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Medicine for curing cerebrovascular diseases and its preparation method

A technology for cerebrovascular disease and medicine, applied in the field of preparation of the medicine, can solve the problems of unestablished surgical treatment indications, lack of surgical treatment and the like

Inactive Publication Date: 2003-12-10
北京正青星光生物医学科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the lack of well-designed prospective surgical treatment compared with medical treatment, no clear indications for surgical treatment have been established at home and abroad.

Method used

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  • Medicine for curing cerebrovascular diseases and its preparation method
  • Medicine for curing cerebrovascular diseases and its preparation method
  • Medicine for curing cerebrovascular diseases and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Grind the gardenia medicinal material into coarse particles, extract twice with 70% ethanol, first use 10 times the amount to extract for 2 hours, and secondly use 8 times the amount to extract for 1.5 hours, combine the extracts, recover the ethanol, and concentrate to The relative density is about 1.20 (60°C), add 10 times the amount of water, let it stand, refrigerate for 24 hours, filter, and discard the upper oil layer and lower sediment. Concentrate the filtrate to an extract with a relative density of about 1.15 (60°C), add 95% ethanol of 6 times the amount of the extract, let it stand for 12 hours, take the supernatant, recover the ethanol, and concentrate to a relative density of about 1.15 (60°C) extract, add diatomite 1:1.8 times the amount of extract, mix well, dry under reduced pressure (50-60°C), crush into 20-mesh powder, and reflux extraction with ethyl acetate three times, each time Dosage 12 times, extract for 2 hours. Combine the ethyl acetate extrac...

Embodiment 2

[0063]Grind the gardenia medicinal material into coarse particles, extract 3 times with 70% ethanol, extract 10 times each time for 2 hours, combine the extracts, recover ethanol, and concentrate to a relative density of about 1.20 (60°C), add 10 Double the amount of water, let it stand, refrigerate for 24 hours, filter, discard the upper oil layer and lower sediment. Concentrate the filtrate to an extract with a relative density of about 1.20 (60°C), add 95% ethanol of 6 times the amount of the extract, let it stand for 12 hours, take its supernatant, recover the ethanol, and concentrate to a relative density of about 1.15 (60°C) extract, add diatomite 1:1.5 times the amount of the extract, mix well, dry under reduced pressure (50-60°C), pulverize into 20-mesh powder, and reflux extract with ethyl acetate three times, each time The dosage is 14 times, and the extraction takes 3 hours. Combine the ethyl acetate extracts, add activated carbon with 40% extract amount, reflux fo...

Embodiment 3

[0065] According to the method of Example 2, the total iridoid glycosides extract powder of Gardenia jasminoides was prepared, 10% of starch and 3% of magnesium stearate were added, mixed, granulated, dried, and compressed to obtain this product. Invented tablet dosage form.

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Abstract

The present invention relates to a medicine for curing cerebrovascular diseases and its preparation method. The effective component of said medicine is gardenia total iridoid glycoide extracted from Chinese medicinal material gardenia root, in which its main component is gardenaside. Said invention also provides dosage form of said medicine, specially provides its capsule preparation.

Description

technical field [0001] The invention relates to a medicine for treating cerebrovascular diseases and a preparation method thereof, in particular to a traditional Chinese medicine preparation which uses the total iridoid glycosides of Gardenia jasminoides contained in Gardenia jasminoides as the active ingredient of the medicine. The treatment has good curative effect, and the invention also provides a preparation method of the medicine. Background technique [0002] Hemorrhagic stroke is a common disease that seriously endangers people's health, and its incidence, prevalence, mortality and disability are high. According to the "International Statistical Yearbook" in 1996, the death rate of hemorrhagic stroke in my country ranks seventh in the world. According to the statistics of WHO in 1998, the annual cost of treating cerebrovascular diseases in major industrialized countries in the world is about 75 billion U.S. dollars, among which the treatment cost of hemorrhagic stro...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P9/10C07H1/08
Inventor 杨奎杨明付超美蒲旭峰周东
Owner 北京正青星光生物医学科技有限公司
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