Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Capsule of corydalis yanhusuo extract for treating cardio vascular disease, and its preparing and effective ingredient content measuring method

A technology of cardiovascular and cerebrovascular diseases and capsules, which is applied in the field of traditional Chinese medicine, can solve the problems of low dissolution rate, long dissolution time of tablets, poor absorbability, etc., and achieve the effects of preventing and slowing down the degradation speed, clinical medication safety, and improving stability

Inactive Publication Date: 2006-08-09
SICHUAN GUOKANG PHARMA
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, due to the technical defects and influence of the traditional Chinese medicine extract tablet itself, the dissolution time of the tablet is long, the dissolution rate is low, the absorption is poor, and the bioavailability is low.
And tablet hygroscopicity is strong, and the main component of extract is quaternary ammonium type (or berberine type) alkaloid in addition, and its stability is relatively poor, easily affected by moisture, light, oxidizing agent etc., and degradation or deterioration, thereby It may affect its efficacy, making it difficult to ensure the safety of medication for patients

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Take Corydalis Corydalis 2000g, grind into coarse powder, and sieve. Heat and reflux extraction with 65%-95% ethanol three times, each time for 4-5 hours. The extracts were combined, filtered, and the filtrate was concentrated under reduced pressure to form a thick paste. The alkaloid content was determined by HPLC method or paper layer folding quantitative method, and 250 g of starch and 150 g of microcrystalline cellulose were added, and granulated. Dry, pass through a 120-mesh sieve twice, and fill into hard capsules. Each capsule contains 5 mg of Corydalis alkaloids.

Embodiment 2

[0011] Corydalis extract thick cream 60g was prepared as above, and its alkaloid content was determined. Take another polyethylene glycol 4000 and measure 200g, first mix 40g polyethylene glycol with the thick paste, pulverize it with a colloid mill, then add the remaining amount of polyethylene glycol and mix to obtain a medicinal solution, and then prepare a gelatin solution (gelatin: glycerin: water=10:5.5:12) for later use. The liquid medicine and the gelatin solution are made of 1000 Daling Soft Capsules by an automatic rolling capsule mechanism. Each soft capsule contains 10mg of Corydalis alkaloids.

Embodiment 3

[0013] Get the Corydalis extract thick cream 600g that makes as above, lactose 50g, polyvinylpyrrolidone 15g, hydroxypropyl methylcellulose 80g, talcum powder 50g. Mix hydroxypropyl methylcellulose with the thick ointment first, then add lactose, make micropills with polyvinylpyrrolidone solution, fill capsules, and prepare 1000 primate sustained-release capsules. Each long-acting sustained-release capsule contains 45.0mg of Corydalis alkaloids.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention provides a kedaling capsule preparation for effectively curing angiocardiopathy and cerebrovascular disease. Said capsule preparation is made up by using corydaline (or chlorinated dehydrocorydaline) as main component and adding conventional additive through a conventional capsule preparation process.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine. It relates to an active ingredient of Corydalis Corydalis extract used for the treatment of cardiovascular and cerebrovascular diseases, and an oral preparation of Corydalis Corydalis alkaloid, in particular to a capsule dosage form, a preparation method and a quality control method for content determination. Background technique [0002] According to the standard WS of traditional Chinese medicine issued by the Ministry of Health 3 - The Kedaling tablet prepared by the method described in B-3167-98 is an extract-type oral preparation made from the traditional Chinese medicine Corydalis Corydalis as raw material through processing and extraction. It is used for the treatment of coronary heart disease, angina pectoris, acute myocardial infarction, old myocardial infarction, chest tightness, breathlessness, palpitation and dizziness. Long-term clinical use and verification ha...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/50A61K9/48A61P9/10G01N30/02G01N33/15
Inventor 冀广沁支春陈家伟石万棋李先楞万玲徐琨
Owner SICHUAN GUOKANG PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com