicament for the treatment of osteoporosis. According to the preparation method of the oleanolic acid derivatives disclosed by the invention, novel anti-osteoporosis oleanolic acid derivatives, which have dual characteristics of inhibiting osteoclast formation and bone resorption activity and promoting bone formation activity, are successfully prepared by introducing different heterocyclic ring systems such as quinoxaline, pyrazole, isoxazole, thiazole, pyran ring at oleanolic acid A ring and introducing different substituents at 28-position and have good practicability.

Osteoporosis is one of the major problems in our aging society. Osteoporosis results in bone fracture in older members of the population, especially in post-menopausal women. In traditional medicine, there are many natural crude drugs that have the potential for use to treat bone diseases. So far, there is no report in literature on anti-osteoporosis (bone forming) activity of Butea species. It was thought to study the anti-osteoporotic activity of this plant. Thus, the present invention provides a pharmaceutical composition from the extracts of Butea monosperma for prevention or treatment of bone disorders, process of preparation and use thereof.

The invention relates to a rabdosia rubescens liquid extract and a preparation method thereof. The preparation method includes cleaning dry rabdosia rubescens with running water, adding double distilled water according to the proportion of 1:(20-28) (g:ml) and stirring and extracting for 10-60 minutes at the temperature of 60-100 DEG C, filtering to obtain clean liquid, concentrating the clean liquid at the temperature of 40 DEG C on a decompressing condition, and finally obtaining the dry powder of the rabdosia rubescens liquid extract. The invention further provides an analysis method of the rabdosia rubescens liquid extract, and further relates to application of the rabdosia rubescens liquid extract on ovariectomized rat model as an anti-osteoporosis agent.

The invention relates to a raw grain-vegetable nutrient rice noodle capable of promoting the calcium supplement and absorption of females and a production process thereof, and belongs to the technical field of food engineering. The raw grain-vegetable nutrient rice noodle comprises a mixture A and a mixture B, wherein the mixture A is prepared by mixing corns, unpolished rice, wheat germs, bone exospore lactobacillus fermentation calcium powder, germinated and dried black beans, germinated and dried green beans and germinated and dried yellow beans; the mixture B is prepared by mixing apples, dried blueberry fruits, carrots, celery and black funguses. The preparation method comprises the following steps of: germinating and drying beans, and then respectively grinding, mixing with the bone exospore lactobacillus fermentation calcium powder in proportion, humidifying, aging, cooling and grinding for standby application; respectively rinsing, draining, dicing, carrying out microwave enzyme deactivation, sterilization and worm egg killing, cooling, prefreezing, and freeze-drying fruits, vegetables and the black funguses for standby application; then mixing, sterilizing, and drying. The raw grain-vegetable nutrient rice noodle disclosed by the invention is increased in isoflavone content after the beans are germinated, can be used for supplementing the calcium by being matched with the bone exospore lactobacillus fermentation calcium powder, promotes the calcium absorption and is suitable for the anti-osteoporosis of the females.

The invention discloses application of general flavone in sophora flavescens in preparing a medicine. The invention is characterized by application of flavonone and flavonone alcohols derivatives in preparing an anti-osteoporosis medicine. The application has the advantages of reliable healing efficacy, non toxic or side effects, rich resource, low price and the like.

The invention relates to a kind of prenylflavonoids and their application in the preparation of anti-osteoporosis drugs. The invention isolated 7 prenylflavonoids from Jackfruit moraceae plants of the genus artocarpus (I) (Artocarpus / I) (I) (heterophyllus / I), were 5'HydroxycudraflavoneA, artochaminB, artelastoxanthone, artoindonesianinQ, kuwanonT, artoheteroidA and artoheteroidB. Activity tests showed that the prenylflavonoids of the invention has strong inhibitory activity on important therapeutic target for osteoporosis -- protease K, the prenylflavones' IC50 is 0.88 - 93.9mM, can be used for preparing drugs for treating osteoporosis.

The invention relates to novel uses of rhodiola effective ingredient in prevention and cure for osteoporosis. As experiment demonstrates: the compound can obviously upgrade osteotropic protein bmp-2 and mRNA expression in an osteoporosis-resisting medicine screening model, obviously facilitates osteoblast proliferation of human, alkaline phosphatase activity and collagen synthesis and increase osteogenous bone formation, thereby possessing prospect of medicine for prevention and cure for osteoporosis.

The invention relates to the technical field of medicines, and relates to applications of a Podocarpium podocarpum extract, and total flavonoids and a kaempferitrin monomer compound separated therefrom in the preparation of medicines or foods for preventing and curing osteoporosis. Dry all grass of Podocarpium podocarpum is extracted and separated as a raw material to obtain the Podocarpium podocarpum extract, the Podocarpium podocarpum extract is used to prepare Podocarpium podocarpum total flavonoids, and the kaempferitrin monomer compound is separated. Results of in vivo and in vitro experiments show that the Podocarpium podocarpum extract, the Podocarpium podocarpum total flavonoids or the kaempferitrin monomer compound has a good anti-osteoporosis bioactivity, so the Podocarpium podocarpum extract, the Podocarpium podocarpum total flavonoids or the kaempferitrin monomer compound can be used for preparing the medicines or foods preventing and treating osteoporosis. The Podocarpium podocarpum extract, the Podocarpium podocarpum total flavonoids or the kaempferitrin monomer compound has a simple preparation method, and provides a new medicine source for the anti-osteoporosis.

The invention discloses a method of extracting triterpene from Achyranthes bidentata Bl. and use of the triterpene for anti-osteoporotics. The method comprises the following steps: dry roots of the Achyranthes bidentata Bl. are crushed; reflux extraction is performed on the crushed roots to obtain ethanol extract by ethanol heating; and the ethanol extract is extracted by esters such as ethyl acetate and the like for 1-4 times to obtain ester extracting solution, or the extract distilled water suspension extracted by the esters such as the ethyl acetate and the like is extracted by alcohol such as n-butyl alcohol and the like for 1-4 times to obtain alcohol extracting solution, finally the aqueous extract is obtained, and the obtained triterpene extract is used in anti-osteoporosis, wherein, the triterpene extract comprises new compounds such as found 28-deglucose Achyranthes saponin E dimethyl ester. The triterpene extract has good effect on anti- osteoporosis, and particularly an estrogen replacement therapy is unnecessary for female osteoporosis. The triterpene extract is a natural substitute drug with low side effect.

The invention provides a novel bone-target nano-particle with high affinity and a method for preparing the novel bone-target nano-particle. The novel bone-target nano-particle comprises PLGA-PEG-COOHpolymer medicine carriers, a bone-target substance tetracycline and hydrophobic medicines. The novel bone-target nano-particle and the method for preparing the novel bone-target nano-particle with thehigh affinity have the advantages that PLGA-b-PEG-COOH polymers can be generated by polymers PLGA-COOH and NH2-PEG-COOH under the effects of EDC / NHS catalysts, surface modification is carried out bythe tetracycline, carriers have bone tissue target performance by the aid of the bone deposition ability of the tetracycline, and accordingly anti-osteoporosis medicines can be effectively delivered to bone tissues; the carriers have the bone tissue target performance by the aid of the bone deposition ability of the tetracycline, and accordingly the anti-osteoporosis medicines can be effectively delivered to the bone tissues.