Water-soluble cannabidiol nano preparation based on cyclodextrin carrier and preparation method thereof
A technology of cannabidiol nano and cannabidiol, which is applied in the direction of medical preparations of non-active ingredients, pharmaceutical formulas, active ingredients of hydroxyl compounds, etc., can solve the problem of inability to achieve on-demand configuration, unsatisfactory solubilization effect, and limited diversity In order to improve the stability and bioavailability, increase the water solubility of the drug, and reduce the irritation and adverse reactions
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Embodiment 1
[0020] Example 1: Preparation of Water-Soluble Cannabidiol Nano-Preparation Based on Hydroxypropyl-β-cyclodextrin
[0021] Add 25mL of 1mmol / mL hydroxypropyl-β-cyclodextrin aqueous solution into a 100mL reaction bottle (distilled water as solvent water), then add 100mmol cannabidiol, stir the reaction at 50°C at 200rpm in the dark for 30d, and then use The undissolved solids were removed by filtration through a 0.1 μm microporous membrane, and the filtrate was vacuum-dried (100Pa, 12h) to obtain a white powder. The water-soluble cannabidiol nano-preparation of cyclodextrin (according to the amount of substances, the preparation is 50% cannabidiol and 50% cyclodextrin, and the particle size obtained by a particle size analyzer is 0.5-1.2nm. 1 H NMR data, 500MHz, D 2 O: δ0.5–2.5(H of CBD and CD, 50H),3.0–4.0(H of CD and CBD,39H),4.83–4.95(H of CD,7H),5.0–5.2(H of CBD,2H )). pass 1 H NMR data conversion can be obtained, the solubility of cannabidiol in water is 157.23mg / mL. ...
Embodiment 2
[0022] Example 2 Preparation of Water-Soluble Cannabidiol Nano-Preparation Based on γ-cyclodextrin
[0023] Add 1mmol / mL γ-cyclodextrin N, N-dimethylformamide-water solution 30mL in a 150mL reaction flask (the solvent is a mixed solvent of analytically pure N,N-dimethylformamide and distilled water, analytically pure N, N-dimethylformamide and distilled water v:v=1:4), then add 3mmol / mL cannabidiol acetone-water suspension 10mL (solvent is the mixed solvent of analytical pure acetone and distilled water, analytical pure acetone and Distilled water (v:v=4:1), stirred at 500rpm in the dark for 3 days at 25°C to complete the reaction, then filtered through a 0.1μm microporous membrane to remove undissolved solids, and the filtrate was vacuum-dried (100Pa, 12h ) to obtain a white powder, and the NMR test results show that it is a water-soluble cannabidiol nano-preparation based on γ-cyclodextrin (according to the amount of substance, the preparation is 12% cannabidiol, 88% cyclode...
Embodiment 3
[0024] Example 3: Preparation of water-soluble cannabidiol nano-preparation based on α-cyclodextrin
[0025]Add 1mmol / L α-cyclodextrin methanol-water solution 10mL in a 50mL reaction bottle (the solvent is a mixed solvent of analytically pure methanol and distilled water, v:v=1:4 for analytically pure methanol and distilled water), then add 10mmol / mL Cannabidiol dimethyl sulfoxide-water suspension 5mL (the solvent is a mixed solvent of analytical pure dimethyl sulfoxide and distilled water, and the v:v=1:1 of analytical pure dimethyl sulfoxide and distilled water), in Stir the reaction at 700rpm in the dark at 30°C for 7 days, then filter through a 0.1μm microporous membrane to remove undissolved solids, and vacuum-dry the filtrate (100Pa, 12h) to obtain a white powder. The NMR test results show that it is based on α- Water-soluble cannabidiol nano-preparation of cyclodextrin (according to the amount of substances, the preparation is composed of 20% cannabidiol and 80% cyclode...
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