153 results about "Theobromine" patented technology

Personal care composition comprising from about 0.05% to about 5% of at least one aquaporin-stimulating compound selected from the group consisting of xanthine, caffeine; 2-amino-6-methyl-mercaptopurine; 1-methyl xanthine; 2-aminopurine; theophylline; theobromine; adenine; adenosine; kinetin; p-chlorophenoxyacetic acid; 2,4-dichlorophenoxyacetic acid; indole-3-butyric acid; indole-3-acetic acid methyl ester; beta-naphthoxyacetic acid; 2,3,5-triiodobenzoic acid; adenine hemisulfate; n-benzyl-9-(2-tetrahydropyranyl)adenine; 1,3-diphenylurea; 1-phenyl-3-(1,2,3-thiadiazol-5-yl)urea; zeatin; indole-3-acetic acid; 6-benzylaminopurine; alpha-napthaleneacetic acid; 6-2-furoylaminopurine; green tea extract; white tea extract; menthol; tea tree oil; ginsenoside-RB1; ginsenoside-RB3; ginsenoside-RC; ginsenoside-RD; ginsenoside-RE; ginsenoside-RG1; ginseng root extract; ginseng flower extract; pomegranate extract, extracts from Ajuga turkestanica; extracts from viola tricolor and combinations thereof; an additional ingredient selected from the group consisting of niacinamide, glycerin and mixtures thereof, and a dermatologically-acceptable carrier.

A composition for suppressing appetite and cravings for substances such as nicotine, coffee, sweets or chocolate while improving energy and enhancing mood comprises theobromine or a salt thereof at an effective amount of from about 250 to 4000 mg. Using such relatively high proportions of theobromine, without added caffeine or ephedrine provides an effective method for promoting weight control or to halt substance cravings without the side effects associated with such stimulants. The composition also includes Rhodiola rosea extract to offset stress effects from reduced food or substance intake, and to further improve mood, and clarity of thought and ability to handle stress, and to also increase endurance while reducing muscle pain.

This invention relates to novel compounds that are substituted xanthine derivatives and pharmaceutically acceptable salts thereof. For example, this invention relates to novel substituted xanthine derivatives that are derivatives of pentoxifylline. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions for which pentoxifylline and related compounds are beneficial.

The present invention provides a method for the preparation of a myceliated cacao bean or other agricultural product. This method includes providing cacao beans or other agricultural substrate, optionally hydrating the cacao beans or other agricultural product, and optionally pasteurizing or sterilizing the cacao beans or other agricultural substrate to provide prepared cacao beans or other agricultural substrate, and a step of inoculating the prepared cacao beans or other agricultural substrate with a prepared fungal component and culturing the inoculated cacao beans or other agricultural substrate to prepare the myceliated product. The methods of the instant invention result in prepared cacao beans or other agricultural substrate having reduced levels of undesirable taste components, such as theobromine, catechin, epicatechin, gallic acid equivalents, and / or 2-methoxy-3-isopropylpyrazine, and increased levels of myceliation products, such as fungal β-glucans, chitin, proteins, glycoproteins, pyrazines and polysaccharides, relative to starting cacao beans or other agricultural substrate.

A novel composition of three recognized antitussive agents, when used in combination, work in an additive fashion to suppress cough. Each drug has a desirable effect of suppressing cough in a unique fashion. However, undesirable side effects can occur in humans at concentrations at which the drug has its maximal antitussive effect. Pharmaceutical compositions of theobromine, dextromethorphan, and an antihistamine with central nervous system effect, such as dexbrompheniramine, maximize cough suppression while decreasing the likelihood of side effects when used in combination.

This invention relates to novel compounds that are substituted xanthine derivatives and pharmaceutically acceptable salts thereof. For example, this invention relates to novel substituted xanthine derivatives that are derivatives of pentoxifylline. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions for which pentoxifylline and related compounds are beneficial.

A stimulant-containing nutrition bar where the stimulant added to the bar exhibits a physical structure which is compatible with the manufacturing process used to prepare a nutrition bar. Simultaneously, the physical structure and the chemical composition of the stimulant reduces the amount of bitter taste which is experienced by a person eating the nutrition bar. Stimulants of the kind which are useful in the nutrition bar must be approved as food grade materials and are typically selected from the group consisting of caffeine, theobromine, green tea with high EGCG, taurine, ginseng, synephrine, and combinations thereof. The amount of stimulant present in the nutrition bar ranges from about 0.08% by weight to about 0.16% by weight of the nutrition bar.

The invention relates to a slow release formulation of hexanone theobromine, which contains hexanone theobromine used as the active components and slow release materials, filling agents, stabilizing agents, lubricants and bonds all used as accessories; wherein, each of the slow release tablet contains hexanone theobromine for 100 to 800mg, the slow release materials at least contain hydroxypropyl methylcellulose. The medicine releasing is controlled by adding slow release materials hydroxypropyl methylcellulose and other slow release materials; simultaneously the stabilizing agents are added in order to elevate the stability of the hexanone theobromine in the slow release formulation.

The invention discloses a making method of theanine of decatechin low-caffeine in the biochemical technical domain, which is characterized by the following: combining film predisposing method and cationic ion exchange fiber adsorbing method; extracting 20-80% theanine detected by high-effective liquid-phased chromatogram; making the total quantity of catechin less than 1% and the total quantity of caffeine, theobromine and caffeine less than 1%. The invention possesses simple technique, short manufacturing period and low cost, which is fit for large scale of industrial manufacturing.

The present invention provides a topical composition comprising about 6% to about 15% nifedipine and about 6% to about 15% pentoxifylline for treating severe vascular occlusive wounds. The present invention also provides a method and a kit for treating the vascular occlusive wound by applying the composition to the open wound, and cleaning and dressing the wound at least once daily.

The present invention comprises compositions comprising combinations of compositions of extracts of kava mate' extract compositions or theobromine. The invention further comprises methods for treating conditions related to mental and physical fatigue, anxiety, muscle tension, nervous depression, headache, obesity, and mild pain as well a enhancement of cognition and mental focus comprising administering effective amounts of the compositions of the present invention.

The invention provides a new method for preparing a theobromine by a 3-methyl xanthine disodium salt methylation with more production value. The theobromine is prepared by using acetone as a solvent to react with a dimethyl sulfate under the existence of a sodium carbonate and then acidified. The invention uses the acetone as the solvent and decreases the hydrolysis loss of the dimethyl sulfate; the sodium carbonate provides an alkaline condition for the methylation reaction and the Ph value is intermediate. The dimethyl sulfate is dropped to carry out the methylation reaction with the advantages of good selectivity and a yield higher than other methylation technique by more than 10 percent. The acetone is recycled and reused, the reaction is relatively complete and has little caffeine by-product, and the acquired analysis content of theobromine crude product HPLC is larger than 90 percent. The invention is extremely applicable to industrial production.The invention relates to a refining method of santheose, which is characterized in that dissolves liquid alkali into crude santheose solution, decolourizes, fitlers, and adds reduction agent into filter liquor, acidifies at 60-80 DEG C until pH=5-6, filters and dries to obtain santheose final product. The inventive method has refining yield of 90%, standard product color, high product quality, low cost and industrialization suitability.

This invention relates to novel compounds that are substituted xanthine derivatives and pharmaceutically acceptable salts thereof. For example, this invention relates to novel substituted xanthine derivatives that are derivatives of pentoxifylline. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions for which pentoxifylline and related compounds are beneficial.

The present invention relates to a composition for external skin application having a skin-moisturizing effect, which comprises gallocatechin gallate as an active ingredient. More particularly, the composition for external skin application comprises gallocatechin gallate as an active ingredient to activate peroxisome proliferator activated receptor isoform alpha (PPAR-α), to stimulate expression of filaggrin and involucrin that are skin-moisturizing factors, and thus to provide excellent anti-drying and skin-moisturizing effects. More particularly, the composition for external skin application may further comprise theobromine and quercetin in addition to gallocatechin gallate to maximize such effects.

The present invention relates to a synergistic pharmaceutical and / or neutraceutical flavanoid composition for management of Diabetes Mellitus, said composition comprising polyphenol of concentration ranging between 85 to 95% (w / w) GAE, theobromine of concentration ranging between 1 to 5% (w / w), and moisture content ranging between 0.5 to 10% (v / w).

The present invention comprises methods and compositions comprising Areca extract compositions and compositions comprising extracts of Ilex paraguariensis or theobromine. Methods of the invention comprise methods of making pharmaceutical or nutriceutical products comprising Areca catechu extract compositions and mate' extract compositions or theobromine, and methods of use of the extracted products and pharmaceutical and nutriceutical products. The present invention also comprises methods for treating conditions related to mental and physical fatigue and obesity, as well as, enhancement of mental focus, cognition, and a sense of well being, comprising administering the compositions of the present invention.

An improved method of treating male erectile dysfunction by enteral administration of a combination of sildenafil citrate and papavarine hydrochloride. An alternate mode of treatment indicated for individuals with known vascular disease includes the contemporaneous administration of pentoxifylline. Further embodiments include administration of zinc monomethionine aspartate.

A parturition hastening accessory ingredient used for artificially propagating briny fishes relates to medicine used for artificially propagating briny fishes. The invention aims to provide accessory medicine for artificially propagating briny fishes, which enables gonadotropic hormones to more quickly act on a target organ, shortens the effect time of ripe fishes, enhances the effect on promoting the sexual maturity and accelerating maturity, improves the rate for hastening parturition and simultaneously reduces the death rate in the post-partum period of the ripe fishes. Adopting hexanone theobromine and calcium hydroxybenzosulfonate which are medical raw materials in the technical scheme, the invention is characterized in that the hexanone theobromine and the calcium dobesilate which are the medical raw materials are finely ground and uniformly mixed to form the parturition hastening accessory ingredient and is used for artificially propagating briny fishes.

The invention discloses a microorganism fertilizer for promoting crop growth and a preparation method therefor. The microorganism fertilizer comprises the components in parts by weight: 100 parts of plant stalks, 0.08-0.16 part of 5A-hydroxyl laxogenin, 0.04-0.10 part of theobromine, 60-80 parts of chitosan hydrochloride, 0.8-1.2 parts of bacillus subtilis bacterium, 6-10 parts of lactobacillus powder, 4-8 parts of yeast powder, 8-20 parts of potassium dihydrogen phosphate, 6-10 parts of ferrous sulfate, 10-15 parts of calcium carbonate, 1-3 parts of magnesium chloride, 1-3 parts of molybdate, 1-3 parts of zinc sulfate, 1-3 parts of manganese sulfate and 1-3 parts of boric acid. The microorganism fertilizer disclosed by the invention comprises 5A-hydroxyl laxogenin and theobromine, the two components have mechanisms that promote growth, and compound use of the two components can further play synergy, so that the crop growth is significantly improved. In addition, after the chitosan hydrochloride is dissolved into soil, animal and plant residues and trace metal elements are decomposed, thereby transforming into nutrients of plants, improving plant immunity, and promoting plant health.

The invention relates to a method for inducing hormone soaked loaches. The method comprises the following steps: (1) selecting a mature loach parent in water at the temperature of between 21 and 29 DEG C; and (2) taking a mixture of domperidone maleate, luteotropin releasing hormone d-ala analog and chorionic gonadotropin as oxytocic hormones, and soaking the loach parent with a soaking solution which is prepared by mixing the oxytocic hormone, pentoxifylline and edible oil in normal saline, wherein the dosage of the domperidone maleate is between 100 and 300mg / kg, the dosage of the luteotropin releasing hormone d-ala analog is between 200 and 600mu g / kg, the dosage of the chorionic gonadotropin is between 15,000 and 30,000IU / kg, and the dosage of the normal saline is between 0.2 and 0.3kg / kg; and when the loach parent is soaked, the temperature of the soaking solution is controlled to be between 21 and 29 DEG C, and the soaking time is controlled to be between 0.5 and 8 hours. The aim of inducing the loach parent can be realized through soaking instead of injection.

The invention relates to a pentoxifylline injection composition and a preparation method thereof, belonging to the technical field of medical preparations. The injection composition is prepared from pentoxifylline, sodium dihydrogen phosphate, taurate, vitamin B6, disodium edetate and the like. The pentoxifylline injection composition is simple and feasible in technique. After the pentoxifylline injection composition is placed under accelerated test conditions for 6 months, the solution is still colorless, the pH value is basically unchanged, the increase of related substances is not obvious, the pentoxifylline content decrease is not obvious, and the product has obviously higher quality and stability than the control product.

A frozen confection product that has a relaxatory effect when consumed is provided, the product comprising a frozen composition and a chocolate composition or a chocolate analogue composition which comprises non-fat cocoa solids. The product comprises at least 0.01 wt% -aminobutyric acid (GABA) and at most 0.05 wt% theobromine.

A topical hair treatment or a topical dermatological or cosmetic composition includes a liquid having approximately 0.2 to 0.5 mg / mL of a xanthene derivative. The xanthene derivative can be a methylxanthene. The methylxanthene can be theophylline, caffeine, and / or theobromine. Preferably, the methylxanthene is caffeine selected from hydrous caffeine, caffeine salts, and complexes dissociated to yield caffeine. Caffeine is present in an amount of approximately 0.3 mg / mL. There is also provided a saw palmetto berry derivative present in the liquid in an amount of approximately 0.02 to 0.05 mg / mL. Preferably, the saw palmetto berry derivative is saw palmetto berry extract, in particular, hydrous saw palmetto berry extract. The saw palmetto berry extract is present in said liquid in an amount of approximately 0.03 mg / mL. The liquid can be a shampoo, a conditioner, and / or a combination shampoo and conditioner.

The invention belongs to the field of fat-reducing foods, and particularly relates to a solid beverage with functions of reducing fat and building muscles. The solid beverage is prepared from the following raw materials in parts by weight: 5-8 parts of ultrafine wheat gluten meal, 4-6 parts of superfine soybean meal, 3-5 parts of superfine coix seed powder, 2-5 parts of superfine corn stigma powder, 2-3 parts of superfine cissus repens powder, 0.5-1 part of withania somnifera extract, 2-3 parts of whey protein powder, 2-4 parts of purified conjac powder, 2-4 parts of flaxseed powder, 1-2 partsof HMB, 1-2 parts of L-arabinose, 0.4-0.5 part of xylooligosaccharide, 0.1-0.5 part of cinnamon polyphenols, 0.1-0.5 part of theobromine and 0.1-0.3 part of green tea polyphenols. The solid beverageis low in cost, has remarkable fat-reducing and muscle-building effects, and cannot generate dependence.

The invention provides a new method for preparing theobromine by 3-methyl xanthine disodium salt methylation with more production value. The theobromine is prepared by using acetone as a solvent to react with dimethyl sulfate under the existence of sodium carbonate and then acidified. The invention uses the acetone as the solvent and decreases the hydrolysis loss of the dimethyl sulfate; the sodium carbonate provides an alkaline condition for the methylation reaction and the pH value is moderate. The dimethyl sulfate is dripped to carry out the methylation reaction with the advantages of good selectivity and a yield higher than other methylation technique by more than 10 percent. The acetone is recycled and reused; the reaction is relatively complete and has little caffeine by-product; the acquired analytic content of theobromine crude product HPLC is larger than 99 percent; therefore, the invention is extremely applicable to industrial production.

The invention relates to a process for the extraction of cocoa shells to provide a theobromine-enriched fraction or composition and a polyphenol-enriched fraction or composition.

The invention discloses an environment-friendly refining method of theobromine, and relates to the technical field of synthetic chemistry. The method comprises the following steps: (1) dissolving a crude product to prepare a sodium salt; (2) carrying out decoloration; and (3) carrying out acidification and crystallization. According to the method provided by the invention, the theobromine in a theobromine crude product is converted into a sodium salt by adding a sodium hydroxide solution and insoluble impurities are filtered out; then, the decoloration effect is ensured by use of a decolorant,and pigment impurities are removed; and then, by controlling the pH value during acidification, the residual rate of theobromine in crystallization mother liquor can be reduced and the purity of theobromine in precipitated crystals can be increased. The prepared finished product of theobromine is white or creamy in appearance, and the residual rate of 3-methylxanthine is less than 0.15% or more,and meets requirements of the quality standard of theobromine; and the refining yield reaches 95% or more, thus reducing the loss amount of theobromine in a refining process.

The present invention pertains to flavor- and / or therapeutically-enhanced delivery of orally-administered medicines, natural substances, therapeutic materials and the like; in particular, the invention relates to apparatus and methods for rendering such items more attractive to a subject in need of same. In some embodiments a theobromine material and / or some marshmallow extract are included in combination with a whole or particles of, for example, a mentholated cough lozenge. The combination can be optionally coated with chocolate (and / or other) flavoring and / or coated, covered by or enveloped within a marshmallow or a marshmallow-flavored substance. The invention thus provides a family of consumable products that can be used to encourage patient compliance with a desired therapeutic regimen. Diverse single- and multiple-unit packaging is also included within the purview of the invention, including a kit of diverse materials including at least one of the inventive consumable products.

A process for preparing theobromine by methylating 3-methyl xanthine disodium salt comprises reacting 3-methyl xanthine disodium salt with dimethyl sulfate by using acetone as solvent in the presence of sodium carbonate and acidifying. The present application also provides a process for refining theobromine which comprises dissolving coarse theobromine in liquid alkaline solution, decolorizing, filtering, adding reducing agent in filtrate, and acidifying at 60-80 °C until pH is 5-6, filtering, and drying to obtain theobromine.

The present invention provides a method for the preparation of a myceliated cacao bean or other agricultural product. This method includes providing cacao beans or other agricultural substrate, optionally hydrating the cacao beans or other agricultural product, and optionally pasteurizing or sterilizing the cacao beans or other agricultural substrate to provide prepared cacao beans or other agricultural substrate, and a step of inoculating the prepared cacao beans or other agricultural substrate with a prepared fungal component and culturing the inoculated cacao beans or other agricultural substrate to prepare the myceliated product. The methods of the instant invention result in prepared cacao beans or other agricultural substrate having reduced levels of undesirable taste components, such as theobromine, catechin, epicatechin, gallic acid equivalents, and / or 2-methoxy-3-isopropylpyrazine, and increased levels of myceliation products, such as fungal β-glucans, chitin, proteins, glycoproteins, pyrazines and polysaccharides, relative to starting cacao beans or other agricultural substrate.