61 results about "Capsule Dosage Form" patented technology

A novel edible polymer based film dosage form manufactured using natural, synthetic, semisynthetic, pharmaceutically acceptable polymers addressing the issues of swallowing difficulties (Dysphagia and Dynaphagia), of tablet or capsule dosage forms and handling and storage difficulties associated with liquid dosage forms, that also includes materials such as emulsifying agents, suspending agents, buffering agents, effervescence agents, colorants, flavorants, sweeteners and specified amounts of bioactive agents, for erectile dysfunction. A flexible film dosage form containing sildenafil citrate, tadalafil or Vardenafil is presented. The film system is enabled to be used in various applications such as oral, mucosal and external environments.

The present invention incorporates medicaments in the empty hard capsule shells (body and cap). The medicament is either physically / molecularly distributed and / or chemically bound to the polymer matrix of the capsule shell composition. Other medicaments in the form of drug-loaded matrices (powders, granules, beads, pellets, mini-tablets, and mini-capsules) can be filled in the drug-loaded empty, hard capsule shells. The same capsule dosage form contains medicaments in the core matrix and in the shell.

Pharmaceutical compositions in unit dose form comprising a hard or soft capsule containing a fill consisting of one or more inert ingredients, and one or more coatings on the capsule, wherein at least one coating comprises at least one active pharmaceutical ingredient.

The present invention relates to pharmaceutical compositions of mesalamine. The composition of the invention is a capsule dosage form filled with a tablet. The invention also relates to process for preparing such compositions. The invention specifically relates to a composition comprising an effective amount of mesalamine having higher bulk density.

The invention relates to a hollow microcapsule, an acidic or alkaline controlled-release microcapsule and preparation methods thereof, belonging to the field of biological agents. The preparation method of the hollow microcapsule comprises the following steps of: preparing a microcapsule through a layer-by-layer self-assembly method by taking calcium carbonate as a core and selecting polyelectrolyte cation and anion with opposite charges under a preparation condition; and then removing the core to obtain the hollow microcapsule. The wall of the hollow microcapsule is formed by alternating PAH / PSS (Polypropylene Amine hydrochloride / Poly Sodium Styrenesulfonate), and the hollow microcapsule can loaded with Cry protoxins of bacillus thuringiensis insecticidal crystal proteins under an acidic condition so as to obtain a microcapsule dosage form with release controlled under an alkaline condition. The microcapsule dosage form keeps the insecticidal activity of the cry protoxins, can assist the cry protoxins to resist the influence of certain environmental factors, also enables the insecticidal proteins to be specifically released in an alkaline environment of an insect midgut and keep stable in a general environment and plays an important role in the actual application of the Bt (Bacillus thuringiensis) insecticidal proteins on pest control.

The present invention relates to a medicine for curing cerebrovascular diseases and its preparation method. The effective component of said medicine is gardenia total iridoid glycoide extracted from Chinese medicinal material gardenia root, in which its main component is gardenaside. Said invention also provides dosage form of said medicine, specially provides its capsule preparation.

The present invention incorporates medicaments in the empty hard capsule shells (body and cap). The medicament is either physically / molecularly distributed and / or chemically bound to the polymer matrix of the capsule shell composition. Other medicaments in the form of drug-loaded matrices (powders, granules, beads, pellets, mini-tablets, and mini-capsules) can be filled in the drug-loaded empty, hard capsule shells. The same capsule dosage form contains medicaments in the core matrix and in the shell.

The invention discloses a preparation method of a Bawei Chenxiang capsule, which comprises the following steps: (1) extracting volatile oil; (2) carrying out alcohol extraction; (3) preparing ox-hearts into freeze-dried powder; (4) carrying out a water extraction process; and (5) preparing a capsule dosage form. The invention has the advantages that the preparation method is scientific and reasonable, integrates modern separation and extraction technologies and extracts related effective components and positions of all medicines according to indication functions so that the efficacy of the medicines is fully applied and the Bawei Chenxiang capsule can achieve the efficacy of the powder of the original prescription with the half dosage of the powder of the original prescription. The capsule preparation avoids the bad odor of medicines and is conveniently taken and carried. After the capsule preparation is changed into capsules, the stability of the medicines is improved.

The invention provides a Chinese patent medicine preparation for curing the depression after cerebral infarction. The invention comprises the drugs calculated according to the proportion by weight as follows: 10 to 20 parts of rhizome of Sichuan lovage, 6 to 10 parts of bupleurum root, 6 to 15 parts of polygala root, 10 to 20 parts of Chinese angelica root, 10 to 30 parts of root of herbaceous peony, 10 to 15 parts of curcuma root, 10 to 20 parts of safflower, 15 to 25 parts of arboruitae seed and 30 to 50 parts of parched wild jujube seed. The Chinese patent medicine preparation adopts the preparation method that the Chinese drug materials are ground into fine powder of more than 100 meshes according to the formulation, and are uniformly mixed, the ozone sterilization processing is performed for 20 minutes, the materials are mixed with honey and stirred uniformly, and then is processed into pill dosage form or capsule dosage form. The preparation is a pure herbal preparation, and has the advantages that the curative effect is remarkable, the production method is simple, the cost is low, the toxic and side effects are less, the preparation is easy to be accepted by the patient, the drugs are mutually combined and has the functions of dispersing and rectifying the depressed liver-energy, stimulating circulation to end stasis, eliminating sputum, inducing resuscitation, waking up the patient from inconsciousness and allaying restlessness, the preparation can be used for curing the depression after cerebral infarction with remarkable curative effect and no obvious toxic and side effects.

The invention discloses application of artemisinin in preparation of drugs for resisting human liver cancer HepG2 and Huh7 cells. The purpose is achieved by inhibiting proliferation of the human livercancer HepG2 and Huh7 cells, and / or adjusting the expression profile of miRNA in the human liver cancer HepG2 and Huh7 cells. The concentration of the artemisinin is lower than or equal to 100 micromoles; the drugs are in an electuary dosage form or a capsule dosage form. The invention further discloses a drug electuary which contains the artemisinin and resists the human liver cancer HepG2 and Huh7 cells, a drug capsule which contains the artemisinin and resists the human liver cancer HepG2 and Huh7 cells and preparation method of the drug capsule. Under the effect of the artemisinin drugs,the proliferation of the human liver cancer HepG2 and Huh7 cells is inhibited, changes of the expression profile of the miRNA in the human liver cancer HepG2 and Huh7 cells are adjusted and controlled, the miRNA potentially adjusting and controlling the liver cancer is discovered, and the foundation is laid for strategic development of the artemisinin in the aspect of liver cancer treatment.

A traditional Chinese medicine preparation for treating megrim comprises, by weight parts, 15-30 parts of poria cocos, 10-15 parts of rhizoma alismatis, 8-12 parts of dried orange peel, 10-15 parts of bighead atractylodes rhizome, 6-10 parts of ginseng, 10-15 parts of prepared pinellia tuber, 6-10 parts of cassia twig, 10-15 parts of rhizoma atractylodis, 6-10 parts of round cardamom, 10-15 parts of rhizoma gastrodiae, 10-12 parts of prepared licorice, 5-9 parts of safflower, 3-8 parts of Japanese eupatorium, 5-10 parts of uncaria and 8-13 parts of fructus tribuli. The raw materials are jointly smashed and processed into fine powder, ozone sterilization is performed for 20 min, unifom mixing is performed, and a capsule dosage form is manufactured. The traditional Chinese medicine preparation brings conventional advantages of traditional Chinese medicine into play, is obvious in treatment effect, a production method is simple and low in cost, and the traditional Chinese medicine preparation is easily accepted by patients. Through clinical experiments for many years, it is proved that the traditional Chinese medicine preparation becomes effectively quickly, subjective symptoms and signs are obviously improved, the traditional Chinese medicine preparation has no side effect, and the megrim does not recur easily.

The invention discloses a processing method of ultra-micro wall-breaking capsule-preparation decoction pieces by traditional Chinese medicines, which mainly comprises the following steps that: pesticide residues are washed by using high pressure after single traditional Chinese medicinal materials are processed and cut in a standardization way, the traditional Chinese medicinal materials are processed into coarse powder after being dried, heavy metal is removed by dipping, then the coarse powder is processed into ultra-micro wall-breaking powder by ultra-micro pulverization, afterwards the powder is sterilized after being combined with the micro-powder of medicinal auxiliary materials with a certain proportion after quality control reaches a standard, and finally, the step of preparing the capsule-preparation decoction pieces is finished. According to the processing method of the ultra-micro wall-breaking capsule-preparation decoction pieces by the traditional Chinese medicines, the decoction pieces of single traditional Chinese medicines are prepared into a novel preparation of the capsule-preparation decoction pieces, which can be directly swallowed without infusion. According to the preparation, the advantages of ultra-micro powder and a capsule preparation are fused, the time of acting can also be controlled, the use quantity of the auxiliary materials is little, the medicine loading quantity is high, and a novel method for modernizing traditional Chinese medicines is initiated.

The invention provides a method for detecting piperine in Chinese patent medicine for weight loss and health food. An ultra-high performance liquid chromatography-ultraviolet spectrum-time of flight mass spectrometry is adopted to carry out qualitative screening and content determination. Chromatographic conditions comprise that a chromatographic column is a C18 chromatographic column; a detectoris a diode array detector; a detection wavelength is 340nm; a scanning wavelength range is 190-400nm; a mobile phase includes A-0.1% formic acid solution and B-0.1% formic acid-acetonitrile; a flow rate is 0.3-0.4mL / min; a column temperature is 25-40 DEG C; a sample injection amount is 0.1-2muL; and an elution gradient program includes 10% B for 0-2min; 90% B for 7-9min;and 10% B for 9.1-10min. Byusing the method, exclusive, sensitive and rapid primary screening can be performed, and the piperine added in the Chinese patent medicine for weight loss and the health food is confirmed. The methodis mainly suitable for analysis of the piperine in tablets and capsule dosage forms.

The present invention provides a kedaling capsule preparation for effectively curing angiocardiopathy and cerebrovascular disease. Said capsule preparation is made up by using corydaline (or chlorinated dehydrocorydaline) as main component and adding conventional additive through a conventional capsule preparation process.

The invention discloses a preparation method of a nitrochloroform capsule. The preparation method comprises the following steps: (1) taking sodium alginate solid or the sodium alginate solid and an auxiliary material to obtain a wall material water solution with the mass concentration of 0.5 to 3.5 percent, and standing for 24 hours for later use; (2) putting a core material nitrochloroform into the wall material water solution, adding a proper amount of emulgator tween 80 or tween 60, tween 20 and octenyl succinic acid modified starch, and performing high-speed emulsion dispersion for 30 to 60min to obtain emulsified liquid; (3) preparing the obtained emulsified liquid into the nitrochloroform capsule by adopting a piercing-solidifying method. The product is used for solving the existingproblem that in a process of applying nitrochloroform, the drug loss amount is great and the application environment is bad; in a process of applying the nitrochloroform capsule, peculiar smell is avoided, and a person applying the drug does not need special safeguard procedures, the production process of the capsule is simple and convenient, the production is low, the drug volatilization amount can be reduced by a capsule coating technology, the drug application cost is reduced, and remarkable environmental benefit and economic benefit are achieved.

The invention discloses a traditional Chinese medicine preparation for curing cancer, namely a detoxicating pill and a preparation method thereof. The traditional Chinese medicine preparation mainly comprises the following medicines according to parts by weight: 30-300 of paris polyphylla, 20-200 of pseudo-ginseng, 10-100 of trigone, 10-100 of rhizoma zedoariae, 20-200 of radix psammosilene, 20-200 of atractylis ovata, 10-100 of tuckahoe, 10-100 of rosin and 20-200 of safflower root. The invention provides a preferred preparation method of the traditional Chinese medicine preparation according to the requirements of prescription medicine properties and capsule dosage forms. The traditional Chinese medicine preparation and the preparation method thereof are a summary of clinical experience for many years by an inventor and have the special effects of curing gastric cancer, esophagus cancer, colon cancer, rectum cancer, and the like.

The invention discloses a traditional Chinese medicine preparation for curing femoral head necrosis and vasculitis, namely a bone magic pill and a preparation method thereof. The traditional Chinese medicine preparation is formed mainly by mixing the following medicines: deer bone, achyranthes, pseudo-ginseng, rosin, honeysuckle, radix rehmanniae, licorice and dandelion. The invention provides a preferably preparation method of the traditional Chinese medicine preparation according to the requirements of prescription medicine properties and capsule dosage forms. The traditional Chinese medicine preparation and the preparation method thereof are a summary of clinical experience for many years by an inventor and have the special effects of curing the femoral head necrosis and the vasculitis.

The invention relates to a medicament for treating dementia and a preparation method thereof. The medicament is prepared from radix-polygoni multiflori, epimedium herbs, yams, tuckahoe, prepared rhizome of rehmannia, root barks of peony trees, alisma orientale, dogwood fruit, acorus gramineus and arisaema cum biles and usually prepared into a capsule dosage form and has good curative effect on the dementia. Through clinical treatment and observation, for the treatment to the dementia and compared with medicaments of the same class, the medicament not only has obviously improved curative effect, but also has no toxic side effect, and under the condition of lack of effective treatment medicaments to the dementia clinically at present, the medicament has significant medical value.

The invention relates to the technical field of traditional Chinese medicine and biology, in particular to a method for preparation of periplaneta americana active peptide from periplaneta Americana. The method includes: selecting dried and fresh imagoes of periplaneta americana as the raw materials, conducting crushing homogenizing, enzymolysis, fishy smell removal, enzyme inactivation, centrifugation, sterilization and ultrafiltration, then according to oral solution production practices, performing filling to obtain oral solution dosage forms; making dry powder according to spray drying or freeze drying production process practices, and performing filling to obtain capsule dosage form and bottled freeze-dried powder dosage form. The nutritional value, the absorption and utilization rate and food safety are greatly improved. Also the periplaneta americana active peptide has anti-tumor, immunity enhancing, tissue repair, antibacterial, antiviral, heart strengthening and pressure boosting, microcirculation improving and other pharmacological activities. The preparation method of the periplaneta americana active peptide has the characteristics of rigorous and reasonable process and strong operability, and is easy for realizing industrial production.

There is provided a dosages form comprising rivaroxaban and one or more pharmaceutically acceptable excipients. The present invention also provides a stable capsule dosage form comprising rivaroxaban and one or more pharmaceutically acceptable excipients. The invention also relates to process of preparation of such compositions.

The present invention provides an extended-release capsule dosage form of metoprolol succinate in the form of coated discrete units and processes for their preparation.

The invention discloses a medicine for treating mammary gland hyperplasia. , Shanjia Tablets as raw materials, the medicine can be made into a variety of medicaments for clinical use, with capsules as the preferred dosage form, the medicine of the present invention has good curative effect on various hyperplasia of mammary glands, and the clinical application is safe and reliable.

The present invention relates to an enteric coating tablet comprising: a core containing, as an active ingredient, dimethyl fumarate or a pharmaceutically acceptable salt thereof; and an enteric coating layer, and provides a tablet, which exhibits an effect equal to that of a capsule dosage form currently on the market, can be prepared through a simple preparation process, and is a dosage form having excellent storage stability and administration convenience, and thus can be applied to various patient groups.