166results about How to "Improve the disintegration effect" patented technology

A medical drug, in particular, solid preparations containing a medicinal ingredient with high tendency toward gelation, characterized by simultaneously containing a surface modifier and an acid or base. This characteristic realizes improvement to the disintegration easiness, production efficiency and stability of the solid preparations containing the above medicinal ingredient.

The invention relates to an oral troche which contains repaglinide or pharmaceutically acceptable derivatives of repaglinide as well as a preparation method of the oral troche. According to the preparation method, powder of repaglinide or pharmaceutically acceptable derivatives of repaglinide is directly pressed into troche, so that the production cost is remarkably lowered, and the disintegration and the dissolution rate are greatly improved. The bioavailability and the stability of the medicine can be improved, and the problem of low content uniformity of existing small-dose medicines formed by the direct pressing method is overcome, so that the quality of the troche is better guaranteed.

The invention discloses a tomato nutrient chewable tablet and a preparation method thereof. The active ingredient of the tomato nutrient chewable tablet comprises tomato and oligoisomaltose. The tomato nutrient chewable tablet of the invention has high nutrition value and distinctive flavor, combines the dual health care efficacies of lycopene and oligoisomaltose, can be easily carried with and eaten anytime and anywhere. The invention adopts a method of rolling powder into tablet directly for preparing the tomato nutrient chewable tablet so that the problem that wet granulating is required before rolling during the production process of nutrient chewable tablet of the same category is solved and no rolling accessories or additives are necessary, thus simplifying the process procedure and improving the process efficiency.

An oral disintegrating tablet of azimycin is prepared from azimycin, water-soluble filler, disintegrant, lubricant, and wetting agent or adhesive.

The invention discloses a hydraulic pulper. The hydraulic pulper comprises a tank body, rotors, a screen plate, a bracket, a first support column and a second support column, wherein the screen plate is positioned at the lower end of the tank body, and is used for supporting the tank body; a material dropping opening and a water spray pipe are arranged at the top part of the tank body, the bottom part of the tank body is provided with a slag outlet and a pulp outlet, the slag outlet is positioned above the screen plate, and the pulp outlet is positioned under the screen plate; the cross section of the tank body is in a splay shape, and the tank body comprises a first cavity and a second cavity; the first support column is arranged in the middle of the first cavity, and the second support column is arranged in the middle of the second cavity; the rotors comprise a first rotor and a second rotor, motors are respectively arranged at the lower parts of the first rotor and the second rotor, and the rotation directions of the two motors are opposite; the first rotor is sheathed on the first support column, the second rotor is sheathed on the second support column, and the first rotor and the second rotor are not positioned on the same horizontal surface. Compared with the prior art, the hydraulic pulper has the advantages that the dead corner is avoided, the utilization rate of energy is higher, and the pulping efficiency is higher.

The invention relates to stable enalapril maleate capsules and a preparation method thereof, and belongs to the technical field of medicine. Enalapril maleate, lactose monohydrate, microcrystalline cellulose, startch, hydroxypropyl methyl cellulose, sodium alga acid, poloxamer 407, polyethylene glycol 4000 and L-arginine are preferably used as medical components of the stable enalapril maleate capsules, the degradation speed of the enalapril maleate is remarkably decreased through the mutual synergistic effect, the stability of the enalapril maleate capsules is greatly improved, and it is ensured that clinical medicine is safe, effective and capable of being stored for a long time.

The invention discloses an anti-permeation type tundish light coating and a preparation method thereof. The anti-permeation type tundish light coating comprises the following components in parts by weight: 73-99 parts of magnesite and/or forsterite with the granularity less than or equal to 1mm, 0.1-15 parts of quartz sand, 0.2-4 parts of sulfamic acid, 0.1-3.0 parts of an organic plasticizer agent, 0.5-5 parts of composite fiber, 0.02-0.25 part of high-efficiency air entraining agent and 0.01-0.15 part of metal aluminum powder. The coating disclosed by the invention is small in volume density, high in pressure resisting intensity after being baked, small in low melt and capable of effectively preventing slag permeation and solving the problems of a conventional light coating in construction, baking and use.

The invention relates to a roxithromycin capsule and a preparation method of the roxithromycin capsule. The roxithromycin capsule is prepared from the following constituents in percentage by weight:50-75 % of roxithromycin, 5-25 % of corn starch, 10-30 % of low-substituted hydroxypropyl cellulose, 0.5-6 % of a wetting agent, 0.5-3 % of a binder, and 0.5-3 % of a lubricant, wherein the binder ispolyvinylpyrrolidone; the wetting agent is selected from sodium dodecyl sulfate, Tween 80 and poloxamer; and the lubricant is selected from one or more of micropowder silica gel, magnesium stearate and talcum powder.

A fluidized bed apparatus has a rotary rotor 4 arranged at the bottom center thereof, a disintegrator mechanism 5 arranged above the rotary rotor 4, and a cylindrical draft tube 6 installed above the disintegrator mechanism 5. A fluidizing gas jetted from a gas dispersion plate 3 causes powder particles P in a processing container 1 to form a fluidized bed in which they circulate so as to ascend through the gap between the outer periphery of the rotary rotor 4 and the bottom inner wall of the processing container 1, the space between the disintegrator mechanism 5 and the inner wall of the processing container 1, and the space between the outer periphery of the draft tube 6 and the inner wall of the processing container 1, and descend through the inner portion of the draft tube 6.

The present invention provides a preparation with improved disintegration property, a preparation showing improved bioavailability of a medicament, production methods thereof and the like. A rapidly disintegrating preparation comprising granules comprising a medicament coated with a coating layer containing sugar or sugar alcohol; and a disintegrant. A production method of a rapidly disintegrating preparation including a step of producing granules comprising a medicament, a step of forming a coating layer containing sugar or sugar alcohol on the obtained granules and a step of mixing the coated granules with a disintegrant and molding the mixture.

The invention discloses an intestinal disease treatment pharmaceutical composition and a preparation method thereof. The intestinal disease treatment pharmaceutical composition comprises, by weight, 100 parts of calcium polycarbophil, 7.5-30 parts of disintegrant, 19-48 parts of stuffing, 0.5-4 parts of lubricant and 2.5-8 parts of propylene glycol. The propylene glycol added into the intestinal disease treatment pharmaceutical composition has function of improving tissue structure of the composition and making gaps among particles more uniform so as to quicken disintegration of the particles in an acid environment. As the intestinal disease treatment pharmaceutical composition is prepared by a way of adding the disintegrant in granulation and mixing the disintegrant after granulation, the intestinal disease treatment pharmaceutical composition tablet has good disintegration effect.

The invention provides an erythromycin ethylsuccinate chewable tablet and a preparation method thereof, and relates to the technical field of medicine production. The erythromycin ethylsuccinate chewable tablet consists of erythromycin ethylsuccinate, starch and sucrose. The tablet disclosed by the invention is capable of overcoming the shortcomings of a normal chewable tablet, and reducing the variety and dosage of accessories in the erythromycin ethylsuccinate chewable tablet; and the medicine preparation is excellent in performance, high in bioavailability, good in stability, high in patient acceptability and free from grittiness, and has important clinical application value.

The invention relates to the field of pharmaceutical preparation, and specifically relates to a dimemorfan phosphate tablet composite and a preparation method thereof. The composite comprises the following active ingredients in percentage by weight: 8-8.2% of dimemorfan phosphate tablets, 72-73% of microcrystalline cellulose, 9-10% of calcium bicarbonate, 6-7% of sodium carboxymethyl starch, and 0.7-1% of magnesium stearate. The method for preparing a dimemorfan phosphate tablet composite provided by the embodiment of the invention comprises the steps of sieving, mixing, granulating, total mixing, pelleting and the like. A dimemorfan phosphate tablet disclosed by the embodiment of the invention has the advantages of low cost and good pharmaceutical effect, becomes one of the domestic low-cost and high-efficiency antibechic, and has an extremely good promotion value; and the preparation method of dimemorfan phosphate tablets provided by the embodiment of the invention has the advantages of simple preparation process and high production efficiency.

The invention relates to molding material mixtures containing a molding base material, water glass, amorphous silicon dioxide and an oxidic boron compound, and the production of molds and cores, in particular for metal casting.

The invention provides aspirin composition freeze-dried tablets and a preparation method thereof, and relates to the technical field of medicine and medicine production. The aspirin composition freeze-dried tablets comprise aspirin, starch and sucrose, wherein starch and sucrose are used as accessories. Ordinary corn starch is treated by a heating process, so that the bonding and disintegration effects of starch in the tablets can be improved, and the forming property of the tablets can be improved; only starch and sucrose are required to be used as the accessories of the aspirin composition freeze-dried tablets. A two-cooling two-heating freeze-drying process is adopted for the aspirin composition freeze-dried tablets, and by twice cooling and twice heating, better forming property of the tablets can be achieved, and the dissolubility of the tablets is improved, so that the bioavailability of the tablets is improved. According to the tablets, the defects of ordinary aspirin tablets are overcome, the sort and using amounts of the accessories in the aspirin tablets are reduced, the tablets are high in dissolubility and bioavailability, and the curative effects and safety of clinical mediation are ensured.