The invention relates to a
metformin hydrochloride sustained-release
capsule and its preparation method. The
metformin hydrochloride sustained-release
capsule is prepared by steps of
coating a
metformin hydrochloride granule sustained-release material and putting into an enteric
capsule. In comparison with the prior art, sustained-release granules and enteric capsule filling technology are combined together to prepare the new
dosage form of
metformin hydrochloride sustained-release (enteric-coated) capsule. As the sustained-release granule
coating and enteric capsule filing technology is adopted,
metformin hydrochloride will not be disintegrated and will not stimulates
gastric mucosa, and adverse reactions such as
nausea, stomachache, diarrhoea and the like caused by medication can be avoided. Meanwhile,
metformin hydrochloride will not be damaged by gastric juice, and
bioavailability of metformin hydrochloride is raised. In addition, the product provided by the invention is also a sustained-release enteric-coated preparation. The
medicine can be stably released in a body, effective
plasma concentration is maintained for a long time, and toxic and
side effect which might be caused by higher
plasma concentration within a short time are avoided. The frequency for taking the
medicine is reduced, and
patient compliance is also raised.