144results about How to "Improve neurological function" patented technology

A neurostimulator device for use with groups (e.g., more than four groups) of electrodes. The neurostimulator may include a stimulation assembly configured to deliver different stimulation to each of the groups. The neurostimulator may also include at least one processor configured to direct the stimulation assembly to deliver stimulation to the groups. The stimulation delivered to at least one of the groups may include one or more waveform shapes other than a square or rectangular wave shape. The processor may receive data from one or more sensors and use that data to modify the stimulation delivered. The neurostimulator may be configured to communicate with an external computing device. The neurostimulator may send data to and / or receive data and / or instructions from the computing device. The computing device may use information collected by one or more sensors to at least partially determine stimulation parameters to communicate to the neurostimulator.

Methods and compositions are disclosed for enhancing neurogenesis, resolving neuropathy and improving neurological health and functioning using fungal extracts and their active ingredients, including species of mushrooms and mycelia containing psilocybin and psilocin, combined with erinacines and hericenones or fungal extracts containing those active ingredients, with the addition of nicotinic acid. The compositions may optionally be combined with nervine plants.

The invention relates to dose escalation enzyme replacement therapy using acid sphingomyelinase (ASM) for the treatment of human subjects having acid sphingomyelinase deficiency (ASMD), and, in particular, patients with non-neurological manifestations of Niemann-Pick Disease (NPD), and in certain embodiments, NPD type B.

A method for treating a subject having Parkinson's disease or Alzheimer's disease is provided. The method includes noninvasively delivering light energy having a wavelength of about 630 nanometers to about 904 nanometers to the brain of the subject. Delivering the light energy includes (i) irradiating the scalp with light energy having an incident power density between about 10 mW / cm2 to about 10 W / cm2, (ii) transmitting a portion of the light energy through the scalp and the skull to the brain, wherein the transmitted light energy has a power density of at least about 0.01 mW / cm2 at a depth of approximately 2 centimeters below the dura, or both (i) and (ii).

Methods and compositions are disclosed for enhancing neurogenesis, resolving neuropathy and improving neurological health and functioning using fungal extracts and their active ingredients, including species of mushrooms and mycelia containing psilocybin and psilocin, combined with erinacines and hericenones or fungal extracts containing those active ingredients, with the addition of nicotinic acid. The compositions may optionally be combined with nervine plants.

The invention provides a selenium-enriched five-cereal nutritional instant powder and a preparation method thereof, not only realizes the preparation of instant composite coarse cereal powder under the no addition condition, and has the advantages that the product taste is fine, has the fragrance of puffing coarse cereals, the selenium quantification can be realized, and the product is suitable for demands for selenium supplementation of crowds with selenium deficiency. The five-cereal nutritional instant powder rich in selenium comprises selenium-enriched rice and various cereals as well as auxiliary materials, can be selenium-containing hair nourishing brain strengthening nutrient powder, selenium-containing children's nutrient powder, selenium-containing blood and qi nourishing nutrient powder or selenium-enriched liver nourishing and protecting nutrient powder. The preparation method comprises the steps of soaking fresh five cereals taken as raw materials, mixing the soaked five cereals and water, drying and smashing to obtain five-cereal powder; mixing the five-cereal powder and ethyl alcohol to prepare soft material, then carrying out granulation to obtain five-cereal instant particles; and drying the five-cereal instant particles to obtain the five-cereal instant powder. The preparation method for the five-cereal nutritional instant powder is simple, the obtained five-cereal instant powder is easy to dissolve, the instant time is less than 20 seconds, and the agglomeration probability is low.

The present invention provides TrkB agonist antibodies. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof to improve nerve function, including treatment of peripheral neuropathies, such as Charcot-Marie-Tooth disease.

Panaxadiol saponin is prepared into food product or medicine preparation capable of repairing damaged or fatigued cerebral cell and cerebral nerve cell, treating and improving insomnia and amnesia caused by long term intense nerve, improving haemodynamic and blood quality, improving brain function, and improving sleep quality.

The invention relates to a preparation method of notoginseng leaf total saponins, and belongs to the technical field of natural medicine extraction. The preparation method comprises the following steps: adding a solvent to notoginseng leaves, carrying out ultrasonic wave countercurrent continuous extraction, filtering, collecting filtrate, concentrating to obtain clear paste, adding a natural clarifying agent for clarification, centrifuging, adding ethyl alcohol to a clear solution to ensure that the ethyl alcohol content of the clear solution is 30-50%, and carrying out alcohol precipitation; and purifying the clear solution subjected to alcohol precipitation by using a desugaring resin column, eluting by using ethyl alcohols with different concentrations, decolorizing by using anion exchange resin after desugaring, finally concentrating, and carrying out microwave drying so as to obtain the notoginseng leaf total saponins. The preparation method has the advantages that the obtained notoginseng leaf total saponins are off-white, the texture of the powder is loose, the yield of total glycosides is above 8%, the content of the total glycosides is not lower than 90% (UV-ultraviolet), the obtained notoginseng leaf total saponins mainly comprise Rb3, Rc, Fc, Fa and the like, and the content of the Rb3 is greater than or equal to 40% (HPLC- High Performance Liquid Chromatography); the process is simple, the realization of industrialization is facilitated, and the product quality is substantially improved.

The invention belongs to the technical field of medicine, and concretely relates to caffeoyl substituted pentacyclic triterpenoid derivatives as shown in a formula I and a purpose thereof in preparing medicaments or health products for preventing and treating brain injury and / or neurological dysfunction and / or cognitive dysfunction caused by cerebral ischemia, hypoglycemia and cerebral anoxia. Experiments verify that the derivatives is capable of protecting nerve cells under conditions of hypoglycemia and hypoxia, can substantially improve neurological damage induced by cerebral ischemia, and thus is expected to be developed as medicaments for preventing and treating the brain injury caused by the cerebral ischemia, the hypoglycemia and the cerebral anoxia as well as improving corresponding neuroethology functions.

The present invention relates to a medicine for curing cerebrovascular diseases and its preparation method. The effective component of said medicine is gardenia total iridoid glycoide extracted from Chinese medicinal material gardenia root, in which its main component is gardenaside. Said invention also provides dosage form of said medicine, specially provides its capsule preparation.

The invention provides a fig / yam natural fruit for improving sleep and a preparation method thereof, relating to a fruit improving sleep quality and a preparation method thereof. The fig / yam natural fruit is prepared by raw materials such as fig, millet, lotus root, lotus seed, sunflower seed, Chinese date, longan, mulberry, light wheat powder, oat, spina date seed, yam, indian bread with hostwood, cortex albiziae, lily, tuber fleeceflower stem, cornaceae, schisandra chinensis, acanthopanax root, fcus taua powder, potato powder, granulated sugar, whole milk powder and natural essence. The fig / yam natural fruit has the effects of tranquilizing the nerves, mediating qi and blood, nourishing the five internal organs and promoting the secretion of saliva, can be used for improving the sleep quality and curing sleep disorder, and is free of side effects.

A system includes a guidance device that provides feedback to a user to compress a patient's chest at a rate of between about 90 and 110 compressions per minute and at a depth of between about 4.5 centimeters to about 6 centimeters. The system includes a pressure regulation system having a pressure-responsive valve that is configured to be coupled to a patient's airway. The pressure-responsive valve is configured to remain closed during successive chest compressions in order to permit removal at least about 200 ml from the lungs in order to lower intracranial pressure to improve survival with favorable neurological function. The pressure-responsive valve is configured to remain closed until the negative pressure within the patient's airway reaches about −7 cm H2O, at which time the pressure-responsive valve is configured to open to provide respiratory gases to flow to the lungs through the pressure-responsive valve.

An acetylglutamide injection for improving brain function and treating coma, palsy, hypointelligence, dysmnesia, etc is prepared through mixing acetylglutamide and phosphate buffering liquid, ultrasonic treating, cold storage, ultrafiltration, mixing with Na2EDTA solution in dark condition, pouring in containers, sterilizing and lamp examining.

Neuro-enhancing agents, compositions and methods are disclosed herein. Preferred neuro-enhancing agents of the present invention include progesterone and metabolites of progesterone, such as 3α-hydroxy-5α-pregnan-20-one (THP). These agents yield neuro-enhancing effects on neural cells that include neural progenitor and / or stem cells, whereby the agents stimulate mitosis of neural progenitor cells, stimulate neurite growth and organization, protect against neural loss, or one or more of these neural processes. Thus, the neuro-enhancing agents, compositions and methods disclosed herein are useful to reverse or prevent neurological disease or defects associated with neural loss or degeneration, such as Alzheimer's disease, neurological injuries, including injuries resulting from radiation therapy, and age-related neurological decline, including impairments in memory and learning.

The invention discloses a novel stem cell preparation and application thereof in vascular intervention therapy of cerebral apoplexy and provides a preparation method and steps of stem cells in the stem cell preparation and their application in the preparation of pharmaceuticals used for treating patients with cerebral apoplexy. The novel stem cell preparation has a good effect after transplanting, preparation cost is low, acquired cells are easy to massively amplify, new fields are opened for the treatment of nervous system diseases such as cerebral apoplexy, and good news are brought to the patients with cerebral apoplexy. The stem cells in the preparation are higher in differentiation degree, is capable of promoting neural functional recovery of patients during vascular intervention therapy of cerebral apoplexy, enables higher cell colonization, is easy to prepare and convenient to apply, and has curative effect evidently higher than like drugs.

The invention discloses a traditional Chinese medicine composition for treating acute stroke and a preparation method thereof. The traditional Chinese medicine composition mainly comprises the following raw medicines: senna leaf, giant knotweed rhizome, artificial bovine calculus powder, concretio silicea bambusae and trichosanthes fruit seed. The traditional Chinese medicine composition provided by the invention has the efficacy of dredging intestines and inducing resuscitation, is suitable for the symptoms of viscera and phlegm retention and viscera qi obstruction caused by the acute stroke, and is used for treating phlegm retention and viscera qi obstruction of yang and yin shutting syndromes of viscera caused by the stroke. The traditional Chinese medicine composition for treating patients suffering from acute stroke can improve clinical curative effect, reduce mortality and improve the life quality of patients; and the clinical application is safe without side effects.

The invention relates to a medicine compound from Chinese traditional medicines and its manufacturing method, the utilization of the medicine and its ingredients. The medicine is applied to cure spirit and nerve system diseases, such as anxiety neurosis and depressions.

The invention relates to fish feed and particularly relates to odontobutis obscurus compound feed. The invention further relates to a preparation method of the odontobutis obscurus compound feed. The odontobutis obscurus compound feed provided by the invention is prepared from the following components in parts by mass: 20 to 29 parts of fish meal, 6 to 15 parts of clam worms, 5 to 15 parts of coarse rice powder, 5 to 16 parts of sea clam shells, 7 to 16 parts of Chinese yams, 3 to 11 parts of figs, 4 to 13 parts of arrowheads, 4 to 14 parts of taros, 3 to 10 parts of mushrooms, 2 to 9 parts of broccolis, 2 to 11 parts of longan kernels, 3 to 10 parts of isatis roots, 4 to 14 parts of scutellaria baicalensis, 3 to 9 parts of fish oil, 1 to 4 parts of olive oil and 1 to 4 parts of compound multi-vitamin. After the odontobutis obscurus compound feed provided by the invention is used for feeding, the feed coefficient of odontobutis obscurus feed is low, and odontobutis obscurus meat has high content of crude protein, low content of crude fat and high content of flavor amino acids.

The invention provides a medicament for preventing and treating neurologic damage and related diseases thereof, and in particular relates to the application of a neurotrophic factor mixture secreted by adult stem cells from fat or an adult stem cell in vitro culture from the fat in preventing and / or treating the neurologic damage and the related diseases thereof. The neurotrophic factor mixture exists in the cell in vitro culture; the neurotrophic factor mixture and the cell in vitro culture can generate a synergistic effect, which reinforces activity greatly, reduces clinical dose obviously, reduces treating cost and reduces side effects; and the medicament can be effectively used for the neurologic damage and the related diseases thereof, such as preventing and / or treating the anoxic ischemic encephalopathy without processing steps such as further extracting, purifying and the like or adding a carrier, which fills the gap of the deficiency of conventional preventing and treating means for the neurologic damage and the related diseases thereof, simultaneously reduces the side effects and untoward effects, and further contributes to the reduction of the production cost of the medicament and popularization and application.

Methods, pharmaceutical compositions and kits for regenerating or repairing neural tissue, decreasing apoptosis and improving neurological function following injury using human umbilical cord tissue-derived cells are disclosed.

The invention relates to fish feed, in particular to elopichthys bambusa compound feed. The invention also relates to a preparation method of the elopichthys bambusa compound feed. The elopichthys bambusa compound feed comprises the following components in parts by mass: 18 to 27 parts of fish meal, 6 to 15 parts of dried fish, 4 to 18 parts of shrimp head meal, 5 to 16 parts of sweet potato meal, 7 to 19 parts of euphorbia humifusa, 4 to 17 parts of herba polygoni avicularis, 5 to 18 parts of plantago depressa, 4 to 17 parts of geranium strictipes, 3 to 16 parts of wax gourd, 2 to 9 parts of arrowhead, 2 to 13 parts of tricholomagambosum, 3 to 14 parts of pumpkin seed, 4 to 14 parts of semen torreya, 3 to 9 parts of fish oil, 1 to 4 parts of olive oil and 1 to 4 parts of compound Vitamin. After the elopichthys bambusa compound feed provided by the invention is fed, the elopichthys bambusa feed coefficient is low, the crude protein content in the elopichthys bambusa muscle is high, the crude fat content is low, and the flavor amino acid content is high.

Intravenous administration of bone marrow cells collected from rat bone marrow or peripheral blood to a rat cerebral infarction model was found to be effective in treating cerebral infarction. Human and murine bone marrow stem cells showed similar effects. Mesenchymal cells such as bone marrow cells, cord blood cells, or peripheral blood cells can be used as agents for in vivo administration against cranial nerve diseases.

The invention provides brain-boosting and intelligence-enhancing sealwort health-care tea which comprises the following raw materials in parts by weight: 10-50 parts of sealwort, 10-20 parts of fructus alpiniae oxyphyllae, 10-20 parts of polygala tenuifolia, 10-20 parts of radix rehmanniae preparata, 10-20 parts of angelica sinensis, 10-20 parts of radix curcumae, 10-20 parts of fructus psoraleae, 10-20 parts of poria with hostwood, 10-20 parts of semen juglandis, 10-20 parts of codonopsis pilosula, 10-20 parts of semen biotae, 10-20 parts of astragalus membranaceus, 10-20 parts of prepared fleece flower roots, 10-20 parts of radix paeoniae alba, 10-20 parts of schisandra chinensis, 10-20 parts of rhizoma atractylodis macrocephalae, 10-20 parts of albizia flowers, 10-20 parts of tuber fleeceflower stems, 10-20 parts of rhizoma acori graminei and 10-20 parts of mulberries. The brain-boosting and intelligence-enhancing sealwort health-care tea provided by the invention has the effects of invigorating kidney and nourishing essence, reducing phlegm and inducing resuscitation, boosting brain and enhancing intelligence and promoting blood circulation to dissipate stasis. The brain-boosting and intelligence-enhancing sealwort health-care tea contains neurotrophic factor-like components which can promote repair of memory-related damaged brain tissues caused by vascular factors, so that neurotransmitter AHC secretion is increased, the activity of SOD (Superoxide Dismutase) is improved, and the contents of excitatory amino acids and oxygen radicals in brain tissues are reduced.

The invention relates to a dendritic cell bacterin, in particular to a dendritic cell bacterin which can effectively promote the functional recovery of spinal cord injury and a manufacturing method thereof.