Preparation and application of florfenicol slowly-releasing micropill for treating animal digestive canal infection

Abstract

The invention relates to preparation and application of florfenicol slowly-releasing micropills for treating animal digestive canal infection. The implementation comprises the following steps: weighing drug accessories and florfenicol raw materials according to the proportion of weight ratio 0.1-10:1, preparing micropills whose grain size dimension is between 0.5 to 3mm, wrapping a non-pH dependency high molecular polymer film outside the micropills, wherein the film contains low molecular water-soluble materials. Slowly-releasing micropills containing florfenicol is wrapped by non-pH dependency high molecular polymer materials, water-soluble materials such as mannidex, antacidin or natrii chloridum are added in the wrapping film, after people take the wrapped micropill orally, the water-soluble component in the wrapping film is dissolved to form a pore passage, and the drug is slowly released from the pore passage and exerts the long-term curative effect in the intestinal tract. The drug is different from traditional drug feeding modes in that higher drug concentration can be kept in intestinal tracts for long time, directional distribution of the drug in the intestinal tract can lower the side effects of drug to other organs and tissues, and the treatment cost can be lowered due to less drug dosage.

Description

technical field [0001] The invention relates to a preparation method of sustained-release pellets, in particular to the preparation and application of florfenicol sustained-release pellets for treating animal digestive tract infections. Background technique [0002] At present, digestive tract diseases caused by bacteria are common diseases in mammals, such as diarrhea and enteritis. For such gastrointestinal diseases, the existing treatment methods are mostly oral premixes of sensitive antibacterial drugs, or intramuscular injections. Although the above treatment methods can kill pathogenic bacteria in the intestinal tract to a certain extent, At the same time, there are two disadvantages: after injection or oral administration, the systemic distribution of the drug leads to a decrease in the concentration of the drug at the treatment site. In addition, the accumulation of the drug at the non-treatment site will cause unnecessary side effects. [0003] Therefore, to provid...

AI Technical Summary

Problems solved by technology

For such gastrointestinal diseases, the existing treatment methods are mostly oral premixes of sensitive antibacterial drugs, or intramuscular injections. Although the above treatment methods can kill pathogenic bacteria in the intestinal tract to a certain extent, At the same time, there are two disadvantages: after injection or oral administration, the systemic distribution of the drug leads to a decrease in the concentration of the drug at the treatment site; in addition, the accumulation of the drug in the non-treatment site will produce unnecessary toxic side effects