Tandospirone dispersible tablets or coating dispersible tablets, and preparation method thereof

Abstract

The present invention provides tandospirone dispersible tablets, which is prepared from the following raw materials and auxiliary materials: 1-8% by weight of tandospirone or a pharmaceutically acceptable salt, 65-90% by weight of a filler, and 4-30% of a disintegrant. According to the present invention, the prepared tandospirone dispersible tablets have characteristics of rapid disintegration rate and high dissolution rate compared with the conventional tablets, can be efficiently absorbed in the digestive tract so as to obtain high bioavailability, can be taken after being dispersing in water, has fragrant and sweet taste, and is more suitable for people with poor absorption of oral formulations, people with swallowing difficulty, and old people or children with low medication compliance.

Description

technical field [0001] The invention relates to a tandospirone dispersible tablet or a coated dispersible tablet and a preparation method thereof. Background technique [0002] Tandospirone is a new type of anti-anxiety drug successfully developed by Sumitomo Pharmaceutical Co., Ltd. of Japan. It was approved for marketing in Japan in 1996 and entered the Chinese market in 2004. It is widely used in the field of anti-anxiety in China. [0003] Tandospirone acts selectively on 5-HT in the brain 1A Receptors, the action sites are concentrated in the hippocampus, amygdala and other limbic systems of the emotional center and project to the raphe nucleus of the 5-HT nerve, through the activation of presynaptic 5-HT 1A Receptors, inhibit neuron firing, reduce the synthesis of 5-HT, and at the same time inhibit the post-synaptic 5-HT 1A The receptor has a partial agonistic effect, so as to comprehensively regulate the 5-HT function of the synapse and exert an anti-anxiety effect....

AI Technical Summary

Problems solved by technology

[0006] The film-coated tablets and ordinary capsules currently on the market have the problems of long disintegration time or large particle size after disintegration, and slow dissolution, which affects the absorption of the drug, so it is difficult to increase the blood concentration after oral administration

If simply increasing the dosage to overcome the problem of low blood concentration will bring about an increased risk of adverse reactions

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