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Anti-dementia medicinal orally disintegrating tablet and preparation method thereof

A technology for oral disintegrating tablets and medicines, which is applied in the directions of medicine combinations, medicine formulations, and devices for making medicines into special physical or taking forms, and can solve the problems of slow absorption, inconvenient taking, and difficult to swallow.

Active Publication Date: 2012-07-04
BEIJING QUANTUM HI TECH PHARMA TECHCO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Injection administration is extremely inconvenient for patients, and compliance is poor; ordinary oral preparations such as tablets and capsules must be taken with water or liquid preparations, which are not only inconvenient to take, difficult to swallow, but also difficult to absorb. It is slow, not suitable for the elderly, children, and patients with difficulty in swallowing such as those who are bedridden and difficult to change

Method used

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  • Anti-dementia medicinal orally disintegrating tablet and preparation method thereof
  • Anti-dementia medicinal orally disintegrating tablet and preparation method thereof
  • Anti-dementia medicinal orally disintegrating tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0131] Huperzine A 50mg

[0132] Mannitol 7.00g

[0133] Pullulan 7.20g

[0134] Citric acid 0.06g

[0135] Acesulfame K 0.10g

[0136] Purified water 185.59g

[0137] A total of 1000 pieces were made.

[0138] The specific preparation method is as follows: mix huperzine A, mannitol, pullulan, citric acid, and acesulfame K evenly, add purified water in the prescribed amount to it, and mix to form a homogeneous solution; After inflating, pour it into the mold accurately; pre-freeze at -40°C to -170°C for 1 to 60 minutes, then transfer to a freeze dryer, and freeze at a pressure of 0.01mbar to 10mbar and at a temperature of -30°C to 30°C After drying for 1-10 hours, the orally disintegrating tablet of huperzine A of the present invention is obtained; in the above method, after the pre-freezing step, an ice crystal incubation step can also be added before transferring to the lyophilizer, that is, the mold filled with the solution after pre-freezing , placed in a low tempera...

Embodiment 2

[0140] Huperzine A 50mg

[0141] Glycine 7.00g

[0142] Pullulan 7.20g

[0143] Citric acid 0.06g

[0144] Acesulfame K 0.10g

[0145] Purified water 185.59g

[0146] A total of 1000 pieces were made.

[0147] The specific preparation method is as follows: mix huperzine A, glycine, pullulan, citric acid, and acesulfame K evenly, add the purified water of the prescribed amount to it, and mix to make a homogeneous solution; the following preparation method is the same as the implementation example 1.

Embodiment 3

[0149] Huperzine A 50mg

[0150] Glycine 3.60g

[0151] Mannitol 3.00g

[0152] Pullulan 4.00g

[0153] Sodium alginate 3.00g

[0154] Citric acid 0.06g

[0155] Aspartame 0.08g

[0156] Purified water 186.21g

[0157] A total of 1000 pieces were made.

[0158] The specific preparation method is as follows: mix huperzine A, glycine, mannitol, pullulan, sodium alginate, citric acid, and aspartame evenly, add purified water in the prescribed amount to it, and mix to make Homogeneous solution; The following preparation method is the same as in Example 1.

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Abstract

The invention discloses an anti-dementia medicinal orally disintegrating tablet and a preparation method thereof, and relates to an anti-dementia medicinal orally disintegrating tablet and a prescription and a process for preparing the anti-dementia medicinal orally disintegrating tablet with a freeze-drying method. The anti-dementia medicinal orally disintegrating tablet disclosed by the invention is prepared from a main medicament and medicinal auxiliary materials, can be taken without water, is quickly disintegrated after being put into mouth, and is suitable for patients suffering from dysphagia such as the aged, children and the like; meanwhile, the anti-dementia medicinal orally disintegrating tablet is suitable for taking under the condition that a water source is difficult to obtain during traveling; the anti-dementia medicinal orally disintegrating tablet has the advantages of convenience for taking, quick absorption, small first pass effect, small irritation on digestive canal mucosa and the like, and has a wide market application prospect; and moreover, the anti-dementia medicinal orally disintegrating tablet can be used for remarkably reducing the side effects of an anti-dementia medicament. Moreover, the invention further relates to a preparation method of the anti-dementia medicinal orally disintegrating tablet.

Description

Technical field: [0001] The invention relates to an orally disintegrating anti-dementia drug tablet and a preparation method thereof, in particular to an orally disintegrating anti-dementia drug tablet prepared by a freeze-drying method. Background technique: [0002] Dementia refers to mental deterioration caused by psychogenic (such as praecox) or by diseases that damage brain matter (such as neurosyphilis or arteriosclerosis), and is a syndrome caused by progressive brain diseases with a slow course. With the acceleration of the aging society worldwide, neurodegenerative diseases of brain function decline, Alzheimer's disease and dementia have become the fourth largest killers after cardiovascular and cerebrovascular diseases, cancer and stroke. At present, among the nearly 6 billion people in the world, about 400 million people have entered the old age. By 2025, the world's elderly population over 65 years old will reach 800 million, and my country will also enter an agi...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/4748A61K31/445A61K31/13A61K31/55A61K31/27A61P25/28A61J3/00
Inventor 王丛威王洪飞王丽滨赵淑欣周立运
Owner BEIJING QUANTUM HI TECH PHARMA TECHCO
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