32results about How to "Overcome the disadvantage of prone to drug resistance" patented technology

A freeze-dried powder-injection of staphylococcus lysozyme for preventing and treating the endometritis of cow and the skin mucosa infection of other animals, and cleaning and restoring the postpartum uterus of cow is composed of staphylococcus lysozyme, bovine serum albumin, glycine, mannitol, and phosphate. Its preparing process is also disclosed.

The invention discloses a biological sterilization preparation, a preparation method and an application thereof, the biological sterilization preparation takes water as a carrier, and comprises the following components by weight percent: 0.001-10% of biological antibacterial peptide K11; and 0.01 to 1% of polyhexamethylene biguanide (PHMB). The product has a good sterilizing effect. A core sterilization component of the preparation is novel antibacterial peptide which has a very strong sterilization effect on staphylococcus aureus, escherichia coli, candida albicans and viruses. The sterilization rate can reach 99.9% after 2-5 minutes of in-vitro experiment. The product is high in safety, free of toxicity or residues to human bodies, high in stability and capable of being used as a preventive drug. The main acting component is a biological agent, and the defects that a traditional chemical preparation has irritation to mucosa, and bacteria easily generate drug resistance are overcome. The composition is easily accepted by organisms and has no toxic or side effect. The product is suitable for long-term use or preventive medication.

The invention relates to a traditional Chinese medical oral liquid used for curing diarrhea of poultries, which comprises two medicines of heartleaf houtluynia and honeysuckle. The medicament is suitable for curing the infection of digestive canal such as diarrhea and the like of poultries caused by germ. Based on the fact that the specific physiological structure of poultries can not digest wood fibre owing to the short genital tracts, the medicament is made into a dosage form of oral liquid which can be dispersed in drinking water and can be taken by sick poultries through drinking water, thereby being convenient for absorbing, and achieving the purpose of taking effect rapidly.

The invention belongs to the technical field of medicines, and specifically relates to a suppository for treating mammal endometritis. The preparation disclosed in the invention comprises the following components of: by weight, 0.004-0.01% of staphylococcus lysozyme, 0.1-4% of lysozyme, 10-80% of semisynthetic fatty glyceride, 1-20% of poloxamer 188(F68), 1-20% of HPMC, 5-50% of sodium bicarbonate and 5-50% of sodium dihydrogen phosphate. After the preparation provided by the invention enters into mammal uterus through administration, the preparation can undergo effervescence decomposition in a body fluid. The medicine is mixed in foams and rapidly released. Contact area between the medicine and mucosal of uterus becomes larger and the medicine can penetrate into deep portions of mucosa wrinkles so as to prolong the action time between the medicine and the mucosa, raise the concentration of the medicine on local tissues, further enhance the curative effect and effectively kill various pathogens which can cause endometritis.

The invention belongs to the technical field of medicines, and particularly relates to an effervescent suppository for treating mammal vaginitis. A preparation disclosed by the invention consists of the following components in percentage by weight: 0.01-0.04 percent of recombinant lysostaphin, 10-50 percent of lactose, 5-30 percent of microcrystalline cellulose, 1-20 percent of polyoxyl[40]stearate, 1-10 percent of povidone, 5-40 percent of sodium bicarbonate, 5-40 percent of sodium dihydrogen phosphate and 0.1-5 percent of superfine silica powder. The preparation can disintegrate in an effervescent manner in the presence of body fluid after entering the vagina of a mammal, and medicaments are released rapidly by being mixed in foam, so that the contact area between the medicaments and vaginal mucosa is increased, the medicaments can permeate deep into mucosa folds, the acting time of the medicaments on mucosa is prolonged, the local tissue medicament concentration is increased, the treatment effect is enhanced, and various pathogenic bacteria causing vaginitis are killed effectively.

The invention provides a formula of medicine for preventing and curing coccidiosis of chicken, which comprises Chinese medicinal antibiotic medicament and Nicarbazinum, the Chinese medicament is in the form of compound powder preparation which comprises dichroa febrifuga 500-1000ppm, coptis root 500-100 ppm, green chiretta 500-1000ppm.

The invention discloses a pesticide composition for preventing and treating banana thrips. The composition comprises active ingredients and an auxiliary agent, and the active ingredients comprise d-limonene and diethyl aminoethyl hexanoate. The active ingredients account for 2.5%-12% of the total weight of the pesticide composition. The diethyl aminoethyl hexanoate has a prevention and treatment effect on the banana thrips, the d-limonene and the diethyl aminoethyl hexanoate are compounded to achieve an obvious synergistic effect, and the prevention and treatment effect on the banana thrips is superior to the prevention and treatment effect of a single component of the diethylaminoethyl hexanoate and the d-limonene on the banana thrips.

The invention relates to a traditional Chinese medical oral liquid used for curing enteritis of poultries and cattle, which comprises three medicaments of potentilla, ash bark and phellodendron. The medical oral liquid is suitable for curing infection of digestive canal of poultries and cattle and curing the enteritis caused by germs and virus. Based on the fact that the specific physiological structure of the poultries can not digest wood fibre owing to the short genital tracts, the medicaments are made into a dosage form of oral liquid which can be dispersed in water and can be taken by sick poultries through drinking water, thereby being convenient for absorbing, and achieving the purpose of taking effect rapidly.

The invention discloses an agricultural bactericidal composition containing bupirimate and azoxystrobin. The agricultural bactericidal composition is prepared from effective components including the bupirimate and the azoxystrobin. The agricultural bactericidal composition solves the problem of insecticide resistance caused by long-term use of single doses of two products, namely the bupirimate and the azoxystrobin separately, and a mixture of the bupirimate and the azoxystrobin has the obvious synergism on controlling powdery mildew.

The invention belongs to the technical field of medicines, and specifically relates to a suppository for treating mammal endometritis. The preparation disclosed in the invention comprises the following components of: by weight, 0.004-0.01% of staphylococcus lysozyme, 0.1-4% of lysozyme, 10-80% of semisynthetic fatty glyceride, 1-20% of poloxamer 188(F68), 1-20% of HPMC, 5-50% of sodium bicarbonate and 5-50% of sodium dihydrogen phosphate. After the preparation provided by the invention enters into mammal uterus through administration, the preparation can undergo effervescence decomposition in a body fluid. The medicine is mixed in foams and rapidly released. Contact area between the medicine and mucosal of uterus becomes larger and the medicine can penetrate into deep portions of mucosa wrinkles so as to prolong the action time between the medicine and the mucosa, raise the concentration of the medicine on local tissues, further enhance the curative effect and effectively kill various pathogens which can cause endometritis.

The invention discloses a biological antibacterial polypeptide preparation as well as a preparation method and application of the biological antibacterial polypeptide preparation. The biological antibacterial polypeptide preparation takes water as a carrier and is prepared from the following components in percentage by weight: 0.1 percent to 10 percent of a biological antibacterial peptide BQ and 0.01 percent to 1 percent of polyhexamethylene biguanidine. The biological antibacterial polypeptide preparation has good sterilization effect. A core sterilization component of the preparation is a novel antibacterial peptide and has very high sterilization effect on staphylococcus aureus, escherichia coli, candida albicans and viruses. When an in-vitro experiment is carried out for 2min to 5min, 99.9 percent of sterilization rate can be realized. The biological antibacterial polypeptide preparation has high safety, has no toxicity to or residues to human bodies, has high stability and can be used as a prevention medicine. The main acting component is a biological preparation and the disadvantages that a traditional chemical preparation has irritation on mucosa and bacteria easily have drug resistance are overcome. The biological antibacterial polypeptide preparation is easily accepted by organisms, has no toxic side effect and is suitable for long-time utilization or used as the prevention medicine.

The invention discloses a herbicide composition containing sulfometuron methyl and MCPA-Na. The herbicide composition comprises the sulfometuron methyl and the MCPA-Na as active components and other additives comprising acetone, sodium hydroxide, sodium lignosulfonate, sodium chloride, xanthan gum and organic silicon. The herbicide composition solves a problem of drug resistance on the sulfometuron methyl in various weeds, is improved in fast-acting property and is long in effective time.

The invention relates to a Chinese medicinal granular formulation for increasing egg production of poultry which is prepared from 9 Chinese medicinal materials including astragalus, japanese teasel, atractylodes, eucommia bark, white peony root, psoralea fruit, Chinese yam, jujube, villous amomum. The medicament has effects of clearing away heat and toxic material, resolving dampness and fortifying the spleen, supplying qi and strengthening yang that is mainly used for treating egg production reduced and recovering egg production capability, can increase egg production and delay egg production fastigium. At the same time, the medicament formulation is the granular formulation by considering special physiological structure of poultry that genital tract is short and can not digest wood fibre, and can be dispersed rapidly, the sick poultry takes medicament by drinking water which is convenient and is easy to absorb, and can get rapid effect.

The invention discloses a pesticide composition for controlling banana thrips. The composition includes active ingredients and auxiliary agents, and the active ingredients include d-limonene and diethyl aminoethyl hexanoate. The active ingredient accounts for 2.5% to 12% of the total weight of the pesticide composition. The invention finds that diethyl aminoethyl hexanoate has a preventive and control effect on banana thrips, and the compounding of d-limonene and diethyl aminoethyl hexanoate has obvious synergistic effect, and the control effect on banana thrips is better than the single component of diethyl hexanoate and d-limonene Control effect on banana thrips.

The invention discloses a formula of a traditional Chinese medicine for preventing and curing chicken diseases and relates to the technical field of formula for preventing and curing the chicken diseases. The formula is prepared from the following raw materials: 0.4-0.5g of herba portulacae, 0.4-0.8g of radix isatidis, 0.20-0.50g of shiny chinquefoil herbs, 0.05-0.16g of tangerine peels and 0.05-0.16g of fructus crataegi. The formula is a pure traditional Chinese medicine formula, has obvious curative effect on preventing and curing gastrointestinal diseases and virus communicable diseases of chicken, overcomes the disadvantage that the chicken are liable to have drug resistance after being treated by western drugs, does not have side and toxic effects, is obvious in effect of promoting growth action of the chicken, is available in materials and lower in cost and can be popularized and applied in a large range.

The invention belongs to the technical field of medicines, and particularly relates to an effervescent suppository for treating mammal vaginitis. A preparation disclosed by the invention consists of the following components in percentage by weight: 0.01-0.04 percent of recombinant lysostaphin, 10-50 percent of lactose, 5-30 percent of microcrystalline cellulose, 1-20 percent of polyoxyl[40]stearate, 1-10 percent of povidone, 5-40 percent of sodium bicarbonate, 5-40 percent of sodium dihydrogen phosphate and 0.1-5 percent of superfine silica powder. The preparation can disintegrate in an effervescent manner in the presence of body fluid after entering the vagina of a mammal, and medicaments are released rapidly by being mixed in foam, so that the contact area between the medicaments and vaginal mucosa is increased, the medicaments can permeate deep into mucosa folds, the acting time of the medicaments on mucosa is prolonged, the local tissue medicament concentration is increased, the treatment effect is enhanced, and various pathogenic bacteria causing vaginitis are killed effectively.

The invention relates to a weeding composition containing ethanone,1-[3-(trifluoromethyl)phenyl]-o-[2,6-bis[(4,6-dimethoxy-2-pyrimidinyl)oxy]benzoyl]oxime and cyhalofop-butyl and relates to the technical field of production of weedicide. Effective components comprise the ethanone,1-[3-(trifluoromethyl)phenyl]-o-[2,6-bis[(4,6-dimethoxy-2-pyrimidinyl)oxy]benzoyl]oxime and the cyhalofop-butyl. The weight part ratio of the ethanone,1-[3-(trifluoromethyl)phenyl]-o-[2,6-bis[(4,6-dimethoxy-2-pyrimidinyl)oxy]benzoyl]oxime to the cyhalofop-butyl in the weeding composition ranges from (1 to 0.1) to (1 to 20). The ethanone,1-[3-(trifluoromethyl)phenyl]-o-[2,6-bis[(4,6-dimethoxy-2-pyrimidinyl)oxy]benzoyl]oxime and the cyhalofop-butyl are compounded so that the weeding composition has the effect of preventing and controlling weeds of paddy rice fields in an efficient and broad-spectrum manner; meanwhile, a weed control spectrum range is expanded; the weeding composition has a prevention and controleffect on various weeds of direct seeding paddy rice fields, such as barnyard grass, green bristlegrass, monochoria vaginalis, ammannia baccifera, ludwigia prostrate, rotala indica, digitaria sanguinalis, leptochloa chinensis, cyperus rotundus and sirpus yagara; the weeding composition has no influences on crops and the effect is better than that of single utilization of two weedicide varieties including the ethanone,1-[3-(trifluoromethyl)phenyl]-o-[2,6-bis[(4,6-dimethoxy-2-pyrimidinyl)oxy]benzoyl]oxime and cyhalofop-butyl.

The invention discloses an agricultural bactericidal composition containing bupirimate and azoxystrobin. The agricultural bactericidal composition is prepared from effective components including the bupirimate and the azoxystrobin. The agricultural bactericidal composition solves the problem of insecticide resistance caused by long-term use of single doses of two products, namely the bupirimate and the azoxystrobin separately, and a mixture of the bupirimate and the azoxystrobin has the obvious synergism on controlling powdery mildew.