143 results about "Iridoid" patented technology

The invention discloses an extraction and purification process for medicinal components of Scrophulariaceae, namely an extraction and purification process for iridoid and phenylpropanoid components: pulverizing dry roots of Scrophulariaceae, soaking, water extraction, concentration of the extract, and ethanol precipitation , resin adsorption, ethanol elution, concentrated drying and other procedures obtained. The extraction and purification process of the invention has high extraction rate, can reach more than 50%, stable and controllable quality, simple method and low composition, and is suitable for large-scale industrial production, thereby providing a new way for the development and utilization of Scrophulariaceae.

The present invention relates to an application of iridoid in the preparation of anti-osteoporosis medicines, which belongs to the medicines technical field. The invention provides an application of iridoid which is shown in a general formula I in the preparation of medicines used for treating and / or preventing osteoporosis. Experiments found that ALP activity in UMR106 cells is taken as guidance for tracing and separating an extract of iridoid possessing general formula I, the extract and each separated component are researched from the aspects of osteoblast propagation and antioxidation activity, the iridoid possessing the general formula I has the effects of substantially promoting alkaline phosphatase activity and osteoblast differentiation, so that the iridoid has anti-osteoporosis effect and can be used for preparing the medicines used for treating or preventing osteoporosis. The component of specnuezhenide and a compound G13 possesses the effects of substantially promoting the alkaline phosphatase activity and osteoblast differentiation, and the specnuezhenide has effects for obviously promoting UMR-106 cell proliferation, a better effect is obtained when the specnuezhenide is used for anti-osteoporosis effect.

The invention discloses an application of iridoids in preparing drugs for promoting nerve cell proliferation and / or differentiation and a method for treating diseases related to nerve cell proliferation and / or differentiation by using the same.

The invention belongs to the medication technical field, and in particular relates to application of iridoid in preparing anti-tumor medicine. Animal experiments proves the compound has obvious inhibiting effect on various cancer cells without toxic effect or side effect, so that the compound can be used for preparing the anti-tumor medicine. The invention further provides a medicine composition using the iridoid as an active composition for treating tumor. The compound can either be extracted from plants, or obtained by a chemical synthesizing method.

The invention discloses a serial of iridoids compounds with the structural formula (I), the application of the compounds in preparing medicaments applied to the prevention or treatment of nervous system degenerative disorders such as senile dementia and the like, the medical compositions containing the compounds and a preparation method of the compounds. The structural formula is as shown above, wherein, various groups are defined in the instruction.

The present invention relates to a medicine for curing cerebrovascular diseases and its preparation method. The effective component of said medicine is gardenia total iridoid glycoide extracted from Chinese medicinal material gardenia root, in which its main component is gardenaside. Said invention also provides dosage form of said medicine, specially provides its capsule preparation.

The invention discloses a total effective part extractive of morinda officinalis, a preparation method and application thereof in medicaments for treating snoring, and the total effective part comprises the following components in percentage by weight: 50-90 percent of morinda officinalis total polysaccharide, 2-5 percent of morinda officinalis total anthraquinone, 5-30 percent of morinda officinalis total iridoids and the like. The preparation method comprises the following steps of: drying the morinda officinalis, and crushing into 10-100 meshes; heating with water for reflux extraction; processing the extract by using a weak base anion exchange resin column, collecting the cross-flow liquid and water eluent, and condensing and drying to obtain the total polysaccharide; carrying out reflux extraction on the dregs of decoction with petroleum ether or 6# extraction solvent oil or other organic solvents with polarity similar to that of the dregs, and removing low-polarity components, such as essential oil and the like; heating the residual dregs with ethanol water with a certain concentration for reflux extraction, and condensing the extract to prepare the total anthraquinone and total iridoids; and then merging the three components, and drying to obtain the total effective part extractive of morinda officinalis. The product of the invention is used for treating snoring (also called as Sleep apnea syndrome (SAS)), and has the advantages of quick and remarkable curative effect, no toxic or side effect, low price, convenient use and the like.

The invention relates to a hair dye and particularly relates to a natural durable hair dye prepared from iridoid and amino acid and a hair dyeing method. The hair dye provided by the invention contains an agent A, an agent B and an agent C, wherein the agent A contains 8-12% of amino acid, 1.0-5.0% of thickening agent, 0.5-1% of vitamin C and the balance of water, and the pH value of the agent A is adjusted to 8-10; the agent B contains 2-5% of iridoid, 1.0-5.0% of thickening agent, 2-4% of phenethyl alcohol and the balance of water; the agent C contains 3-12% of hydrogen peroxide, 1-5% of thickening agent and the balance of water. The hair dyeing method comprises the steps of firstly, discoloring hair, and then, washing and drying; then, uniformly coating the agent A on the hair, and keeping at the temperature of 30-35 DEG C for 15-25min; next, uniformly coating the agent B on the hair, and keeping at the temperature of 30-35 DEG C for 15-25min; finally, uniformly coating the agent C on the hair, keeping at the temperature of 30-35 DEG C for 20-25min, washing and drying the hair. No substances capable of generating toxicity to human bodies are generated in preparation and application processes of the hair dye; the hair dye is good in safety, capable of dyeing the air into various colors such as black, red, yellow, purplish red and the like, plentiful in dyed colors and favorable in fastness.

The invention belongs to the medication technical field, in particular relates to application of a mother-nucleus conjugated iridoid in preparing anti-tumor medicine. Animal experiments proves the compound has obvious inhibiting effect to various cancer cells without toxic or side effect, so that the compound can be used for preparing the anti-tumor medicine. The invention further provides a medicine composition using the mother-nucleus conjugated iridoid as an active composition for treating tumor. The compound can either be extracted from plants, or obtained by a chemical synthesizing method.

The present invention relates to the technological process of extracting secoiridoid glycoside product from medicinal plant gentian. Gentian herb or its root, leaf and flower as material is reflux extracted with hydrophilic solvent, separated and enriched with macroporous resin with selective adsorption on water soluble components, to obtain secoiridoid glycoside product with secoiridoid glycoside content over 20 %. The technological process of the present invention is simple, easy in operation, safe and high in repeatability, and may be used in industrial production.

A provided preparation method for the effective part of valerianajatamansi epoxy iridoid ester comprises: A, using an extraction solvent to performing extraction on medicinal material valerianajatamansi to obtain the extract; B, concentrating the extract, adding water, mixing, extracting with dichloromethane to obtain the extract liquor, extracting the extract liquor to obtain epoxy iridoid ester crude extract; and C, performing positive column chromatography on the epoxy iridoid ester crude product, eluting with an eluant, collecting the eluate and drying to obtain the effective part of valerianajatamansi epoxy iridoid ester, wherein the eluant is an eluant composed of petroleum ether and ethyl acetate with a volume ratio of 15-2:1. The valerianajatamansi epoxy iridoid ester effective part prepared by employing the method is strong in biological activity, simple in operation and low in production cost, has the advantages of being stable in stable, controllable and the like, and is applicable to preparation of cancer treating medicines.

The invention provides the application of iridoid compound to the preparation of ovarian cancer resistance medicament. The iridoid compound is isovaleric acid base dihydro valerian element or isovaleric acid base dihydro valepotriate J which has the following structural formula. The experiments on the toxic and killing effect of the isovaleric acid base dihydro valerian element or the isovaleric acid base dihydro valepotriate J on the p 53 wild ovarian cancer cells A2780, the p53 mutated OVCAR-3 cells and the normal ovarian cells IOSE144 show that the isovaleric acid base dihydro valerian element or the isovaleric acid base dihydro valepotriate J has the selective toxic and killing effect on the ovarian cancer cells and can inhibit the proliferation of ovarian cancer cells and kill the ovarian cancer cells. The iridoid compound can be used as the active component to prepare the ovarian cancer resistance medicament. The invention provides the novel ovarian cancer treatment medicament for the clinical treatment of the ovarian cancer and brings the joyous news to the patients with the ovarian cancer. The iridoid compound has higher application value.

The invention discloses a novel iridoids compound with a structure shown in formula I and a neuroprotective effect thereof, a preparation method of the compound I and an application of a pharmaceutically acceptable salt of the compound in the preparing of medicines for treating and preventing central nervous system diseases, and an application of the compound or the pharmaceutically acceptable salt thereof in the preparing of medicines with nerve cell protection effects. The cell survival rate of a 18mg / L group of the compound with the structure shown in formula I is obviously higher than a glutamic acid group (P(0.01)), so that the compound with the structure shown in formula I has an obvious protection effect on PC12 (pheochromocytoma-12) cells damaged by glutamic acid and can be used for preventing and treating central nervous system diseases such as cerebral infarction, Alzheimer disease, Parkinson disease, anxiety disorder and the like.

A scorphularoside for preparing the medicine to treat ischemic cerebral apoplexy is prepared from scrophularia root through extracting in alcohol, filtering, concentrating, depositing in alcohol, filtering supernatant, concentrating, chromatographing, eluting white water and then alcohol, concentrating the eluting liquid and drying.

The present invention comprises compositions and methods for the treatment of liver disease, particularly treatments for infection by HCV and / or HBV. The present invention comprises antiviral compositions comprising lamiridosin, derivatives of lamiridosin or iridoids that are effective in inhibiting one or more steps in the infection of cells by HCV or HBV. Methods for treating subjects, particularly humans, infected with HCV or HBV are provided.

The invention discloses a long-acting skin marking pen based on a genipin coloring principle. The long-acting skin marking pen comprises raw materials as follows: 1%-6% of genipin, 1%-3% of gentian violet, 20%-30% of ethyl alcohol, 10%-20% of propylene glycol, 0.3%-0.5% of xanthan gum, 2%-3% of polyvinylpyrrolidone and 60%-70% of water. The genipin is added, is an iridoid compound and can react with silk fibroin to form a final color product, the color product can permanently dye hard membrane outer layers of human skin to form black blue temporary tattoo unit skin is regenerated after 2-3 weeks, so that the duration is up to 2-3 weeks after coloring by the skin marking pen, a traditional invasive laser dotting making manner can be replaced, pain experience of patients during marking can be avoided; secondly, the long-acting skin marking pen can avoid the condition that colors fade after marking by common skin marking pens to affect treatment accuracy.

The invention belongs to the field of traditional Chinese medicine, and particularly relates to eucommia ulmoides composition for treating cardiovascular diseases. Ingredients of the composition are from traditional Chinese medicine eucommia ulmoides and specifically comprise, in percentage by weight, 10%-80% of total flavonoids of eucommia ulmoides, 10%-80% of iridoid of eucommia ulmoides and 10%-80% of lignans of eucommia ulmoides. Preferably, the composition comprises, in percentage by weight, 20%-40% of total flavonoids of eucommia ulmoides, 40%-60% of iridoid of eucommia ulmoides and 20%-50% of lignans of eucommia ulmoides. Single effective parts of eucommia ulmoides are combined, and the eucommia ulmoides composition with remarkable curative effect and clinic development prospect is obtained through adjustment of relevant weight ratios.

The invention relates to the technical field of natural medicaments, and in particular relates to a method for extracting iridoid active ingredients from plantain seeds. In the method provided by the invention, a plantain seed extract is obtained through adopting a solvent for extraction and refining with a chromatographic process or a combination of chromatography and a solvent extraction method. The prepared plantain seed extract contains more than 50% by weight of iridoid active ingredients. The method is simple and has an industrial application prospect.

The invention discloses iridoid ester compounds and a preparation method thereof, and application of the iridoid ester compounds in cancer therapy. The structure of the iridoid ester compounds is disclosed as Formula (I) or Formula (II). The preparation method comprises the following steps: A. extracting a medicinal material by using an extraction solvent to obtain an extracting solution; B. concentrating the extracting solution, adding water for suspension, extracting respectively with organic solvents with gradually increasing polarity to obtain an extract, and concentrating the extract to obtain an iridoid ester crude extract; C. passing the iridoid ester crude extract through a normal-phase column, and eluting with an eluting agent; collecting the eluate, and drying to obtain an extract which is enriched with two novel iridoid ester compounds; and D. carrying out reverse-phase medium-pressure column chromatography and preparative high-efficiency liquid-phase column chromatography on the extract to obtain the two novel iridoid ester compounds. The preparation method is simple to operate and low in production cost; and the obtained product can be used for preparing cancer therapeutic drugs, and has favorable development prospects.

The invention provides application of iridoid with a general formula (I) in preparation of medicines for treating or preventing SARS (severe acute respiratory syndromes). R1 is selected from H, CH3, COOH or COOCH3; R2 is selected from H or OH; R3 is selected from H, OH, and OCOCH3; R4 is selected from H, OH or CH3; R5 is selected from H, CH3, OCOCH3, OH or CH2OH; R6 is selected from H, OH or CH3; and R7 is selected from H or OH. The IC50 (half maximal inhibitory concentration) value of compound 6 beta-hydroxyipolamiide is 138.8 muM, the IC50 value of compound shanzhiside methyl ester is 104.1 muM, and the IC50 value of compound 8-o-acetyl shanzhiside methyl ester is 125 muM.

The invention discloses a gentianella acuta extract for treating arrhythmia. The extract consists of ketone compounds, iridoid compounds and flavonoid compounds. The invention also discloses a preparation method and application of the gentianella acuta extract. The gentianella acuta extract disclosed by the invention comprises 20-40% of ketone compounds based on the total weight of the extract, 5-15% of iridoid compounds based on the total weight and a small amount of flavonoid compounds, wherein the ketone compounds include 1,3,5,8-tetrahydroxy tetrahydro-ketone, nor-chiratin, 3,8-O-beta-D-diglucopyranose-1,5-dihydroxy-keton, nor-bellidifolin, 1,3,5-trihydroxy-ketone, 2-O-beta-D-n glucopyranose-1-hydroxy-5,6-dimethoxy-ketone and 1,2,8-trihydroxy-5,6-dimethoxy-ketone; the iridoid compounds include gentiopicroside, swertiamarin and decentapicrin; the flavonoid compounds include isoorientin and isovitexin. Chemical and pharmacological experiments prove that the gentianella acuta extract can be used for treating arrhythmia caused by coronary heart disease and ischemic heart disease. The gentianella acuta extract can be made into drugs of various dosage forms independently or by compatible combination or can be used as a raw medicine.

The invention provides an armyworm and spica parallelangula alpheraky attractant and application thereof to planting of buckwheat in saline-alkali soil. The armyworm and spica parallelangula alpheraky attractant comprises the following components: p-cymene, alpha-curcumene, propylgallate, 1H-Benzotriazole, terpenol phthalate, split-ring lactone iridoid, himachalol, 4-terpineol, trans-2,4-decadienal, 2-methyl-3-(4-tolyl)-2-acrolein, 2-(1,1-dimethyl)-cyclohexanol and 1,4-butanediol dipropanoate. When the armyworm and spica parallelangula alpheraky attractant is applied to planting of buckwheat in saline-alkali soil, the average daily trap quantity of armyworms is 21-28 per trap, and the average daily trap quantity of spica parallelangula alpheraky is 28-36 per trap; the pest incidence of armyworms is only 6-9%, and the pest incidence of spica parallelangula alpheraky is only 5-8%; the pest occurrence area of armyworms is only 12-18% and the pest occurrence area of spica parallelangula alpheraky is only 9-16%.

The invention discloses a fermentation processing method of noni enzyme. The method comprises the steps of selecting fresh, non-moldy and pest-free noni for use; juicing, carrying out ultrasonic treatment on juice, then mixing the obtained juice with sterile water, and carrying out ultrasonic treatment on the mixed liquid to obtain a mixture A; cooking the mixture A, then adding saccharifying enzyme into the cooked mixture A for fermenting, filtering, adding lactobacillus thermophilus for fermenting, filtering, and adding lactobacillus plantarum for fermenting so as to obtain a mixture G; sterilizing the mixture G, filling, and testing whether the product is qualified or not. The fermentation processing method adopts step-by-step fermentation in three stages, thus protecting original components of the noni from being damaged, and maintaining more than 150 amino acids, xeronine and xeronine converting enzyme, iridoids, alkaloids, vitamins, minerals, and the like; after the method is adopted, the dissolving-out amount of effective components reaches up to 95% or above, and the dissolved effective components are very easy to absorb by a human body; the noni enzyme can remove and decompose residual hormone fertilizers, pesticides and the like in the noni; the product meets the standard of China and has a high medical value for the treatment of chronic syndromes of middle-aged and aged people.

The invention discloses an analysis method for researching a fingerprint spectrum of a Mailuoning injection based on UPLC-DAD-MS. On the basis of research on early-stage chemical components, the UPLC-DAD-MS liquid chromatography-mass spectrometry fingerprint spectrum of the Mailuoning injection is established, and 23 main components including 13 organic acids, 1 coumarin, 2 iridoid, 1 flavone, 1 lignan, 3 saponins and 2 other components can be directly analyzed and identified. According to the method, optimized chromatographic conditions can be rapidly obtained; therefore, the optimal fingerprint spectrum is obtained, reproducibility is good, the relative retention time and the relative peak area variation are both less than 5%; the main chemical component composition of the Mailuoning injection is accurately illustrated, which is of great significance to illustration of the pharmacodynamic material basis of the Mailuoning injection, and lays a foundation for improvement of the qualitycontrol standard of the Mailuoning injection, establishment of a scientific and reasonable quality control method and optimization of a preparation process.

The invention relates to a compound extracted from Tibetan medicine eriophyton wallichii with antioxidant activity and an extracting method thereof. The compound is identified as new iridoid through modern spectral analysis, wherein the molecular weight is 780, and the molecular formula is C34H52O20. The extracting method comprises the following steps of: pulverizing whole eriophyton wallichii; extracting with ethanol; sequentially extracting by using petroleum ether, ethylacetate and water saturated n-butanol; carrying out chromatography on the n-butanol part by macroporous absorption resin; and carrying out column chromatography on 30 percent of an elution part sequentially through MCI-GEL CHP20P, ODS-A and Sephadex LH-20 so as to obtain wallchiiside F. The new iridoid has simple preparation method, low cost and obvious activity and provides a new compound for developing medicaments having antioxidant effects.

The invention discloses iridoids, and a preparation method and application thereof. The structural formula of the iridoids is disclosed as Figure 1. The preparation method comprises the following steps: leaching Gentiana triflora Pall. in an organic solvent to obtain a leaching solution; extracting the leaching solution, and concentrating the extracting solution to obtain an extract; and separating and purifying the iridoids from the extract. The iridoids are applicable to preparing anti-inflammatory agents. Compared with the prior art, the iridoids disclosed by the invention are new compounds having strong anti-inflammatory activity, and can be used for preparing anti-inflammatory agents.

The invention discloses the usage of iridoid compounds in preparing the drug for the treatment of benign prostatic phyperplasia. The compounds come from valerianaceae plants which have a long medical history and excellent safety. The drug-effect substance of the compounds is clearer than original spider fragrant plant extract. The invention makes the possibility for good market outlook of new anti benign prostatic phyperplasia medicament.

The invention belongs to the field of traditional Chinese medicines, and particularly relates to an eucommia targeting preparation for treating colon cancer and a preparation method thereof. The eucommia targeting preparation comprises eucommia composition and auxiliary materials, wherein the eucommia composition comprises, in percentage by weight, 10-80% of eucommia phenylpropanoids, 10-80% of eucommia iridoid and 10-80% of eucommia polysaccharide; the auxiliary materials comprise one or more of pectin, pectic calcium, polyacrylic resin, chitosan, beta-cyclodextrin, lactose, calcium hydrophosphate, glucan, amylose, guar gum, chondroitin sulfate, sodium alginate, talcum powder, aerosil, calcium bicarbonate and magnesium stearate.

The invention discloses a method of separating epivogeloside from iridoids in extracts of honeysuckles through cation exchange resin, wherein the method includes the steps of: a) soaking the cation exchange resin with an ethanol solution being 20% in volume fraction for packing a column; b) packing the treated cation exchange resin treated in the step a) as a filler in the chromatographic column; c) with an equilibrium liquid, equilibrating the chromatographic column for loading the sample; d) dissolving a crude product of a honeysuckle extract in deionized water to prepare a honeysuckle extract solution; e) injecting the honeysuckle extract solution into the chromatographic column; and f) eluting the target substance from the chromatographic column with an eluent. The method is simple in operation, is less in energy consumption, is short in time consumption, is low in cost and is high in purity. The method overcomes the defects of complex steps and operations, high cost, low yield and low purity of a conventional process.