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Sangju effervescent tablet for treating common cold

A technology of effervescent tablets and mulberry leaves, which is applied in anti-infective drugs, drug delivery, plant raw materials, etc., and can solve the problems of increasing costs, limiting the application of effervescent agents in traditional Chinese medicine, production, transportation, carrying, and inconvenient use

Inactive Publication Date: 2006-03-08
JIANGXI HERBFINE HI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When traditional Chinese medicine is made into an effervescent dosage form, water extraction and alcohol extraction are usually used to obtain a variety of mixed macromolecular effective substances, including pectin, sugars, polysaccharides and other viscous substances. The disintegration is affected by viscous substances, and the disintegration is slow. On the other hand, in order to ensure the curative effect, the single-tablet Chinese medicine effervescent dosage form is taken in a large amount, which also affects the disintegration speed. In order to ensure disintegration, the excipients have to be increased The dosage makes some effervescent tablets need to be 4-5g / tablet, which not only increases the cost, but also brings inconvenience to production, transportation, carrying and use
The disintegration speed of traditional Chinese medicine effervescent preparations is as long as several minutes, and the advantages are not prominent compared with traditional Chinese medicine granules, which limits the application of traditional Chinese medicine effervescent preparations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] 1. Preparation of Sangju cold extract: Take 200 parts of mulberry leaves, 80 parts of chrysanthemum, 160 parts of bitter almond, 120 parts of forsythia, 64 parts of mint, 160 parts of bellflower, 160 parts of reed root, 64 parts of licorice, a total of eight flavors. Press the bitter almonds to remove the fatty oil, add water to distill to obtain 160 parts of bitter almond water; extract the volatile oil from mint; 160 parts of almond water were combined and dried to obtain a dry cream powder, and the peppermint volatile oil was wrapped with a little dextrin and then mixed with the dry cream powder to obtain the Sangju cold extract. The drying of the extract in the process is vacuum drying or spray drying. The drying temperature under reduced pressure is controlled at 50-80°C, preferably 60°C. A total of 63 copies of Sangju Ganmao extract were obtained, with a yield of 6.3%.

[0054] 2. Prepare Sangju cold effervescent solid tablets (100 tablets)

[0055] Formula rat...

Embodiment 2

[0064] 1, the preparation of Sangju cold extract: with embodiment 1.

[0065] 2. Sangju Ganmao Ring-shaped Effervescent Tablets (100 Tablets)

[0066] Formula ratio:

[0067] Sangju Cold Extract 77g Tartaric Acid 138g

[0068] Cyclamate 5g essence 2g

[0069] Sodium Bicarbonate 126g PEG 4000 5g

[0070] Crospovidone 24g PVP 23g

[0071] 3. Preparation method

[0072] The Sangju cold extract obtained by spray drying is sealed and stored for later use; tartaric acid, sodium bicarbonate, and microcrystalline cellulose are respectively crushed through a 100-mesh sieve, and sealed and stored for later use; cyclamate and essence are crushed through a 100-mesh sieve, and PEG 4000 is crushed 140-mesh sieve; during the preparation process, the environmental temperature of the preparation is controlled at 25°C and the humidity is below 45%; according to the required proportion, the Sangju cold extract and tartaric acid are evenly mixed, and then cyclamate and essence are added to m...

Embodiment 3

[0075] 1, the preparation of Sangju cold extract: with embodiment 1.

[0076] 2. Prepare Sangju Ganmao Ring-shaped Effervescent Tablets (100 tablets)

[0077] Formula ratio:

[0078] Sangju Cold Extract 44g Citric Acid 125g

[0079] Aspartame 7g Acesulfame K 5g Flavor 2g

[0080] Sodium bicarbonate 78g Potassium carbonate 90g

[0081] Sodium Carboxymethyl Cellulose 37g Magnesium Stearate 12g

[0082] 3. Preparation method

[0083]The Sangju cold extract obtained by spray drying is sealed and stored for later use; malic acid, citric acid, sodium bicarbonate, potassium carbonate, and cross-linked polyvinylpyrrolidone are respectively crushed through a 100-mesh sieve, and sealed and stored for later use; acesulfame potassium and essence are crushed Pass through a 100-mesh sieve, and the magnesium stearate is pulverized and passed through a 140-mesh sieve; during the preparation process, the ambient temperature of the formulation is controlled at 25°C and the humidity is belo...

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Abstract

The present invention relates to a Chinese medicine Sangju Ganmao effervescent tablet for curing wind-heat common cold, headache, cough, mouth dryness and sore throat. Specially, it is a ring-shaped effervescent tablet made up by using 8 Chinese medicinal materials of mulberry leaf, chrysanthemum flower, bitter apricot kernel, forsythia fruit, peppermint and others. Said invention also provides its preparation method.

Description

technical field [0001] The invention relates to the technical field of Chinese patent medicine effervescent tablets, in particular to Sangjumao effervescent tablets. Background technique [0002] At present, the main effervescent tablets in my country are health care products, such as vitamin C, calcium supplement effervescent tablets, and effervescent tablets for gynecological external use, such as Jieeryin effervescent tablets, metronidazole vaginal effervescent tablets, etc. But oral Chinese medicine effervescent preparations are less. And make the effervescent tablet of oral pure Chinese medicine preparation by Sangju cold formula, rarely see report. In addition, annular tablets have been used in the food industry for a long time, but they are rarely used in the field of medicine, especially in the field of effervescent tablet preparation, and there are few reports. [0003] Traditional Chinese medicine effervescent tablet is a new dosage form, which has the advantages ...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61K9/20A61K9/46A61P31/00A61P11/00
Inventor 罗晓健杨世林王跃生文毅黄周华曾燕斌傅国强
Owner JIANGXI HERBFINE HI TECH
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