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Extraction and Refining Technology of Medicinal Components of Scrophulariae Scrophulariae

A technology for medicinal ingredients and Scrophulariaceae, which is applied in the field of extraction and refining of iridoid and phenylpropanoid components in Scrophulariaceae, can solve the problem of low content of iridoids and phenylpropanoid components and difficulty in realizing large-scale industrialization Production, restricting product application and other issues, to achieve the effect of low cost, stable and controllable quality, and simple method

Inactive Publication Date: 2011-12-14
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In recent years, there are also a few reports on the extraction of iridoids and phenylpropanoids in Scrophulariaceae, such as ultrasonic extraction, semi-bionic extraction, etc. The content of iridoids and phenylpropanoids in products prepared by these methods It is relatively low, and contains a large amount of impurities such as proteins and sugars. It is difficult to control the quality, and it is difficult to realize large-scale industrial production, which limits the application of the product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] 15 kg of dried roots of Scrophulariaceae were dried at 35°C and crushed. Add 75L of water to soak for 2 hours, then add the soaked Scrophulariaceae into the extraction tank at a material-to-liquid ratio of 1:6, and extract 3 times for 3 hours each time. The extracts were filtered, combined, and concentrated in vacuo to obtain 7.5 L of concentrated solution. Add 95% ethanol to the concentrated solution to a final concentration of 60%, refrigerate and precipitate twice for 24 hours each time, filter the ethanol precipitated solution, combine them, and conduct vacuum concentration to obtain 5 L of concentrated solution. The concentrate was statically adsorbed with 15kg D1400 macroporous resin for 0.5 hour, washed with 8 times column volume of water, and then eluted with 5 times column volume of 40% ethanol. Collect the 40% ethanol eluate, concentrate in vacuo to obtain the extract, and freeze-dry to obtain the product. It has been determined that the total content of iri...

Embodiment 2

[0019] 15 kg of dried roots of Scrophulariaceae were dried at 40°C and crushed. Add 90L of water to soak for 3 hours, then add the soaked Scrophulariaceae into the extraction tank at a material-to-liquid ratio of 1:6, and extract twice for 2 hours each time. The extracts were filtered, combined, and concentrated in vacuo to obtain 10 L of concentrated solution. Add 95% ethanol to the concentrated solution to a final concentration of 80%, refrigerated precipitation once, 48 hours each time, filter the alcohol precipitated solution, combine them, and conduct vacuum concentration to obtain a concentrated solution of 7.5 L. The concentrated solution was statically adsorbed with 5kg D1400 macroporous resin for 0.75 hours, washed with 12 times column volume of water, and then eluted with 10 times column volume of 40% ethanol. Collect the 40% ethanol eluate, concentrate in vacuo to collect the cream, and dry in vacuo at 60°C to obtain the product. It has been determined that the to...

Embodiment 3

[0021] 15 kg of dried roots of Scrophulariaceae were dried at 60°C and crushed. Add 105L of water to soak for 2 hours, then add the soaked Scrophulariaceae into the extraction tank with a material-to-liquid ratio of 1:8, and extract twice for 3 hours each time. The extracts were filtered, combined, and concentrated in vacuo to obtain 10 L of concentrated solution. The concentrate was added with 95% ethanol to a final concentration of 70%, refrigerated and precipitated three times for 48 hours each time, the alcohol precipitated liquid was filtered, combined, and concentrated in a vacuum to obtain 7.5 L of a concentrate. The concentrate was statically adsorbed with 5kg D1300 type macroporous resin for 0.25 hours, washed with 10 times column volume of water, and then eluted with 5 times column volume of 60% ethanol. Collect the 60% ethanol eluate, concentrate in vacuo to collect the cream, and dry in vacuo at 50°C to obtain the product. It has been determined that the total co...

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PUM

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Abstract

The invention discloses an extraction and purification process for medicinal components of Scrophulariaceae, namely an extraction and purification process for iridoid and phenylpropanoid components: pulverizing dry roots of Scrophulariaceae, soaking, water extraction, concentration of the extract, and ethanol precipitation , resin adsorption, ethanol elution, concentrated drying and other procedures obtained. The extraction and purification process of the invention has high extraction rate, can reach more than 50%, stable and controllable quality, simple method and low composition, and is suitable for large-scale industrial production, thereby providing a new way for the development and utilization of Scrophulariaceae.

Description

technical field [0001] The invention relates to a method for extracting and refining iridoids and phenylpropanoids in Scrophulariaceae. Background technique [0002] Scrophulariaceae contains a variety of iridoids and phenylpropanoids, such as harpagoside, harpagoside, cinnamic acid, ergoside, angroside C, etc. Pharmacological studies have shown that these ingredients have analgesic and anti-inflammatory properties. , antibacterial, liver protection, anti-oxidation, immune enhancement and other effects. It is worth mentioning that the iridoids and phenylpropanoids in Scrophulariaceae have a more prominent effect on the cardiovascular system, such as dilating coronary arteries, lowering blood pressure, anti-platelet aggregation, promoting fibrinolysis, and improving blood rheology. It has a good curative effect on congestive heart failure. [0003] In recent years, there are also a few reports on the extraction of iridoids and phenylpropanoids in Scrophulariaceae, such as u...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/808A61P1/16A61P7/02A61P9/04A61P9/10A61P9/12A61P29/00A61P31/04A61P37/04A61P39/06A61K125/00
Inventor 李医明张雪梅王瑞吴喜民吴迎春贾琦
Owner SHANGHAI UNIV OF T C M
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