120 results about "Digestive canal" patented technology

The invention relates to a liquid forage and the preparation method, which comprises the following components in weight percentage: corn 20 to 60 percent, puffing soybean 15 to 50 percent, whey powder 2 to 15 percent, blood plasma protein 1 to 10 percent, fish meal 2 to 15 percent, treacle 1 to 7 percent, soybean oil 1 to 5 percent , CaHPO4 0.1 to 2 percent, stone powder 0.1 to 1 percent, NaCl 0.1 to 2 percent, choline 0.1 to 1 percent, L-Lys (L- lysine salt) 0.1 to 1 percent, DL-Met (methionine) 0.1 to 1 percent, pre-mixture 1.00 to 4.00 percent, and deflocculant 0.1 to 2 percent. Compared with the dry forage, the invention enhances the food intake of weaned newborn pigs; the invention also increases the feeding speed; the liquid forage can avoid the damages of dry forage to the intestinal wall morphology of weaned newborn pigs; liquid forage is beneficial to the inner environment of the digestive canal of newborn pigs; the enhancement of growing performance of early weaning newborn pigs can also be gained from the increase of ADFI, and simultaneously low pH value is also helpful to the protein digestion in the stomach of newborn pigs. The invention has the advantages of the regulation of the growing performance, the influence on the immunity function, and the balance of intestinal microbiological flora of early isolated weaning newborn pigs to reduce the cultivation cost greatly.

Disclosed are a phosphate-binding polymer having a true specific gravity of 1.18-1.24, tablets that solely consist of the particles of a phosphate-binding polymer having an average particle size of no more than 400 μm, with at least 90% being occupied by particles no larger than 500 μm, and having a true specific gravity of 1.18-1.24 and a water content of 1-14%, or tablets that contain both the particles and crystalline cellulose and / or low substituted hydroxypropyl cellulose, and a process for producing such tablets. The phosphate-binding polymer can be formulated as tablets either alone or in combination with specified additives. Whichever the case, the tablets have satisfactory hardness, contain the active ingredient in high proportion, have high phosphate-binding capability and exhibit rapid disintegrability in an acidic to neutral region while having little sensitivity to the strength of agitation. The tablets are excellent pharmaceutical preparations that undergo reduced variations in bioavailability in spite of movements within the digestive tracts and pH changes.

The invention provides an enteron intelligent drug releasing capsule system and a method used for carrying out intelligent drug releasing of enteron of animal or human body. The system comprises a drug releasing electronic capsule and an information processing device; the drug releasing electronic capsule comprises a shell, a mini-typed battery, a sensor module, a drug releasing function module and a central control module; the parts are encapsulated inside the shell; the sensor module detects the physical chemistry or biochemical parameters inside the enteron with given time interval, and carries out the drug releasing intelligently according to the sensor module detection information. The system and the method of the invention can detect the physical chemistry or biochemical parameters of the enteron in real-time and control the drug releasing intelligently on the basis of the parameter processing, thus leading the drug to be released in the enteron within the best time and at the best position; the system and the method of the invention are novel noninvasine intelligent disease diagnosis and treatment system and method.

The invention belongs to the field of traditional Chinese medicine technology, in particular to a traditional Chinese medicine combination of clearing away heat and toxic material, anti-inflammation and detumescence and a preparation method thereof. The components and the parts by weight of the traditional Chinese medicine combination are as follows: 2-5 shares of baikal skullcap root, 6-12 shares of dandelion herb, 1-4 shares of corydalis, 2-5 shares of dyers woad root. The invention can cure the respiratory infection, the infection of digestive canal, surgical infection and the urinary tract infection; and the invention can be made into pelletized granule type. As the correctives is added into the traditional Chinese medicine combination, the problem that the taste is affected by the corydalis is solved, and patients are easy to accept the medicine combination owing to the small dosage, the better absorption. The invention is a traditional Chinese medicine combination of clearing away heat and toxic material, anti-inflammation and detumescence which has the advantages that the quality can be controlled, the healing effect can be exerted fully, the dose is reasonable, the medicine is portable and is convenient for carrying, the invention has remarkable economic and social benefits and is suitable for industrial production.

The invention discloses a betaxolol hydrochloride ion-sensitive eye-use in-situ gel. Every 1000 parts of a finished product of the gel comprise: 1-5 parts of betaxolol hydrochloride, 2-10 parts of an ion-sensitive gel material, 22-50 parts of an osmotic pressure conditioning agent, 0.1-5 parts of a bacteriostatic agent, and balance of injection water. Under an in-vitro condition, the eye-use in-situ gel provided by the invention is a solution which can flow freely. When the solution is dropped into eyes, the solution contacts cations such as Na<+>, K<+>, Ca<2+> and the like in tears, and the solution is subjected to gelatinization, such that a non-chemical-crosslinked semisolid preparation is formed. Therefore, the affinity of betaxolol hydrochloride and eye mucosal tissues is effectively ensured, and the retention time of the medicine in eyes is prolonged. Therefore, possible side effect caused by a large amount of medicine which is absorbed into systemic circulation through nasal mucosa or digestive tract is avoided.

The invention discloses a ramosetron hydrochloride freeze-dried powder injection and a preparation method thereof. Under illumination, the solution of the existing ramosetron hydrochloride has poor stability, poordrug effects and high drug adverse effects; and the solids of the existing ramosetron hydrochloride have good stability. Therefore, the ramosetron hydrochloride freeze-dried powder injection improves product stability and safety. A preclinical research shows that an antagonistic activity of ramosetron hydrochloride to 5-HT3 acceptors is stronger and more stable than that of the existing 5-HT3 acceptor antagonist; and ramosetron hydrochloride has stronger effect of treatment on chemotherapeutic drug-caused emesis. Therefore, ramosetron hydrochloride is clinically used for preventing and treating digestive tract symptoms such as nausea and emesis caused by cancer-resistant drugs.

The disclosed molecular identification method and specific primer with upper / lower primer as SEQ ID No:1 / 2 for dominant flora structure in aquatic animal enteron comprise: 1) obtaining different fragments and contents of enteron as sample; 2)extracting sample total DNA; 3) with former DNA as template, taking PCR amplification; 4) taking denaturized gradient gel electrophoresis to target fragment, obtaining DGGE fingerprint spectrum by Ag dyeing, and setting another sequenching group; 5) taking cluster and semi-quantitative analysis; 6) recovering dominant strip as template for PCR amplification and sequenching; 7) comparing and analyzing the result to determine structure.

The invention belongs to the technical field of endoscopes, and discloses a digestive tract endoscope bending and fixing device. The digestive tract endoscope bending and fixing device comprises an outer sleeve arranged on an endoscope tube in a sleeving mode; the outer sleeve comprises a plurality of circular rings arranged on the endoscope tube in a sleeving mode; the circular rings are connected in series through inflation tubes sequentially penetrating through the circular rings; and the inflation tube between every two circular rings is of an inflation expansion telescopic structure. According to the digestive tract endoscope bending and fixing device, when an endoscope tube needs to be bent, gas is introduced into the inflation tube on the opposite side of the bent side, the inflation expansion telescopic structure extends, the distance between the circular rings on the opposite side of the bent side is increased, the distance between the circular rings on the opposite side of the bent side is not changed, and therefore the outer sleeve is bent; and the endoscope tube in the outer sleeve is driven to be synchronously bent, and the endoscope body can be bent to a greater extent through the bending of the original bending part. The device is further provided with air cushions in different directions, so that the lifting and fixing effects can be achieved, and endoscopic examination and treatment are facilitated.

The present invention relates to a novel digestive canal pharmaceutical preparation and its preparation method, the first contribution of the present invention is to give more choices to people in general oral administration preparations, wherein, oral administration preparations such as honey pill, micropill, concentration pill, water pill, gel preparation, cream, tablet, chewing tablet, powder agent, granule, capsule, slow release capsule etc. is convenient, capable of suitable for different consumption level people; the second contribution of the present invention is to upgrade the general oral administration preparations into stomach retention floating oral administration preparation by inducting corresponding supplementary, greatly prolonging medicine retain time in stomach, greatly increasing the local focal medicine effective concentrate in stomach, in order to short period of treatment, promote clinic effective rate and cure rate to provide necessary condition; the third contribution of the present invention is to upgrade the oral administration preparations and the stomach retention floating oral administration preparation into loading far infrared auxiliary therapeutic function oral administration preparation by inducting corresponding supplementary nanocrystallization, leading product curative effect to promote further.

Chinese amphioxus galactose agglutinin AmphiGAL13 gene and its production are disclosed. The process is carried out by constructing cDNA library, large-scaled sequencing, and separating out AmphiGAL13 gene from digestive tube of Chinese amphioxus. It expresses recombinant amphioxus GST-PGAL13 protein by GST fusion and obtains agglutinin by EK enzyme digestion. It can be used to develop and research for natural small molecule biological granular preparation.

The invention discloses a cDNA sequence and an amino acid sequence of coding lugworm fibrinolytic enzyme which are respectively shown in SEQIDNo.1 and SEQIDNo.2 in a sequence table, and belongs to the field of medical biological engineering. The cDNA sequence has the beneficial effects that according to the cDNA sequence of the lugworm fibrinolytic enzyme, the coding gene of the fibrinolytic enzyme can be cloned from digestive tract tissue of lugworm, and can be expressed in a prokaryotic expression system or a eukaryotic expression system through a gene recombination technology. The recombinant lugworm fibrinolytic enzyme has plasminogen activation activity, and can be used as a new thrombolytic medicament in genetic engineering.

The invention provides a lipid nano-particle which is easy to absorb by an intestinal tract, wherein a magnetic resonance contrast agent, namely gadolinium diethylenetriaminepentaacetic acid (Gd-DTBA) is loaded, and glyceryl monostearate and lecithin are taken as lipid materials. The invention applies lipidosome nano-particles which are easy to absorb by the intestinal tract to enveloping the magnetic resonance contrast agent, namely the gadolinium diethylenetriaminepentaacetic acid which is clinically used most commonly to ensure that the magnetic resonance contrast agent, namely the gadolinium diethylenetriaminepentaacetic acid which is not absorbed by a digestive canal can be absorbed into an intestinal wall in a large quantity to make the intestinal wall produce MRI enhancement, displays pathological changes through the difference of normal intestinal walls and the pathological changes on the absorption and distribution of the lipid nano-particle, and can reflect the absorption function condition of the lipid nano-particle caused by the pathological changes. The method has the following advantages: the local administration is performed, and no intravenous and systemic administration are needed; the method may realize the evaluation of an intestinal absorption function; the nano-particle enters cells to realize the horizontal visualization of the cells; and the nano-particle mainly adopts lymph transport and can realize lymphatic imaging which are favorable for the lymphatic target display of intestinal pathological changes.

Provided is a novel use of formaldehyde in preparing pharmaceuticals for prevention and cure of animal diseases caused by pathogenic microorganisms through infection of digestive canal by means of digestive tract administration, wherein formaldehyde can deactivate pathogenic microorganisms and their toxins, make it lose pathogenicity while keeping the antigenicity. The invention realizes the advantages of broad spectrum, quick and sure effects, small dosage, less administration, lower price and removal of drug resistance and medicinal residual produced by the application of antibiotics.

The invention relates to a brivaracetam oral controlled-release preparation and a preparation method thereof. The controlled-release preparation is a single-chamber osmotic pump controlled-release preparation, and is composed of a drug tablet core, a membrane-controlled coating system and a drug-release hole. The drug tablet core comprises 30-60wt% of brivaracetam, and the membrane-controlled coating accounts for 3-8 (w / w, %) of the total preparation. The controlled-release preparation disclosed by the invention has an in-vitro zero-level constant-speed drug release curve, can form a sphericalpreparation after water absorption swelling, and is not prone to being adhered to the wall of a digestive tract to cause too high local drug concentration.

The invention discloses a multifunctional endoscopic minimally invasive hoe scaler, which comprises a catheter, hemostatic forceps, a hoe scaler, an operating handle, an operation control device and an online physiological monitoring device, and is characterized in that: the head part of the catheter is connected with the hemostatic forceps, and the tail part of the catheter is connected with the operating handle in a matching way; the hemostatic forceps consist of two halves of bullet-shaped hollow forceps heads which can be opened and closed; the hoe scaler is a plasma hoe scaler; the operating handle is provided with a hemostatic forceps push ring capable of moving forward and backward and a hoe scaler control handle; the operation control device comprises a hemostatic forceps operation control device and a hoe scaler operation control device; and the online physiological monitoring device comprises an electric physiological catheter probe and a signal layer formed by winding three electric physiological catheter probe connecting leads. According to the minimally invasive hoe scaler, the defects of the conventional digestive canal tumor treatment are overcome, the scaler and the hemostatic forceps are combined, the minimally invasive hoe scaler has the functions of biopsy forceps, incision and hemostatic forceps after being electrified, convenience is brought to examination, incision and timely hemostasis, and the complications of hemorrhage are reduced.

The invention provides a digestive tract tumor PDX model and a construction method of a standardized model library. The method comprises the following steps: conducting sampling, treating a collected peripheral blood sample of a digestive tract tumor, obtaining tumor cells, conducting treating and culturing, stably passing the tumor cells to n generations, constructing a digestive tract tumor PDX model and evaluating the model. A Chinese population human-derived digestive tract tumor transplantation animal model and a corresponding primary tumor cell line are established in a digestive tract tumor PDX standardized model library, an important in-vivo model is provided for biological research of tumors, searching of diagnostic markers and drug screening, randomness and blindness of drug use are avoided, disturbance by factors such as original tissue samples is avoided, the digestive tract tumor PDX model can be stably subcultured to three generations or more, and the construction of the digestive tract tumor PDX model standard sample library provides bioinformatics for exploring new targets and searching and analyzing clinical characteristics of digestive tract tumors, and assists in research of a fatal mechanism of digestive tract tumors and treatment of patient tumors.

The invention discloses an anti-dementia medicinal orally disintegrating tablet and a preparation method thereof, and relates to an anti-dementia medicinal orally disintegrating tablet and a prescription and a process for preparing the anti-dementia medicinal orally disintegrating tablet with a freeze-drying method. The anti-dementia medicinal orally disintegrating tablet disclosed by the invention is prepared from a main medicament and medicinal auxiliary materials, can be taken without water, is quickly disintegrated after being put into mouth, and is suitable for patients suffering from dysphagia such as the aged, children and the like; meanwhile, the anti-dementia medicinal orally disintegrating tablet is suitable for taking under the condition that a water source is difficult to obtain during traveling; the anti-dementia medicinal orally disintegrating tablet has the advantages of convenience for taking, quick absorption, small first pass effect, small irritation on digestive canal mucosa and the like, and has a wide market application prospect; and moreover, the anti-dementia medicinal orally disintegrating tablet can be used for remarkably reducing the side effects of an anti-dementia medicament. Moreover, the invention further relates to a preparation method of the anti-dementia medicinal orally disintegrating tablet.

The invention discloses a piezoelectric precision driving-based linear bidirectional actuator and a working method thereof. The actuator mainly comprises phosphor bronze substrates, piezoelectric ceramic sheets and a connection rod, wherein the piezoelectric ceramic sheets are arranged on upper end surfaces of the phosphor bronze substrates. Most of traditional actuators are complicated in structures, are rotation actuators and are difficult to miniaturize. The actuator is formed by oppositely arranging a pair of phosphor bronze substrates and connecting the phosphor bronze substrates by the connection rod, the phosphor bronze substrates are asymmetric in structures, and bidirectional movement of a device on a straight line can be achieved by respectively applying sine-cosine voltages ontothe piezoelectric ceramic sheets on the two phosphor bronze substrates, The piezoelectric precision driving-based linear bidirectional actuator is simple in structure, is easy to miniaturize, can beused in occasions such as medicine supply to a biopsy passage in a digestive canal endoscope and moving of a medicine machine such as biopsy forceps, stable, reliable, accurate and controllable bidirectional moving on a predetermined rail is achieved, and feeding action in a micro passage is achieved.

The biological tissue image detection method provided by the embodiment of the invention is used for a computer vision technology (CV). The method comprises: acquiring a first biological tissue image;determining image feature information of the first biological tissue image through a classification model; when the classification model identifies that the image feature information of the first biological tissue image does not meet the digestive tract detection condition, removing the first biological tissue image; when the classification model identifies that the image feature information of the first biological tissue image meets the digestive tract detection condition, transmitting the first biological tissue image to a detection model; and detecting the first biological tissue image through the detection model. The invention further provides a device, equipment and a medium, low-quality images are filtered out through classification of the classification model, so that it is ensuredthat the detection model only detects high-quality biological tissue images, and the detection efficiency and the detection accuracy of biological tissue image detection are improved under the condition that an existing detection model is not rewritten.

The invention belongs to the technical field of molecular biology and in particular relates to a tumor blood vessel and M1 type macrophage targeting peptide and application thereof. Aiming at the problem that a small molecular targeting peptide for preparing a medicine for diagnosing or treating tumors is lacked, the invention provides the tumor blood vessel and M1 type macrophage targeting peptide TCP-2 and a carrier thereof. The small molecular targeting peptide has an amino acid sequence shown as SEQ ID NO: 1, can be used for specifically targeting tumor blood vessels and M1 type macrophages and can be used for preparing the targeting medicine for diagnosing or treating the tumors; especially, the mall molecular targeting peptide is used for treating digestive tract tumors and providesa new choice for targeting therapy of the tumors.

The invention provides a Lelrozol orally-disintegrating tablet and its preparation method. The Lelrozol orally-disintegrating tablet contains a primary component which is Lelrozol, and auxiliary components comprising a disintegrating agent, a filler, a flavoring agent and the like. The Lelrozol orally-disintegrating tablet has the advantages of rapid disintegration in the oral cavity, and entrance to the digestive tract along with swallowing, has the characteristics of convenient administration, fast absorption, high biological availability and the like, can improve the compliances of patients, and can increase the clinical drug choices of doctors and the patients.

The invention discloses a digestive tract focus auxiliary identification and positive feedback system based on a cloud platform. The digestive tract focus auxiliary identification and positive feedback system comprises a data collection device, a cloud platform, an online error correction module and an online optimization module, wherein the data collection device is configured to collect a to-be-identified digestive tract image and transmit the to-be-identified digestive tract image to the cloud platform; the cloud platform is configured to establish an inference model, construct a training set to perform optimization training on the inference model, utilize the inference model to carry out alimentary canal position and lesion type inference on the received image, and respectively store the image and digestive tract focus identification results; the online error correction module is configured to check an inference result online and mark and correct the wrongly inferred result for a doctor client; and the online optimization module is configured to add a corrected image into the training set and train the inference model again. According to the digestive tract focus auxiliary identification and positive feedback system, the accuracy of digestive tract focus identification can be improved, and the detection rate of digestive system diseases is improved.

The invention discloses a method for preparing compound simvastatin nicotinate sustained-release capsules, and belongs to the field of medicinal preparations. Components of the simvastatin nicotinate sustained-release capsules can exert a synergistic effect in vitro and comprehensively regulate the components of blood fat, so that the medicinal effect is furthest exerted, the toxic or side effect of the medicament can be reduced, fluctuation of blood concentration in vitro is reduced, and the administration frequency of a patient is reduced; and by designing pellets, the contact area between the medicament and the digestive tract is greatly improved, and the bioavailability of the medicament is improved. The method is strong in specificity, good in reproducibility, high in precision and convenient to operate; the capsules can be well applied to treatment of hyperlipidemia and abnormal mixed blood fat; and safety, effectiveness and controllability of clinical medication are really ensured.

The invention relates to preparation and application of florfenicol slowly-releasing micropills for treating animal digestive canal infection. The implementation comprises the following steps: weighing drug accessories and florfenicol raw materials according to the proportion of weight ratio 0.1-10:1, preparing micropills whose grain size dimension is between 0.5 to 3mm, wrapping a non-pH dependency high molecular polymer film outside the micropills, wherein the film contains low molecular water-soluble materials. Slowly-releasing micropills containing florfenicol is wrapped by non-pH dependency high molecular polymer materials, water-soluble materials such as mannidex, antacidin or natrii chloridum are added in the wrapping film, after people take the wrapped micropill orally, the water-soluble component in the wrapping film is dissolved to form a pore passage, and the drug is slowly released from the pore passage and exerts the long-term curative effect in the intestinal tract. The drug is different from traditional drug feeding modes in that higher drug concentration can be kept in intestinal tracts for long time, directional distribution of the drug in the intestinal tract can lower the side effects of drug to other organs and tissues, and the treatment cost can be lowered due to less drug dosage.

The invention discloses a multifunctional digestive endoscope treatment device, and specifically relates to the field of medical technology. The device of the invention includes a computer, one side of which is provided with a treatment mechanism. The treatment mechanism includes a water bucket, one side of which is provided with a connection bucket. The top of the water bucket is provided with amicro water pump, a water outlet end of which is provided with a first pipeline. One end of the first pipeline is provided with a second pipeline and a hose. The bottom of the hose is fixedly providedwith a cylinder, the bottom of which is fixedly provided with a camera and a flushing pipe. The camera is disposed at one side of the flushing pipe. The hose is firstly inserted into the affected part of a patient's digestive tract; secondly, the affected part and the lens of the camera are rinsed; thirdly, the cleaning solution is sucked into the collection bucket; and finally, the camera is used to photograph the cleaned affected part and the photograph is transmitted to the computer. Thereby, cleaning and diagnosis are carried out successively to achieve a single insert and extract action,which effectively reduces patient pains.

The invention provides a method for preparing a traditional Chinese medicine for curing deficiency in heart and spleen depressive psychosis, and the method belongs to the medical appliance technical field. The depressive psychosis adopts the antidepressant medications for patients with pixilation disease and the imipramine therapy and causes the symptoms such as dry mouth, constipation, sweatiness, fremitus, blurred vision and dysuria. The technical proposal of the invention is as follows: the raw medicines of radix codonopsitis, broiled milk veteh, heterophylly falsestarwort root, atractylis ovata, bidens tripartita, malt extract, Chinese date, tuckahoe, angelica, radix paeoniae alba, lungyen pulp, spina date seed, semen biotae shelled, semen biotae shelled, polygala, cortex albiziae, caulis polygoni multiflori, wheat, ulmaceae, cinnamon and liquorice are placed into 1200 milliliters of water to be steeped for 30 minutes and are decocted by slow fire, the decocted liquid medicine is filtered by gauze to eliminate dregs, and 560 milliliters of liquid medicine which is the traditional Chinese medicine for curing deficiency in heart and spleen depressive psychosis is made. The traditional Chinese medicine has the advantages of simple preparation, fewer side effect and low toxicity. After the medicine is taken orally, the medicine can be absorbed in a digestive canal; therefore, the curative effect is stable and is not easy to rebound.

The invention relates to a traditional Chinese medical oral liquid used for curing diarrhea of poultries, which comprises two medicines of heartleaf houtluynia and honeysuckle. The medicament is suitable for curing the infection of digestive canal such as diarrhea and the like of poultries caused by germ. Based on the fact that the specific physiological structure of poultries can not digest wood fibre owing to the short genital tracts, the medicament is made into a dosage form of oral liquid which can be dispersed in drinking water and can be taken by sick poultries through drinking water, thereby being convenient for absorbing, and achieving the purpose of taking effect rapidly.

The present invention provides tandospirone dispersible tablets, which is prepared from the following raw materials and auxiliary materials: 1-8% by weight of tandospirone or a pharmaceutically acceptable salt, 65-90% by weight of a filler, and 4-30% of a disintegrant. According to the present invention, the prepared tandospirone dispersible tablets have characteristics of rapid disintegration rate and high dissolution rate compared with the conventional tablets, can be efficiently absorbed in the digestive tract so as to obtain high bioavailability, can be taken after being dispersing in water, has fragrant and sweet taste, and is more suitable for people with poor absorption of oral formulations, people with swallowing difficulty, and old people or children with low medication compliance.