36 results about "Ph dependency" patented technology

Abuse resistant pharmaceutical formulations are provided that contain one or more abusable drugs and one or more abuse deterrent components. The abuse deterrent component(s) prevent the abusable drug(s) from being removed/extracted to an appreciable extent and/or rate. The abuse deterrent component(s) may be in the form of pellets, beads, beadlets, granules, powders, or the like, and may comprise a core that contains a material that is both hydrophilic and hydrophobic, and optionally a pH-dependent coating.

A genetically modified non-human animal is provided, wherein the non-human animal expresses an antibody repertoire capable of pH dependent binding to antigens upon immunization. A genetically modified non-human animal is provided that expresses a single light chain variable domain derived from a single rearranged light chain variable region gene in the germline of the non-human animal, wherein the single rearranged light chain variable region gene comprises a substitution of at least one non-histidine encoding codon with a histidine encoding codon. Methods of making non-human animals that express antibodies comprising a histidine-containing universal light chain are provided.

A sustained release formulation for opioid drugs is described. The formulation contains an opioid-ion exchange resin complex having a hybrid coating. The hybrid coating contains a cured polyvinylacetate polymer and a pH-dependent enteric coating layer mixed therein. Also provided are methods of making and using same.

Provided is a method and system for the rapid and accurate detection of growth and metabolism of a cellular microorganism in a population of microorganisms in a non-liquid, culture medium. Further provided is a gelled culture medium containing a non-toxic, water-soluble, phosphorescent compound which measures oxygen content (partial pressure) of an microorganism also contained therein, by oxygen-dependent quenching of phosphorescence; or the gel contains a fluorescent pH indicator that demonstrates growth of the microorganism by pH-dependent intensity change or wavelength shift in the emission spectrum. Further provided is a system and method for killing undesirable microorganisms or colonies in the culture medium without harming the surrounding microorganisms.

To provide an infrared shielding film, which has low production cost, can be prepared as a film with a large area, and has excellent reflecting property of infrared light, high visible light transmittance and excellent uniformity of optical characteristics.

An infrared shielding film which has at least one unit on a substrate, the unit having a low refractive index layer that contains first metal oxide particles and a first binder and a high refractive index layer that is arranged adjacent to the low refractive index layer, contains second metal oxide particles and a second binder, and has a higher refractive index than the low refractive index layer, in which at least one layer of the low refractive index layer and the high refractive index layer contains, as a binder, at least one of the following (a) to (c):

(a) a carboxyvinyl polymer that contains a monomer component, which contains a carboxylic acid, in an amount of 20 to 75% by mass of the entire composition,

(b) a copolymer having pH dependency of viscosity, and

(c) a modified polyvinyl alcohol.

Polyfunctional reagents are disclosed that are capable of reversibly binding to target substances, for example nucleic acid, proteins, polypeptides, cells, cell components, microorganisms or viruses, for use in purifying or otherwise manipulating them. The reagents comprise a tagging group for manipulating and/or detecting the target substance when bound to the polyfunctional reagent. The polyfunctional reagents work by binding the target substance at a first pH and then releasing it at a second pH, usually higher than the first. Examples of tagging groups include tagging group members of a specific binding pair which is capable of binding to a specific binding partner and/or a label.

The invention provides a fluid for use in a subterranean formation penetrated by a wellbore, the fluid comprising: (a) water; (b) delayed release acid; (c) a surfactant comprising a tertiary alkyl amine ethoxylate generally represented by the following formula:

wherein R is an alkyl group or groups, X is ethylene oxide, and Y is ethylene oxide; and (e) a gelling agent. The invention also provides a method of fracturing a subterranean formation, comprising the step of forming a foamed fracturing fluid comprising water; a surfactant comprising a tertiary alkyl amine ethoxylate generally represented by the formula above; a gelling agent; and a gas. The method also provides the step of introducing the foamed fracturing fluid into a subterranean formation at a pressure sufficient to create a fracture in the subterranean formation. The method also provides the step of introducing an acid into the subterranean formation.

The invention describes a new device for the measurement of the partial pressure of carbon dioxide. The device is based on a simple construction and can be manufactured in a cost effective way. The pH dependency of the redox potential of organic substances is used to determine an electrical characteristic that depends on the partial pressure of carbon dioxide. The device for the potentiometric determination of the partial pressure of carbon dioxide consists of a housing with an opening for the entrance for gases, a gas permeable membrane, an electrolyte, at least one redox and one reference electrode with electrode contacts that transmit the electrode potential outwards through the housing. The gas permeable membrane has an electronically conductive layer that works as a redox electrode for a pH dependent redox system. The pH dependent redox system is adsorbed, absorbed or chemically bound onto the electronically conductive layer and interacts electrochemically with the electrode such that the pH dependent redox potential adjusts at the electrode according to the present partial pressure of carbon dioxide.

The invention provides a method for reducing bromine levels in brine solutions such as potassium chloride brine solutions. Bromide in solution is converted to hypobromite by the addition of an oxidant such as sodium hypochlorite. Hypobromite is precipitated by the addition of a metal cation such as magnesium under conditions of basic pH. The process is pH dependent such that the most efficient removal of bromine is achieved at a sodium hydroxide concentration of 90-200 mM. The pH optimum is also temperature dependent such that increased temperature lowers the optimal pH for bromide removal. The invention further provides a bromine-reduced potassium chloride product, suitable for uses in industrial applications. By the method of the invention bromine levels in a potassium chloride feed stock can be reduced by 97% or more.

The present invention relates to taste masking system, taste masked formulations, dosage forms made from those formulations and methods of making those formulations that involve dissolving or dispersing a pH dependant polymer and alprazolam in a solvent, granulating using that material or forming layers over a solid support therewith. This can be followed with the use of an overcoating layer.

This invention relates to pharmaceutical dosage forms, particularly to pH dependent pharmaceutical dosage forms with enhanced and/or prolonged distribution of a pharmaceutical compound at a target site. More specifically, this invention relates to a controlled release intravaginal pharmaceutical dosage form and, more particularly, to a pharmaceutical dosage form which comprises microspheres encapsulated and/or embedded within a bioerodible polymeric matrix, together the microspheres and the matrix are formed into a caplet and/or tablet.

The invention relates to preparation and application of florfenicol slowly-releasing micropills for treating animal digestive canal infection. The implementation comprises the following steps: weighing drug accessories and florfenicol raw materials according to the proportion of weight ratio 0.1-10:1, preparing micropills whose grain size dimension is between 0.5 to 3mm, wrapping a non-pH dependency high molecular polymer film outside the micropills, wherein the film contains low molecular water-soluble materials. Slowly-releasing micropills containing florfenicol is wrapped by non-pH dependency high molecular polymer materials, water-soluble materials such as mannidex, antacidin or natrii chloridum are added in the wrapping film, after people take the wrapped micropill orally, the water-soluble component in the wrapping film is dissolved to form a pore passage, and the drug is slowly released from the pore passage and exerts the long-term curative effect in the intestinal tract. The drug is different from traditional drug feeding modes in that higher drug concentration can be kept in intestinal tracts for long time, directional distribution of the drug in the intestinal tract can lower the side effects of drug to other organs and tissues, and the treatment cost can be lowered due to less drug dosage.

A pharmaceutical composition for oral administration comprising donepezil or pharmaceutically acceptable salt thereof, and an effective amount of pH dependent excipient as a taste masking agent, to suppress the release of donepezil in the pH environment of the oral cavity and increase the release of donepezil in acidic environment.

Disclosed herein is a surface-polishable iridium oxide composite hydrogen ion electrode and a method of manufacturing the same, and, more particularly, a surface-polishable iridium oxide composite hydrogen ion electrode, which has a long life due to its excellent physical strength, pH dependency approximate to a theoretical value (59 mV/pH unit), and high surface renewability, and a method of manufacturing the same. The iridium oxide composite hydrogen ion electrode according to the present invention is effective in that, when the electrode is contaminated or inactivated, the surface of the electrode can be regenerated through a simple polishing process because the electrode has high surface renewability, unlike conventional electrodes. The iridium oxide composite electrode according to the present invention can be usefully used in a water-quality monitoring system for monitoring the hydrogen ion concentration of a solution for a long period, an online pH measurement system, and pH measurement for samples, which causes serious contamination of the surface of a sensor.

The invention relates to the technical field of medicine analysis and specifically relates to a method for identifying whether one or more chemicals of theophylline, caffeine and theobromine are added into traditional Chinese medicines for relieving cough and asthma. The method comprises the following steps: pre-conditioning the pH value of a to-be-detected solution; collecting a one-dimensional dynamic surface-enhanced Raman spectrum chart; drawing a pH dependency-two-dimensional correlation surface-enhanced Raman spectrum chart; and identifying whether one or more chemicals of theophylline, caffeine and theobromine are added into a to-be-detected sample. The step of pre-conditioning the pH value in the method can guarantee that the spontaneous change in pH value occurs in the most sensitive scope of substances, a more distinctive dynamic change Raman spectrum chart can be acquired, the specificity is strong, the sensitivity is high, the operation steps are simple, the detection time is short, and whether the theophylline, caffeine or theobromine is added into the traditional Chinese medicines for relieving cough and asthma can be accurately identified.

The invention discloses a hepatoma targeting carbon nano tube loaded with doxorubicin hydrochloride and a preparation method thereof. Amidation reaction of amino in a chitosan structure and carboxyl in lactobionic acid is carried out; galactosyl is coupled to chitosan so as to obtain galactosylated chitosan; the galactosylated chitosan is modified onto the carbon nano tube; therefore, the water solubility and the biocompatibility of the carbon nano tube are increased; simultaneously, the specificity of non-reductive galactose or N-acetyl-galactose is identified and taken by utilizing an asialoglycoprotein acceptor on a liver parenchyma cell membrane, so that the active hepatoma targeting effect is realized; simultaneously, doxorubicin hydrochloride is combined with a vector in a non-covalent manner through phi-phi accumulation acting force; and therefore, the hepatoma targeting carbon nano tube loaded with doxorubicin hydrochloride is prepared. The hepatoma targeting carbon nano tube disclosed by the invention is simple in preparation process, moderate in experimental condition and easy to operate; release of the medicine loaded targeting carbon nano tube has pH dependency, good biocompatibility and obvious in-vivo tumour inhibition effect; and thus, the hepatoma targeting carbon nano tube has good practical value.

The invention discloses an acidic blank pellet core, which comprises a blank pellet core and an organic acid and is used for substituting a common blank pellet core in a sustained-release pellet preparation. Medicaments can be prepared into the sustained-release pellet preparation which can be stably released under the condition that the pH is 1.5 to 7.4, the release pH dependency of most conventional weakly alkaline medicaments is eliminated, the medicinal preparation can be released in stomach and intestinal tracts stably and slowly, and the medicament effect is lasting. Moreover, the invention also discloses a preparation method for the acidic blank pellet core. The method is simple and convenient, and facilitates industrialized production; and the acidic blank pellet core substitutes the conventional blank pellet core, is used for the sustained-release pellet preparation, can eliminate the release pH dependency of the alkaline medicaments, and has a wide application prospect.